scholarly journals Rapid assay for thein vitro chemosensitivity testing of human breast tumours

1989 ◽  
Vol 11 (6) ◽  
pp. 244-244
Author(s):  
R. F. M. Oude Elferink ◽  
H. M. J. Goldschmidt ◽  
H. J. Majoor ◽  
J. F. Leijten
Keyword(s):  
Human Breast ◽  
Breast Tumours ◽  
Chemosensitivity Testing ◽  
Rapid Assay

Rapid assay for thein vitro chemosensitivity testing of human breast tumours

1989 ◽  
Vol 11 (5) ◽  
pp. 155-160 ◽  
Author(s):  
R. F. M. Oude Elferink ◽  
H. M. J. Goldschmidt ◽  
H. J. Majoor ◽  
J. F. Leijten
Keyword(s):  
Human Breast ◽  
Breast Tumours ◽  
Chemosensitivity Testing ◽  
Rapid Assay

The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue

2001 ◽  
Vol 70 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Mumtaz Iscan ◽  
Tuula Klaavuniemi ◽  
Tulay Çoban ◽  
Nilgun Kapucuoğlu ◽  
Olavi Pelkonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Human Breast ◽  
Cytochrome P450 Enzymes ◽  
Breast Tumours

A cross-linking assay allows the detection of receptors for the somatostatin analogue, lanreotide in human breast tumours

1993 ◽  
Vol 29 (11) ◽  
pp. 1589-1592 ◽  
Author(s):  
Grégoire Prévost ◽  
Philippe Provost ◽  
Valérie Sallé ◽  
Monique Lanson ◽  
François Thomas
Keyword(s):  
Cross Linking ◽  
Somatostatin Analogue ◽  
Human Breast ◽  
Breast Tumours

Significance of Ca antigen expression in human breast tumours

1985 ◽  
Vol 13 (2) ◽  
pp. 458-458
Author(s):  
DAKSHA P. TRIVEDI ◽  
HAROLD BAUM ◽  
MICHAEL BAUM
Keyword(s):  
Antigen Expression ◽  
Human Breast ◽  
Breast Tumours

scholarly journals Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours

2018 ◽  
Vol 20 (1) ◽  
Author(s):  
Eleanor Broadberry ◽  
James McConnell ◽  
Jack Williams ◽  
Nan Yang ◽  
Egor Zindy ◽  
...  
Keyword(s):  
Tissue Mechanics ◽  
Circadian Clocks ◽  
Human Breast ◽  
Breast Tumours ◽  
Primary Human Breast

scholarly journals EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Deepika Neelakantan ◽  
Hengbo Zhou ◽  
Michael U. J. Oliphant ◽  
Xiaomei Zhang ◽  
Lukas M. Simon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Tumour Cells ◽  
Human Breast ◽  
Breast Tumours ◽  
Cancer Models ◽  
Pdx Models

Abstract Recent fate-mapping studies concluded that EMT is not required for metastasis of carcinomas. Here we challenge this conclusion by showing that these studies failed to account for possible crosstalk between EMT and non-EMT cells that promotes dissemination of non-EMT cells. In breast cancer models, EMT cells induce increased metastasis of weakly metastatic, non-EMT tumour cells in a paracrine manner, in part by non-cell autonomous activation of the GLI transcription factor. Treatment with GANT61, a GLI1/2 inhibitor, but not with IPI 926, a Smoothened inhibitor, blocks this effect and inhibits growth in PDX models. In human breast tumours, the EMT-transcription factors strongly correlate with activated Hedgehog/GLI signalling but not with the Hh ligands. Our findings indicate that EMT contributes to metastasis via non-cell autonomous effects that activate the Hh pathway. Although all Hh inhibitors may act against tumours with canonical Hh/GLI signalling, only GLI inhibitors would act against non-canonical EMT-induced GLI activation.

scholarly journals Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes

2012 ◽  
Vol 19 (4) ◽  
pp. 509-526 ◽  
Author(s):  
Dennis H Dowhan ◽  
Matthew J Harrison ◽  
Natalie A Eriksson ◽  
Peter Bailey ◽  
Michael A Pearen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Alternative Splicing ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Gene Expression Signature ◽  
Human Breast ◽  
Arginine Methyltransferase ◽  
Breast Tumours

Protein arginine methyltransferase-6 (PRMT6) regulates steroid-dependent transcription and alternative splicing and is implicated in endocrine system development and function, cell death, cell cycle, gene expression and cancer. Despite its role in these processes, little is known about its function and cellular targets in breast cancer. To identify novel gene targets regulated by PRMT6 in breast cancer cells, we used a combination of small interfering RNA and exon-specific microarray profilingin vitrocoupled toin vivovalidation in normal breast and primary human breast tumours. This approach, which allows the examination of genome-wide changes in individual exon usage and total transcript levels, demonstrated thatPRMT6knockdown significantly affected i) the transcription of 159 genes and ii) alternate splicing of 449 genes. ThePRMT6-dependent transcriptional and alternative splicing targets identifiedin vitrowere validated in human breast tumours. Using the list of genes differentially expressed between normal andPRMT6knockdown cells, we generated aPRMT6-dependent gene expression signature that provides an indication of PRMT6 dysfunction in breast cancer cells. Interrogation of several well-studied breast cancer microarray expression datasets with thePRMT6gene expression signature demonstrated that PRMT6 dysfunction is associated with better overall relapse-free and distant metastasis-free survival in the oestrogen receptor (ER (ESR1)) breast cancer subgroup. These results suggest that dysregulation ofPRMT6-dependent transcription and alternative splicing may be involved in breast cancer pathophysiology and the molecular consequences identifying a unique and informative biomarker profile.

scholarly journals A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B

1982 ◽  
Vol 207 (3) ◽  
pp. 633-636 ◽  
Author(s):  
A D Recklies ◽  
A R Poole ◽  
J S Mort
Keyword(s):  
Cathepsin B ◽  
Human Liver ◽  
Cysteine Proteinase ◽  
Human Breast ◽  
Breast Tumours ◽  
Monospecific Antiserum ◽  
Thiol Proteinase

The stable cathepsin B-like cysteine (thiol) proteinase secreted from human breast tumours in culture was shown to be destabilized by mercurial compounds. After such treatment the enzyme cross-reacts in a radioimmunoassay with a monospecific antiserum to human liver cathepsin B. It is suggested that the secreted enzyme may be a precursor form of lysosomal cathepsin B.

Detection of reverse transcriptase in human breast tumours with poly(Cm)·oligo(dG)

Nature ◽  
1975 ◽  
Vol 256 (5513) ◽  
pp. 140-143 ◽  
Author(s):  
GARY F. GERARD ◽  
PAUL M. LOEWENSTEIN ◽  
MAURICE GREEN ◽  
FRITZ ROTTMAN
Keyword(s):  
Reverse Transcriptase ◽  
Human Breast ◽  
Breast Tumours
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