New Drugs in Colorectal Cancer: A Review of Antitumor Activity and Cross-Resistance Patterns of Topoisomerase I Inhibitors, Thymidylate Synthetase Inhibitors, and Oxaliplatin

1998 ◽  
Vol 21 (2) ◽  
pp. 95-103 ◽  
Author(s):  
A. Harstrick ◽  
U. Vanhoefer ◽  
S. Seeber
Keyword(s):  
Colorectal Cancer ◽  
Antitumor Activity ◽  
Topoisomerase I ◽  
New Drugs ◽  
Thymidylate Synthetase ◽  
Cross Resistance ◽  
Topoisomerase I Inhibitors ◽  
Resistance Patterns

Design, synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors

2015 ◽  
Vol 25 (20) ◽  
pp. 4693-4696 ◽  
Author(s):  
Chao Zhang ◽  
Shasha Li ◽  
Liyan Ji ◽  
Shan Liu ◽  
Zhongjun Li ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Topoisomerase I ◽  
Design Synthesis ◽  
Topoisomerase I Inhibitors

Synthesis and Biological Evaluation of 1,5-Naphthyridines as Topoisomerase I Inhibitors. A New Family of Antiproliferative Agents

2015 ◽  
Vol 14 (23) ◽  
pp. 2722-2728 ◽  
Author(s):  
Concepcion Alonso ◽  
Maria Fuertes ◽  
Maria Gonzalez ◽  
Alicia Rodriguez-Gascon ◽  
Gloria Rubiales ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Biological Evaluation ◽  
Antiproliferative Agents ◽  
Topoisomerase I Inhibitors ◽  
New Family ◽  
Synthesis And Biological Evaluation

Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

2017 ◽  
Vol 13 (3) ◽  
Author(s):  
Balazs Balogh ◽  
Anna Carbone ◽  
Virginia Spanò ◽  
Alessandra Montalbano ◽  
Paola Barraja ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Topoisomerase I ◽  
Modeling Methods ◽  
Topoisomerase I Inhibitors
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