Decreased Blood Levels of Tumor Necrosis Factor-Alpha in Patients with Obsessive-Compulsive Disorder

1998 ◽  
Vol 37 (4) ◽  
pp. 182-185 ◽  
Author(s):  
Palmiero Monteleone ◽  
Francesco Catapano ◽  
Michele Fabrazzo ◽  
Alfonso Tortorella ◽  
Mario Maj
Keyword(s):  
Tumor Necrosis Factor ◽  
Obsessive Compulsive Disorder ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Blood Levels ◽  
Obsessive Compulsive ◽  
Necrosis Factor Alpha ◽  
Compulsive Disorder ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
N. Konuk ◽  
I. O. Tekın ◽  
U. Ozturk ◽  
L. Atik ◽  
N. Atasoy ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Necrosis Factor Alpha ◽  
Compulsive Disorder ◽  
Factor Alpha ◽  
Necrosis Factor

Aim. Recent research implicated place of an immune mechanism in the pathophysiology of obsessive-compulsive disorder (OCD). Despite increasing evidence involvement of cytokine release in OCD, results of the studies are inconsistent. The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in OCD patients.Methods. Plasma concentrations of TNF-αand IL-6 were measured in 31 drug-free outpatients with OCD, and 31-year age and sex-matched healthy controls. TNF-αand IL-6 concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA).Results. Both TNF-αand IL-6 levels showed statistically significant increases in OCD patients compared to controls (P<.000,P<.001, resp.). In addition, the age of onset was negatively correlated with TNF-αlevel (r=−.402,P=.025) and duration of illness was weakly correlated with IL-6 levels(r:.357;P:.048)in patients group.Conclusion. OCD patients showed increases in TNF-αand IL-6 levels compared to the healthy controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of OCD.

Blood Levels of Tumor Necrosis Factor Alpha and Its Type 2 Receptor Are Elevated in Patients with Boston Type I Keratoprosthesis

2019 ◽  
Vol 44 (6) ◽  
pp. 599-606 ◽  
Author(s):  
Eleftherios I. Paschalis ◽  
Elise V. Taniguchi ◽  
James Chodosh ◽  
Louis R. Pasquale ◽  
Kathryn Colby ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Blood Levels ◽  
Type I ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Boston Type I Keratoprosthesis ◽  
Necrosis Factor

scholarly journals Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development.

1992 ◽  
Vol 176 (5) ◽  
pp. 1259-1264 ◽  
Author(s):  
S de Kossodo ◽  
G E Grau ◽  
T Daneva ◽  
P Pointaire ◽  
L Fossati ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Tnf Alpha ◽  
Blood Levels ◽  
Lymphoid Tissues ◽  
Necrosis Factor Alpha ◽  
Igf I ◽  
Factor Alpha ◽  
Necrosis Factor

Tumor necrosis factor alpha (TNF-alpha), a major mediator of inflammation, also possesses a wide pleiotropism of actions, suggesting its involvement in physiological conditions. TNF-alpha mRNA is present in mouse embryonic tissues and also in fetal thymus and spleen. Repeated injections of a monospecific polyclonal rabbit anti-mouse TNF-alpha antibody in mice, starting either during pregnancy or at birth, led to a severe but transient growth retardation, already present at birth, reaching a 35% decrease in body weight at 3 wk, with complete recovery at 8 wk. The insulin growth factor I (IGF-I) blood levels were decreased to about 50%; growth hormone release and other endocrine functions were unaltered. A marked atrophy of the thymus, spleen, and lymph nodes was also observed, with lymphopenia and impaired development of T and B cell peripheral lymphoid structures. The pathways involving TNF-alpha in IGF-I release and early body growth are probably distinct from those by which TNF-alpha participates in early development of lymphoid tissues, where its low physiological release may contribute to enhance lymphoid cell expansion.

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