Neuroinflammation in the fetus exposed to maternal obsessive–compulsive disorder during pregnancy: A comparative study on cord blood tumor necrosis factor-alpha levels

2014 ◽  
Vol 55 (4) ◽  
pp. 861-865 ◽  
Author(s):  
Faruk Uguz ◽  
Erdem Onder Sonmez ◽  
Mine Sahingoz ◽  
Zeynel Gokmen ◽  
Mustafa Basaran ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Comparative Study ◽  
Cord Blood ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Obsessive Compulsive ◽  
Necrosis Factor Alpha ◽  
Compulsive Disorder ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Plasma Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Obsessive Compulsive Disorder

2007 ◽  
Vol 2007 ◽  
pp. 1-5 ◽  
Author(s):  
N. Konuk ◽  
I. O. Tekın ◽  
U. Ozturk ◽  
L. Atik ◽  
N. Atasoy ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Necrosis Factor Alpha ◽  
Compulsive Disorder ◽  
Factor Alpha ◽  
Necrosis Factor

Aim. Recent research implicated place of an immune mechanism in the pathophysiology of obsessive-compulsive disorder (OCD). Despite increasing evidence involvement of cytokine release in OCD, results of the studies are inconsistent. The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in OCD patients.Methods. Plasma concentrations of TNF-αand IL-6 were measured in 31 drug-free outpatients with OCD, and 31-year age and sex-matched healthy controls. TNF-αand IL-6 concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA).Results. Both TNF-αand IL-6 levels showed statistically significant increases in OCD patients compared to controls (P<.000,P<.001, resp.). In addition, the age of onset was negatively correlated with TNF-αlevel (r=−.402,P=.025) and duration of illness was weakly correlated with IL-6 levels(r:.357;P:.048)in patients group.Conclusion. OCD patients showed increases in TNF-αand IL-6 levels compared to the healthy controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of OCD.

Decreased Blood Levels of Tumor Necrosis Factor-Alpha in Patients with Obsessive-Compulsive Disorder

1998 ◽  
Vol 37 (4) ◽  
pp. 182-185 ◽  
Author(s):  
Palmiero Monteleone ◽  
Francesco Catapano ◽  
Michele Fabrazzo ◽  
Alfonso Tortorella ◽  
Mario Maj
Keyword(s):  
Tumor Necrosis Factor ◽  
Obsessive Compulsive Disorder ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Blood Levels ◽  
Obsessive Compulsive ◽  
Necrosis Factor Alpha ◽  
Compulsive Disorder ◽  
Factor Alpha ◽  
Necrosis Factor
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