Maternal Exposure to the Synthetic Cannabinoid HU-210: Effects on the Endocrine and Immune Systems of the Adult Male Offspring

1999 ◽  
Vol 7 (1) ◽  
pp. 16-26 ◽  
Author(s):  
Ignacio del Arco ◽  
Raúl Muñoz ◽  
Fernando Rodríguez de Fonseca ◽  
Leticia Escudero ◽  
Jose Luis Martín-Calderón ◽  
...  
Keyword(s):  
Adult Male ◽  
Maternal Exposure ◽  
Synthetic Cannabinoid ◽  
Male Offspring ◽  
Immune Systems

Maternal exposure to diets containing flaxseed flour or flaxseed oil during pregnancy and lactation protects the aortic remodeling in adult male offspring of diabetic rat dams

2015 ◽  
Vol 95 (14) ◽  
pp. 2973-2980 ◽  
Author(s):  
Gabriela Câmara Vicente ◽  
André Manoel Correia-Santos ◽  
Akemi Suzuki ◽  
Luis Guillermo Coca Velarde ◽  
Maurício Alves Chagas ◽  
...  
Keyword(s):  
Adult Male ◽  
Flaxseed Oil ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Diabetic Rat ◽  
Flaxseed Flour ◽  
Pregnancy And Lactation ◽  
Aortic Remodeling

scholarly journals Prenatal exposure to diesel exhaust PM2.5 causes offspring β cell dysfunction in adulthood

2018 ◽  
Vol 315 (1) ◽  
pp. E72-E80 ◽  
Author(s):  
Minjie Chen ◽  
Shuai Liang ◽  
Xiaobo Qin ◽  
Li Zhang ◽  
Lianglin Qiu ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Glucose Homeostasis ◽  
Adult Male ◽  
Diesel Exhaust ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Β Cells ◽  
Β Cell

Environmental stressors that encounter in early-life and cause abnormal fetal and/or neonatal development may increase susceptibility to non-communicable diseases such as diabetes. Maternal exposure to ambient fine particulate matter (PM2.5) is associated with various fetal abnormalities, suggesting that it may program offspring’s susceptibility to diabetes. In the present study, we therefore examined whether maternal exposure to diesel exhaust PM2.5 (DEP), one of the major sources of ambient PM2.5 in urban areas, programs adult offspring’s glucose metabolism. Female C57Bl/6J mice were intratracheally instilled with DEP or vehicle throughout a 7-wk preconceptional period, gestation, and lactation, and the glucose homeostasis of their adult male offspring was assessed. Intraperitoneal glucose tolerance test (IPGTT) revealed that the maternal exposure to DEP significantly impaired adult male offspring’s glucose tolerance. Unexpectedly, it did not influence their insulin sensitivity, whereas it significantly decreased their glucose-induced insulin secretion (GIIS). This deficit in insulin secretion was corroborated by their significant decrease in arginine-induced insulin secretion. Histological analysis demonstrated that the deficit in insulin secretion was accompanied by the decrease in pancreatic islet and β cell sizes. To differentiate the effects of maternal exposure to DEP before birth and during lactation, some offspring were cross-fostered once born. We did not observe any significant effect of cross-fostering on the glucose homeostasis of adult male offspring and the function and morphology of their β cells. Prenatal exposure to DEP programs the morphology and function of β cells and thus homeostatic regulation of glucose metabolism in adult male offspring.

Hypoxia or nutrient restriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring

2006 ◽  
Vol 20 (8) ◽  
pp. 1251-1253 ◽  
Author(s):  
Yi Xu ◽  
Sarah J. Williams ◽  
Darryl O'brien ◽  
Sandra T. Davidge ◽  
Yi Xu ◽  
...  
Keyword(s):  
Adult Male ◽  
Cardiac Remodeling ◽  
Male Offspring ◽  
Nutrient Restriction ◽  
Postischemic Recovery

Maternal Exposure to Δ 9 -Tetrahydrocannabinol ( Δ 9 -THC) Alters Indolamine Levels and Turnover in Adult Male and Female Rat Brain Regions

1997 ◽  
Vol 43 (2) ◽  
pp. 173-178 ◽  
Author(s):  
Francisco Molina-Holgado ◽  
Francisco J. Alvarez ◽  
Isabel Gonzalez ◽  
Maria T. Antonio ◽  
Maria L. Leret
Keyword(s):  
Rat Brain ◽  
Adult Male ◽  
Brain Regions ◽  
Maternal Exposure ◽  
Female Rat ◽  
Male And Female ◽  
Rat Brain Regions

Exposure to threshold doses of nicotine in utero: II. Neuroendocrine response to nicotine in adult male offspring

1994 ◽  
Vol 83 (2) ◽  
pp. 278-284 ◽  
Author(s):  
Russell E. Poland ◽  
Preetam Lutchmansingh ◽  
Denise Au ◽  
Chrissy Hsieh ◽  
Susan Afrane ◽  
...  
Keyword(s):  
Adult Male ◽  
In Utero ◽  
Male Offspring ◽  
Neuroendocrine Response ◽  
Threshold Doses

scholarly journals Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring

2017 ◽  
Vol 5 (6) ◽  
pp. e13210 ◽  
Author(s):  
Marcia S. Silva ◽  
Fabiana Lúcio-Oliveira ◽  
Andre Souza Mecawi ◽  
Lucas F. Almeida ◽  
Silvia G. Ruginsk ◽  
...  
Keyword(s):  
Adult Male ◽  
Male Offspring ◽  
Pregnancy And Lactation ◽  
Neuroendocrine Responses

Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats

Toxicology ◽  
2019 ◽  
Vol 418 ◽  
pp. 11-21 ◽  
Author(s):  
Shuwei Hu ◽  
Kexin Liu ◽  
Hanwen Luo ◽  
Dan Xu ◽  
Liaobin Chen ◽  
...  
Keyword(s):  
Adult Male ◽  
Cholesterol Synthesis ◽  
Male Offspring ◽  
Pka Pathway
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