Study of HLA as a Predisposing Factor and Its Possible Influence on the Outcome of Multiple Sclerosis in the Sanitary District of Calatayud, Northern Spain

1999 ◽  
Vol 18 (4) ◽  
pp. 203-209 ◽  
Author(s):  
M.A. Pina ◽  
J.R. Ara ◽  
P. Lasierra ◽  
P.J. Modrego ◽  
L. Larrad
Keyword(s):  
Multiple Sclerosis ◽  
Northern Spain ◽  
Predisposing Factor ◽  
Sanitary District

Prevalence of Multiple Sclerosis in the Sanitary District of Calatayud, Northern Spain: Is Spain a Zone of High Risk for this Disease?

1998 ◽  
Vol 17 (5) ◽  
pp. 258-264 ◽  
Author(s):  
M.A. Pina ◽  
J.R. Ara ◽  
P.J. Modrego ◽  
F. Morales ◽  
J.L. Capablo
Keyword(s):  
Multiple Sclerosis ◽  
High Risk ◽  
Northern Spain ◽  
Sanitary District

scholarly journals Prevalence of multiple sclerosis in the region of Osona, Catalonia, northern Spain.

1995 ◽  
Vol 58 (5) ◽  
pp. 577-581 ◽  
Author(s):  
E Bufill ◽  
R Blesa ◽  
I Galan ◽  
G Dean
Keyword(s):  
Multiple Sclerosis ◽  
Northern Spain

Multiple sclerosis in Gijon health district, Asturias, northern Spain

2009 ◽  
Vol 96 (6) ◽  
pp. 375-379 ◽  
Author(s):  
D. F. Uria ◽  
M. T. Calatayud ◽  
P. Virgala ◽  
A. Diaz ◽  
C. Chamizo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Health District ◽  
Northern Spain

The epidemiology of multiple sclerosis in the sanitary district of Costa De Ponent (Catalonia-Spain)

1995 ◽  
Vol 56-63 ◽  
pp. 68-68
Author(s):  
M. Huerta ◽  
S. Martinez ◽  
J.J. Hernandez ◽  
C. Marqués ◽  
J.Ma. Ramón ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sanitary District

The prevalence of multiple sclerosis in the Sanitary District of Velez-Malaga, southern Spain

Neurology ◽  
1994 ◽  
Vol 44 (3, Part 1) ◽  
pp. 425-425 ◽  
Author(s):  
O. Fernandez ◽  
G. Luque ◽  
C. S. Roman ◽  
M. Bravo ◽  
G. D. FRCP
Keyword(s):  
Multiple Sclerosis ◽  
Southern Spain ◽  
Sanitary District

scholarly journals Prevalence of multiple sclerosis in Valladolid, northern Spain

1999 ◽  
Vol 246 (3) ◽  
pp. 170-174 ◽  
Author(s):  
Miguel Angel Tola Arribas ◽  
María Isabel Yugueros ◽  
Nieves Fernández-Buey ◽  
Rosario Fernández-Herranz
Keyword(s):  
Multiple Sclerosis ◽  
Northern Spain

Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study

2004 ◽  
Vol 10 (5) ◽  
pp. 526-531 ◽  
Author(s):  
Arash Kheradvar ◽  
Abdol Reza Tabassi ◽  
Behrouz Nikbin ◽  
Farideh Khosravi ◽  
Mehrnaz Naroueynejad ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Protective Factor ◽  
Normal Population ◽  
Human Leukocyte ◽  
Hla Typing ◽  
Predisposing Factor ◽  
Disease Heterogeneity ◽  
High Prevalence

Background: Genetic predisposition in multiple sclerosis (MS) has always been a critical concern in aetiology and progress of the disease. The present study looks into the relations between human leukocyte antigen (HLA), optic neuritis (ON) and MS in the Iranian population. Methods: Patients with potential diagnosis of acute ON underwent a standardized clinical examination for confirming the diagnosis. Selected patients were gathered for HLA typing and clinical follow up. Results: Of the 55 patients, 46 (83.6%) were female. The mean age was 25(± 7.3) with a range of 12-43. Twenty of the 55 (36%) were confirmed for the diagnosis of clinically definite MS (CDMS). Results show that A23, B21, A11 and B51 alleles were present in 4 (20%), 6 (30%), 2 (10%) and 1 (5%) of the CDMS patients, respectively. Ten (50%) and 17 (85%) CDMS patients were positive for HLA class II alleles, DR2 and DQ1, correspondingly. Conclusions: The study strongly suggests the association among DR2, A23 and B21 allele and the evolution of ON to MS. High prevalence of A23 and DR2 alleles in CDMS patients compared with the normal population may suggest an important role for these alleles in the development of MS. The study suggests B51 as a protective factor against development of ON in the normal population. In addition, results do not confirm previous studies considering A11 as a predisposing factor. The present study finally evokes that different classes of HLA have different roles in susceptibility to MS and confirms disease heterogeneity as an important emerging concept in MS.

Bilateral trigeminal neuralgia

1987 ◽  
Vol 67 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Ronald Brisman
Keyword(s):  
Multiple Sclerosis ◽  
Trigeminal Neuralgia ◽  
Morbidity Rate ◽  
Gasserian Ganglion ◽  
Predisposing Factor ◽  
Content Type ◽  
Bilateral Involvement ◽  
Prior Surgery ◽  
Fine Print

✓ Bilateral trigeminal neuralgia occurred in 32 (11.9%) of 269 consecutive patients who were treated with radiofrequency electrocoagulation (RFE). This is a higher incidence than has been reported before and may be explained by the prospective nature of the present study, the long follow-up period, and the inclusion of patients with mild bilateral symptoms. Multiple sclerosis is the most common predisposing factor and occurred in 18% of those with bilateral trigeminal neuralgia. Although patients with bilateral trigeminal neuralgia were more likely to have had prior surgery than those with unilateral neuralgia, they did not have a higher recurrence rate following treatment. Percutaneous RFE of the retrogasserian rootlets and gasserian ganglion, with or without glycerol, is effective in managing patients whose pain is intractable to medical therapy. The preservation of most trigeminal sensory and motor functions, the low morbidity rate, and the ability to repeat the procedure are particularly advantageous for patients with bilateral involvement.

scholarly journals Epstein-Barr virus infection is a predisposing factor in multiple sclerosis: hypothesis based on immunology and epidemiology

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S505
Author(s):  
David López Valencia ◽  
Angela Patricia Medina Ortega ◽  
Diego Fernando Hoyos Samboní ◽  
Tomás Zamora Bastidas ◽  
Luis Reinel Vásquez Arteaga ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Virus Infection ◽  
Epstein Barr Virus ◽  
Epstein Barr Virus Infection ◽  
Predisposing Factor ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection
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