Growth Failure in Prader-Willi Syndrome Is Secondary to Growth Hormone Deficiency

1998 ◽  
Vol 49 (5) ◽  
pp. 216-220 ◽  
Author(s):  
Margaret J. Thacker ◽  
Bryan Hainline ◽  
Lori St. Dennis-Feezle ◽  
Nancy B. Johnson ◽  
Ora Hirsch Pescovitz
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Growth Failure ◽  
Hormone Deficiency ◽  
Prader Willi Syndrome

Adult growth hormone deficiency

2011 ◽  
pp. 152-165
Author(s):  
Aurora Aragon-Alonso ◽  
Mark Sherlock ◽  
Andrew A. Toogood
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Replacement Therapy ◽  
Recombinant Human Growth Hormone ◽  
Hormone Replacement ◽  
Adult Life ◽  
Growth Failure ◽  
Clinical Syndrome ◽  
Hormone Deficiency ◽  
Recombinant Dna Technology

It has been known for many years that growth hormone is essential for normal linear growth, but over the past few years, with the advent of recombinant human growth hormone therapy, the importance of growth hormone during adult life has been described in detail. The growth hormone peptide was first isolated from bovine pituitaries in the 1940s (1), but was found to be species specific and inactive in humans. In 1956, growth hormone was extracted from human cadaveric pituitary tissue (2) and a year later was administered to a 13-year-old boy with hypopituitarism, resulting in an increased growth velocity (3). The first report suggesting growth hormone could have beneficial actions in adulthood was published in 1962 in which a 35-year-old woman with hypopituitarism reported increased vigour, ambition, and wellbeing after 2 months treatment with cadaveric growth hormone (4). However, the limited supply of pituitary-derived growth hormone confined its use to the treatment of children with severe growth failure caused by proven growth hormone deficiency (GHD). In 1985, the association of cadaveric growth hormone treatment with Creutzfeldt–Jakob disease led to its withdrawal from use worldwide (5). Since then, all growth hormone in clinical use has been produced using recombinant DNA technology. The first placebo-controlled trials of growth hormone replacement therapy in adults with GHD were published in 1989 (6, 7). These and subsequent studies have led to the recognition of adult GHD as a specific clinical syndrome and the impact of GHD and replacement therapy in adults with GHD has been studied in detail.

Letter regarding "Prevalence of growth hormone deficiency in previously GH‐treated young adults with Prader‐Willi syndrome" by Donze et al

2019 ◽  
Vol 91 (4) ◽  
pp. 578-579 ◽  
Author(s):  
Charlotte Höybye ◽  
Maithé Tauber ◽  
Moris A. Angulo ◽  
Urs Eiholzer ◽  
Daniel J. Driscoll ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Young Adults ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Prader Willi Syndrome

scholarly journals The prevalence and volumetry of pituitary cysts in children with growth hormone deficiency and idiopathic short stature

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Nicholas Krasnow ◽  
Bradley Pogostin ◽  
James Haigney ◽  
Brittany Groh ◽  
Winston Weiler ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Short Stature ◽  
Growth Failure ◽  
Brain Magnetic Resonance Imaging ◽  
Idiopathic Short Stature ◽  
Hormone Deficiency ◽  
Gh Treatment ◽  
Cyst Volume ◽  
Pituitary Cysts

AbstractBackgroundPituitary cysts have been speculated to cause endocrinopathies. We sought to describe the prevalence and volumetry of pituitary cysts in patients with growth hormone deficiency (GHD) and idiopathic short stature (ISS).MethodsSix hundred and eighteen children evaluated for growth failure at the Division of Pediatric Endocrinology at New York Medical College between the years 2002 and 2012, who underwent GH stimulation testing and had a brain magnetic resonance imaging (MRI) prior to initiating GH treatment were randomly selected to be a part of this study. High resolution MRI was used to evaluate the pituitary gland for size and the presence of a cyst. Cyst prevalence, cyst volume and percentage of the gland occupied by the cyst (POGO) were documented.ResultsFifty-six patients had a cyst, giving an overall prevalence of 9.1%. The prevalence of cysts in GHD patients compared to ISS patients was not significant (13.5% vs. 5.7%, p=0.46). Mean cyst volume was greater in GHD patients than ISS patients (62.0 mm3vs. 29.4 mm3, p=0.01). POGO for GHD patients was significantly greater (p=0.003) than for ISS patients (15.3%±12.8 vs. 7.1%±8.0). Observers were blinded to patient groups.ConclusionsGHD patients had a significantly greater volume and POGO compared to ISS patients. This raises the question of whether cysts are implicated in the pathology of growth failure.

Vitamin D levels in primary growth hormone deficiency disorder Prader–Willi syndrome

Endocrine ◽  
2016 ◽  
Vol 53 (2) ◽  
pp. 619-620 ◽  
Author(s):  
Louise Purtell ◽  
Alexander Viardot ◽  
Lesley V. Campbell
Keyword(s):  
Growth Hormone ◽  
Vitamin D ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Prader Willi Syndrome ◽  
Primary Growth ◽  
Vitamin D Levels

Central precocious puberty and growth hormone deficiency in a boy with Prader-Willi syndrome

2008 ◽  
Vol 167 (12) ◽  
pp. 1455-1458 ◽  
Author(s):  
Antonino Crinò ◽  
Girolamo Di Giorgio ◽  
Riccardo Schiaffini ◽  
Alessandra Fierabracci ◽  
Sabrina Spera ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Precocious Puberty ◽  
Central Precocious Puberty ◽  
Hormone Deficiency ◽  
Prader Willi Syndrome

Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure

1992 ◽  
Vol 121 (6) ◽  
pp. 920-923 ◽  
Author(s):  
Peter D. Gluckman ◽  
Alistair J. Gunn ◽  
Alison Wray ◽  
Wayne S. Cutfield ◽  
Pierre G. Chatelain ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Growth Failure ◽  
Postnatal Growth ◽  
Hormone Deficiency ◽  
Idiopathic Growth Hormone Deficiency ◽  
Postnatal Growth Failure

Is There Growth Hormone Deficiency in Prader-Willi Syndrome?

2000 ◽  
Vol 53 (3) ◽  
pp. 44-52 ◽  
Author(s):  
Urs Eiholzer ◽  
Sara Bachmann ◽  
Dagmar l’Allemand
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Prader Willi Syndrome

Contribution of growth hormone deficiency to the growth failure that follows bone marrow transplantation

1997 ◽  
Vol 130 (5) ◽  
pp. 785-792 ◽  
Author(s):  
R. Brauner ◽  
L. Adan ◽  
J.C. Souberbielle ◽  
H. Esperou ◽  
J. Michon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Hormone ◽  
Bone Marrow Transplantation ◽  
Growth Hormone Deficiency ◽  
Marrow Transplantation ◽  
Growth Failure ◽  
Hormone Deficiency
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