Serum Free and Total Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-1 and Insulin-Like Growth Factor Binding Protein-3Levels in Healthy Elderly Individuals

Gerontology ◽  
1998 ◽  
Vol 44 (5) ◽  
pp. 277-280 ◽  
Author(s):  
J.A.M.J.L. Janssen ◽  
R.P. Stolk ◽  
H.A.P. Pols ◽  
D.E. Grobbee ◽  
S.W.J. Lamberts
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Elderly Individuals ◽  
Serum Free ◽  
Factor Binding ◽  
Factor I ◽  
Healthy Elderly ◽  
Growth Factor I

Expression of Insulin-like Growth Factor Binding Protein-3 and Regulation of the Insulin-like Growth Factor-I Axis in Pig Testis

2018 ◽  
Vol 23 (3) ◽  
pp. 278-285 ◽  
Author(s):  
Hyun-Jung Park ◽  
Won-Young Lee ◽  
Seung-Yeon Chai ◽  
Jae-Seok Woo ◽  
Hak-Jae Chung ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Factor I ◽  
Growth Factor I

Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I

1991 ◽  
Vol 261 (1) ◽  
pp. F22-F28 ◽  
Author(s):  
S. Kobayashi ◽  
D. R. Clemmons ◽  
M. A. Venkatachalam
Keyword(s):  
Growth Factor ◽  
Cultured Cells ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Intense Staining ◽  
Factor Binding ◽  
Factor I ◽  
Collecting Ducts ◽  
Igf I ◽  
Growth Factor I

We report the localization of insulin-like growth factor I (IGF-I) and a 25-kDa form of insulin-like growth factor-binding protein (IGF-BP-1) in adult rat kidney. The antigens were localized using a rabbit anti-human IGF-I antibody, and a rabbit anti-human IGF-BP-1 antibody raised against human 25-kDa IGF-BP-1 purified from amniotic fluid. Immunohistochemistry by the avidin-biotin peroxidase conjugate technique showed that both peptides are located in the same nephron segments, in the same cell types. The most intense staining was in papillary collecting ducts. There was moderate staining also in cortical collecting ducts and medullary thick ascending limbs of Henle's loop. In collecting ducts the antigens were shown to be present in principal cells but not in intercalated cells. In distal convoluted tubules, cortical thick ascending limbs, and in structures presumptively identified as thin limbs of Henle's loops there was only modest staining. The macula densa, however, lacked immunoreactivity. Colocalization of IGF-I and IGF-BP-1 in the same cells supports the notion, derived from studies on cultured cells, that the actions of IGF-I may be modified by IGF-BPs that are present in the same location.

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