Fatherhood in Testicular Cancer Patients with Carcinoma in situ in the Contralateral Testicle

2000 ◽  
Vol 38 (6) ◽  
pp. 725-727 ◽  
Author(s):  
K.D. Jacobsen ◽  
S.D. Fosså
Keyword(s):  
Testicular Cancer ◽  
Cancer Patients ◽  
Carcinoma In Situ

Impaired Testicular Function in Patients With Carcinoma-In-Situ of the Testis

1999 ◽  
Vol 17 (1) ◽  
pp. 173-173 ◽  
Author(s):  
Peter Meidahl Petersen ◽  
Aleksander Giwercman ◽  
Steen W. Hansen ◽  
Jørgen G. Berthelsen ◽  
Gedske Daugaard ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Germ Cell ◽  
Leydig Cell ◽  
Carcinoma In Situ ◽  
Cell Function ◽  
Semen Quality ◽  
Sperm Concentration ◽  
Testicular Dysfunction ◽  
Leydig Cell Function

PURPOSE: To elucidate the biologic association between germ cell neoplasia and testicular dysfunction, through investigation of Leydig cell function and semen quality in men with carcinoma-in-situ (CIS) of the testis. PATIENTS AND METHODS: We examined two groups of men, unilaterally orchidectomized for testicular cancer. Biopsy of the contralateral testis had showed CIS in a group of 24 patients and no evidence of CIS in the other group of 30 patients. Semen quality and serum levels of testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were compared in these two groups of men after orchidectomy but before further treatment for testicular cancer. RESULTS: Significantly higher LH levels (median, 8.1 IU/L v 4.8 IU/L; P < .001) and generally lower testosterone levels (median, 12.5 nmol/L v 15.5 nmol/L; P = .13) were found in the CIS group. The proportion of patients with Leydig cell dysfunction was higher in the group of patients with CIS (11 of 24) than in the group of patients without (two of 30) (P = .01). Sperm concentration and total sperm count were significantly lower (P < .001) in patients with CIS (median, 0.03 × 106/mL and 0.10 × 106, respectively) than in patients without (median, 9.1 × 106/mL and 32 × 106, respectively), whereas the levels of FSH were significantly higher (P < .001) in the former group of men (median, 19.6 IU/L v 9.0 IU/L). CONCLUSION: Not only spermatogenesis but also Leydig cell function is impaired in testes with CIS. This impairment could be due to common factors in the pathogenesis of germ cell neoplasm and testicular dysfunction. Alternatively, CIS cells may have a negative impact on Leydig cell function.

scholarly journals Screening for carcinoma in situ of the contralateral testis in patients with germinal testicular cancer.

BMJ ◽  
1982 ◽  
Vol 285 (6356) ◽  
pp. 1683-1686 ◽  
Author(s):  
J G Berthelsen ◽  
N E Skakkebaek ◽  
H von der Maase ◽  
B L Sorensen ◽  
P Mogensen
Keyword(s):  
Testicular Cancer ◽  
Carcinoma In Situ ◽  
Contralateral Testis

scholarly journals A Nomogram Predicting Survival in Patients with Breast Ductal Carcinoma in Situ with Microinvasion

2021 ◽  
Author(s):  
Yi-Zi Zheng ◽  
Hong-Bin Qin ◽  
Zi-Zheng Li ◽  
He-Sheng Jiang ◽  
Greg Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Regression Model ◽  
Cancer Patients ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Multivariate Logistic Regression Model ◽  
Breast Cancer Patients

Abstract Background: Ductal carcinoma in situ with microinvasion (DCISM) can be challenging to balance the risks of overtreatment versus undertreatment. We aim to identify prognostic factors in patients with DCISM and construct a nomogram to predict breast cancer-specific survival (BCSS).Methods: Women diagnosed with DCISM were selected from the Surveillance, Epidemiology and End Results database (1998-2015). Clinical variables and tumor characteristics were evaluated and Cox proportional-hazards regression model was performed. A nomogram was con­structed from the multivariate logistic regression model to combine all the prognostic factors to predict the prognosis of DCISM patients at 5 years, 10 years, and 15 years. Results: We identified 5,438 total eligible breast cancer patients with a median and max survival time of 78 and 227 months, respectively. Here, patients with poorer survival outcomes were those diagnosed between 1988-2001, African-American race, under 40 years of age, higher tumor N stage, progesterone receptor-negative tumor, and received no surgery (all P < 0.05). The nomogram was constructed by the seven variables and passed the calibration and validation steps. The area under the receiver operating characteristic (ROC) curve (AUC) of both the training set and the validating set (5-year AUC: 0.77 and 0.88, 10-year AUC: 0.75 and 0.73, 15-year AUC: 0.72 and 0.65) demonstrated excellent reliability and robust performance.Conclusion: Our current study is the first to construct nomograms of patients with DCISM which could help physicians identify breast cancer patients that more likely to benefit from more intensive treatment and follow-up.

Screening for Carcinoma In Situ of the Contralateral Testis in Patients With Germinal Testicular Cancer

1983 ◽  
Vol 130 (2) ◽  
pp. 404-404
Author(s):  
J.G. Berthelsen ◽  
N.E. Skakkebaek ◽  
H. von der Maase ◽  
B.L. Sørensen ◽  
P. Mogensen
Keyword(s):  
Testicular Cancer ◽  
Carcinoma In Situ ◽  
Contralateral Testis

Risk Factors for Carcinoma in situ of the Contralateral Testis in Patients with Testicular Cancer

1993 ◽  
Vol 23 (1) ◽  
pp. 115-119 ◽  
Author(s):  
S.J. Harland ◽  
P.A. Cook ◽  
S.D. Fosså ◽  
A. Horwich ◽  
M.C. Parkinson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Testicular Cancer ◽  
Carcinoma In Situ ◽  
Contralateral Testis

scholarly journals Splenogonadal fusion and testicular cancer: case report and review of the literature

2012 ◽  
Vol 10 (1) ◽  
pp. 92-95 ◽  
Author(s):  
Roberto Iglesias Lopes ◽  
Mabel Tatty de Medeiros ◽  
Marco Antônio Arap ◽  
Marcello Cocuzza ◽  
Miguel Srougi ◽  
...  
Keyword(s):  
Case Report ◽  
Testicular Cancer ◽  
Carcinoma In Situ ◽  
Cancer Case ◽  
Obstructive Azoospermia ◽  
Review Of The Literature ◽  
Splenogonadal Fusion ◽  
Left Testicle ◽  
Bilateral Cryptorchidism

A 36 year-old man after tests for assessing male infertility was diagnosed with primary infertility, bilateral cryptorchidism, non-obstructive azoospermia and discontinuous splenogonadal fusion. Carcinoma in situ was found in his left testicle, which was intra-abdominal and associated with splenogonadal fusion. To our knowledge, this is the fourth case of splenogonadal fusion associated with testicular cancer reported. One should always bear in mind the possibility of this association for the left cryptorchid testicle.

scholarly journals Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients

2017 ◽  
Vol 167 (1) ◽  
pp. 205-213 ◽  
Author(s):  
M. L. Gregorowitsch ◽  
H. J. G. D. van den Bongard ◽  
D. A. Young-Afat ◽  
J. P. Pignol ◽  
C. H. van Gils ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma In Situ ◽  
Invasive Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Early Stage ◽  
Severe Depression ◽  
Breast Cancer Patients
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