Modeling Multiscale Necrotic and Calcified Tissue Biomechanics in Cancer Patients: Application to Ductal Carcinoma In Situ (DCIS)

2012 ◽  
pp. 349-380 ◽  
Author(s):  
Paul Macklin ◽  
Shannon Mumenthaler ◽  
John Lowengrub
Keyword(s):  
Cancer Patients ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Tissue Biomechanics ◽  
Calcified Tissue

scholarly journals A Nomogram Predicting Survival in Patients with Breast Ductal Carcinoma in Situ with Microinvasion

2021 ◽  
Author(s):  
Yi-Zi Zheng ◽  
Hong-Bin Qin ◽  
Zi-Zheng Li ◽  
He-Sheng Jiang ◽  
Greg Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Regression Model ◽  
Cancer Patients ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Multivariate Logistic Regression Model ◽  
Breast Cancer Patients

Abstract Background: Ductal carcinoma in situ with microinvasion (DCISM) can be challenging to balance the risks of overtreatment versus undertreatment. We aim to identify prognostic factors in patients with DCISM and construct a nomogram to predict breast cancer-specific survival (BCSS).Methods: Women diagnosed with DCISM were selected from the Surveillance, Epidemiology and End Results database (1998-2015). Clinical variables and tumor characteristics were evaluated and Cox proportional-hazards regression model was performed. A nomogram was con­structed from the multivariate logistic regression model to combine all the prognostic factors to predict the prognosis of DCISM patients at 5 years, 10 years, and 15 years. Results: We identified 5,438 total eligible breast cancer patients with a median and max survival time of 78 and 227 months, respectively. Here, patients with poorer survival outcomes were those diagnosed between 1988-2001, African-American race, under 40 years of age, higher tumor N stage, progesterone receptor-negative tumor, and received no surgery (all P < 0.05). The nomogram was constructed by the seven variables and passed the calibration and validation steps. The area under the receiver operating characteristic (ROC) curve (AUC) of both the training set and the validating set (5-year AUC: 0.77 and 0.88, 10-year AUC: 0.75 and 0.73, 15-year AUC: 0.72 and 0.65) demonstrated excellent reliability and robust performance.Conclusion: Our current study is the first to construct nomograms of patients with DCISM which could help physicians identify breast cancer patients that more likely to benefit from more intensive treatment and follow-up.

scholarly journals Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients

2017 ◽  
Vol 167 (1) ◽  
pp. 205-213 ◽  
Author(s):  
M. L. Gregorowitsch ◽  
H. J. G. D. van den Bongard ◽  
D. A. Young-Afat ◽  
J. P. Pignol ◽  
C. H. van Gils ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma In Situ ◽  
Invasive Breast Cancer ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Early Stage ◽  
Severe Depression ◽  
Breast Cancer Patients

scholarly journals Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients

Oncogene ◽  
2003 ◽  
Vol 22 (1) ◽  
pp. 147-150 ◽  
Author(s):  
Sofia Honorio ◽  
Angelo Agathanggelou ◽  
Marcus Schuermann ◽  
Wulf Pankow ◽  
Paolo Viacava ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Promoter Hypermethylation ◽  
Breast Cancer Patients

Sonographic Findings of Ductal Carcinoma in Situ of the Breast: Comparison with Mammographic Findings

1999 ◽  
Vol 41 (6) ◽  
pp. 1225
Author(s):  
Eung Yeop Kim ◽  
Boo Kyung Han ◽  
Yeon Hyeon Choe ◽  
Seok Jin Nam ◽  
Young Hyeh Ko ◽  
...  
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma

The Myoepithelium as a Risk Predictor in Ductal Carcinoma In Situ of the Breast

2019 ◽  
Author(s):  
Gemma M Wilson ◽  
Barbara J Guild ◽  
Christine L Clarke ◽  
Nirmala Pathmanathan ◽  
J Dinny Graham
Keyword(s):  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Risk Predictor
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