Assignment1 of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping

2000 ◽  
Vol 88 (3-4) ◽  
pp. 288-288 ◽  
Author(s):  
A. Barbon ◽  
S. Ferraboli ◽  
S. Barlati
Keyword(s):  
Glutamate Receptor ◽  
Radiation Hybrid ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Gene ◽  
Radiation Hybrid Mapping ◽  
Hybrid Mapping ◽  
Metabotropic Glutamate

Radiation hybrid mapping of two members of the Toll-like receptor gene family in pigs

2004 ◽  
Vol 35 (3) ◽  
pp. 251-252 ◽  
Author(s):  
A. Franceschi ◽  
P. Cassini ◽  
D. Scalabrini ◽  
S. Botti ◽  
C.M. Bandi ◽  
...  
Keyword(s):  
Gene Family ◽  
Radiation Hybrid ◽  
Receptor Gene ◽  
Radiation Hybrid Mapping ◽  
Toll Like Receptor ◽  
Hybrid Mapping ◽  
Receptor Gene Family

scholarly journals Regulation of neuron-specific gene transcription by stress hormone signalling requires synaptic activity in zebrafish

2019 ◽  
Author(s):  
Helen Eachus ◽  
Dheemanth Subramanya ◽  
Harriet E. Jackson ◽  
Guannyu Wang ◽  
Kieran Berntsen ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Gene ◽  
Model Organism ◽  
Receptor Expression ◽  
Synaptic Activity ◽  
Specific Gene ◽  
Metabotropic Glutamate ◽  
Synaptic Neurotransmission ◽  
The Brain

AbstractThe Glucocorticoid Receptor (GR) co-ordinates metabolic and behavioural responses to stressors. We hypothesised that GR influences behaviour by modulating specific epigenetic and transcriptional processes in the brain. Using the zebrafish as a model organism, the brain methylomes of wild-type and grs357 mutant adults were analysed and GR-sensitive, differentially methylated regions (GR-DMRs) were identified. Two genes with GR-DMRs exhibited distinct methylation and transcriptional sensitivities to GR: the widely expressed direct GR target fkbp5 and neuron-specific aplp1. In larvae, neural activity is required for GR-mediated transcription of aplp1, but not for that of fkbp5. GR regulates metabotropic glutamate receptor gene expression, the activities of which also modulated aplp1 expression, implicating synaptic neurotransmission as an effector of GR function upstream of aplp1. Our results identify two distinct routes of GR-regulated transcription in the brain, including a pathway through which GR couples endocrine signalling to synaptic activity-regulated transcription by modulating metabotropic glutamate receptor expression.

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