scholarly journals Association between type-three metabotropic glutamate receptor gene (GRM3) variants and symptom presentation in treatment refractory schizophrenia

2011 ◽  
Vol 26 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Jeffrey R. Bishop ◽  
Del D. Miller ◽  
Vicki L. Ellingrod ◽  
Timothy Holman
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Gene ◽  
Symptom Presentation ◽  
Metabotropic Glutamate ◽  
Treatment Refractory

scholarly journals Regulation of neuron-specific gene transcription by stress hormone signalling requires synaptic activity in zebrafish

2019 ◽  
Author(s):  
Helen Eachus ◽  
Dheemanth Subramanya ◽  
Harriet E. Jackson ◽  
Guannyu Wang ◽  
Kieran Berntsen ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Gene ◽  
Model Organism ◽  
Receptor Expression ◽  
Synaptic Activity ◽  
Specific Gene ◽  
Metabotropic Glutamate ◽  
Synaptic Neurotransmission ◽  
The Brain

AbstractThe Glucocorticoid Receptor (GR) co-ordinates metabolic and behavioural responses to stressors. We hypothesised that GR influences behaviour by modulating specific epigenetic and transcriptional processes in the brain. Using the zebrafish as a model organism, the brain methylomes of wild-type and grs357 mutant adults were analysed and GR-sensitive, differentially methylated regions (GR-DMRs) were identified. Two genes with GR-DMRs exhibited distinct methylation and transcriptional sensitivities to GR: the widely expressed direct GR target fkbp5 and neuron-specific aplp1. In larvae, neural activity is required for GR-mediated transcription of aplp1, but not for that of fkbp5. GR regulates metabotropic glutamate receptor gene expression, the activities of which also modulated aplp1 expression, implicating synaptic neurotransmission as an effector of GR function upstream of aplp1. Our results identify two distinct routes of GR-regulated transcription in the brain, including a pathway through which GR couples endocrine signalling to synaptic activity-regulated transcription by modulating metabotropic glutamate receptor expression.

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