Influence of Plasma Exchange on Serum Levels of Cytokines and Adhesion Molecules in ANCA-Positive Renal Vasculitis

1998 ◽  
Vol 16 (2) ◽  
pp. 72-80 ◽  
Author(s):  
V. Tesař ◽  
E. Jelínková ◽  
Z. Mašek ◽  
M. Jirsa Jr. ◽  
J. Žabka ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Adhesion Molecules ◽  
Serum Levels ◽  
Renal Vasculitis

Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment

2006 ◽  
Vol 155 (6) ◽  
pp. 1270-1274 ◽  
Author(s):  
M. Caproni ◽  
W. Volpi ◽  
B. Giomi ◽  
D. Torchia ◽  
E. Del Bianco ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Chronic Urticaria ◽  
Serum Levels ◽  
Cellular Adhesion ◽  
Cellular Adhesion Molecules

scholarly journals Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989385
Author(s):  
Gehan A Hegazy ◽  
Zuhier Awan ◽  
Enayat Hashem ◽  
Nabil Al-Ama ◽  
Asmaa Basha Abunaji
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Serum Levels ◽  
Macrovascular Complications ◽  
Soluble Adhesion Molecules

Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed to investigate serum levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), and endothelium selectin (sE-selectin) in T2DM patients with macrovascular complications. Methods A cross-sectional study of 21 controls, 30 T2DM patients without CVDs, and 30 T2DM patients with CVDs was conducted. Serum levels of soluble adhesion molecules including sVCAM-1, sICAM-1, and sE-selectin were determined using ELISA. Results Serum levels of sVCAM-1, sICAM-1, and sE-selectin were higher in T2DM patients than in controls. Levels of serum sVCAM-1 were higher in T2DM patients with CVDs compared with T2DM patients without CVDs. In T2DM patients with CVDs, significant positive associations were observed between sVCAM-1, sICAM-1, and sE-selectin levels (r = 0.575, p = 0.001 and r = 0.378, p = 0.040). Conclusions Circulating levels of soluble adhesion molecules were elevated in T2DM patients, regardless of whether the patients had cardiovascular complications. Only sVCAM-1 was considered a useful marker for the prediction of CVDs in T2DM patients.

Serum levels of selected adhesion molecules in patients with coronary artery disease

2002 ◽  
Vol 83 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Katarzyna Mizia-Stec ◽  
Barbara Zahorska-Markiewicz ◽  
Tadeusz Mandecki ◽  
Joanna Janowska ◽  
Andrzej Szulc ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Adhesion Molecules ◽  
Serum Levels ◽  
Artery Disease

Serum levels of adhesion molecules correlate with insulin resistance

2002 ◽  
Vol 161 (1) ◽  
pp. 243-244 ◽  
Author(s):  
Kazunari Matsumoto ◽  
Yasunori Sera ◽  
Seibei Miyake ◽  
Yukitaka Ueki
Keyword(s):  
Insulin Resistance ◽  
Adhesion Molecules ◽  
Serum Levels

Modification of Cytokine Levels and CD34+ Stem Cell Adhesion Molecules during Mobilization in Multiple Myeloma (MM) Patients.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5068-5068
Author(s):  
Patrizia Zappasodi ◽  
Alessandro Corso ◽  
Chiara Rusconi ◽  
Mara De Amici ◽  
Erica Consensi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Peripheral Blood ◽  
Cell Adhesion Molecules ◽  
Serum Levels ◽  
High Baseline ◽  
Cytokine Levels ◽  
Baseline Levels

Abstract The mechanisms underlying the mobilization of peripheral blood stem cells (PBSC) are still unknown, even though studies on healthy donors and on cancer patients have hypothesised a central role for CD34+ stem cells adhesion molecules and for chemokines serum levels. The type of mobilizing regimen and the pathologic condition can exert different effects on cytokine levels and adhesion molecules expression. To evaluate the modification of these parameters during mobilization we studied 10 MM patients treated with DCEP chemotherapy (Decadron, Cyclophosphamide, Etoposide, cis-Platin) followed by G-CSF (5 mg/kg/day starting 48 hours after chemotherapy until PBSC collection). The expression of four CD34+ cell adhesion molecules (Thy1, L-selectin, VLA4, CXCR4) was measured in the bone marrow before mobilization therapy and in the leukapheresis product. Serum levels of five cytokines (TGF-β, IL-8, HGF, VEGF-A, sVCAM-1) were assessed, through specific ELISA kits, before therapy, 5 days after the G-CSF stimulation and at stem cells collection. Each parameter was correlated with the number of CD34+ cells collected. Thy1 significantly decreased (p=0.007) and L-selectin significantly increased (p=0.038) in nearly all cases. By contrast, no statistically significant differences were observed for VLA4 and CXCR4 due to a consistent variability. Serum levels of IL-8 showed an increase at day 5, then a significant decrease at the time of the harvest (p=0.013); VEGF-A constantly increased (p<0.001) and TGF-β decreased (p=0.001). The modifications registered for sVCAM-1 and HGF did not reach statistical significance. The expression of CD34+ adhesion molecules did not correlate with the number of PBSC collected, while among cytokines, high baseline levels of TGF-β and VEGF-A significantly correlated with high number of CD34+ stem cells yielded (p=0.016, p=0.042 respectively). In conclusion, this study shows that during stem cells mobilization in MM Thy-1 expression significantly decreases while L-selectin increases; the behaviour of VLA-4 and CXCR4 is extremely variable. As regards cytokines, we found a statistically significant increase of VEGF-A level, while TGF-β, which induces the stem cell homing, decreases during the mobilization allowing stem cells to migrate in the peripheral blood. High baseline levels of TGF-β and VEGF-A predict a good stem cells harvest.

Serum Profile Of Multiple Cytokines and Adhesion Molecules In Newly Diagnosed AML Patients Differs In Those Who Did Not Reach Complete Remission After Anthracycline/Cytarabine Induction Therapy

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 4997-4997
Author(s):  
Tomas Kupsa ◽  
Jan M Horacek ◽  
Martina Vasatova ◽  
Ladislav Jebavy ◽  
Pavel Zak
Keyword(s):  
Overall Survival ◽  
Growth Factor ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Inverse Correlation ◽  
Serum Levels ◽  
The Other ◽  
Prognostic Indicators ◽  
Newly Diagnosed ◽  
Significant Difference

Abstract Background Cytokines and adhesion molecules have been studied as markers of immune system activation in various diseases including AML/MDS. Cytokines are soluble molecules taking part in intercellular communication with a specific role in cell proliferation and differentiation control. Further knowledge gained from multiple cytokine and adhesion molecule analysis should allow better diagnosis and disease management. Aims The aim of our study was to evaluate baseline serum levels of multiple cytokines and adhesion molecules in Caucasian population AML patients and compare it with standard prognostic indicators in patients with AML. Methods A total of 28 consecutive newly diagnosed AML patients (11 males, 17 females, age 21 to 71 years, mean 52.3 ± 12.1, median 55.4 years, 8 with better risk, 13 with intermediate risk, 7 with high risk according to cytogenetics and molecular genetics) were administered 3+7 induction regimen with escalated dose of daunorubicin 90mg/m2. We evaluated serum levels of the following 22 cytokines and adhesion molecules: interleukins (IL-1 alpha, IL-1 beta, IL-2, IL-3, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-23), vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), epidermal growth factor (EGF), monocyte chemotactic protein-1 (MCP-1), E-selectin, L-selectin, P-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1). All biomarkers were measured by biochip array technology on Evidence Investigator analyzer (Randox) at the diagnosis of AML and compared with standard prognostic indicators in AML. Probability values (p) < 0.05 were considered statistically significant. Results As there was no significant difference between younger and elderly patients, we evaluated the cohort as a whole. Comparing serum cytokine and adhesion molecule levels in patients who did not achieve CR after induction therapy (n=6, 21.5%) to those who achieved CR (n=22, 78,5%) a statistically significant increase in serum IL-2 (5.42 ± 5.42 ng/L vs. 2.02 ± 1.84 ng/L; p < 0,05), IL-7 (11.71 ± 10.77 ng/L vs. 3.50 ± 1.51 ng/L; p < 0.05), IL-8 (241.9 ± 225.3 ng/L vs. 34.31 ± 25.47 ng/L; p < 0.005), IL-10 (7.74 ± 6.83 ng/L vs. 2.83± 2.68 ng/L; p < 0.05) was found. Both groups differed from healthy individuals in serum levels of IL-4, IL-6, IL-13, VCAM-1, ICAM-1, E-selectin and L-selectin. We found moderate inverse correlation between overall survival and levels of VCAM-1 and E-selectin. There was no significant difference in cytokines and adhesion molecules levels among established prognostic subgroups in AML. Conclusions The results in general are in agreement with outcome of our pilot trial. Compared with the other studies of cytokine levels in newly diagnosed AML, our data indicate different conclusions. IL-2, IL-4 and IL-10 were more likely to be higher in those who attained remission (Kornblau et al., Blood 2010). We did not find association between IL-6 and IL-10 levels and survival in our studied group (Correa et al, Cytokine 2013). On the other hand we documented inverse correlation between levels of some adhesion molecules and overall survival. Whether these alterations depend on the studied population is not known definitely. To assess their predictive value for patient outcome, further studies in a larger number of patients is necessary. Acknowledgment The work was supported by Specific research project “Analysis of defined prognostic factors in acute myeloid leukemia” (FMHS) and by a long-term organisation development plan 1011 (FMHS). Disclosures: No relevant conflicts of interest to declare.

scholarly journals Randomized Trial of Plasma Exchange or High-Dosage Methylprednisolone as Adjunctive Therapy for Severe Renal Vasculitis

2007 ◽  
Vol 18 (7) ◽  
pp. 2180-2188 ◽  
Author(s):  
David R.W. Jayne ◽  
Gill Gaskin ◽  
Niels Rasmussen ◽  
Daniel Abramowicz ◽  
Franco Ferrario ◽  
...  
Keyword(s):  
Randomized Trial ◽  
Plasma Exchange ◽  
Adjunctive Therapy ◽  
Renal Vasculitis
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