Elevation of Serum Levels of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-1 and Type IV Collagen, and Plasma Levels of Metalloproteinase-9 in Polycystic Kidney Disease

2000 ◽  
Vol 20 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Chifuyu Ushiyama ◽  
Shingo Suzuki ◽  
Isao Ebihara ◽  
Noriaki Shimada ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Plasma Levels ◽  
Type Iv Collagen ◽  
Serum Levels ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Polycystic Kidney ◽  
Tissue Inhibitor ◽  
Type Iv ◽  
Metalloproteinase 9

Changes in concentrations of type IV collagen and tissue inhibitor of metalloproteinase-1 in patients with paraquat poisoning

2001 ◽  
Vol 21 (6) ◽  
pp. 445-447 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Chifuyu Ushiyama ◽  
Noriaki Shimada ◽  
Kayo Hayashi ◽  
Isao Ebihara ◽  
...  
Keyword(s):  
Type Iv Collagen ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Type Iv ◽  
Paraquat Poisoning

scholarly journals Hepatic Production of Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney Disease

2018 ◽  
Vol 103 (6) ◽  
pp. 2319-2328 ◽  
Author(s):  
Frank Bienaimé ◽  
Ariane Ambolet ◽  
Béatrice Aussilhou ◽  
François Brazier ◽  
Marie Fouchard ◽  
...  
Keyword(s):  
Growth Factor ◽  
Kidney Disease ◽  
Fibroblast Growth Factor ◽  
Polycystic Kidney Disease ◽  
Plasma Levels ◽  
Autosomal Dominant ◽  
Fibroblast Growth ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney ◽  
Cystic Liver

Abstract Context The bone-derived hormone fibroblast growth factor (FGF) 23 controls phosphate homeostasis and urinary phosphate excretion. FGF23 plasma levels increase in the early stage of renal insufficiency to prevent hyperphosphatemia. Recent evidence suggests that this increase has effects on cardiac and immune cells that compromise patients’ health. Patients with autosomal dominant polycystic kidney disease (ADPKD) have been reported to have higher FGF23 concentrations than other patients with similar renal function. The significance of this finding has remained unknown. Methods and Results Analyzing the FGF23 plasma levels in 434 patients with ADPKD and 355 control subjects with a measured glomerular filtration rate (mGFR) between 60 and 120 mL/min per 1.73 m2, we confirmed that patients with ADPKD had higher FGF23 plasma concentrations than controls. Remarkably, this difference did not translate into renal phosphate leakage. Using different assays for FGF23, we found that this discrepancy was explained by a predominant increase in the cleaved C-terminal fragment of FGF23, which lacks phosphaturic activity. We found that FGF23 plasma concentration independently correlated with the severity of cystic liver disease in ADPKD. We observed that, in contrast to control liver tissues, the cystic liver from patients with ADPKD markedly expressed FGF23 messenger RNA and protein. In line with this finding, the surgical reduction of polycystic liver mass was associated with a decrease in FGF23 plasma levels independently of any modification in mGFR, phosphate, or iron status. Conclusion Our findings demonstrate that severely polycystic livers produce FGF23 and increase levels of circulating FGF23 in patients with ADPKD.

scholarly journals Type IV choledochal cyst with polycystic kidney disease: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuxin He ◽  
Zhuwen Yu ◽  
Weichang Chen
Keyword(s):  
Case Report ◽  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Choledochal Cyst ◽  
Polycystic Kidney ◽  
Choledochal Cysts ◽  
Cross Sectional ◽  
Caroli Disease ◽  
Type Iv ◽  
Autosomal Dominant Polycystic Kidney

Abstract Background Choledochal cysts are divided into 5 types. Physicians believe that Caroli disease (which refers to type V biliary cysts) is a special type of biliary cyst caused by a mutation in the PKHD1 gene and is associated with autosomal recessive polycystic kidney disease (ARPKD). There is currently no clear association between other types of choledochal cysts and polycystic kidney disease. Case presentation We report a 65-year-old male patient with jaundice, decreased appetite, and itchy skin. His biochemistry test results indicated obstructive jaundice disease. Cross-sectional imaging showed a type IVA choledochal cyst accompanied by autosomal dominant polycystic kidney disease (ADPKD). Due to economic difficulties, the patient achieved percutaneous transhepatic cholangial drainage (PTCD) instead of surgery. Conclusion To our knowledge, this is the second case report of the coexistence of type IVA choledochal cysts and ADPKD. We conclude that it is vital to be aware that the above condition is a possibility. This case report will aid earlier diagnosis and management and possibly prevent further damage to liver and kidney function.

scholarly journals Plasma matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 as prognostic biomarkers in critically ill patients

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 50-56
Author(s):  
Izabela Duda ◽  
Łukasz Krzych ◽  
Halina Jędrzejowska-Szypułka ◽  
Joana Lewin-Kowalik
Keyword(s):  
Matrix Metalloproteinase ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Levels ◽  
Matrix Metalloproteinase 9 ◽  
Prognostic Biomarkers ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 1 ◽  
Metalloproteinase 9

AbstractMatrix metalloproteinase 9 (MMP-9) plays an important role in inflammatory and pathological processes by enabling the inflow of leukocytes to the site of infection or tissue damage. MMP-9 and tissue inhibitor of metalloproteinase 1 (TIMP-1) have been described as potential prognostic biomarkers in various clinical settings. The aim of the study was to evaluate the usefulness of plasma levels of MMP-9 and TIMP-1 as well as the MMP-9/ TIMP-1 ratio in predicting the outcome in patients admitted to the intensive care unit (ICU). The study included 56 critically ill patients with multiple organ failure. Plasma levels of MMP-9 and TIMP-1 were determined on hospitalization day 1, 2, 3 and 7. Nineteen (35.7%) patients died. The level of TIMP-1 was statistically significantly higher on day 1 and 7 of hospitalization in non-survivors, as compared to survivors (p=0.01). A statistically significant positive correlation was found between MMP-9 and TIMP-1. The MMP-9/TIMP-1 ratio was comparable in both groups during of observation (0.62 on day 1). The MMP-9/TIMP-1 ratio was positively correlated with the level of lactate and negatively correlated with platelet count. Likewise, TIMP-1 was positively correlated with the level of lactate. The level of MMP-9 was higher in the non-survivor group only on day 7 of observation. In conclusion, although TIMP-1 and MMP-9 concentrations were higher in non-survivors and the MMP-9/TIMP-1 ratio was related to some parameters of critical illness, further research is needed to verify whether they can serve as reliable biomarkers for early prognostication of ICU patients.

scholarly journals Bilateral Nephrectomy for Adult Polycystic Kidney Disease Does Not Affect the Graft Function of Transplant Patients and Does Not Result in Sensitisation

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Maria Irene Bellini ◽  
Sotiris Charalmpidis ◽  
Paul Brookes ◽  
Peter Hill ◽  
Frank J. M. F. Dor ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Histopathological Examination ◽  
Graft Function ◽  
Length Of Hospital Stay ◽  
Papillary Renal Cell Carcinoma ◽  
Serum Levels ◽  
Polycystic Kidney ◽  
Adult Polycystic Kidney Disease ◽  
Transplant Patients

Background. Native nephrectomy in Adult Polycystic Kidney Disease (ADPKD) patients is a major operation with controversy related to timing and indications. We present our single centre experience in transplanted patients and future candidates for transplantation. Methods. Retrospective analysis from an anonymised database of bilateral nephrectomies for ADPKD patients. Results were reported as median, range, and percentage. Differences between groups were tested using ANOVA and t-test. Surgery was performed between January 2012 and July 2018. Results. Thirty-three patients underwent bilateral native nephrectomy for APKD. 18 had a functioning kidney transplant (transplant group, 55%) while 15 patients were on dialysis (dialysis group, 45%) at the time of surgery; 8 patients of the latter group (24% of the whole cohort) were eventually transplanted. 53% were males, with median age of 55 years (27-71). Indications to surgery were the following: space (symptoms related to the size of the native kidneys or need to create space for transplantation) (59%), recurrent cyst infection (36%), haematuria (15%), pain (24%), and weight loss associated with cystic alteration on imaging (3%). In the transplant group, postoperative kidney function was not affected; haemoglobin serum levels significantly dropped in the whole cohort: 121 (82-150) g/L, versus 108 (58-154) g/L (p<0.001), with 14 patients being transfused perioperatively. Elevation of anti-HLA antibodies was noted in one female patient on dialysis, with no change in DSA levels and no rejection after transplant for all 26 transplanted patients. Median postoperative length of hospital stay was 9 days (6-71). One patient died (3%) after six months. Median follow-up for the whole cohort was 282 days (13-1834). Histopathological examination revealed incidental renal neoplasms in five cases (15%): 1 pT1a papillary renal cell carcinoma and 4 papillary adenomas. Conclusions. Native nephrectomy for ADPKD could be safely performed in case of refractory symptoms, suspect of cancer or to create space for transplantation. It does not affect graft function or DSA status of transplanted patients or the prospect of transplantation of those on the waiting list.

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