Effect of Cholesterol Feeding on DNA Damage in Male and Female Syrian Hamsters

1999 ◽  
Vol 43 (1) ◽  
pp. 47-51 ◽  
Author(s):  
E. Turley ◽  
N.C. Armstrong ◽  
J.M.W. Wallace ◽  
W.S. Gilmore ◽  
V.J. McKelvey-Martin ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cholesterol Feeding ◽  
Male And Female ◽  
Syrian Hamsters

Effects of Injections and/or Chronic Implants of Melatonin and 5-Methoxytryptamine on Plasma Thyroid Hormones in Male and Female Syrian Hamsters

1984 ◽  
Vol 39 (4) ◽  
pp. 361-366 ◽  
Author(s):  
Mary K. Vaughan ◽  
Bruce A. Richardson ◽  
Larry J. Petterborg ◽  
Anke P. Holtorf ◽  
George M. Vaughan ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Male And Female ◽  
Syrian Hamsters

Injections and/or implants of 6-chloromelatonin and melatonin: effects on plasma thyroid hormones in male and female syrian hamsters

1984 ◽  
Vol 20 (6) ◽  
pp. 1471
Author(s):  
M.K. Vaughan ◽  
B.A. Richardson ◽  
L.J. Petterborg ◽  
G.M. Vaughan ◽  
R.J. Reiter
Keyword(s):  
Thyroid Hormones ◽  
Male And Female ◽  
Syrian Hamsters

Conditioned defeat in male and female syrian hamsters

2003 ◽  
Vol 44 (3) ◽  
pp. 293-299 ◽  
Author(s):  
Kim L Huhman ◽  
Matia B Solomon ◽  
Marcus Janicki ◽  
Alvin C Harmon ◽  
Stacie M Lin ◽  
...  
Keyword(s):  
Male And Female ◽  
Syrian Hamsters ◽  
Conditioned Defeat

scholarly journals Social housing and social isolation: Impact on stress indices and energy balance in male and female Syrian hamsters ( Mesocricetus auratus )

2017 ◽  
Vol 177 ◽  
pp. 264-269 ◽  
Author(s):  
Amy P. Ross ◽  
Alisa Norvelle ◽  
Dennis C. Choi ◽  
James C. Walton ◽  
H. Elliott Albers ◽  
...  
Keyword(s):  
Energy Balance ◽  
Social Isolation ◽  
Social Housing ◽  
Mesocricetus Auratus ◽  
Male And Female ◽  
Stress Indices ◽  
Syrian Hamsters

scholarly journals TMIC-17. ASTROCYTE SENESCENCE CONTRIBUTES TO SEX DIFFERENCES IN THE AGE-RELATED INCREASE IN GLIOBLASTOMA INCIDENCE

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi250-vi251
Author(s):  
Lauren Broestl ◽  
Jasmin Sponagel ◽  
Gina Rhee ◽  
Lucia Grandison ◽  
Najla Kfoury ◽  
...  
Keyword(s):  
Dna Damage ◽  
Sex Differences ◽  
Incidence Rates ◽  
Paracrine Signaling ◽  
Male And Female ◽  
Cycle Arrest ◽  
Age Related ◽  
Anti Cancer ◽  
A Cell ◽  
Tumor Types

Abstract Incidence rates for glioblastoma increase exponentially with age in a sex-specific manner, with a steeper increase observed in men. This suggests that age may be a more significant factor in promoting male tumors than female tumors. Drivers in the age-related cancer increase include both the accumulation of DNA damage and microenvironment changes, specifically an increase in the number of senescent cells. Cellular senescence comprises two distinct components – a cell cycle arrest program that prevents proliferation of mutated cells and acts as a potent anti-cancer mechanism, and a paracrine signaling component that can have both pro- and anti-tumorigenic properties. The contribution of senescence to brain tumor incidence and outcome is currently unknown; additionally, no research has been done on whether there are sex differences in mechanisms of senescence induction or in the secretory phenotype of senescent cells. Using both wildtype astrocytes and a glioblastoma model, we show that female cells have a lower threshold for senescence induction in response to oxidative stress, telomere shortening, and DNA damage, and that sex differences in senescence induction in response to DNA damage are in part mediated by differences in the regulation of p21. In addition, we show that male and female senescent astrocytes differ in their secretory phenotypes. Male senescent astrocytes secrete more tumor promoting factors, and conditioned media from male but not female senescent astrocytes promotes tumor cell proliferation. These findings provide a potential explanation for sex differences in glioblastoma incidence rates. Achieving a better understanding of mechanisms of senescence and how they differ in male and female cells could advance development of senescence directed therapies and potentially improve cancer treatment for a range of tumor types.

Differential Regulation of Kiss1 Expression by Melatonin and Gonadal Hormones in Male and Female Syrian Hamsters

2010 ◽  
Vol 25 (2) ◽  
pp. 81-91 ◽  
Author(s):  
L. Ansel ◽  
M. Bolborea ◽  
A.H. Bentsen ◽  
P. Klosen ◽  
J.D. Mikkelsen ◽  
...  
Keyword(s):  
Gonadal Hormones ◽  
Differential Regulation ◽  
Male And Female ◽  
Syrian Hamsters
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