Proliferating Cell Nuclear Antigen Immunoreactivity and the Presence of P53 Mutation in Basaloid Squamous Cell Carcinoma of the Larynx

Oncology ◽  
1998 ◽  
Vol 55 (5) ◽  
pp. 382-383 ◽  
Author(s):  
Mehmet Umut Akyol ◽  
Ayşe Dursun ◽  
Gülen Akyol ◽  
Naci Edalι
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
P53 Mutation ◽  
Nuclear Antigen ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Proliferating Cell ◽  
Basaloid Squamous

scholarly journals Prognostic value of p27Kip1expression in Basaloid Squamous Cell Carcinoma of the larynx

BMC Cancer ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Grazia Salerno ◽  
Dolores Di Vizio ◽  
Stefania Staibano ◽  
Giampiero Mottola ◽  
Giuseppe Quaremba ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Basaloid Squamous

Basaloid squamous cell carcinoma of the larynx

1999 ◽  
Vol 121 (5) ◽  
pp. 647-650 ◽  
Author(s):  
Tzung-Shiahn Sheen ◽  
Yih-Leong Chang ◽  
Jenq-Yuh Ko ◽  
Chen-Tu Wu ◽  
Shiann-Yann Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Basaloid Squamous

scholarly journals Assessment of proliferating cell nuclear antigen (PCNA) expression at the invading front of oral squamous cell carcinoma

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Emily Ming-Chieh Lu ◽  
Jithendra Ratnayake ◽  
Alison Mary Rich
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Pearson Correlation ◽  
Predictor Variable ◽  
Nuclear Antigen ◽  
Prognostic Information ◽  
Proliferating Cell

Abstract Background Accurate prediction of the behaviour of oral squamous cell carcinoma (OSCC) is necessary to determine prognosis and provide appropriate treatment. Therefore, it is important to investigate potential prognostic markers to determine their predictive ability. Histological assessment of specific features at the invading front of oral squamous cell carcinomas has shown to provide accurate and reproducible prognostic information. Proliferating cell nuclear antigen (PCNA) is a nuclear marker known to reflect cell turnover and may be used as a marker for tumour aggressiveness. Methods Twenty cases of OSCC were histologically assessed to evaluate the correlation between proliferating cell nuclear antigen expression and invasive front grading. Each case was first assessed on a haematoxylin and eosin stained slide and an invading front grading (IFG) score was determined. In order to obtain a PCNA score, immunohistological staining was carried out using the peroxidase-labelled streptavidin-biotin technique with the monoclonal antibody PC10. Results In all cases, tumour islands had a periphery of intensely stained proliferating cell nuclear antigen-positive epithelial cells. The average IFG score was 8 ± 1.8, and the average PCNA score was 75% ± 11.2. Regression analysis was done using data from the IFG score and PCNA score and taking the latter as the predictor variable. The Pearson correlation coefficient was 0.134, with a p-value of 0.572. Conclusion Since the correlation between PCNA score and IFG score was not significant (p > 0.05), we conclude that there is no association between cell proliferation at the invading tumour front and the histological grading of OSCC.

Basaloid squamous cell carcinoma of the larynx

2002 ◽  
Vol 116 (01) ◽  
Author(s):  
Adil Eryilmaz ◽  
Celil Gocer ◽  
Aydin Acar ◽  
Muharrem Dagli ◽  
Levent Albayrak
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Carcinoma Of The Larynx ◽  
Basaloid Squamous
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