Interferon-Responsive Protein Kinase (p68) and Proliferating Cell Nuclear Antigen Are Inversely Distributed in Head and Neck Squamous Cell Carcinoma

Tumor Biology ◽  
1998 ◽  
Vol 19 (1) ◽  
pp. 52-59 ◽  
Author(s):  
G. Kenneth Haines III ◽  
Ralph J. Panos ◽  
Philip M. Bak ◽  
Tim Brown ◽  
Mike Zielinski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Neck Squamous Cell Carcinoma ◽  
Nuclear Antigen ◽  
Proliferating Cell

scholarly journals Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Liyong Zhang ◽  
Zhihong Li ◽  
Yehai Liu ◽  
Shuping Xu ◽  
Manuj Tandon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Protein Kinase D1

scholarly journals The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma

2016 ◽  
Vol 370 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Traci R. Tuttle ◽  
Michelle L. Mierzwa ◽  
Susanne I. Wells ◽  
Sejal R. Fox ◽  
Nira Ben-Jonathan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cyclic Gmp ◽  
Therapeutic Target ◽  
Neck Squamous Cell Carcinoma ◽  
Protein Kinase G

scholarly journals Assessment of proliferating cell nuclear antigen (PCNA) expression at the invading front of oral squamous cell carcinoma

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Emily Ming-Chieh Lu ◽  
Jithendra Ratnayake ◽  
Alison Mary Rich
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Proliferating Cell Nuclear Antigen ◽  
Pearson Correlation ◽  
Predictor Variable ◽  
Nuclear Antigen ◽  
Prognostic Information ◽  
Proliferating Cell

Abstract Background Accurate prediction of the behaviour of oral squamous cell carcinoma (OSCC) is necessary to determine prognosis and provide appropriate treatment. Therefore, it is important to investigate potential prognostic markers to determine their predictive ability. Histological assessment of specific features at the invading front of oral squamous cell carcinomas has shown to provide accurate and reproducible prognostic information. Proliferating cell nuclear antigen (PCNA) is a nuclear marker known to reflect cell turnover and may be used as a marker for tumour aggressiveness. Methods Twenty cases of OSCC were histologically assessed to evaluate the correlation between proliferating cell nuclear antigen expression and invasive front grading. Each case was first assessed on a haematoxylin and eosin stained slide and an invading front grading (IFG) score was determined. In order to obtain a PCNA score, immunohistological staining was carried out using the peroxidase-labelled streptavidin-biotin technique with the monoclonal antibody PC10. Results In all cases, tumour islands had a periphery of intensely stained proliferating cell nuclear antigen-positive epithelial cells. The average IFG score was 8 ± 1.8, and the average PCNA score was 75% ± 11.2. Regression analysis was done using data from the IFG score and PCNA score and taking the latter as the predictor variable. The Pearson correlation coefficient was 0.134, with a p-value of 0.572. Conclusion Since the correlation between PCNA score and IFG score was not significant (p > 0.05), we conclude that there is no association between cell proliferation at the invading tumour front and the histological grading of OSCC.

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