Comparison of Euro-Collins Solution, Low-Potassium Dextran Solution Containing Glucose, and ET-Kyoto Solution for Lung Preservation in an Extracorporeal Rat Lung Perfusion Model

1998 ◽  
Vol 30 (5) ◽  
pp. 297-304 ◽  
Author(s):  
T. Bando ◽  
J.M. Albes ◽  
T. Nüsse ◽  
H. Wada ◽  
S. Hitomi ◽  
...  
Keyword(s):  
Lung Perfusion ◽  
Rat Lung ◽  
Lung Preservation ◽  
Perfusion Model ◽  
Low Potassium ◽  
Dextran Solution

scholarly journals Therapeutic effect of surfactant inhalation during warm ischemia in an isolated rat lung perfusion model

2012 ◽  
Vol 25 (10) ◽  
pp. 1096-1105 ◽  
Author(s):  
Akihiro Ohsumi ◽  
Fengshi Chen ◽  
Daisuke Nakajima ◽  
Jin Sakamoto ◽  
Tetsu Yamada ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Lung Perfusion ◽  
Warm Ischemia ◽  
Rat Lung ◽  
Perfusion Model ◽  
Isolated Rat Lung ◽  
Isolated Rat

INNOVATIVE RAT LUNG PERFUSION MODEL USING MINIATURE ARTIFICIAL LUNG FOR DEOXYGENATION

ASAIO Journal ◽  
2003 ◽  
Vol 49 (2) ◽  
pp. 160
Author(s):  
H Izumi ◽  
H Arai ◽  
N Tabuchi ◽  
H Tanaka ◽  
H Sunamori
Keyword(s):  
Lung Perfusion ◽  
Artificial Lung ◽  
Rat Lung ◽  
Perfusion Model

Improvements in Lung Preservation: 3 Years' Experience With a Low-Potassium Dextran Solution

2005 ◽  
Vol 41 (1) ◽  
pp. 16-19 ◽  
Author(s):  
P. Gámez ◽  
M. Córdoba ◽  
I. Millán ◽  
L. Madrigal ◽  
F. Alfageme ◽  
...  
Keyword(s):  
Lung Preservation ◽  
Low Potassium ◽  
Dextran Solution

Effects of immediate versus delayed ex-vivo lung perfusion in a porcine cardiac arrest donation model

2019 ◽  
Vol 42 (7) ◽  
pp. 362-369 ◽  
Author(s):  
Carolin Olbertz ◽  
Nikolaus Pizanis ◽  
Hagen Bäumker ◽  
Simon Becker ◽  
Clemens Aigner ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Lung Perfusion ◽  
Large Animal Model ◽  
Large Animal ◽  
Ex Vivo Lung Perfusion ◽  
Promising Tool ◽  
Group I ◽  
Low Potassium ◽  
Dextran Solution ◽  
Circulatory Death

Objective:Ex-vivo lung perfusion is a promising tool to evaluate and recondition marginal donor lungs usually after a cold static preservation. The concept of continuous organ perfusion is supposed to reduce ischemic damage; however, the optimal perfusion protocol has not been established yet. The aim of this study was to compare immediate ex-vivo lung perfusion (I-EVLP) to delayed ex-vivo lung perfusion (D-EVLP) after a certain cold static preservation period on lung function in a large animal model.Methods:In a porcine model, lungs were procured after circulatory death and 60 min of no-touch warm ischemia. Lungs were preserved with single-flush cold low potassium dextran solution and prepared either for I-EVLP (n = 8) or stored cold for 9 h with subsequent D-EVLP (n = 8). Functional outcomes and morphology were compared during 4 h of ex-vivo lung perfusion, using STEEN SolutionTMas perfusion solution.Results:Pulmonary functional data, perfusate activities of lactate dehydrogenase, alkaline phosphatase, and products of lipid peroxidation did not differ significantly. There was a trend toward lower wet–dry ratio (I-EVLP: 13.4 ± 2.9; D-EVLP: 9.1 ± 2.5) and higher ΔpO2in D-EVLP group (I-EVLP: 209 ± 51.6 mmHg; D-EVLP: 236.3 ± 47.3 mmHg).Conclusion:In this donation-after-circulatory-death model, 9 h of cold static preservation followed by ex-vivo lung perfusion results in comparable pulmonary function to I-EVLP as indicated by oxygenation capacities and wet–dry ratio. Our findings indicate that prolonged cold static preservation prior to ex-vivo lung perfusion is as safe and effective as I-EVLP in the procurement of donor lungs.

EPC-K 1 Is Effective in Lung Preservation in an Ex Vivo Rabbit Lung Perfusion Model

1997 ◽  
Vol 63 (4) ◽  
pp. 954-959 ◽  
Author(s):  
Itaru Nagahiro ◽  
Motoi Aoe ◽  
Motohiro Yamashita ◽  
Hiroshi Date ◽  
Akio Andou ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Lung Perfusion ◽  
Rabbit Lung ◽  
Lung Preservation ◽  
Perfusion Model
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