scholarly journals Effect of Donepezil on Group II mGlu Receptor Agonist- or Antagonist-Induced Amnesia on Passive Avoidance in Mice

2003 ◽  
Vol 10 (4) ◽  
pp. 319-325 ◽  
Author(s):  
Tomoaki Sato ◽  
Koh-ichi Tanaka ◽  
Yoshiko Ohnishi ◽  
Masahiro Irifune ◽  
Takashige Nishikawa
Keyword(s):  
Passive Avoidance ◽  
Receptor Antagonist ◽  
Receptor Agonist ◽  
Memory Performance ◽  
Memory Function ◽  
Avoidance Performance ◽  
Ache Inhibitor ◽  
Avoidance Task ◽  
Mglu Receptor ◽  
Group Ii

We examined the effect of the acetylcholinesterase (ACHE) inhibitor, donepezil hydrocloride (DONP), on group II metabotropic glutamate (mGlu) receptor agonist- or antagonist-induced amnesia in the step-through passive avoidance task in male mice. DCG-IV, a group II mGlu receptor agonist, at dose of 50 ng and LY341495, a group II mGlu receptor antagonist, at dose of 300 ng, significantly attenuated the latency on the step-through task. The subcutaneous injection of DONP at dose of 1 mg/kg 1 hour before passive avoidance performance ameliorated the amnesia induced by DCG-IV and LY341495, whereas donepezil alone did not affect task latency. The results suggest that activation of group II mGlu receptors and disinhibition of the cAMP/PKA signaling pathway (caused by group II mGlu receptor antagonist) have a negative action on step-through passive avoidance memory performance, and that group II mGlu receptors and ACh interact to modulate learning and memory function.

The combination of agomelatine and ritanserin exerts a synergistic interaction in passive avoidance task

2014 ◽  
Vol 34 (8) ◽  
pp. 787-795
Author(s):  
F İlkaya ◽  
M Yüce ◽  
AE Ağrı ◽  
H Güzel ◽  
H Balcı ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Receptor Antagonist ◽  
Retention Time ◽  
Memory Function ◽  
Memory Deficit ◽  
Synergistic Interaction ◽  
Acquisition Time ◽  
Avoidance Task ◽  
Synergistic Activity ◽  
Reference Drug

Agomelatine is a potent agonist at melatonergic 1 and 2 (MT1 and MT2) receptors and an antagonist at serotonin-2C (5HT-2C) receptors. It was suggested that psychotropic effects of agomelatine is associated with its melatonergic and serotonergic effects. In this study, we aimed to evaluate the effects of agomelatine alone or in combination with ritanserin (5HT-2A/2C antagonist) on memory and learning. Male Balb-C mice (25–30 g) were used, and all drugs and saline were administrated by intraperitoneal (i.p.) route 30 min prior to evaluating retention time. Whilst agomelatine was administered at the doses of 1, 10 and 30 mg/kg, ritanserin was administered at the doses of 0.1, 1 and 10 mg/kg. To evaluate memory function, passive avoidance test was used. On the first day, acquisition time and on the second day (after 24h), retention time of mice were recorded. To evaluate the synergistic activity, only the least doses of agomelatine and ritanserine were used, that is, 1 and 0.1 mg/kg, respectively. Scopolamine (1 mg/kg) was used as a reference drug, so it was combined with drug groups. Our results show that 5HT-2A/2C receptor antagonist ritanserin (1 and 4 mg/kg, i.p.) and agomelatine (10 and 30 mg/kg, i.p.) improve memory deficit induced by scopolamine, whilst a synergistic interaction is observed between ritanserin and agomelatine (0.1 mg/kg and 1 mg/kg, i.p., respectively) when they were administered at their ineffective doses. According to our findings, we concluded that agomelatine improves memory deficit and thus improves the effect of agomelatine arises from its 5HT-2C receptor antagonist activity.

Anxiolytic-like activity of MGS0039, a selective group II mGlu receptor antagonist, is serotonin-and GABA-dependent

2011 ◽  
Vol 63 (4) ◽  
pp. 880-887 ◽  
Author(s):  
Katarzyna Stachowicz ◽  
Joanna Wierońska ◽  
Helena Domin ◽  
Shigeyuki Chaki ◽  
Andrzej Pilc
Keyword(s):  
Receptor Antagonist ◽  
Mglu Receptor ◽  
Group Ii

scholarly journals Reconstruction of GABAergic Transmission and Behavior by Striatal Cell Grafts in Rats with Ischemic Infarcts in the Middle Cerebral Artery

1993 ◽  
Vol 4 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Hitoo Nishino ◽  
Noritaka Aihara ◽  
András Czurko ◽  
Takeshi Hashitani ◽  
Yoshiaki Isobe ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Passive Avoidance ◽  
Cerebral Artery ◽  
Avoidance Performance ◽  
Rat Striatum ◽  
Gaba Uptake ◽  
Avoidance Task ◽  
Magnetic Resonance Imaging Mri ◽  
Gaba Transmission ◽  
And Behavior

Fetal striatal cell suspensions were grafted stereotaxically into the infarcted striatum of rats, and reconstruction of striatopallidal GABA transmission and behavior were investigated. Occlusion of the middle cerebral artery (MCA) for one hour induced ischemic infarcts mainly in the lateral striatum, as detected by magnetic resonance imaging (MRI) and histology. Ischemic rats had deficits in the performance of a passive avoidance task, both acquisition and retention, but no changes in general circadian actograms. In these animals pallidal GABA, detected by microdialysis, decreased to about half of control levels. There were suggestions of an improvement in passive avoidance performance in the grafted animals. Pallidal GABA concentrations recovered almost to control levels, and were increased by infusions of the GABA uptake blocker nipecotic acid. These data indicate that neural transplantation is a promising approach to improve the deficits in chemical transmission and behavior following ischemic infarcts in rat striatum.

Antidepressant-like effects of scopolamine in mice are enhanced by the group II mGlu receptor antagonist LY341495

2016 ◽  
Vol 111 ◽  
pp. 169-179 ◽  
Author(s):  
Karolina Podkowa ◽  
Adrian Podkowa ◽  
Kinga Sałat ◽  
Tomasz Lenda ◽  
Andrzej Pilc ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Mglu Receptor ◽  
Group Ii
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