scholarly journals Txicological Aspects of Newly Designed Macrocyclic Complexes of Iron(II)

2002 ◽  
Vol 8 (6) ◽  
pp. 315-321 ◽  
Author(s):  
Ashu Chaudhary ◽  
R. V. Singh
Keyword(s):  
Binding Sites ◽  
Brine Shrimp ◽  
Condensation Reaction ◽  
Octahedral Geometry ◽  
Macrocyclic Complexes ◽  
Spectral Studies ◽  
X Ray ◽  
Mass Spectral ◽  
Molar Ratios ◽  
Elemental Analyses

Brine shrimp lethality of a new series of 16 to 26-membered macrocycles of iron(II) containing tetraaza groups and prepared by the template condensation reaction of diacarboxylic acids (malonic, succinic, glutaric or adipic) with 2,6-diaminopyridine and diethylenetriamine in 1:2:2 molar ratios have been studied. Structures and bonding of the macrocyclic complexes have been proposed based on elemental analyses, IR, electronic, X-ray and mass spectral studies. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles. The formation of the complexes as [Fe(Ln)Cl2] has been established on the basis of the chemical composition. The complexes have also been screened against several microbes.

scholarly journals Synthesis, Characterization, Stability and Cytotoxic Evaluation of Novel Titanium(IV) Complexes of 8-Hydroxyquinoline and 2-Hydroxy-N-phenylbenzylamine Derivatives

2020 ◽  
Vol 32 (3) ◽  
pp. 683-689
Author(s):  
Blassan Samuel ◽  
Madhvesh Pathak
Keyword(s):  
Spectral Studies ◽  
Breast Carcinoma Cell Line ◽  
Human Breast ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Molar Ratios ◽  
New Class ◽  
Elemental Analyses ◽  
Moisture Sensitive ◽  
Uv Visible

A new class of moisture stable heteroleptic titanium(IV) complexes, synthesized from 8-hydroxyquinoline of the type [(Q)2Ti(2-O-5-X-C6H3CH2NC6H4R] (3a-j), was prepared by reacting the antecedent molecule [(Q2)Ti(OiPr)2] (2) with various 2-hydroxy-N-phenyl-benzylamine analogues in 1:1 molar ratios in dry toluene (where, HQ = 8-hydroxyquinoline; iPr = isopropyl; R = H, 4-CH3, 4-OCH3, 2-Cl, 4-Cl, 2-Br, 4-Br; X= H, Br). Moisture sensitive study disclosed that these new metal complexes were unreacted for 72 h. Mass spectral data were employed for proving the mono-nuclearity of the new derivatives. Thermal decomposition pattern of the new derivatives was explained by thermogravimetric analyses. Elemental analyses data are in concordance with their expected values. The hexa-coordinated way of titanium-ligand linkage is further proved through NMR, FTIR, and UV-visible spectral studies. The cytotoxic efficiency of new complexes was tested against MDA-MB-231 human breast carcinoma cell line. Complex 3a exhibited the highest cytotoxic potential of 0.039 μM in comparison to all its analogues of this series by employing cisplatin as the standard

scholarly journals Antimicrobial, Antifertility and Antiinflammatory Approach to Tetradentate Macrocyclic Complexes of Iron(II) and Manganese(II)

2002 ◽  
Vol 8 (6) ◽  
pp. 347-353 ◽  
Author(s):  
Ashu Chaudhary ◽  
D. P. Jaroli ◽  
R. V. Singh
Keyword(s):  
Molecular Weight ◽  
Reproductive Organs ◽  
Spectral Studies ◽  
Central Metal Atom ◽  
Central Metal ◽  
Testicular Sperm ◽  
Mass Spectral ◽  
Sperm Density ◽  
Elemental Analyses

Some antifertility inhibitors of 18 to 24-membered tetraazamacrocyclic complexes of iron(II) and manganese(II) have been synthesised by the template condensation using 1,3-phenylenediamine with malonic acid, succinic acid, glutaric acid and adipic acid. The reaction proceed smoothly to completion. The complexes were characterized by elemental analyses, molecular weight determinations, infrared, electronic, magnetic moment, mössbaur and mass spectral studies. The elemental analyses are consistent with the formation of the complexes [M(N4Ln)Cl2] (M = Fe(lI) or Mn(II)). All these complexes are stable and monomeric in nature as indicated by the molecular weight determinations. The spectral studies confirm the octahedral geometry around the central metal atom. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs have been examined and discussed.

scholarly journals Synthesis and Bio-Spectral Studies of Co(II) Complex of 5-Chloro-2,4-Dihydroxy Butyrophenoneoxime (CDHBOX)

2010 ◽  
Vol 6 (3) ◽  
pp. 1120-1133
Author(s):  
F. Rehman ◽  
M. Bhardwaj ◽  
U.K. Jetley
Keyword(s):  
Spectral Data ◽  
Standard Free Energy ◽  
Spectral Studies ◽  
Curvularia Lunata ◽  
Mass Spectral ◽  
Ir Studies ◽  
Free Energy Of Formation ◽  
Escherchia Coli ◽  
Elemental Analyses ◽  
Point Determination

Co(II) complex of 5-chloro-2,4-dihydroxy butyrophenoneoxime (CDHBOX) was synthesized from 5-chloro-2,4-dihydroxy butyrophenoneoxime by using standard protocol, and characterized by elemental analyses, melting point determination and spectral data. The ML2 (metal/ligand) stoichiometry of the complex was determined by spectrophotometric and potentiometric studies, and mass spectral data. The value of stability constant of the complex was found to be 6.94x 108 while its standard free energy of formation is 12.155 kcal/mol at 27ºC. Beer’s law is obeyed in the concentration range 2-15 ppm of Co. The value of molar extinction coefficient and sensitivity as per Sandell’s scale were found to 3.35x 103 L.mol-1cm-1and 0.017 μg Co/cm2 respectively. The value of activation energy and the Arrhenius constant Arrhenius constant were found as 4.949 kjmol-1, 74.39. The IR studies reveal that the phenolic proton is lost on complexation and the oxygen of the phenolic (–OH) and nitrogen of the oximino (=NOH) groups coordinate with Co(II) ion. The electronic spectra and magnetic susceptibility measurement indicate that the complex is paramagnetic and tetrahedral in nature. The antimicrobial activity of different concentrations of ligand and its Co(II)-complex  has been evaluated against Curvularia lunata, Fusarium oxysporum and Alternaria alternata fungi  and Streproproteus, Staph, Escherchia coli, Klebsella, and pseudomonas bacteria. The results indicated that the ligand (CDHBOX) and its Co(II) complex have good anti-microbial properties. 

scholarly journals Synthesis and spectral studies of Cu(II), Ni(II), Co(II), Mn(II), Zn(II) and Cd(II) complexes of a new macroacyclic ligand n,n’-bis(2-benzothiazolyl)-2,6-pyridinedicarboxamide

2006 ◽  
Vol 71 (5) ◽  
pp. 529-542 ◽  
Author(s):  
Kalagouda Gudasi ◽  
Siddappa Patil ◽  
Ramesh Vadavi ◽  
Rashmi Shenoy ◽  
Manjula Patil
Keyword(s):  
Liquid Nitrogen ◽  
Magnetic Moments ◽  
Thermal Studies ◽  
Liquid Nitrogen Temperature ◽  
Octahedral Geometry ◽  
Spectral Studies ◽  
Conductance Data ◽  
X Band ◽  
Elemental Analyses ◽  
Uv Visible

A new macroacyclic amide ligand N,N?-bis(2-benzothiazolyl)-2,6-pyridinedicarboxamide (BPD), formed by the condensation of 2,6-pyridinedicarbonyldichloride with 2-aminobenzothiazole and its Cu(II), Ni(II), Co(II), Mn(II), Zn(II) and Cd(II) complexes were synthesized. Their structures were elucidated on the basis of elemental analyses, conductance measurements, magnetic moments, spectral (IR, NMR UV-Visible, EPR and FAB) and thermal studies. The complexes exhibit an octahedral geometry around the metal center. Conductance data of the complexes suggested them to be 1:1 electrolytes. The pentadentate behavior of the ligand was proposed on the basis of spectral studies. The X-band EPR spectra of the Cu(II) and Mn(II) complexes in the polycrystalline state at room (300 K) and liquid nitrogen temperature (77 K) were recorded and their salient features are reported.

Preparation and Spectroscopic Characterisation of a Series of Heterobimetallic N-phenyldiethanolaminate-alkoxide Derivatives of Oxovanadium(V)

2005 ◽  
Vol 2005 (6) ◽  
pp. 352-355 ◽  
Author(s):  
Rajendra Singh Ghadwal ◽  
Ram C. Mehrotra ◽  
Anirudh Singh
Keyword(s):  
Molecular Weight ◽  
Spectral Studies ◽  
Metal Alkoxides ◽  
Nmr Studies ◽  
Mass Spectral ◽  
Elemental Analyses ◽  
Derivatives Of ◽  
Spectroscopic Characterisation

Reaction of VO(OPri)3 with two equivalents of N-phenyldiethanolamine (PhDEAH2) yields a homometallic complex [VO(PhDEA)(PhDEAH)] 1, which reacts with a number of metal alkoxides to afford heterobimetallic oxovanadium(V) complexes of the types [VO(PhDEA)2{M(OR)n-1}] [where PhDEA = C6H5N(CH2CH2O–)2], [M =: Al (n = 3, R = Pri) 2; Al (n = 3, R = But) 3; Ti (n = 4, R = Pri) 4; Zr (n = 4, R = Pri) 5; Nb (n = 5, R = Pri) 6; Ta (n = 5, R = Pri) 7. The derivative [VO(PhDEA)(OSiPh3)] 8 has been prepared by the equimolar interaction of [VO(PhDEA)(OPri)] with Ph3SiOH. All of these complexes have been characterised by spectroscopic (IR; 1H, 13C, 27Al and 51V NMR) studies, elemental analyses, and molecular weight measurements. The derivative 2 has also been characterised by FAB mass spectral studies, which supports for its monomeric nature.

Meso-pyrrolyl BODIPY based colorimetric optical sensor for Cu2+ ions

2020 ◽  
Vol 24 (09) ◽  
pp. 1121-1128
Author(s):  
P. Sabari ◽  
Rima Sengupta ◽  
B. Umasekhar ◽  
Mangalampalli Ravikanth
Keyword(s):  
Schiff Base ◽  
2D Nmr ◽  
Spectral Studies ◽  
Strong Absorption Band ◽  
X Ray ◽  
Mass Spectral ◽  
Imine Nitrogen ◽  
Phenolic Oxygen ◽  
Td Dft ◽  
Cation Sensing

A simple meso-pyrrolyl BODIPY-Schiff base conjugate was synthesized by reacting ([Formula: see text]-formylpyrrolyl) BODIPY with 2-aminophenol in ethanol at reflux followed by recrystallization from CH2Cl2/petroleum ether, affording the conjugate in 72% yield. The conjugate was thoroughly characterized by HR-MS, 1D and 2D NMR and X-ray crystallographic techniques. The X-ray structure of the meso-pyrrolyl BODIPY-Schiff base conjugate revealed that the meso-pyrrole and the phenyl substituents were deviated by an angle of [Formula: see text] and [Formula: see text], respectively, from the plane of the BF2-dipyrrin core. The absorption spectrum of the conjugate was similar to the ([Formula: see text]-formylpyrrolyl) BODIPY with a strong absorption band at 508 nm, whereas the fluorescence of the ([Formula: see text]-formylpyrrolyl) BODIPY was completely quenched in the BODIPY-Schiff base conjugate. Furthermore, cation sensing studies revealed that the conjugate has a specific sensing ability for the Cu(II) ion even in the presence of the other metal ions, as verified by the visual, absorption and mass spectral studies. The DFT optimized structure revealed that the Cu(II) ion was bound to pyrrolic nitrogen, imine nitrogen, phenolic oxygen and two water molecules in a distorted square pyramidal fashion. TD-DFT studies accounted well for the absorption spectra of the BODIPY-Schiff base conjugate and its Cu[Formula: see text] bound complex.

scholarly journals Template synthesis of macrocyclic complexes of Co(II), Ni(II), Cu(II), Zn(II) and Cd(II): Spectroscopic, antibacterial and antifungal studies

2010 ◽  
Vol 75 (6) ◽  
pp. 763-772 ◽  
Author(s):  
Dharam Singh ◽  
Vandna Malik ◽  
Ramesh Kumar ◽  
Krishan Kumar
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Metal Ion ◽  
Inhibitory Concentration ◽  
Condensation Reaction ◽  
Carbonyl Oxygen ◽  
Macrocyclic Complexes ◽  
Spectral Studies ◽  
Distorted Octahedral Geometry ◽  
Divalent Metal Ions

A new series of macrocyclic complexes of the type [M(C17H14N4O2)X2], where M = Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and X = Cl-, NO3-, CH3COO-was synthesized by the condensation reaction of malonyldihydrazide with benzil in the presence of divalent metal ions. The complexes were characterized with the aid of elemental analyses, conductance measurements, magnetic susceptibilities, electronic, NMR and infrared spectral studies. On the basis of these studies, a six coordinate distorted octahedral geometry, in which two nitrogen and two carbonyl oxygen atoms are suitably placed for coordination towards metal ion, is proposed for all the complexes. The complexes were tested for their in vitro antibacterial activity and antifungal activities. The minimum inhibitory concentration shown by these complexes were compared with the minimum inhibitory concentration shown by standard drugs.

scholarly journals Condensation reaction and crystallization of urea-formaldehyde resin during the curing process

BioResources ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. 2924-2936
Author(s):  
Zhongjian Ding ◽  
Zhongqiang Ding ◽  
Tianlin Ma ◽  
Hua Zhang
Keyword(s):  
Condensation Reaction ◽  
Urea Formaldehyde ◽  
Formaldehyde Resin ◽  
Curing Process ◽  
Chemical Methods ◽  
X Ray ◽  
Molar Ratios ◽  
Ph Values ◽  
Uf Resin ◽  
Resin Curing

Urea-formaldehyde (UF) resins were synthesized with different molar ratios and solid contents, and simultaneously they were cured under conditions of different pH values. The curing behaviors of cured UF resins were examined by synchronous thermal analysis (TG-DSC). The crystallinity of cured UF resin was analyzed by X-ray diffractometry. The gel time of cured UF resin was recorded by chemical methods. The results indicate that condensation reactivity leads condensation reaction and crystallization to play various roles during the curing process of UF resin. The condensation reaction and crystallization in the curing process interact to result in different structures of cured resin. A new mechanism for UF resin curing (reaction-crystallization) is thus proposed.

Synthesis and Characterization of Tris(nicotinohydroxamato) Vanadium(III) Complex

2020 ◽  
Vol 12 (5) ◽  
pp. 695-701
Author(s):  
Sonika Sharma ◽  
Neeraj Sharma
Keyword(s):  
Pathogenic Bacteria ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Nitrogen Atmosphere ◽  
Spectral Studies ◽  
Mass Spectral ◽  
E Coli ◽  
Concentration Method ◽  
Elemental Analyses

The tris(nicotinohydroxamato) vanadium(III) complex of composition [V(C5H4NCONHO)3] have been synthesized by the reaction of VCl3 with three equivalents of potassium salts of nicotinohydroxamate in methanol medium under nitrogen atmosphere. The characterization of complex has been accomplished by elemental analyses, molar conductivity, magnetic moment measurements, IR, electronic and mass spectral studies. An octahedral geometry around vanadium, inferred from physicochemical and spectral studies has been proposed for complex. The antimicrobial activities of the newly synthesized complex, ligand and precursor VCl3 have been evaluated against some pathogenic bacteria as E. coli, S. aureus, S. typhi, S. paratyphi, S. epidermidis and K. pneumoniae and fungi such as A. niger, B. fulva and M. circinelloid by minimum inhibitory concentration method. The complex exhibited promising antimicrobial activity relative to free ligand and metal precursor.

Isolation and structure of cribrostatins 1 and 2 from the blue marine sponge Cribrochalinasp

1992 ◽  
Vol 70 (4) ◽  
pp. 1170-1175 ◽  
Author(s):  
George R. Pettit ◽  
Jeremiah C. Collins ◽  
Delbert L. Herald ◽  
Dennis L. Doubek ◽  
Michael R. Boyd ◽  
...  
Keyword(s):  
Cell Line ◽  
Marine Sponge ◽  
Leukemia Cell ◽  
Lymphocytic Leukemia ◽  
Leukemia Cell Line ◽  
Spectral Studies ◽  
X Ray ◽  
Mass Spectral ◽  
P388 Cell ◽  
Lymphocytic Leukemia Cell

The blue marine sponge cribrostatins 1 (1, 8.8 × 10−6% yield) and 2 (2, 3.1 × 10−6% yield) active against the P388 lymphocytic leukemia cell line (ED50 1.58 and 2.73 μg/mL respectively) have been isolated. The previously known isoquinolinequinones mimosamycin (3), renierone (4), and O-demethylrenierone (5) were also isolated and shown to display activity against the P388 cell line (ED50 0.73, 2.75, and 8.36 μg/mL, respectively). Importantly, both cribrostatin 1 and mimosamycin showed selective activity against all of the nine human melanoma cell lines employed by the U.S. National Cancer Institute. Structural determinations were accomplished utilizing high field nuclear magnetic resonance (400 MHz) and mass spectral studies. Confirmation of the cribrostatin 1 structure was achieved by X-ray crystallographic techniques.

Sign in / Sign up

Export Citation Format

Share Document