scholarly journals Antiandrogen and Antimicrobial Aspects of Coordination Compounds of Palladium(II), Platinum(II) and Lead(II)

2001 ◽  
Vol 8 (3) ◽  
pp. 149-158 ◽  
Author(s):  
R. V. Singh ◽  
S. C. Joshi ◽  
Shalini Kulshrestha ◽  
Pooja Nagpal ◽  
Anil Bansal
Keyword(s):  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Testicular Sperm ◽  
Sperm Density

Synthesis, characterization and antimicrobial activities of an interesting class of biologically potent macrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed. The resulting biologically active [M(MaLn)(R2)]Cl2 and [Pb(MaLn)(R2)X2] (where, M = PdII or PtII and X = Cl or NO3) type of complexes have been synthesized by the reactions of macrocyclic ligands (MaLn) with metal salts and different diamines in 1:1:1 molar ratio in methanol. Initially the complexes were characterized by elemental analyses, molecular weight determinations and conductivity measurements. The mode of bonding was established on the basis of IR, H1 NMR, C13 NMR, Pt195 NMR, Pb207 NMR, XRD and electronic spectral studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged by benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium and platinum complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedral geometry is suggested for lead complexes.

scholarly journals Synthesis, Characterization and Antifertility Activity of New Unsymmetrical Macrocyclic Complexes of Tin(II)

2000 ◽  
Vol 7 (5) ◽  
pp. 237-243 ◽  
Author(s):  
Kripa Sharma ◽  
S. C. Joshi ◽  
R. V. Singh
Keyword(s):  
Metal Ion ◽  
Amino Nitrogen ◽  
Pathogenic Fungi ◽  
Ring Expansion ◽  
Macrocyclic Complexes ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Testicular Sperm ◽  
Sperm Density

A new series of unsymmetrical macrocyclic complexes of tin(ll) has been prepared by the template process using bis(3-oxo-2-butylidene)propane-1,3-diamine as precursor. This affords a method to synthesize these complexes with various ring sizes. The tetradentate macrocyclic precursor [N4mL] reacts with SnCl2 and different diamines in a 1:1:1 molar ratio in refluxing methanol to give complexes of the type [Sn(N4mL)Cl2]. The ring expansion has been achieved by varying the diamine between the two diacetyl amino nitrogen atoms. The macrocyclic precursor and its metal complexes have been characterized on the basis of elemental analysis, molar conductance, molecular weight determinations, IR, H1 NMR,C13 NMR, Sn119 NMR and electronic spectral studies. An octahedral geometry around the metal ion is suggested for these complexes. On the basis of molecular weights and conductivity measurements, their monomeric and non-electrolytic nature has been confirmed. The precursor and complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemicals parameters of reproductive organs have been examined and discussed.

scholarly journals Toxicity, Spectroscopic Characterization and Electrochemical Behaviour of New Macrocclic Complexes of Lead(II) and Palladium(II) Metals

2000 ◽  
Vol 7 (4) ◽  
pp. 211-218 ◽  
Author(s):  
Anil Bansal ◽  
Randhir Singh ◽  
R. V. Singh
Keyword(s):  
Electrochemical Behaviour ◽  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Spectroscopic Characterization ◽  
Palladium Complexes ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Planar Geometry ◽  
Template Process

Tetraazamacrocyclie complexes of lead and palladium have been synthesized by the template process using the bis(benzil)ethylenediamine precursor. The tetradentate macrocycle (maL) reacts with PbCl2, PdCl2 and different diamines in a 1:1:1 molar ratio in methanol to give several solid complexes of the types [Pb(maL)(R)Cl2] and [Pd(maL)(R)]Cl2 (where R = 2,6-diaminopyridine or 1,2-phenylenediamine). The macrocycle and its metal complexes have been characterized by elemental analysis, molecular weight determinations, molar conductivity, IR, 1H NMR, 13C NMR, electronic, mass and electrochemical studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged by benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedral geometry is suggested for lead complexes. The macrocycle along with its complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential.

scholarly journals Fertility Inhibitor Heterobimetallic Complexes of Platinum(II) and Palladium(II): Synthetic, Spectroscopic and Antimicrobial Aspects

2000 ◽  
Vol 7 (2) ◽  
pp. 105-113 ◽  
Author(s):  
Kripa Sharma ◽  
S. C. Joshi ◽  
R. V. Singh
Keyword(s):  
Sperm Morphology ◽  
Pathogenic Fungi ◽  
Reproductive Organs ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Testicular Sperm ◽  
Heterobimetallic Complexes ◽  
Sperm Density ◽  
Square Planar ◽  
Elemental Analyses

Synthetic, spectroscopic and antimicrobial aspects of some fertility inhibitor heterobimetallic complexes have been carried out. These heterobimetallic chelates [M(C5H5N3)2M2'(R)4]Cl2 (M = Pd or Pt and M' = Si, Sn, Ti and Zr) have been successfully synthesinzed via the reaction of M(C5H7N3)2Cl2 with group four or fourteen dichlorides in 1:2 stoichiometric proportions. The products were characterized by elemental analyses, molecular weight determinations, magnetic susceptibility measurements, conductance, and IR multinuclear NMR and electronic spectral studies. A square planar geometry has been suggested for all the complexes with the help of spectral data. Conductivity data strongly suggest that chlorine atoms are ionic in nature due to which complexes behave as electrolytes. All the complexes have been evaluated for their antmicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.

scholarly journals Synthesis, Characterization, In Vitro and In Vivo Screening of Unsymmetrical Borole Complexes of 2-Hydroxy-N-Phenylbenzamide and its Derivatives

2000 ◽  
Vol 7 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Taruna Pandey ◽  
R. V. Singh
Keyword(s):  
Pathogenic Fungi ◽  
Reproductive Organs ◽  
Molar Ratio ◽  
Testicular Sperm ◽  
Sperm Density ◽  
Bactericidal Properties ◽  
Boron Complexes

Biochemical aspects, synthesis and characterization of some boron complexes of 2-hydroxy-N-phenylbenzamide (HOPhBenz) and its semicarbazone (HOPhBenz.SCZH) and thiosemicarbazone (HOPhBenz.TSCZH) are described. These derivatives were prepared by the reactions of 2-isopropoxy-4-methyl-1,3,2-dioxaborolane, and 2-isopropoxy-4-methyl-1,3,2-dioxaborinane with 2-hydroxy-N-phenylbenzamide, 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarboxamide (HOPhBenz.SCZH), and 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarbothioamide(HOPhBenz.TSCZH) in a 1:1 molar ratio. In order to assess the increase of the inhibitor potency, (HOPhBenz), (HOPhBenz.SCZH), (HOPhBenz.TSCZH) and their boron complexes have been tested in vitro against a number of pathogenic fungi and bacteria at different concentrations and were found to possess remarkable fungicidal and bactericidal properties. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs are discussed.

scholarly journals Antimicrobial, Antifertility and Antiinflammatory Approach to Tetradentate Macrocyclic Complexes of Iron(II) and Manganese(II)

2002 ◽  
Vol 8 (6) ◽  
pp. 347-353 ◽  
Author(s):  
Ashu Chaudhary ◽  
D. P. Jaroli ◽  
R. V. Singh
Keyword(s):  
Molecular Weight ◽  
Reproductive Organs ◽  
Spectral Studies ◽  
Central Metal Atom ◽  
Central Metal ◽  
Testicular Sperm ◽  
Mass Spectral ◽  
Sperm Density ◽  
Elemental Analyses

Some antifertility inhibitors of 18 to 24-membered tetraazamacrocyclic complexes of iron(II) and manganese(II) have been synthesised by the template condensation using 1,3-phenylenediamine with malonic acid, succinic acid, glutaric acid and adipic acid. The reaction proceed smoothly to completion. The complexes were characterized by elemental analyses, molecular weight determinations, infrared, electronic, magnetic moment, mössbaur and mass spectral studies. The elemental analyses are consistent with the formation of the complexes [M(N4Ln)Cl2] (M = Fe(lI) or Mn(II)). All these complexes are stable and monomeric in nature as indicated by the molecular weight determinations. The spectral studies confirm the octahedral geometry around the central metal atom. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs have been examined and discussed.

scholarly journals Synthesis and Characterization of New Lead(II) and Organotin(IV) Complexes of Schiff Bases Derived from Histidine and Methionine

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Har Lal Singh ◽  
J. B. Singh
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Analytical Data ◽  
Molar Conductance ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Tetrahedral Geometry ◽  
H Nmr ◽  
Carboxylate Oxygen

New Schiff base (HL) ligand is prepared via condensation of isatins and amino acids in 1:1 molar ratio. Metal complexes are prepared and characterized by elemental analysis, molar conductance, electronic, infrared, and multinuclear magnetic resonance (1H NMR, 13C NMR, and 119Sn NMR). The analytical data showed that the ligand acts as bidentate toward metal ions via azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of metal : ligand (1 : 2) to from metal complexes (Pb(II)(L)2 and Bu2Sn(L)2, where L is the Schiff base ligands of histidine and methionine). The conductivity values between 15 and 25 Ω−1cm2 mol−1 in DMF imply the presence of nonelectrolyte species. On the basis of the above spectral studies, distorted octahedral and tetrahedral geometry have been proposed for the resulting organotin(IV) and lead(II) complexes.

scholarly journals Synthesis, Structural Investigations and Antimicrobial Activities of Homo Binuclear Complexes Derived from 2-Amino-4-chlorophenol

2020 ◽  
Vol 32 (4) ◽  
pp. 759-764
Author(s):  
K. Savitha ◽  
S. Vedanayaki
Keyword(s):  
Metal Complexes ◽  
Magnetic Moment ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Antimicrobial Activities ◽  
Molar Conductance ◽  
Azomethine Nitrogen ◽  
Planar Geometry ◽  
Binuclear Complexes ◽  
Central Metal

Co(II), Ni(II) and Cu(II) homo binuclear Schiff base metal complexes were synthesized from terephthalaldehyde and 2-amino-4-chlorophenol in methanol using template method. The structure of the ligand and its metal complexes were established by elemental, molar conductance, UV, magnetic moment, IR, 1H & 13C NMR, EPR, mass, thermal and PXRD. Molar conductance values showed that all complexes were non-electrolytic in nature. The IR spectral data provides the coordination of azomethine nitrogen and oxygen with central metal ion. UV, ESR and magnetic moment values suggest square planar geometry for Co(II), Ni(II) and Cu(II) complexes. TGA and DSC analysis data show the thermal stability of the ligand and its metal complexes. The crystalline nature of ligand and its metal complexes were investigated by powder-XRD. The DNA cleavage activities of all the complexes assayed on PUC18 DNA shows nuclease ability.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Mixed Schiff Base Ligand Complexes of Co(II), Ni(II), Cu(II) and Zn(II)

2011 ◽  
Vol 8 (3) ◽  
pp. 1258-1263 ◽  
Author(s):  
A. K. Mapari ◽  
M. S. Hate ◽  
K. V. Mangaonkar
Keyword(s):  
Antimicrobial Activity ◽  
Thermogravimetric Analysis ◽  
Schiff Bases ◽  
Free Ligand ◽  
Antimicrobial Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Azomethine Nitrogen ◽  
Diffusion Method ◽  
Spectral Studies

The mixed ligand complexes of Co(II), Ni(II), Cu(II) and Zn(II) with Schiff basesN-(2-hydroxy-1-naphthylidene)-4-methylaniline (L1H) andN-(2-hydroxybenzylidene)-2,3-dimethylaniline (L2H) have been synthesized and characterized. The resulting complexes were characterized by elemental analysis, thermogravimetric analysis, magnetic moment measurements, conductivity measurements,1H NMR, IR, UV-visible and ESR spectral studies. The Schiff bases acts as bidentate monobasic ligands, coordinating through deprotonated phenolic oxygen and azomethine nitrogen atoms. The complexes are non-electrolytic in DMSO. The presence of the two coordinated water molecules in these complexes was indicated by IR spectra and thermogravimetric analysis of the complexes. From the analytical and spectral data the stoichiometry of these complexes have been found to be [M(L1)(L2)(H2O)2] {where M = Co(II) , Ni(II), Cu(II) and Zn(II)}. It is found that Co(II), Ni(II), Cu(II) and Zn(II) complexes exhibited octahedral geometry. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion method. It is found that the metal complexes have higher antimicrobial activity than the free ligand.

scholarly journals Synthesis, Characterization and Antimicrobial Activity of Cu(II), Co(II) and Ni(II) Complexes with O, N, and S Donor Ligands

2008 ◽  
Vol 5 (3) ◽  
pp. 577-583 ◽  
Author(s):  
Vidyavati Reddy ◽  
Nirdosh Patil ◽  
S. D. Angadi
Keyword(s):  
Schiff Base ◽  
Magnetic Measurements ◽  
Antimicrobial Activities ◽  
Octahedral Geometry ◽  
Donor Ligands ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Conductivity Measurements ◽  
Schiff Base Ligands ◽  
Plate Method

The complexes of the type ML2[where M = Cu(II), Co(II), and Ni(II)] L = 1-phenyl-1-ene-3-(2-hydroxyphenyl)-prop-2-ene with 3- substituted-5-mercapto-4-amino-1,2,4-triazoles. Schiff base ligands have been prepared by reacting 3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one and 3-phenyl/pyridyl-4-amino-5-mercapto-1,2,4-triazoles in an alcoholic medium. The complexes are non-electrolytes in DMF. The resulting complexes were characterized by elemental analysis, magnetic measurements, conductivity measurements and spectral studies. The Schiff base acts as a tridentate dibasic and coordinating through the deprotonated oxygen, thioenolic sulphur and azomethine nitrogen atoms. It is found that Cu(II), Co(II), and Ni(II) complexes exhibited octahedral geometry. The antimicrobial activities of ligands and its complexes were screened by cup plate method.

scholarly journals Spectroscopic Characterization and Antimicrobial Activities of Some Heavy Metals Complexes of 2-hydroxy phenyl piperonalidene

2013 ◽  
Vol 10 (3) ◽  
pp. 627-637
Author(s):  
Baghdad Science Journal
Keyword(s):  
Spectroscopic Characterization ◽  
Antimicrobial Activities ◽  
Heat Of Formation ◽  
Molar Ratio ◽  
Ratio Method ◽  
Spectral Studies ◽  
In Vitro Tests ◽  
Tetrahedral Geometry ◽  
Antibacterial And Antifungal

An antibacterial and antifungal piperonal-derived compound and its Rh(III), Pd(II), Pt(IV), and Cd(II) metal complexes were synthesized and characterized by spectroscopic methods, conductivity, metal analyses and magnetic moment measurements. The nature of the complexes formed in ethanolic solution was studied following the molar ratio method. From the spectral studies, octahedral geometry was suggested for rhodium (III) and platinum (IV) complexes, while a square planer structure was suggested for palladium (II) complex and a tetrahedral geometry for cadmium (II) complex. Structural geometries of these compounds were also suggested in gas phase by using hyperchem-8 program for the molecular mechanics and semi-empirical calculations. The heat of formation and binding energy for the prepared compounds was calculated by using PM3 and AMBER methods. The theoretically vibration spectra for the imine and its starting material was evaluated by using PM3 method. Preliminary in vitro tests for antibacterial and antifungal activity showed that most of the prepared compounds display a good activity to (Staphylococcus aureus), (Escherichia coli) and (Candida albicans).

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