scholarly journals Toxicity, Spectroscopic Characterization and Electrochemical Behaviour of New Macrocclic Complexes of Lead(II) and Palladium(II) Metals

2000 ◽  
Vol 7 (4) ◽  
pp. 211-218 ◽  
Author(s):  
Anil Bansal ◽  
Randhir Singh ◽  
R. V. Singh
Keyword(s):  
Electrochemical Behaviour ◽  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Spectroscopic Characterization ◽  
Palladium Complexes ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Planar Geometry ◽  
Template Process

Tetraazamacrocyclie complexes of lead and palladium have been synthesized by the template process using the bis(benzil)ethylenediamine precursor. The tetradentate macrocycle (maL) reacts with PbCl2, PdCl2 and different diamines in a 1:1:1 molar ratio in methanol to give several solid complexes of the types [Pb(maL)(R)Cl2] and [Pd(maL)(R)]Cl2 (where R = 2,6-diaminopyridine or 1,2-phenylenediamine). The macrocycle and its metal complexes have been characterized by elemental analysis, molecular weight determinations, molar conductivity, IR, 1H NMR, 13C NMR, electronic, mass and electrochemical studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged by benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedral geometry is suggested for lead complexes. The macrocycle along with its complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential.

scholarly journals Antiandrogen and Antimicrobial Aspects of Coordination Compounds of Palladium(II), Platinum(II) and Lead(II)

2001 ◽  
Vol 8 (3) ◽  
pp. 149-158 ◽  
Author(s):  
R. V. Singh ◽  
S. C. Joshi ◽  
Shalini Kulshrestha ◽  
Pooja Nagpal ◽  
Anil Bansal
Keyword(s):  
Macrocyclic Ligand ◽  
Pathogenic Fungi ◽  
Antimicrobial Activities ◽  
Biologically Active ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Spectral Studies ◽  
Planar Geometry ◽  
Testicular Sperm ◽  
Sperm Density

Synthesis, characterization and antimicrobial activities of an interesting class of biologically potent macrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed. The resulting biologically active [M(MaLn)(R2)]Cl2 and [Pb(MaLn)(R2)X2] (where, M = PdII or PtII and X = Cl or NO3) type of complexes have been synthesized by the reactions of macrocyclic ligands (MaLn) with metal salts and different diamines in 1:1:1 molar ratio in methanol. Initially the complexes were characterized by elemental analyses, molecular weight determinations and conductivity measurements. The mode of bonding was established on the basis of IR, H1 NMR, C13 NMR, Pt195 NMR, Pb207 NMR, XRD and electronic spectral studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged by benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium and platinum complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedral geometry is suggested for lead complexes.

scholarly journals Synthetic, Spectroscopic and Biocidal Aspects of Heterobimetallic Complexes Comprising Platinum(II) and a Group Four or Fourteen Element

2000 ◽  
Vol 7 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Kripa Sharma ◽  
R. V. Singh
Keyword(s):  
Molecular Weight ◽  
Magnetic Measurements ◽  
Pathogenic Fungi ◽  
Molar Ratio ◽  
Planar Geometry ◽  
Conductivity Data ◽  
Heterobimetallic Complexes ◽  
Square Planar ◽  
Growth Inhibiting

Heterobimetallic complexes with varying amines have been synthesized by the reaction of [Pt(C2H8N2)2]Cl2 with group four or fourteen organometallic dichlorides, viz., R2MCl2 and Cp2M'Cl2 in a 1:2 molar ratio in MeOH (where M=Si or Sn, M'= Ti or Zr and R=Ph or Me). These complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, conductance, IR, H1 NMR and electronic spectra. The spectral data suggest a square planar geometry for all the complexes. Conductivity data suggest that they behave as electrolytes. These monometallic precursors along with their complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential.

scholarly journals Synthesis, Characterization and Antifertility Activity of New Unsymmetrical Macrocyclic Complexes of Tin(II)

2000 ◽  
Vol 7 (5) ◽  
pp. 237-243 ◽  
Author(s):  
Kripa Sharma ◽  
S. C. Joshi ◽  
R. V. Singh
Keyword(s):  
Metal Ion ◽  
Amino Nitrogen ◽  
Pathogenic Fungi ◽  
Ring Expansion ◽  
Macrocyclic Complexes ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Testicular Sperm ◽  
Sperm Density

A new series of unsymmetrical macrocyclic complexes of tin(ll) has been prepared by the template process using bis(3-oxo-2-butylidene)propane-1,3-diamine as precursor. This affords a method to synthesize these complexes with various ring sizes. The tetradentate macrocyclic precursor [N4mL] reacts with SnCl2 and different diamines in a 1:1:1 molar ratio in refluxing methanol to give complexes of the type [Sn(N4mL)Cl2]. The ring expansion has been achieved by varying the diamine between the two diacetyl amino nitrogen atoms. The macrocyclic precursor and its metal complexes have been characterized on the basis of elemental analysis, molar conductance, molecular weight determinations, IR, H1 NMR,C13 NMR, Sn119 NMR and electronic spectral studies. An octahedral geometry around the metal ion is suggested for these complexes. On the basis of molecular weights and conductivity measurements, their monomeric and non-electrolytic nature has been confirmed. The precursor and complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemicals parameters of reproductive organs have been examined and discussed.

scholarly journals Synthesis, Spectroscopic Characterization, Antibacterial and Short Term in vitro Cytotoxicity Studies of Copper(II) Complexes of Novel Tridentate N,N,S Donor Ligand 2-Benzoylpyridine-N(4),N(4)-(N,N-diethyl-N-methylamine-2,2'-diyl)thiosemicarbazone

2019 ◽  
Vol 31 (10) ◽  
pp. 2269-2274
Author(s):  
Janey Mary Mathew ◽  
Varughese Philip ◽  
Jesty Thomas
Keyword(s):  
Spectroscopic Characterization ◽  
Positive Control ◽  
In Vitro Cytotoxicity ◽  
Planar Geometry ◽  
Blue Dye ◽  
Short Term ◽  
Donor Ligand ◽  
Cytotoxicity Studies ◽  
Uv Visible

A tridentate N,N,S-donor ligand, 2-benzoylpyridine-N(4),N(4)-(N,N-diethyl-N-methylamine-2,2'-diyl)thiosemicarbazone (Hbptsc) has been synthesized and characterized by elemental CHN analysis, UV-visible, FT-IR and 1H NMR spectroscopy. Copper(II) complexes of the ligand, Hbptsc synthesized have been characterized by elemental analysis, UV-visible spectra, FTIR spectra and EPR spectroscopic simulation. The complexes hold the stoichiometry of the type [CuLX] where X= Cl (1), NO3 (2), SO4 (3), N3 (4), SCN (5) confirmed by the molar conductivity studies of 10-3 M solutions in DMF at room temperature. The EPR spectra of the complexes recorded in DMF at 77 K shows an axial type spectra with two distinct g-values, g|| and g⊥ indicating a four coordinated planar geometry. The antimicrobial studies of the copper(II) complexes shows an appreciable activity against both gram positive and gram negative bacteria using streptomycin as positive control. The short term in vitro cytotoxicity studies following trypan blue dye exclusion method exhibits pronounced activity against the Dalton’s Lymphoma Ascites tumour cells extruded from the peritoneal cavity of mice.

scholarly journals Synthesis, Characterization And Antitumor Activity Of Copper(II) Complexes, [CuL2] [HL1-3=N,N-Diethyl-N'-(R-Benzoyl)Thiourea (R=H, o-Cl and p-NO2)]

2005 ◽  
Vol 3 (3-4) ◽  
pp. 299-316 ◽  
Author(s):  
Wilfredo Hernández ◽  
Evgenia Spodine ◽  
Lothar Beyer ◽  
Uwe Schröder ◽  
Rainer Richter ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Elemental Analysis ◽  
Copper Complexes ◽  
Mammary Adenocarcinoma ◽  
Molar Ratio ◽  
High Yield ◽  
Planar Geometry ◽  
Cytotoxic Activities ◽  
High Accumulation

The copper (II) complexes (CuL2) were prepared by reaction ofCu(CH3COO)2with the corresponding derivatives of acylthioureas in a Cu:HL molar ratio of 1:2. Acylthiourea ligands, N,N-diethyl-N'-(R-benzoyl) thiourea (HL1-3) [R=H, o-Cl and p-NO2] were synthesized in high yield (78-83%) and characterized by elemental analysis, infrared spectroscopy,1H and13C NMR spectroscopy. The complexes CuL2were characterized by elemental analysis, IR, FAB(+)-MS, magnetic susceptibility measurements, EPR and cyclic voltammetry. The crystal structure of the complex Cu(L2)2shows a nearly square-planar geometry with two deprotonated ligands (L) coordinated to CuIIthrough the oxygen and sulfur atoms in acisarrangement. The antitumor activity of the copper(II) complexes with acylthiourea ligands was evaluatedin vitroagainst the mouse mammary adenocarcinoma TA3 cell line. These complexes exhibited much higher cytotoxic activity (IC50values in the range of 3.9-6.9 μM) than their corresponding ligands (40-240 μM), which indicates that the coordination of the chelate ligands around the CuIIenhances the antitumor activity and, furthermore, this result confirmed that the participation of the nitro and chloro substituent groups in the complex activities is slightly relevant. The high accumulation of the complexes Cu(L2)2and Cu(L3)2in TA3 tumor cells and the much faster binding to cellular DNA than Cu(L1)2are consistent with thein vitrocytotoxic activities found for these copper complexes.

scholarly journals Preparation, Spectroscopic Characterization, Theoretical Investigations, and In Vitro Anticancer Activity of Cd(II), Ni(II), Zn(II), and Cu(II) Complexes of 4(3H)-Quinazolinone-Derived Schiff Base

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5973
Author(s):  
Ubale Panchsheela Ashok ◽  
Shiva Prasad Kollur ◽  
Nishad Anil ◽  
Bansode Prakash Arun ◽  
Sanjay Namdev Jadhav ◽  
...  
Keyword(s):  
Density Functional Theory ◽  
Schiff Base ◽  
Anticancer Activity ◽  
Density Functional ◽  
Human Cancer ◽  
Chemical Reactivity ◽  
Molar Ratio ◽  
Azomethine Nitrogen ◽  
Functional Theory

Herein, we report the synthesis and characterization of a new Schiff base ligand 3-[[(E)-(3-hydroxyphenyl)-methylidene]amino]-2-methyl-quinazolin-4(3H)-one (HAMQ) and its Cd(II), Ni(II), Zn(II), and Cu(II) complexes (C1–C4). The ligand HAMQ was synthesized by reacting 3-hydroxybenzaldehyde and 3-amino-2-methyl-4(3H)-quinazolinone in a 1:1 molar ratio. The structure of the ligand and its complexes (C1–C4) were evaluated using ultraviolet (UV)–visible (Vis) light spectroscopy, 1H-NMR, Fourier-transform infrared (FT-IR) spectroscopy, MS, elemental analysis, conductance data, and thermogravimetric analysis (TGA). The characterization results suggested that the bidentate ligand, HAMQ, coordinated to the metal center through the lactum oxygen and the azomethine nitrogen. Moreover, all the metal complexes were analyzed using powder X-ray diffraction studies, which revealed that all of them belong to a triclinic crystal system. The research was supplemented by density functional theory (DFT) studies on the IR and UV–Vis spectra, as well as the chemical reactivity of the HAMQ and its four metallic derivatives making use of conceptual density functional theory (CDFT) by means of KID (Koopmans in DFT) methodology. The synthesized complexes displayed significant in vitro anticancer activity against human cancer cell lines (HeLa and HCT-115).

scholarly journals Synthesis, Characterization, In Vitro and In Vivo Screening of Unsymmetrical Borole Complexes of 2-Hydroxy-N-Phenylbenzamide and its Derivatives

2000 ◽  
Vol 7 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Taruna Pandey ◽  
R. V. Singh
Keyword(s):  
Pathogenic Fungi ◽  
Reproductive Organs ◽  
Molar Ratio ◽  
Testicular Sperm ◽  
Sperm Density ◽  
Bactericidal Properties ◽  
Boron Complexes

Biochemical aspects, synthesis and characterization of some boron complexes of 2-hydroxy-N-phenylbenzamide (HOPhBenz) and its semicarbazone (HOPhBenz.SCZH) and thiosemicarbazone (HOPhBenz.TSCZH) are described. These derivatives were prepared by the reactions of 2-isopropoxy-4-methyl-1,3,2-dioxaborolane, and 2-isopropoxy-4-methyl-1,3,2-dioxaborinane with 2-hydroxy-N-phenylbenzamide, 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarboxamide (HOPhBenz.SCZH), and 1-[(2-hydroxyphenyl)-1-N-phenylamino]hydrazinecarbothioamide(HOPhBenz.TSCZH) in a 1:1 molar ratio. In order to assess the increase of the inhibitor potency, (HOPhBenz), (HOPhBenz.SCZH), (HOPhBenz.TSCZH) and their boron complexes have been tested in vitro against a number of pathogenic fungi and bacteria at different concentrations and were found to possess remarkable fungicidal and bactericidal properties. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs are discussed.

scholarly journals Palladium Complexes Based on 2-Hydrazinopyridine Ligand: Synthesis, Spectroscopic Studies, DFT Calculations, and Cytotoxicity

2021 ◽  
Vol 11 (6) ◽  
pp. 14316-14335
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Thermal Studies ◽  
Spectroscopic Studies ◽  
Palladium Complexes ◽  
Geometric Optimization ◽  
Planar Geometry ◽  
Cytotoxic Activities ◽  
Ic50 Values

Three new palladium complexes based on 2-hydrazinopyridine (hzpy) ligand, coupled with oxalate (ox), malonate (ma) and pyrophosphate (pyph) ligands, were prepared; [Pd(hzpy)(ox)], [Pd(hzpy)(ma)] and [Pd(hzpy)(pyph)]. The spectroscopic and thermal studies of the complexes suggested that the complexes were of square planar geometry. The complexes were thermally stable with an overall activation energy of 678, 981, and 633 kJ mol–1 for [Pd(hzpy)(ox)]. [Pd(hzpy)(ma)] and [Pd(hzpy)(pyph)], respectively. Geometric optimization of the three complexes was performed at DFT/B3LYP/SDD level through Gaussian 09. TDDFT and frequency calculations were studied to investigate the electronic and vibrational transitions. The potential in vitro cytotoxic activities of the three complexes was studied. The complexes exhibited a moderate cytotoxic effect against four cancer cell lines; MCF-7 (human breast cancer cell line), HepG-2 (human Hepatocellular carcinoma), PC-3 cells (human prostate carcinoma), and HEP-2 (Larynx carcinoma). The IC50 values of the three complexes exhibited a good performance against PC-3 cell line with low IC50 values reached 2.87 μg/ml for [Pd(hzpy)(ox)] compared to the IC50 of Vinblastine sulfate (42.4 μg/ml).

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