scholarly journals Transition Metal Ion Complexes of Schiff-bases. Synthesis, Characterization and Antibacterial Properties

2001 ◽  
Vol 8 (3) ◽  
pp. 137-143 ◽  
Author(s):  
Zahid H. Chohan ◽  
Asifa Munawar ◽  
Claudiu T. Supuran
Keyword(s):  
Escherichia Coli ◽  
Transition Metal ◽  
Schiff Bases ◽  
Metal Ion ◽  
Bacterial Species ◽  
Analytical Data ◽  
Antibacterial Properties ◽  
Octahedral Geometry ◽  
Complexation Reaction ◽  
New Compounds

Some novel transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] complexes of substituted pyridine Schiff-bases have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff-bases act as deprotonated tridentate for the complexation reaction with Co(II), Ni(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)2] where [M=Co(II), Cu(II), Ni(II) and Zn(II) and HL=HL1, HL2, HL3 and HL4] show an octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff bases and their complexes have been screened for antibacterial activity against the strains such as Escherichia coli,Staphylococcus aureus, and Pseudomonas aeruginosa. The complexed Schiff bases have shown to be more antibacterial against one more bacterial species as compared to uncomplexed Schiff-bases.

scholarly journals Copper (II) Acylhydrazinates. Their Synthesis and Characterization

2001 ◽  
Vol 8 (3) ◽  
pp. 171-177 ◽  
Author(s):  
Zahid H. Chohan ◽  
M. A. Farooq ◽  
Claudiu T. Supuran
Keyword(s):  
Escherichia Coli ◽  
Schiff Bases ◽  
Metal Ion ◽  
Bacterial Species ◽  
Analytical Data ◽  
Synthesis And Characterization ◽  
Tetradentate Ligand ◽  
Base Function ◽  
Enolic Form ◽  
Square Planar

Acylhydrazine derived furanyl and thienyl Schiff bases and their Cu(II) complexes have been prepared and characterized on the basis of their physical, spectral and analytical data. The preferred enolic form of the Schiff base function as a tetradentate ligand during coordination to the metal ion yielding a square planar complex. The Schiff bases and their complexes with different anions were tested for their antibacterial activity against bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa andKlebsiella pneumonae.

scholarly journals Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases

2001 ◽  
Vol 8 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Zahid H. Chohan ◽  
Maimoon F. Jaffery ◽  
Claudiu T. Supuran
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Schiff Bases ◽  
Bacterial Species ◽  
Analytical Data ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Resistant Strains ◽  
New Compounds

Schiff bases were obtained by condensation of 2-amino-l,3,4-thiadiazole with 5-substituted-salicylaldehydes which were further used to obtain complexes of the type [M(L)2]Cl2, where M=Co(II), Cu(II), Ni(II) or Zn(II). The new compounds described here have been characterized by physical, spectral and analytical data, and have been screened for antibacterial activity against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of these Schiff bases increased upon chelation/complexation, against the tested bacterial species, opening new aproaches in the fight against antibiotic resistant strains.

scholarly journals Biologically Active Transition Metal Chelates of Ni(II), Cu(II) and Zn(II) With 2-Aminothiazole-Derived Schiff-bases: Their Synthesis, Characterization and the Role of Anions (NO3 , SO42− , C2O42- and CH3CO2− ) on Their Antibacterial Properties

1999 ◽  
Vol 6 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Zahid H. Chohan
Keyword(s):  
Schiff Bases ◽  
Metal Ion ◽  
Bacterial Species ◽  
Analytical Data ◽  
Antibacterial Properties ◽  
Metal Chelates ◽  
Biologically Active ◽  
Transition Metal Chelates ◽  
Active Transition

Biologically active nickel(ll), copper(ll) and zinc(ll) chelates with thiazole-derived nitro- and chlorosalicylaldehyde Schiff-bases having the same metal ion but different anions, e.g. nitrate, sulfate, oxalate and acetate have been synthesized and characterized on the basis of their physical, spectral and analytical data. In order to evaluate the possible participating role of anions on the antibacterial properties, these ligands and their synthesized metal chelates with various anions have been screened against bacterial species Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.

scholarly journals Antibacterial Co(II) and Ni(II) Complexes of N-(2-Furanylmethylene)-2-Aminothiadiazole and Role of SO42− ,NO3− , C2O42− and CH3CO2− anions on Biological Properties

2002 ◽  
Vol 8 (5) ◽  
pp. 287-291 ◽  
Author(s):  
Zahid H. Chohan ◽  
Abdul Rauf ◽  
Claudiu T. Supuran
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Schiff Base ◽  
Analytical Data ◽  
Biological Properties ◽  
Octahedral Geometry ◽  
Complexation Reaction ◽  
Bacterial Strains ◽  
Tridentate Ligands

Co(II) and Ni(II) complexes with a Schiff base, N-(2-furanylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The synthesized Schiff-bases act as tridentate ligands during the complexation reaction with Co(II) and Ni(II. metal ions. They possess the composition [M(L)2]Xn (where M=Co(II) or Ni(II), L=, X=NO3− , SO42− , C2O42− or CH3CO2− and n=1 or 2) and show an octahedral geometry. In order to evaluate the effect of anions upon chelation, the Schiff-base and its complexes have been screened for antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

scholarly journals Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases

2000 ◽  
Vol 7 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Zahid H. Chohan ◽  
M. A. Farooq ◽  
M. S. Iqbal
Keyword(s):  
Escherichia Coli ◽  
Schiff Bases ◽  
Metal Ion ◽  
Bacterial Species ◽  
Biological Properties ◽  
Molar Conductance ◽  
Schiff Base Ligands ◽  
Enolic Form ◽  
Elemental Analyses ◽  
Bivalent Transition Metal

Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions. These synthesized metal(II) complexes have been characterized on the basis of their elemental analyses, magnetic moment, molar conductance, and IR and electronic spectral data. All of the Schiff base ligands function as tridentates and the deprotonated enolic form is preferred for coordination. In order to evaluate the effect of anions on the bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff bases have been screened against bacterial species., Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results are reported.

scholarly journals Biologically Active Co(II) and Ni(II) Complexes of N-(2-Thienylmethylene)-2-Aminothiadiazole

2002 ◽  
Vol 8 (6) ◽  
pp. 323-327 ◽  
Author(s):  
Zahid H. Chohan
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Schiff Base ◽  
Analytical Data ◽  
Octahedral Geometry ◽  
Biologically Active ◽  
Complexation Reaction ◽  
Bacterial Strains

Co(II) and Ni(II) complexes Schiff base, N-(2-thienylmethylene)-2-aminothiadiazole have been prepared and characterized by their physical, spectral and analytical data. The title Schiff-base acts as NNS donor tridentate during the complexation reaction with these metal ions having a composition, [M(L)2]Xn where M=Co(II) or Ni(II), L=, X=NO3− , SO42− , C2O42− or CH3CO2− and n=1 or 2 and show an octahedral geometry. In order to evaluate the effect anions upon chelation, the Schiff-base and its new complexes have been screened for their antibacterial activity against bacterial strains e.g., Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

scholarly journals Biological Role of Anions (Sulfate, Nitrate , Oxalate and Acetate) on the Antibacterial Properties of Cobalt (II) and Nickel(II) Complexes With Pyrazinedicarboxaimide Derived, Furanyl and Thienyl Compounds

1999 ◽  
Vol 6 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Zahid H. Chohan ◽  
M. Praveen
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Metal Ion ◽  
Bacterial Species ◽  
Analytical Data ◽  
Antibacterial Properties ◽  
Biologically Active ◽  
And Staphylococcus Aureus ◽  
Definitive Role

A number of biologically active complexes of cobalt(II) and nickel(II) with pyrazinedicarboxaimido derived thienyl and furanyl compounds having the same metal ion but different anions such as sulphate, nitrate, oxalate and acetate have been synthesized and characterized on the basis of their physical, spectral and analytical data. In order to evaluate the role of anions on their antibacterial properties, these ligands and their synthesized metal complexes with various anions have been screened against bacterial species Escherichia coil,Pseudomonas aeruginosa and Staphylococcus aureus. The title studies have proved a definitive role of anions in increasing the antibacterial properties.

scholarly journals Pharmacological Role of Anions (Sulphate, Nitrate, Oxalate and Acetate) on the Antibacterial Activity of Cobalt(II), Copper(II) and Nickel(II) Complexes With Nicotinoylhydrazine-Derived ONO, NNO and SNO Ligands

1996 ◽  
Vol 3 (5) ◽  
pp. 211-217 ◽  
Author(s):  
Zahid Hussain Chohan ◽  
Abdur Rauf
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Metal Ion ◽  
Bacterial Species ◽  
Biologically Active ◽  
Schiff Base Ligands ◽  
Mixed Ligands ◽  
And Staphylococcus Aureus

Mixed ligands biologically active complexes of cobalt(II), copper(II) and nickel(II) with nicotinoylhydrazine-derived ONO, NNO and SNO donor schiff-base ligands having the same metal ion but different anions such as sulphate, nitrate, oxalate and acetate have been synthesised and characterised on the basis of their physical, analytical and spectral data. In order to evaluate the role of anions on their bioability, these ligands and their synthesised metal complexes with various anions have been screened against bacterial species such as Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and the title studies have proved a definative role of anions in increasing the biological activity

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