scholarly journals Effectiveness of Photodynamic Therapy and Nd-YAG Laser Treatment for Obstructed Tracheobronchial Malignancies

1999 ◽  
Vol 5 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Kinya Furukawa ◽  
Tetsuya Okunaka ◽  
Hideki Yamamoto ◽  
Takaaki Tsuchida ◽  
Jitsuo Usuda ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Laser Treatment ◽  
Tumor Response ◽  
Careful Consideration ◽  
Alternative Therapies ◽  
Yag Laser ◽  
Segmental Bronchus ◽  
Laser Group ◽  
Tokyo Medical ◽  
Medical University

Since 1980, advanced lung carcinomas were treated with palliative laser therapy for the purpose of opening the endobronchial stenosis and obstruction by either photodynamic therapy (PDT) or Nd-YAG laser treatment at Tokyo Medical University. A total of 258 lesions were treated, 81 by PDT and 177 by Nd-YAG laser treatment. PDT achieved effective results in 61 (75%) of 81 lesions. In the Nd-YAG laser group, 143 (81%) of 177 lesions showed effective results. When the tumor was located in the trachea or main bronchi, effective results were obtained in 73% (19 of 26) of cases treated by PDT and in 93% of cases (64 of 69) treated by Nd-YAG laser. However, in cases in which the tumor was located in lobar or segmental bronchi, the tumor response was effective in 76% (42 of 55) of PDT-treated patients and 73% (79 of 108) of Nd-YAG laser-treated patients. With a mortality rate of 0%, the greatest advantage of PDT over Nd-YAG treatment was safety. Considering complications, PDT seems to be useful for obstruction of lobar and segmental bronchus. Nevertheless, when deciding among alternative therapies, physicians treating patients with advanced lung carcinoma should give careful consideration to the benefit and complications of both laser therapies and decide the most suitable modality.

Photodynamic therapy using Laserphyrin for centrally located early stage lung cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 7229-7229 ◽  
Author(s):  
J. Usuda ◽  
H. Kato ◽  
T. Okunaka ◽  
K. Furukawa ◽  
H. Honda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Early Stage ◽  
Stage I ◽  
University Hospital ◽  
Early Stage Lung Cancer ◽  
Endobronchial Ultrasonography ◽  
Tokyo Medical ◽  
Medical University ◽  
Stage Lung Cancer

7229 Background: In central type early stage lung cancer, the tumor must be located only as far as the segmental bronchi and be carcinoma in situ or with only limited invasion into the bronchial wall. Laserphyrin (mono-L-aspartyl chlorine e6, NPe6) is a second generation photosensitize and approved by the Japanese government and has been on sale from June 2004. Methods: Four h after the administration of Laserphyrin 40 mg/m2, we irradiated using diode laser (100 mJ/cm2). Before PDT, we evaluated the tumor lesions and tumor depth using autofluorescence bronchoscopy and endobronchial ultrasonography (EBUS), and we confirmed the area of laser irradiation. Results: From February 1980 to December 2005, a total number of 204 patients with 264 lesions of centrally located early stage lung cancer underwent photodynamic therapy (PDT) in the Department of Thoracic Surgery, Tokyo Medical University Hospital. There were 185 clinical stage 0 lesions and 79 stage I lesions. CRs and PRs were obtained in 224 lesions (84.8%) and 40 lesions (15.2%) out of 264 lesions. From July 2004 to December 2005, we performed Laserphyrin-PDT for 28 lesions of centrally located early stage lung cancer in Tokyo Medical University Hospital. The rate of CR was 92.9% (26 lesions) in 28 lesions. For Laserphyrin-PDT, Skin photosensitivity was very low and the clean-up bronchoscopies were not frequently needed, and the period of hospitalization was shorter compared to that for Photofrin-PDT. Conclusions: We conclude that PDT using Laserphyrin will be a standard option for stage 0 (TisN0M0) and stage I (T1N0M0) centrally located early stage lung cancer. No significant financial relationships to disclose.

Photodynamic therapy (PDT) of lung cancer: experience of the Tokyo Medical University

2004 ◽  
Vol 1 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Harubumi Kato ◽  
Masahiko Harada ◽  
Shu Ichinose ◽  
Jitsuo Usuda ◽  
Takaaki Tsuchida ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Cancer Experience ◽  
Tokyo Medical ◽  
Medical University

Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital

2006 ◽  
Vol 38 (5) ◽  
pp. 371-375 ◽  
Author(s):  
H. Kato ◽  
J. Usuda ◽  
T. Okunaka ◽  
K. Furukawa ◽  
H. Honda ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Research ◽  
University Hospital ◽  
Tokyo Medical ◽  
Medical University

Adjuvant Laser Treatment of Bladder Cancer: 8 Years' Experience with the Nd-YAG Laser 1064 nm

1989 ◽  
Vol 63 (5) ◽  
pp. 476-478 ◽  
Author(s):  
M. BEER ◽  
D. JOCHAM ◽  
ANNETTE BEER ◽  
G. STAEHLER
Keyword(s):  
Bladder Cancer ◽  
Laser Treatment ◽  
Yag Laser

Theoretical and Experimental Investigations Prove Nd: YAG Laser Treatment to Be Safe

1981 ◽  
Vol 1 (3) ◽  
pp. 253-262 ◽  
Author(s):  
T H. Halldórsson ◽  
W. Rother ◽  
J. Langerholc ◽  
F. Frank
Keyword(s):  
Laser Treatment ◽  
Experimental Investigations ◽  
Yag Laser
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