scholarly journals Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects with Toxicological Screening

2006 ◽  
Vol 2006 ◽  
pp. 1-10 ◽  
Author(s):  
Ashu Chaudhary ◽  
Ran Vir Singh
Keyword(s):  
Succinic Acid ◽  
Elemental Analysis ◽  
Electronic Spectra ◽  
Phthalic Acid ◽  
Reproductive Organs ◽  
Male Rats ◽  
Albino Rats ◽  
Toxicological Screening ◽  
Conductivity Measurements ◽  
Molar Ratios

Antifertility and histopathological investigations were carried out on reproductive organs of male albino rats induced by tetraazamacrocyclic complexes of iron(II). The complexes were synthesized by the template condensation of 1,2-diaminoethane, 1,3-diaminopropane with succinic acid and phthalic acid in2:2molar ratios which are abbreviated as [Fe(TAMLn)OAc] (n=1or 2 andTAMLnrepresents tetraazamacrocyclic ligand). The complexes have been characterized by elemental analysis, conductivity measurements, IR, and electronic spectra.

scholarly journals Synthesis, Characterization, and Antimicrobial and Antispermatogenic Activity of Bismuth(III) and Arsenic(III) Derivatives of Biologically Potent Nitrogen and Sulfur Donor Ligands

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Latika Dawara ◽  
S. C. Joshi ◽  
R. V. Singh
Keyword(s):  
Metal Complexes ◽  
Reproductive Organs ◽  
Benzyl Ester ◽  
Male Rats ◽  
Donor Ligands ◽  
Control Group ◽  
Albino Rats ◽  
Spectroscopic Techniques ◽  
Molar Ratios ◽  
Sulfur Donor Ligands

A series of Bi(III) and As(III) complexes with two N∩S donor ligands, 1-(4-chloro-2-oxo-2H-chromen-3-yl)-methylene)-thiosemicarbazide (L1H) and N′-[1-(2-oxo-2H-chrome-3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester (L2H) have been synthesized by the reaction of BiCl3 and Ph3As with ligands in 1 : 1 and 1 : 2 molar ratios. All the synthesized compounds were characterized by elemental analyses, melting point determinations, and a combination of electronic, IR, 1H NMR, 13C NMR spectroscopic techniques, and X-ray diffraction for structure elucidation. In order to evaluate the effect of metal ions upon chelation, both the ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The metal complexes have shown to be more antimicrobial against the microbial species as compared to free ligands. Both the ligands and their corresponding metal complexes have been tested for their antifertility activity in male albino rats. The marked reduction in sperm motility and density resulted in infertility. Significant alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.

REPRODUCTIVE TOXICITY OF CHLORPYRIFOS, CYPERMETHRIN AND THEIR INTERACTION IN MALE ALBINO RATS

2018 ◽  
pp. 69-86
Author(s):  
Asmaa ELnamaky ◽  
Amal Halawa ◽  
Mamdouh Abouelmaged
Keyword(s):  
Reproductive Toxicity ◽  
Prostatic Acid Phosphatase ◽  
Serum Levels ◽  
Reproductive Organs ◽  
Male Rats ◽  
Albino Rats ◽  
Glutathione S Transferase ◽  
Significant Drop ◽  
Sperm Abnormalities ◽  
Pituitary Glands

he present work was designed to investigate the reproductive toxicity induced by oral administration of chlorpyrifos (CPF), cypermethrin (CYP) and their combination in adult male albino rats. Forty mature male albino rats were separated into four groups (10 each), the first group was used as control, while second, third and fourth groups received orally 1/20 LD50 of CPF (10 mg/kg b.wt), 1/20 LD50 of CYP (17.22 mg/kg b.wt) and 1/40 LD50 of CPF plus 1/40 LD50 of CYP (5 mg/kg b.wt CPF plus 8.61 mg/kg b.wt CYP) respectively for 26 days. The results revealed that exposure to CPF and/or CYP induced a significant decrease in the reproductive organs weight. Moreover, a significant decrease in spermatic picture (sperm cell concentration and viability) was observed with high percent of sperm abnormalities. Serum levels of testosterone and pituitary gonadotropins (FSH and LH) have been declined significantly in all treated groups. Significant elevations were observed in malondialdehyde and nitric oxide concentrations, while antioxidant enzymes superoxide dismutase and glutathione-S-transferase activities were decreased significantly as a result of induced oxidative stress. A significant drop in prostatic acid phosphatase activity was observed. Additionally, the results showed some histopathological alterations in the reproductive organs as well as neurological lesions in brain and pituitary glands. In conclusion, CPF and CYP induce deleterious effects on reproductive efficiency of male rats which reflect more obvious impacts when both combined

scholarly journals Effect of Phyllanthus amarus on Some Reproductive Indices of Male Albino Rats

2019 ◽  
pp. 1-8
Author(s):  
P. B. Ekpo ◽  
N. E. Edu ◽  
A. J. Umoyen ◽  
T. L. Thomas ◽  
S. O. Abraham
Keyword(s):  
Medicinal Plants ◽  
Sperm Count ◽  
Reproductive Organs ◽  
Male Rats ◽  
Albino Rats ◽  
Phyllanthus Amarus ◽  
Experimental Animals ◽  
Treatment Groups ◽  
Randomized Design ◽  
Group B

Background: Medicinal plants have been a good source of drugs for humans, but chronic and prolong use of medicinal plants like Phyllanthus amarus for the treatment of malaria and other disorders are issues of concerns. This study evaluated the effect of Phyllanthus amarus on reproductive organs and sperm parameters in albino rats. Materials and Methods: Twenty-four healthy male albino rats of 12 weeks old were assigned into four groups with six rats in each group using a Completely Randomized Design (CRD). The experimental animals were orally treated with Phyllanthus amarus. Group A served as the control and was given only water and feed; Group B, C and D  received 100 mg/kgBW, 200 mg/kgBW and 300 mg/kgBW of Phyllanthus amarus respectively. Data obtained were analyzed using analysis of variance (ANOVA). The treatments lasted for a period of 65 days after two weeks of acclimatization. Results: The results showed statistically significant (p<0.05) reduction in weight of testes and epididymes, sperm motility, sperm viability, sperm count and sperm head abnormalities in male  rats treated with Phyllanthus amarus when compared to the control. The sperm pH was not significantly (p>0.05) affected by Phyllanthus amarus among the different treatment groups in the experimental animals. Conclusion: Findings from the present study indicate that Phyllanthus amarus possesses a dose-dependent anti-fertility activity in amale albino rats under a sub-chronic course of administration.

scholarly journals Synthetic, Biochemical, Antifertility and Antiinflammatory Aspects of Manganese and Iron Complexes

2002 ◽  
Vol 9 (1-2) ◽  
pp. 97-107 ◽  
Author(s):  
Ashu Chaudhary ◽  
Anita Phor ◽  
Sanjay Sharma ◽  
Anita Gajraj ◽  
R. V. Singh
Keyword(s):  
Elemental Analysis ◽  
Magnetic Moment ◽  
Phthalic Acid ◽  
Spectral Studies ◽  
Octahedral Structure ◽  
X Ray ◽  
Molar Ratios ◽  
Structural Aspects ◽  
Growth Inhibiting

Manganese(II) and iron(II) macrocyclic complexes of polyamide groups have been synthesized by the template codensation of diamines (2,6 diaminopyridine, 1,2 phenylenediamine and 1,3 phenylenediame) and triamine (diethylenetriamine) with phthalic acid in 1:2:2 molar ratios. On the basis of elemental analysis, IR, electronic, magnetic moment, Mössbauer, mass and X-ray spectral studies, octahedral structure has been assigned to [M(N4macn)Cl2] (M = Mn(II) and Fe(II), n = 1 to 4) complexes. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. An attempt has been made to correlate the structural aspects of the compounds with their antiinflammatory and antifertility activities.

scholarly journals Preparation, Study and Theortical Treatment of Co(II) Ni(II) Cu(II) and Zn(II) Schiff Base Coplexes with Sodium [N-(hydroxyl naphtholidine) Glycine imino].

2012 ◽  
Vol 9 (4) ◽  
pp. 608-615
Author(s):  
Baghdad Science Journal
Keyword(s):  
Schiff Base ◽  
Amino Acid ◽  
Elemental Analysis ◽  
Magnetic Moments ◽  
Molar Conductivity ◽  
Molar Ratio ◽  
Conductivity Measurements ◽  
Molar Ratios ◽  
Tridentate Schiff Base ◽  
Amino Acid Glycine

Anew Schiff base (NaHL) has been prepared from the reaction between the salt of amino acid glycine with 2-hydroxy naphthaldehyde. By tridentate Schiff base of (ONO), donors were characterized by using U.V and spectrophotometer techniques. Complexes of Co(II) Ni(II) Cu(II) and Zn(II) ion with the ligand have been prepared, these complexes were identified by infrared, electronic spectral data, elemental analysis, magnetic moments, and molar conductivity measurements. It is concluded from the elemental analysis that all the complexes have (1:2) [metal:ligand] molar ratios, octahedral, with the exception to Zn(II) complex which have (1:1)[metal:ligand] molar ratio.

scholarly journals Changes in reproductive organs, semen characteristics and intra-testicular oxidative stress in adult male rats caused by azithromycin

2017 ◽  
Vol 5 (2) ◽  
pp. 72 ◽  
Author(s):  
Mossad El-Sayed ◽  
Mohamed Kandiel ◽  
Dalia Ebied
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cells ◽  
Experimental Period ◽  
Reproductive Organs ◽  
Post Treatment ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Albino Rats ◽  
Stress Markers ◽  
Vascular Congestion

This study aimed to evaluate the numerous azithromycin (as a member of macrolides) effects on the male reproductive organs, spermio-gram, testicular oxidative stress markers of adults’ male albino rats. Azithromycin was administered orally once daily to male rats (200-250 b.wt.) at a dose of 45 mg (therapeutic) or 90 mg/kg b.wt. (double-therapeutic) for three or six days and scarified at the first, thirty and sixty days after the last dose of administration. A significant decrease as the index weight of the reproductive organs as well as sperm motility, livability and cell concentration, but sperm abnormalities increased at varying times post-treatment with azithromycin administration. Testosterone hormone level did not vary significantly after azithromycin dosing for three days along the experimental period. However, it differed at the first day after the end of azithromycin dosing for six days. The intra-testicular oxidative stress alteration mostly occurred at the thirty-day post-treatment in the three- and six-days protocols. In the three-days protocol, there was a significant decrease in malondialdehyde level and superoxide dismutase enzyme activity in a double-therapeutic group. In the six-days regimen, there was an increased activity of catalase enzyme, accompanied with a significant decrease in malondialdehyde levels as well as glutathione peroxidase enzymes. Double therapeutic dose for six days’ treatment was associated with vascular congestion and perivascular inflammatory cells and ho-mogenous eosinophilic material infiltration into the stroma of testes. The lumen of seminiferous tubules and epididymis showed azoo-spermia. From these results, it could be concluded that azithromycin administration has hazard effects on male adult’s rats’ fertility governed with the spermiogram, oxidative stress and the histopathological alternations during the post-treatment period.

scholarly journals Antispermatogenic Activity of the Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative in Male Albino Rats

2006 ◽  
Vol 2006 ◽  
pp. 1-6 ◽  
Author(s):  
Pankaj K. Sharma ◽  
H. Rehwani ◽  
A. K. Rai ◽  
R. S. Gupta ◽  
Y. P. Singh
Keyword(s):  
Oral Administration ◽  
Reproductive System ◽  
Biochemical Parameters ◽  
Reproductive Organs ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Control Group ◽  
Albino Rats ◽  
Sperm Density

Triphenylantimony(V) derivative,Ph3Sb(OPri)[SC6H4N:C(CH3)CH2C(O)CH3],1b, and the corresponding benzothiazoline ligand [1, 2],HNC6H4SC︹(CH3)CH2C(O)CH3,1a, have been tested for their effects on the reproductive system of male albino rats. The oral administration of both1aand1bat the dose level of 10 mg/rat/day produced significant reduction in the weights of testes, epididymides, seminal vesicles, and ventral prostate. Significant decrease in sperm motility as well as in sperm density resulted in 100% sterility. Significant (P<.01) alterations were also found in biochemical parameters of reproductive organs in treated male rats as compared to the control group. Production of preleptotene, pachytene, and secondary spermatocytes was decreased by 42%, 43%, 39%, and by 44%, 49%, 55% in the ligand,1a, and organoantimony(V) derivative,1b, treated rats, respectively. These results indicate that both compounds1aand1bare antispermatogenic in nature and on oral administration in male rats, and finally caused sterility. A comparison indicates that the organoantimony(V) derivative1bis more effective pertaining to its antispermatogenic activity than the corresponding ligand1a.

scholarly journals Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

2006 ◽  
Vol 2006 ◽  
pp. 1-7 ◽  
Author(s):  
D. Shanker ◽  
A. K. Rai ◽  
Y. P. Singh ◽  
H. Rehwani ◽  
V. Khushalani ◽  
...  
Keyword(s):  
Condensation Reaction ◽  
Reproductive Organs ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Ventral Prostate ◽  
Control Group ◽  
Albino Rats ◽  
Elemental Analyses ◽  
Pachytene Spermatocytes ◽  
Antimony Complex

BenzothiazolineHNC6H4SC︹(C6H5)CH:C(OH)COOCH3 1prepared by the condensation reaction of aroyl pyruvate and 2-aminothiophenol has been treated withPh3Sb(OPri)2to yieldPh3Sb[SC6H4NC(C6H5)CH:CO︹COOCH3] 2. These compounds have been characterized by elemental analyses and molecular weight determinations. The probable structures of the ligand as well as antimony complex have been tentatively proposed on the basis of IR and NMR (H1andC13) spectral evidences. Both compounds have been tested for their antifertility activity in male albino rats. The oral administration of compounds1and2at the dose level of 10 mg/rat/day significantly reduced the weights of testes, epididymides, ventral prostate, and seminal vesicles. The production of preleptotene spermatocytes was decreased by36.57%;57.23%, pachytene spermatocytes by40.06%;62.01%, and secondary spermatocytes by52.45%;63.22%, following the treatment of compounds1and2, respectively. The marked reduction in sperm motility and density resulted in infertility by100%. Significant (P<.01) alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.

A Study on the Effect of Samoa Extract (Cleome droserifolia) on Sperm Quality in Male Albino Rats Exposed to Pyrethroid

2021 ◽  
pp. 39-45
Author(s):  
Nura I. Al-Zail ◽  
Salah F. Kamies
Keyword(s):  
Sperm Quality ◽  
Group Iv ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Protective Agent ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Induced Changes

Pyrethroid cyhalothrin (PC) is an insecticide that is used worldwide for pest control in agriculture and household use. Samoa extract (SE) is a potent antioxidant protecting cells from oxidative stress. The present study investigates the protective and therapeutic effect of SE on PC-induced changes in sperm quality in male rats. Fifty adult male albino rats were divided into five groups: group I: served as control; group II: received PC i.p. only (6.2 mg/kg b.wt.); group III: received SE only (100 mg/kg b.wt., p.o.) for eight weeks; group IV: received SE as a protective agent daily for eight weeks, then followed by the administration of PC (i.p.) three times a week for two weeks; group V: exposed to PC (i.p.) three times a week for two weeks, then treated with the SE daily for 8 weeks. Results showed that PC caused markedly impaired sperm quality (a count, viability, motility, and abnormality). Compared to PC-treated animals, SE in the protective group markedly restored the alteration of sperm indices. However, SE in the curative group was found to be less effective in restoring PC-induced alterations. In conclusion, the data of this study revealed that the SE as a protective agent is more effective than as a therapeutic agent. Keywords: Samoa; Pyrethroid; Sperm quality; Rat

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