scholarly journals Does Intraperitoneal Chemotherapy Increase the Incidence of Anastomotic Leakage after Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yu Yang ◽  
Yuxuan Li ◽  
Xiaohui Du
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Anastomotic Leakage ◽  
Incidence Rate ◽  
Intraperitoneal Chemotherapy ◽  
Meta Analysis ◽  
Abdominal Cavity ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery ◽  
Increased Risk

Purpose. To identify and evaluate the influence of intraperitoneal chemotherapy without hyperthermia (ICwh) to the incidence of anastomotic leakage (AL) after colorectal cancer surgery. Methods. A systematic review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses in order to review all studies investigating the relationship between ICwh and AL in patients undergoing colorectal surgery. The primary outcome was overall incidence rate of anastomotic leakage. Results. Four studies were included in the final review. ICwh was associated with an overall increased risk of anastomotic leakage [OR 2.05 (1.06, 3.98), P = 0.03 ]. But there was no significant increased incidence rate when fluorouracil was implanted into the abdominal cavity for ICwh [OR 2.48 (0.55, 11.10), P = 0.24 ]. Conclusions. This meta-analysis provides some evidence to suggest ICwh may increase the incidence of postoperative AL in colorectal cancer. However, fluorouracil implantation for ICwh does not increase the risk of AL, which seems to be a relatively safe method of ICwh.

Oncological safety of laparoscopic versus open colorectal cancer surgery in obesity: a systematic review and meta‐analysis

2019 ◽  
Vol 89 (12) ◽  
pp. 1549-1555 ◽  
Author(s):  
Stephen Bell ◽  
Joseph C. Kong ◽  
Peter W. G. Carne ◽  
Martin Chin ◽  
Paul Simpson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Meta Analysis ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery ◽  
Oncological Safety

scholarly journals Worldwide Incidence of Colorectal Cancer, Leukemia, and Lymphoma in Inflammatory Bowel Disease: An Updated Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-18 ◽  
Author(s):  
Chelle L. Wheat ◽  
Kindra Clark-Snustad ◽  
Beth Devine ◽  
David Grembowski ◽  
Timothy A. Thornton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Incidence Rate ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Increased Risk ◽  
Inflammatory Bowel ◽  
Substantial Heterogeneity

Background/Aims. Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer (CRC). In addition, there may be an association between leukemia and lymphoma and IBD. We conducted a systematic review and meta-analysis of the IBD literature to estimate the incidence of CRC, leukemia, and lymphoma in adult IBD patients.Methods. Studies were identified by a literature search of PubMed, Cochrane Library, Medline, Web of Science, Scopus, EMBASE, and ProQuest Dissertations and Theses. Pooled incidence rates (per 100,000 person-years [py]) were calculated through use of a random effects model, unless substantial heterogeneity prevented pooling of estimates. Several stratified analyses and metaregression were performed to explore potential study heterogeneity and bias.Results. Thirty-six articles fulfilled the inclusion criteria. For CRC, the pooled incidence rate in CD was 53.3/100,000 py (95% CI 46.3–60.3/100,000). The incidence of leukemia was 1.5/100,000 py (95% CI −0.06–3.0/100,000) in IBD, 0.3/100,000 py (95% CI −1.0–1.6/100,000) in CD, and 13.0/100,000 py (95% CI 5.8–20.3/100,000) in UC. For lymphoma, the pooled incidence rate in CD was 0.8/100,000 py (95% CI −0.4–2.1/100,000). Substantial heterogeneity prevented the pooling of other incidence estimates.Conclusion. The incidence of CRC, leukemia, and lymphoma in IBD is low.

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