scholarly journals Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Lotfollah Kamali Hakim ◽  
Mohsen Yazdanian ◽  
Mostafa Alam ◽  
Kamyar Abbasi ◽  
Hamid Tebyaniyan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Cavity ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Vital Role ◽  
Biocompatible Materials ◽  
Oral Diseases ◽  
Oral Infections ◽  
Advantages And Disadvantages ◽  
Dental Diseases

Biomaterials applications have rapidly expanded into different fields of sciences. One of the important fields of using biomaterials is dentistry, which can facilitate implantation, surgery, and treatment of oral diseases such as peri-implantitis, periodontitis, and other dental problems. Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. Therefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and oral diseases. Also, biomaterials could be utilized as carriers in biocompatible drug delivery systems. For instance, natural polymeric substances, such as gelatin, chitosan, calcium phosphate, alginate, and xanthan gum are used to prepare different forms of delivery systems. In addition, some alloys are conducted in drug complexes for the better in transportation. Delivery systems based on biomaterials are provided with different strategies, although individual biomaterial has advantages and disadvantages which have a significant influence on transportation of complex such as solubility in physiological environments or distribution in tissues. Biomaterials have antibacterial and anti-inflammatory effects and prolonged time contact and even enhance antibiotic activities in oral infections. Moreover, these biomaterials are commonly prepared in some forms such as particulate complex, fibers, microspheres, gels, hydrogels, and injectable systems. In this review, we examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems.

An overview of Osmotic Drug Delivery System: An update review

2017 ◽  
Vol 6 (7) ◽  
pp. 5426 ◽  
Author(s):  
Hiren J. Patel ◽  
Vaishnavi P. Parikh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Life Cycle Management ◽  
Delivery Systems ◽  
Osmotic Pump ◽  
Factors Affecting ◽  
Advantages And Disadvantages ◽  
New Chemical Entities ◽  
History Of ◽  
Novel Drug

The pharmaceutical industry has faced several marked challenges in order to bring new chemical entities (NCEs) into the market over the past few decades. Various novel drug delivery approaches have been used as a part of life cycle management from which Osmotic drug delivery systems look the most promising one. After discussing the history of osmotic pump development, this article looks at the principles, advantages and disadvantages of osmotic drug delivery systems. Then, the basic components of osmotic pump and factors affecting the design of oral osmotic drug delivery systems are discussed in detail. In the later part of the manuscript, various types of osmotic pumps available in the market and evaluation methods for osmotic drug delivery systems are discussed in detail.

scholarly journals Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4175
Author(s):  
Abhishek Lal ◽  
Mohammad Khursheed Alam ◽  
Naseer Ahmed ◽  
Afsheen Maqsood ◽  
Ruba K. Al-Qaisi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Temporomandibular Joint ◽  
Drug Delivery Systems ◽  
Viral Infections ◽  
Fungal Infections ◽  
Delivery Systems ◽  
Temporomandibular Joint Disorders ◽  
Oral Infections ◽  
Limited Effectiveness ◽  
Nano Drug Delivery

The oral cavity is an intricate environment subjected to various chemical, physical, and thermal injuries. The effectiveness of the local and systemically administered drugs is limited mainly due to their toxicities and poor oral bioavailability that leads to the limited effectiveness of the drugs in the target tissues. To address these issues, nanoparticle drug delivery systems based on metals, liposomes, polymeric particles, and core shells have been developed in recent years. Nano drug delivery systems have applications in the treatment of patients suffering from temporomandibular joint disorders such as preventing degeneration of cartilage in patients suffering from rheumatoid arthritis and osteoarthritis and alleviating the pain along with it. The antibacterial dental applications of nano-drug delivery systems such as silver and copper-based nanoparticles include these agents used to arrest dental caries, multiple steps in root canal treatment, and patients suffering from periodontitis. Nanoparticles have been used in adjunct with antifungals to treat oral fungal infections such as candida albicans in denture wearers. Acyclovir being the most commonly used antiviral has been used in combination with nanoparticles against an array of viral infections such as the herpes simplex virus. Nanoparticles based combination agents offer more favorable drug release in a controlled manner along with efficient delivery at the site of action. This review presents an updated overview of the recently developed nanoparticles delivery systems for the management of temporomandibular joint disorders along with the treatment of different oral infections.

scholarly journals Therapeutic potential of exosomes and their derivatives

2018 ◽  
pp. 129-131
Author(s):  
И.Ю. Малышев ◽  
Л.В. Кузнецова ◽  
О.П. Буданова
Keyword(s):  
Drug Delivery ◽  
Immune System ◽  
Drug Delivery Systems ◽  
Therapeutic Potential ◽  
Delivery Systems ◽  
Current Data ◽  
Natural Origin ◽  
Advantages And Disadvantages ◽  
Efficient Delivery ◽  
Synthetic Drug

В обзоре представлены современные данные о механизмах диагностики, планирования и оценки успешности терапии различных заболеваний с помощью экзосом, об использовании их как нанопереносчиков (т.е. нановезикул для эффективной доставки молекул). За последние годы разработано большое количество разных, в основном синтетических, систем доставки лекарственных средств, недостатками этих систем является плохая биосовместимость и органическая неспособность к высокоточной доставке загруженных веществ. По сравнению с синтетическими системами доставки лекарственных средств, экзосомы - вследствие своего естественного происхождения - могут обладать большими преимуществами, такими, как лучшая биосовместимость и повышенная устойчивость к разрушительному воздействию иммунной системы. Описана технология производства наноструктур, разработка и производство с помощью бионанотехнологий так называемых «полностью синтетических экзосомоподобных нановезикул», преимущества и недостатки этих методов. This review presents current data on mechanisms for diagnosis, planning, and evaluation of success in the treatment of various diseases using exosomes as nanocarriers (i.e., nanovesicles for efficient delivery of molecules). In recent years, a large number of different, mainly synthetic drug delivery systems has been developed. Disadvantages of these systems are poor biocompatibility and organic inability to deliver high-precision loaded substances. Compared with synthetic drug delivery systems, exosomes due to their natural origin may provide great advantages, such as better biocompatibility and increased resistance to detrimental effects of the immune system. This review describes in detail a technology of nanostructure production, the development and production of so-called fully synthetic exosome-like nanovesicles using bionanotechnology, and advantages and disadvantages of these methods.

scholarly journals Aptamers Chemistry: Chemical Modifications and Conjugation Strategies

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 3 ◽  
Author(s):  
Fadwa Odeh ◽  
Hamdi Nsairat ◽  
Walhan Alshaer ◽  
Mohammad A. Ismail ◽  
Ezaldeen Esawi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pharmacological Properties ◽  
Chemical Modifications ◽  
New Class ◽  
Advantages And Disadvantages ◽  
Dna Oligonucleotides ◽  
Low Toxicity ◽  
Group Diversity

Soon after they were first described in 1990, aptamers were largely recognized as a new class of biological ligands that can rival antibodies in various analytical, diagnostic, and therapeutic applications. Aptamers are short single-stranded RNA or DNA oligonucleotides capable of folding into complex 3D structures, enabling them to bind to a large variety of targets ranging from small ions to an entire organism. Their high binding specificity and affinity make them comparable to antibodies, but they are superior regarding a longer shelf life, simple production and chemical modification, in addition to low toxicity and immunogenicity. In the past three decades, aptamers have been used in a plethora of therapeutics and drug delivery systems that involve innovative delivery mechanisms and carrying various types of drug cargos. However, the successful translation of aptamer research from bench to bedside has been challenged by several limitations that slow down the realization of promising aptamer applications as therapeutics at the clinical level. The main limitations include the susceptibility to degradation by nucleases, fast renal clearance, low thermal stability, and the limited functional group diversity. The solution to overcome such limitations lies in the chemistry of aptamers. The current review will focus on the recent arts of aptamer chemistry that have been evolved to refine the pharmacological properties of aptamers. Moreover, this review will analyze the advantages and disadvantages of such chemical modifications and how they impact the pharmacological properties of aptamers. Finally, this review will summarize the conjugation strategies of aptamers to nanocarriers for developing targeted drug delivery systems.

scholarly journals PORPHYSOMES-A PARADIGM SHIFT IN TARGETED DRUG DELIVERY

2018 ◽  
Vol 10 (2) ◽  
pp. 1 ◽  
Author(s):  
Revathy B. Menon ◽  
Lakshmi V. S. ◽  
Aiswarya M. U. ◽  
Keerthana Raju ◽  
Sreeja C. Nair
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Delivery Systems ◽  
Optimum Dose ◽  
Advantages And Disadvantages ◽  
The Right ◽  
Aqueous Core

A novel drug delivery system is the one that ensures optimum dose at the right time, at the right location. Porphysomes are among those drug delivery systems. Porphysomes are a means of vesicular drug delivery systems. They are liposome-like structures composed completely of porphyrin lipid. The porphysomes encapsulates the active medicament in vesicular structure. They are having an aqueous core which can be loaded with the medicament. They have the capacity to destroy the disease tissues. They absorb the heat in the near infrared region and release this heat to destroy the diseased tissues. Porphysomes are having immense applications in the field of positron-electron therapy (PET), photoacoustic imaging, photothermal therapy etc. This review article discusses regarding the Porphysome-the drug delivery system, its advantages and disadvantages, composition, method of preparation, applications and various aspects related to the porphysomal drug delivery.

scholarly journals A Comprehensive Review on Self-Nano Emulsifying Drug Delivery Systems: Advancements & Applications

2020 ◽  
pp. 576-583
Author(s):  
Srikanth Reddy Sokkula ◽  
Suresh Gande
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Large Scale ◽  
Antihypertensive Drugs ◽  
Drug Loading ◽  
Delivery Systems ◽  
Water Soluble ◽  
Scale Production ◽  
Advantages And Disadvantages ◽  
Water Soluble Drugs

Lipid-based drug delivery systems are extensively reported in literature for enhancing the drug solubility, permeability and bioavailability. These systems include   simple oil solutions, coarse, multiple and dry emulsions, complex self-emulsifying, microemulsifying or nanoemulsifying drug delivery systems. Self-emulsifying systems are further classified as self-microemulsifying drug delivery systems (SMEDDS) and self-nanoemulsifying drug delivery systems (SNEDDS) are most prevailing and commercially viable oil based approach for drugs that exhibit low dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, they drew the interest of researchers in order to deal with the challenges of poorly water-soluble drugs. SNEDDS is a proven method for enhancing solubility and bioavailability of lipophilic compounds. Considering the ease of large-scale production and the robustness of SNEDDS, several formulations techniques are commercially available. The stability of SNEDDS can be further enhanced by solidifying liquid SNEDDS. Controlled release and supersaturated SNEDDS received patient compliance with larger drug loading. Presence of biodegradable ingredients and ‘drug-targeting opportunities’ facilitate SNEDDS a clear merit and distinction amongst available solubility enhancement techniques. In this article attempt was made to present an overview of SNEDDS, their mechanism, formulation excipients and potentials of SNEDDS, recent advancements, advantages and disadvantages of SNEDDS formulations. The article also focuses on reviewing the application of SNEDDS in enhancing bioavailability of antihypertensive drugs.

scholarly journals Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5294 ◽  
Author(s):  
Yana Zorkina ◽  
Olga Abramova ◽  
Valeriya Ushakova ◽  
Anna Morozova ◽  
Eugene Zubkov ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Drug Delivery ◽  
Alzheimer's Disease ◽  
Drug Delivery Systems ◽  
Neuropsychiatric Disorders ◽  
Delivery Systems ◽  
Target Cells ◽  
Advantages And Disadvantages ◽  
Experimental Drugs ◽  
Neuropsychiatric Diseases

Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. One of the problem-solving methods is the usage of nanocontainer systems. In this review we summarized the data about nanoparticles drug delivery systems and their application for the treatment of neuropsychiatric disorders. Firstly, we described and characterized types of nanocarriers: inorganic nanoparticles, polymeric and lipid nanocarriers, their advantages and disadvantages. We discussed ways to interact with nerve tissue and methods of BBB penetration. We provided a summary of nanotechnology-based pharmacotherapy of schizophrenia, bipolar disorder, depression, anxiety disorder and Alzheimer’s disease, where development of nanocontainer drugs derives the most active. We described various experimental drugs for the treatment of Alzheimer’s disease that include vector nanocontainers targeted on β-amyloid or tau-protein. Integrally, nanoparticles can substantially improve the drug delivery as its implication can increase BBB permeability, the pharmacodynamics and bioavailability of applied drugs. Thus, nanotechnology is anticipated to overcome the limitations of existing pharmacotherapy of psychiatric disorders and to effectively combine various treatment modalities in that direction.

Inorganic-organic Nanomaterials for Therapeutics and Molecular Imaging Applications

2020 ◽  
Vol 10 (6) ◽  
pp. 748-765
Author(s):  
Alaa A.A. Aljabali ◽  
Mohammad A. Obeid
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cell Labeling ◽  
Bibliographic Databases ◽  
Medical Applications ◽  
Advantages And Disadvantages ◽  
Naturally Occurring

Background:: Surface modification of nanoparticles with targeting moieties can be achieved through bioconjugation chemistries to impart new Functionalities. Various polymeric nanoparticles have been used for the formulation of nanoparticles such as naturally-occurring protein cages, virus-like particles, polymeric saccharides, and liposomes. These polymers have been proven to be biocompatible, side effects free and degradable with no toxicity. Objectives:: This paper reviews available literature on the nanoparticles pharmaceutical and medical applications. The review highlights and updates the customized solutions for selective drug delivery systems that allow high-affinity binding between nanoparticles and the target receptors. Methods:: Bibliographic databases and web-search engines were used to retrieve studies that assessed the usability of nanoparticles in the pharmaceutical and medical fields. Data were extracted on each system in vivo and in vitro applications, its advantages and disadvantages, and its ability to be chemically and genetically modified to impart new functionalities. Finally, a comparison between naturally occurring and their synthetic counterparts was carried out. Results:: The results showed that nanoparticles-based systems could have promising applications in diagnostics, cell labeling, contrast agents (Magnetic Resonance Imaging and Computed Tomography), antimicrobial agents, and as drug delivery systems. However, precautions should be taken to avoid or minimize toxic effect or incompatibility of nanoparticles-based systems with the biological systems in case of pharmaceutical or medical applications. Conclusion:: This review presented a summary of recent developments in the field of pharmaceutical nanotechnology and highlighted the challenges and the merits that some of the nanoparticles- based systems both in vivo and in vitro systems.

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