scholarly journals UPLC-MS/MS Determination of Linezolid and Heme in Plasma of Infected Patients and Correlation Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yingying Wang ◽  
Xuemei Ye ◽  
Qin Lan ◽  
Xiaofang Ke ◽  
Lufeng Hu ◽  
...  

Linezolid can cause serious haematological toxicity, such as thrombocytopenia and aneamia. Heme, composed of iron and porphyrin, is an important component of hemoglobin. In order to investigate the relationship between the concentration of linezolid and heme in the plasma of infected patients, a UPLC-MS/MS method that can determine the concentrations of linezolid and heme simultaneously was developed and validated. A total of 96 healthy subjects and 81 infected patients, who received blood routine blood tests, were included and determined by the UPLC-MS/MS method. The results showed that the concentration of linezolid was 5.08 ± 3.46   μ g / mL in infected patients who were treated with linezolid. The heme in healthy subjects was 7.05 ± 8.68   μ g / mL , and it was significantly decreased to 0.88 ± 0.79   μ g / mL in infected patients ( P < 0.01 ). Spearman correlation analysis showed that linezolid had a high negative correlation with platelet (PLT) ( R = − 0.309 ). Heme had a high positive correlation with hemoglobin (Hb) ( R = 0.249 ) in healthy subjects and infected patients. The ROC analysis showed that heme had diagnostic value to distinguish low Hb (110 g/L). In conclusion, there was a positive correlation between heme and Hb, and this correlation was also observed in infected patients. A high concentration of linezolid was inclined to decrease PLT. Monitoring of heme and linezolid helps in the early diagnose of low Hb and PLT.

2021 ◽  
Vol 07 (02) ◽  
pp. 29-35
Author(s):  
Kamil Zakir oğlu İbrahimli ◽  

The importance of the statistical method is great in the study of natural and economic processes. It is possible to conduct analyzes and obtain results with the help of this method. Sometimes phenomena and processes co-exist and develop interdependently. In this case, it is necessary to determine the relationship between them, to express this relationship. Key words: perfect positive correlation, perfect negative correlation, direction of correlation, degree of correlation, methods of calculating correlation, Spearman᾽s method


Author(s):  
Melda Akbaba

In the current study, it is aimed to determine the effect of diversity management on organizational socialization in tourism enterprises. For this purpose, a questionnaire was conducted with 215 employees who work in hotel enterprises with tourism operation certificate. Regression and correlation analysis were performed using the data obtained from the survey. Analysis results reveal that the diversity management practices in hotel enterprises positively affect the dimensions of organizational socialization, and organizational socialization dimensions are significantly explained by the diversity management dimensions. In addition, according to the correlation analysis results, there is a high positive correlation between diversity management and organizational socialization. In this context, the positive management of employee differences within the organization and non-discriminative approach positively affects the relationships of the employees with other and can increase their level of organizational socialization through job adaptation.


2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Marvelous Sungirai ◽  
Lawrence Masaka ◽  
Tonderai Maxwell Benhura

A study was carried out to determine the relationship between linear body measurements and live weight in Landrace and Large White pigs reared under different management conditions in Zimbabwe. Data was collected for body length, heart girth, and live weight in 358 pigs reared under intensive commercial conditions. The stepwise multiple linear regression method was done to develop a model using a random selection of 202 records of pigs. The model showed that age, body length, and heart girth were useful predictors of live weight in these pigs with significantly high positive correlations observed. The model was internally validated using records of the remaining 156 pigs and there was a significantly high positive correlation between the actual and predicted weights. The model was then externally validated using 40 market age pigs reared under communal conditions and there was a significantly low positive correlation between the actual and predicted weights. The results of the study show that while linear measurements can be useful in predicting pig weights the appropriateness of the model is also influenced by the management of the pigs. Models can only be applicable to pigs reared under similar conditions of management.


1956 ◽  
Vol 48 (2) ◽  
pp. 194-209 ◽  
Author(s):  
K. L. Blaxter ◽  
J. A. F. Rook

1. Methods of estimating water retention in the body of cattle are discussed, and it is shown that methods based on determinations of the initial and final body-water content are of low accuracy and are not suitable for the indirect estimation of fat balance over a period of 24 days.2. Analyses of tissues from young and adult cattle showed that with the exception of serum, brain, skin and bone, water content of the tissues may be predicted from the following equation:Water(g./100g.) = 0·292 Na(mg./100g.) + 0·147 K(mg./100g.).This equation shows that 1 m.equiv. of the Na of tissues is associated with more water than is 1 m.equiv. of the K.3. No differences between cattle aged from less than 1 week to more than 5 years were observed in the relationship between water and Na and K content.4. The equation applied also to the contents of the digestive tract, other than those of the abomasum which gave low results, ascribed to the presence of a high concentration of H+ ions.5. Analyses of whole foetuses for Na, K and H2O showed that their water content could be predicted accurately. The same was true of amniotic fluid, but the water content of allantoic fluid was underestimated by 50%.6. It was shown that despite the anomalous behaviour of brain, serum, skin and bone, accurate predictions of the water content of the animal could be made from simultaneous determinations of Na and K retentions, providing a correction was made for the storage of bound Na in bone.7. Data are presented which indicate that the equations apply equally well to the tissues of the sheep.


Author(s):  
Melda Akbaba

In the current study, it is aimed to determine the effect of diversity management on organizational socialization in tourism enterprises. For this purpose, a questionnaire was conducted with 215 employees who work in hotel enterprises with tourism operation certificate. Regression and correlation analysis were performed using the data obtained from the survey. Analysis results reveal that the diversity management practices in hotel enterprises positively affect the dimensions of organizational socialization, and organizational socialization dimensions are significantly explained by the diversity management dimensions. In addition, according to the correlation analysis results, there is a high positive correlation between diversity management and organizational socialization. In this context, the positive management of employee differences within the organization and non-discriminative approach positively affects the relationships of the employees with other and can increase their level of organizational socialization through job adaptation.


1963 ◽  
Vol 12 (3) ◽  
pp. 723-728
Author(s):  
Richard H. O'Connell

A high positive correlation was found between audiogenic seizure latency and subsequent activity in a complex maze for 22 rats. The relationship appeared to be independent of the type of seizure, and it disappeared as familiarity with the maze increased. The maze activity of rats who failed to display seizure could not be predicted by considering them to be Ss with very long latencies.


2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Musarlin Musarlin ◽  
Ayub M. Padangaran ◽  
Muhaimin Hamzah

The system of chain supply in goldfish hatchery enterprise can be detected through the members of the chain, flow of the chain, and process of chain in goldfish hatchery business. The purposes of this study were to analyze the system of supply chain in goldfish hatchery enterprise, to analyze incomes generated from the goldfish hatchery enterprise, to analyze the correlation between the system of supply chain and incomes generated from the goldfish hatchery enterprise. The study was conducted at Unit Pembenihan Rakyat (UPR) in Konawe Regency in province of Sulawesi Tenggara, from April to September 2014. The population in this study was all farmers that own the UPR. Determination of respondents is done by census method. The number of respondents is 8 people. Data analysis was carried out in a qualitative descriptive way to assess supply chain systems, while the Kendal Rank Correlation analysis was used to determine the relationship of supply chain systems with goldfish hatchery income. The results of the study show that the supply chain mechanism of the goldfish hatchery commodity involves main suppliers, hatchery farmers, farmer-collectors, government, and farmer-raisers or end consumers. The flow of the goldfish hatchery commodity consists of three chains, namely: main suppliers à hatchery farmers à government à farmer-raiser; main suppliers à hatchery farmers à farmer-raiser, and main suppliers à hatchery farmers à farmer-collectors. The Kendal coefficient correlation was 90.6%, which indicates a significant correlation between supply chain and incomes generated from goldfish hatchery enterprise. Keywords: supply chain; goldfish hatchery; income; UPR; Konawe Regency


2017 ◽  
Vol 5 (1) ◽  
Author(s):  
V. Karpagavalli ◽  
R. Subhashini

The purpose of the study is to find employees Psychological Capital is related to Job Satisfaction. The Sampling for the study consist of 30 women employees working in IT/ITES Sector in Chennai. According to the result of Correlation analysis, no positive correlation was statistically found between Hope and Optimism subdimension of psychological capital and job satisfaction. On the other hand there was a Positive and significant relationship between Self-efficacy, Resilience and Job satisfaction.


2019 ◽  
Vol 11 (1) ◽  
pp. 55
Author(s):  
Hendry Sundah ◽  
Toar Mambu ◽  
Ferdinand Tjandra ◽  
Heber B. Sapan ◽  
Winfrid M. Sumanti

Abstract: Nutritional status is one of the factors that influence the metabolic and physiological conditions. Cancer patients, especially colorectal cancer (CRCA), will suffer from decreased nutritional status during their sickness. CONUT score is beneficial to evaluate the nutritional and immunity status of the patients and has been proved to correlate with post operative complications and length of stay. This study was aimed to evaluate the relationship between CONUT score and postoperative complications in CRCA patients. This was an analytical observational study with a cross sectional design. Subjects were 38 patients of CRCA that underwent operation and were admitted at Surgery Inpatients Installation of Prof. Dr. R. D. Kandou Hospital Manado. The result of logistic regression analysis indicated that there was a significant correlation between CONUT score and the risk of complication. The higher the CONUT score, the higher the risk of complication. The determination of complication diagnostic value based on CONUT score was obtained by using ROC curve. The ROC analysis showed that the AUC of CONUT score was 0.977 >0.700 and the cutoff point of CONUT score was 5.5. Patients with CONUT score >5.50 had a tendency to get postoperative complications with the sensitivity of 86.6%, specifity of 95.6%, and accuracy of 94.74%. Conclusion: CONUT score can be used as a screening method to predict the occurence of postoperative complications in CRCA patients.Kata kunci: colorectal cancer, CONUT score, postoperative complicationsAbstrak: Salah satu faktor yang memengaruhi keadaan metabolik dan fisiologik ialah status nutrisi. Penderita kanker terlebih kanker kolorektal (KKR) akan mengalami pengurangan nutrisi selama perjalanan penyakit. CONUT score bermanfaat untuk mengevaluasi status gizi dan imunitas pasien serta terbukti berkolerasi dengan komplikasi serta jumlah hari rawat di rumah sakit pasca pembedahan. Penelitian ini bertujuan untuk mengetahui hubungan CONUT score dengan komplikasi pasca pembedahan KKR. Jenis penelitian ialah analitik obser-vasional dengan desain potong lintang. Subyek penelitian ialah 38 pasien KKR yang menjalani operasi dirawat di Instalasi Rawat Inap Bedah RSUP Prof. Dr. R. D. Kandou Manado. Hasil analisis regresi logistik menyatakan terdapat hubungan yang sangat bermakna antara CONUT score dan kejadian komplikasi. Hubungan ini menyatakan bahwa makin tinggi CONUT score makin besar risiko terjadinya komplikasi. Penentuan nilai diagnostik kom-plikasi berdasarkan CONUT score diperoleh melalui kurva ROC. Berdasarkan analisis ROC diperoleh AUC CONUT score 0,977 >0,700. Hasil analisis ROC memperoleh titik potong CONUT score = 5,5. Pasien dengan CONUT score >5,50 memiliki kecenderungan mengalami komplikasi dengan sensitivitas 86,6%, spesifitas 95,6%, dan nilai akurasi 94,74%. Simpulan: CONUT score dapat digunakan sebagai metode skrining untuk memrediksi terjadinya komplikasi pasca pembedahan kanker kolorektal.Kata kunci: karsinoma kolorektal (KKR), CONUT score, komplikasi pasca pembedahan


1968 ◽  
Vol 26 (3_suppl) ◽  
pp. 1083-1088 ◽  
Author(s):  
James J. Mc Grath ◽  
James F. O'Hanlon

Relationships among 48 Ss' ages and IQs and their rates of subjective times (RST) were examined. A strong positive correlation was obtained between age and RST. In general the older the man, the faster was his RST. The strength of this relationship did depend, however, upon the interval of time S was required to estimate for the determination of his RST. In general, the shorter the interval the stronger was the relationship. No relationship was found between IQ and RST.


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