scholarly journals Obesity Animal Models for Acupuncture and Related Therapy Research Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-29
Author(s):  
Xuwen Zhang ◽  
David Val-Laillet
Keyword(s):  
Animal Models ◽  
Evaluation Criteria ◽  
Rodent Models ◽  
Pharmacological Treatments ◽  
Preclinical Models ◽  
Surgical Interventions ◽  
The Past ◽  
Obesity Research ◽  
The Face ◽  
Research Studies

Obesity and related diseases are considered as pandemic representing a worldwide threat for health. Animal models are critical to validate the effects and understand the mechanisms related to classical or innovative preventive and therapeutic strategies. It is, therefore, important to identify the best animal models for translational research, using different evaluation criteria such as the face, construct, and predictive validity. Because the pharmacological treatments and surgical interventions currently used for treating obesity often present many undesirable side effects, relatively high relapse probabilities, acupuncture, electroacupuncture (EA), and related therapies have gained more popularity and attention. Many kinds of experimental animal models have been used for obesity research studies, but in the context of acupuncture, most of the studies were performed in rodent obesity models. Though, are these obesity rodent models really the best for acupuncture or related therapies research studies? In this study, we review different obesity animal models that have been used over the past 10 years for acupuncture and EA research studies. We present their respective advantages, disadvantages, and specific constraints. With the development of research on acupuncture and EA and the increasing interest regarding these approaches, proper animal models are critical for preclinical studies aiming at developing future clinical trials in the human. The aim of the present study is to provide researchers with information and guidance related to the preclinical models that are currently available to investigate the outcomes of acupuncture and related therapies.

Pharmacological and Behavioral Rodent Models of OCD

2017 ◽  
Author(s):  
Summer L. Thompson ◽  
Stephanie C. Dulawa
Keyword(s):  
Animal Models ◽  
Psychiatric Disorder ◽  
Symptom Relief ◽  
Human Condition ◽  
Rodent Models ◽  
Pharmacological Treatments ◽  
First Line ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Effective Use

Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder characterized by obsessions and/or compulsions. Only half of patients respond to first-line pharmacological treatments, and symptom relief is typically partial, even in responders. Gaining a better understanding of OCD etiology could lead to better treatments, and potentially to prevention. Animal models are a useful tool for studying neurobiological mechanisms underlying psychiatric phenotypes. Effective use of animal models requires identification of reliable, quantifiable features of the disorder of interest that can be measured across species. The modeled phenotypes then require assessment for predictive validity: the accuracy with which a model makes accurate predictions about the human condition. Once a model has been shown to make accurate predictions, using it to study neurobiological mechanisms is justified. The validity of spontaneous and induced rodent models of OCD is reviewed in this chapter.

Bioengineered in vitro Vascular Models for Applications in Interventional Radiology

2019 ◽  
Vol 24 (45) ◽  
pp. 5367-5374 ◽  
Author(s):  
Xiaoyun Li ◽  
Seyed M. Moosavi-Basri ◽  
Rahul Sheth ◽  
Xiaoying Wang ◽  
Yu S. Zhang
Keyword(s):  
Interventional Radiology ◽  
Animal Models ◽  
Blood Vessels ◽  
In Vitro Models ◽  
The Past ◽  
Endovascular Interventions ◽  
Conventional Animal ◽  
Vascular Structures

The role of endovascular interventions has progressed rapidly over the past several decades. While animal models have long-served as the mainstay for the advancement of this field, the use of in vitro models has become increasingly widely adopted with recent advances in engineering technologies. Here, we review the strategies, mainly including bioprinting and microfabrication, which allow for fabrication of biomimetic vascular models that will potentially serve to supplement the conventional animal models for convenient investigations of endovascular interventions. Besides normal blood vessels, those in diseased states, such as thrombosis, may also be modeled by integrating cues that simulate the microenvironment of vascular disorders. These novel engineering strategies for the development of biomimetic in vitro vascular structures will possibly enable unconventional means of studying complex endovascular intervention problems that are otherwise hard to address using existing models.

Conventional versus Mindfulness-based Interventions for Anxiety and Worry: A Review and Recommendations

2020 ◽  
Vol 16 (1) ◽  
pp. 60-67
Author(s):  
Deah Jo Abbott ◽  
Caleb Wayne Lack
Keyword(s):  
Treatment Options ◽  
Additional Treatment ◽  
Third Wave ◽  
Stage Model ◽  
Pharmacological Treatments ◽  
The Past ◽  
Behavioral Therapies ◽  
Cognitive Behavioral Therapies ◽  
Specific Disorders ◽  
Psychiatric Problems

Anxiety disorders are among the most prevalent and most functionally impairing psychiatric problems experienced by the population. Both pharmacological and psychological evidencebased treatments exist for a number of specific disorders, but may fail to fully relieve symptoms, pointing to the need for additional treatment options. Often considered to be part of the “third wave” of cognitive-behavioral therapies, treatments incorporating mindfulness have emerged in the past two decades as increasingly popular with clinicians and frequently sought out by consumers. The present article reviews the extant literature regarding the efficacy and effectiveness of mindfulnessbased treatments for anxiety, worry, and related problems. Although they have not attained the solid empirical status of CBT or certain pharmacological treatments, the extant research shows mindfulness- based interventions appear to be a promising and useful treatment for people suffering from anxiety and worry. Further work should be done, levels 3-5 of the NIH stage model to determine whether or not they should be further implemented.

Epilogue: On the Current and Future State of Historical Writing

2018 ◽  
Author(s):  
Allan Megill
Keyword(s):  
Historical Writing ◽  
Conceptual Difficulty ◽  
Universal History ◽  
The Past ◽  
Initial Decision ◽  
Future State ◽  
The Face ◽  
History Of

This epilogue argues that historians ought to be able to produce a universal history, one that would ‘cover’ the past of humankind ‘as a whole’. However, aside from the always increasing difficulty of mastering the factual material that such an undertaking requires, there exists another difficulty: the coherence of universal history always presupposes an initial decision not to write about the human past in all its multiplicity, but to focus on one aspect of that past. Nevertheless, the lure of universal history will persist, even in the face of its practical and conceptual difficulty. Certainly, it is possible to imagine a future ideological convergence among humans that would enable them to accept, as authoritative, one history of humankind.

Maxillofacial Bony Considerations in Facial Transplantation

2021 ◽  
Author(s):  
Aurora G. Vincent ◽  
Anne E. Gunter ◽  
Yadranko Ducic ◽  
Likith Reddy
Keyword(s):  
Soft Tissue ◽  
Current Literature ◽  
Preoperative Planning ◽  
Surgical Anatomy ◽  
The Past ◽  
Facial Transplantation ◽  
Tissue Transfer ◽  
Reconstructive Ladder ◽  
The Face ◽  
Facial Wounds

AbstractAlloplastic facial transplantation has become a new rung on the proverbial reconstructive ladder for severe facial wounds in the past couple of decades. Since the first transfer including bony components in 2006, numerous facial allotransplantations across many countries have been successfully performed, many incorporating multiple bony elements of the face. There are many unique considerations to facial transplantation of bone, however, beyond the considerations of simple soft tissue transfer. Herein, we review the current literature and considerations specific to bony facial transplantation focusing on the pertinent surgical anatomy, preoperative planning needs, intraoperative harvest and inset considerations, and postoperative protocols.

scholarly journals Deep-Emotion: Facial Expression Recognition Using Attentional Convolutional Network

Sensors ◽  
2021 ◽  
Vol 21 (9) ◽  
pp. 3046
Author(s):  
Shervin Minaee ◽  
Mehdi Minaei ◽  
Amirali Abdolrashidi
Keyword(s):  
Deep Learning ◽  
Facial Expression ◽  
Facial Expression Recognition ◽  
Expression Recognition ◽  
Visualization Technique ◽  
Convolutional Network ◽  
The Past ◽  
Multiple Datasets ◽  
The Face ◽  
Traditional Approaches

Facial expression recognition has been an active area of research over the past few decades, and it is still challenging due to the high intra-class variation. Traditional approaches for this problem rely on hand-crafted features such as SIFT, HOG, and LBP, followed by a classifier trained on a database of images or videos. Most of these works perform reasonably well on datasets of images captured in a controlled condition but fail to perform as well on more challenging datasets with more image variation and partial faces. In recent years, several works proposed an end-to-end framework for facial expression recognition using deep learning models. Despite the better performance of these works, there are still much room for improvement. In this work, we propose a deep learning approach based on attentional convolutional network that is able to focus on important parts of the face and achieves significant improvement over previous models on multiple datasets, including FER-2013, CK+, FERG, and JAFFE. We also use a visualization technique that is able to find important facial regions to detect different emotions based on the classifier’s output. Through experimental results, we show that different emotions are sensitive to different parts of the face.

scholarly journals Chronic (Rasmussen’s) Encephalitis in an Adult

2003 ◽  
Vol 30 (3) ◽  
pp. 263-265 ◽  
Author(s):  
Richard Wennberg ◽  
Sukriti Nag ◽  
Mary-Pat McAndrews ◽  
Andres M. Lozano ◽  
Richard Farb ◽  
...  
Keyword(s):  
Visual Field ◽  
Right Visual Field ◽  
Loss Of Consciousness ◽  
Mild Head Injury ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
The Past ◽  
Rasmussen’S Encephalitis ◽  
The Face ◽  
The Right

A 24-year-old woman was referred because of incompletely-controlled complex partial seizures. Her seizures had started at age 21, after a mild head injury with brief loss of consciousness incurred in a biking accident, and were characterized by a sensation of bright flashing lights in the right visual field, followed by numbness and tingling in the right foot, spreading up the leg and to the arm, ultimately involving the entire right side, including the face. Occasionally they spread further to involve right facial twitching with jerking of the right arm and leg, loss of awareness and, at the onset of her epilepsy, rare secondarily generalized convulsions. Seizure frequency averaged three to four per month. She was initially treated with phenytoin and clobazam and subsequently changed to carbamazepine 800 milligrams per day. She also complained that her right side was no longer as strong as her left and that it was also numb, especially the leg, but felt that this weakness had stabilized or improved slightly over the past two years.

The Zeitgeist of Matthew Arnold

PMLA ◽  
1957 ◽  
Vol 72 (5) ◽  
pp. 977-996 ◽  
Author(s):  
Fraser Neiman
Keyword(s):  
Matthew Arnold ◽  
Natural Right ◽  
The Past ◽  
The Face

At least since Matthew Arnold exploited the term Zeitgeist in Literature and Dogma, the expression has been variously a source of irritation and confusion to a number of his critics. Identifying it with a tendency to disparage the past, an exasperated contemporary reviewer of that work in Blackwood's Edinburgh Magazine cried, “Can anything be more unscientific than such a spirit? It is the very apotheosis of self-opinion intoxicated by its own pride, and flaunting its own dogmatisms with a crude audacity in the face of preceding dogmas.” Among other critics of Arnold, R. H. Hutton protested that the Zeitgeist was a will-o'-the-wisp “who misleads us at least as much as he enlightens”; W. H. Dawson concluded that for Arnold it was “a fetish, a talisman, a thaumaturgy”; for W. H. Paul it became a bore; Hugh Kingsmill began his caricature of Don Matthew, “So forth he sallied, mounted on Zeit-Geist, a hobby horse.” Still others, less annoyed than these by the reiteration, have themselves borrowed it as they write of him—sometimes effectively, because with consistency of meaning, as H. F. Lowry in his edition of Arnold's letters to Clough; sometimes bewilderingly, as when one reads such a statement as this: “Expediency, which had become in Burke's hands an anti-revolutionary doctrine, was equated by Arnold with the Zeitgeist, a force which, in his conception of it, was quite as revolutionary as that of natural right.”

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