scholarly journals Debilitating Manifestation of a Disease with Multiple Names: A Severe Case of Sclerosing Mesenteritis

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Valeriia Klymenko ◽  
Reba Varughese ◽  
Katherine A Woolley ◽  
Joseph M Wetherell ◽  
Haritha Mopuru ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Abdominal Pain ◽  
Treatment Plan ◽  
Severe Case ◽  
Severe Abdominal Pain ◽  
Unknown Etiology ◽  
Sclerosing Mesenteritis ◽  
Inflammatory Condition ◽  
Mesenteric Adipose Tissue ◽  
Adipose Inflammation

Sclerosing mesenteritis (SM) is a rare inflammatory condition with unknown etiology that affects the mesenteric adipose tissue. We present a case of a 49-year-old male with severe abdominal pain who underwent abdominal biopsy confirming the presence of adipose inflammation and necrosis. The diagnosis of SM was made, and the patient was treated with prednisone and tamoxifen. As this condition is rare, there are no standard guidelines for management. This case aims to outline a possible treatment plan.

scholarly journals Extensive Sclerosing Mesenteritis of the Rectosigmoid Colon Associated with Erosive Colitis

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
C. Nobili ◽  
L. Degrate ◽  
R. Caprotti ◽  
C. Franciosi ◽  
B. E. Leone ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Inflammatory Process ◽  
Clinical Presentation ◽  
Inflammatory Cells ◽  
Contrast Enema ◽  
Sclerosing Mesenteritis ◽  
Small Bowel Mesentery ◽  
Common Site ◽  
Rectosigmoid Colon ◽  
Mesenteric Adipose Tissue

Sclerosing mesenteritis is a rare, idiopatic, usually benign, inflammatory process of the mesenteric adipose tissue. The most common site of involvement is the small bowel mesentery. We present a case of sclerosing mesenteritis of the rectosigmoid colon as a cause of severe abdominal pain, abdominal obstruction, and ischemic colic mucosal lesions. Contrast enema, colonoscopy, angiography, and CT were the imaging modalities used. A 20 cm diameter, fibrotic mass causing extensive compression of rectosigmoid colon was found at laparotomy. Histological examination showed extended fibrosis, inflammatory cells infiltration, lipophages, and granulomas within the mesenteric adipose tissue associated with erosive colitis. Clinical presentation and treatment are discussed.

scholarly journals A severe case of sclerosing mesenteritis

2019 ◽  
Vol 12 (7) ◽  
pp. e229035 ◽  
Author(s):  
Sofia Costa Corado ◽  
Heitor Almeida ◽  
José Rodrigues Baltazar
Keyword(s):  
Emergency Department ◽  
Adipose Tissue ◽  
Surgical Treatment ◽  
Small Bowel ◽  
Bowel Obstruction ◽  
Severe Case ◽  
Benign Disease ◽  
Sclerosing Mesenteritis ◽  
Short Period

Sclerosing mesenteritis is a rare benign disease presenting with chronic inflammation of the mesenteric adipose tissue and variable degrees of fibrosis. A 47-year-old black man presented to the emergency department with symptoms of small bowel obstruction, requiring surgical treatment. The laparotomy revealed a stenosis of the distal ileum with mesenteric thickening and an enterectomy was performed. The postoperative period was complicated by the maintenance of bowel obstruction. The patient underwent a second laparotomy, in which the fibrosing process of the mesentery was much aggravated, and an ileo-colic resection was needed. After knowledge of the histological diagnosis, the patient was started on immunomodulators with clinical improvement. At 26 months of follow-up, patient is asymptomatic under medical treatment. This is the first report, to our knowledge, of a patient with progressive fibrosis in such short period of time requiring surgical re-intervention for bowel obstruction, owing to sclerosing mesenteritis.

Severe abdominal pain in low dosage clofazimine

Pathology ◽  
1993 ◽  
Vol 25 (1) ◽  
pp. 24-26 ◽  
Author(s):  
Pek-Yoon Chong ◽  
Thiow-Kong Ti
Keyword(s):  
Abdominal Pain ◽  
Severe Abdominal Pain ◽  
Low Dosage

Diabetic thoracic radiculopathy: a case of a young woman with clinical improvement following immunotherapy

2020 ◽  
Vol 13 (12) ◽  
pp. e236412
Author(s):  
Alfonsa C Taiello ◽  
Vincenzo La Bella ◽  
Rossella Spataro
Keyword(s):  
Abdominal Pain ◽  
Young Woman ◽  
Clinical Improvement ◽  
Type I Diabetes ◽  
Severe Abdominal Pain ◽  
Full Recovery ◽  
Type I ◽  
Sustained Improvement ◽  
Immune Mediated ◽  
Paravertebral Muscles

Thoracic radiculopathy is a rare cause of thoracic-abdominal or abdominal pain in subjects with poorly controlled diabetes. We present a case of a young woman with type I diabetes and a severe abdominal pain in both lower quadrants. An extensive diagnostic gastroenterological and gynaecological workup did not disclose abnormalities. Electromyography revealed an initial polyneuropathy and significant neurogenic abnormalities in the T10-T12 paravertebral muscles. Following the hypothesis that the radiculopathy-related abdominal pain might have an immuno-mediated pathogenesis, the patient underwent a complex trial of immunotherapy, which was accompanied by a sustained improvement over months to full recovery. This report would support the hypothesis that immune-mediated mechanisms are still active even months after onset of symptoms.

Whole-Exome Sequencing Solved over 2-Decade Kidney Disease Enigma

Nephron ◽  
2021 ◽  
pp. 1-6
Author(s):  
Suramath Isaranuwatchai ◽  
Ankanee Chanakul ◽  
Chupong Ittiwut ◽  
Chalurmpon Srichomthong ◽  
Vorasuk Shotelersuk ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Kidney Disease ◽  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Treatment Plan ◽  
Unknown Etiology ◽  
Pediatric Case ◽  
Steroid Resistant ◽  
Steroid Resistant Nephrotic Syndrome ◽  
Whole Exome

Chronic kidney disease of unknown etiology (CKDu) has been a problem in renal practice as indefinite diagnosis may lead to inappropriate management. Here, we report a 54-year-old father diagnosed with CKDu at 33 years old and his 8-year-old son with steroid-resistant nephrotic syndrome. Using whole-exome sequencing, both were found to be heterozygous for c.737G>A (p.Arg246Gln) in LMX1B. The diagnosis of LMX1B-associated nephropathy has led to changes in the treatment plan with appropriate genetic counseling. The previously reported cases with this particular mutation were also reviewed. Most children with LMX1B-associated nephropathy had nonnephrotic proteinuria with normal renal function. Interestingly, our pediatric case presented with steroid-resistant nephrotic syndrome at 8 years old and progressed to ESRD requiring peritoneal dialysis at the age of 15 years. Our report emphasized the need of genetic testing in CKDu for definite diagnosis leading to precise management.

scholarly journals Young Man With Severe Abdominal Pain

2016 ◽  
Vol 68 (5) ◽  
pp. 544-552
Author(s):  
Aaron Lewandowski ◽  
Steven Dorsey
Keyword(s):  
Abdominal Pain ◽  
Severe Abdominal Pain

scholarly journals A case of hereditary angioedema due to C1-inhibitor deficiency with recurrent abdominal pain diagnosed 40 years after the occurrence of the initial symptom

2021 ◽  
Author(s):  
Daisuke Honda ◽  
Isao Ohsawa ◽  
Keiichi Iwanami ◽  
Hisaki Rinno ◽  
Yasuhiko Tomino ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Hereditary Angioedema ◽  
Recurrent Abdominal Pain ◽  
Acute Attack ◽  
Severe Abdominal Pain ◽  
Initial Symptom ◽  
C1 Inhibitor ◽  
Self Administration ◽  
C1 Inhibitor Deficiency ◽  
Appropriate Treatment

AbstractHereditary angioedema due to C1-inhibitor deficiency (HAE-C1-INH) is a rare disease, which induces an acute attack of angioedema mediated by bradykinin. HAE-C1-INH can cause serious abdominal pain when severe edema develops in the gastrointestinal tract. However, because it takes a long time, 13.8 years on average in Japan, from the occurrence of the initial symptom to the diagnosis due to low awareness of the disease, undiagnosed HAE-C1-INH patients sometimes undergo unnecessary surgical procedures for severe abdominal pain. We herein present a 56-year-old patient with HAE-C1-INH, who underwent numerous abdominal operations. He frequently needed hospitalization with the administration of opioid due to severe abdominal pain. However, after he was accurately diagnosed with HAE-C1-INH at 55 years of age, he could start self-administration for an acute attack with icatibant, a selective bradykinin B2 receptor antagonist. Consequently, he did not need hospitalizing for ten months after the beginning of the treatment. A series of an accurate diagnosis and appropriate treatment for HAE-C1-INH improved his quality of life. Thus, HAE-C1-INH should be considered, when we meet patients with unidentified recurrent abdominal pain. This case highlights significance of an early diagnosis and appropriate treatment for HAE-C1-INH.

Mesenteric adipose tissue alterations resulting from experimental reactivated colitis

2007 ◽  
Vol 13 (11) ◽  
pp. 1357-1364 ◽  
Author(s):  
Alessandra Gambero ◽  
Marta Maróstica ◽  
Mario José Abdalla Saad ◽  
José Pedrazzoli
Keyword(s):  
Adipose Tissue ◽  
Mesenteric Adipose Tissue ◽  
Tissue Alterations

scholarly journals Global Adiposity and Thickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome (PCOS)

2013 ◽  
Vol 98 (3) ◽  
pp. 1254-1263 ◽  
Author(s):  
Susana Borruel ◽  
Elena Fernández-Durán ◽  
Macarena Alpañés ◽  
David Martí ◽  
Francisco Álvarez-Blasco ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Mesenteric Adipose Tissue ◽  
Adipose Tissue Depots
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