Mesenteric adipose tissue alterations resulting from experimental reactivated colitis

2007 ◽  
Vol 13 (11) ◽  
pp. 1357-1364 ◽  
Author(s):  
Alessandra Gambero ◽  
Marta Maróstica ◽  
Mario José Abdalla Saad ◽  
José Pedrazzoli
Keyword(s):  
Adipose Tissue ◽  
Mesenteric Adipose Tissue ◽  
Tissue Alterations

Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis

2012 ◽  
Vol 47 (8-9) ◽  
pp. 943-950 ◽  
Author(s):  
Thayane Rodrigues Leite Clemente ◽  
Aline Noronha dos Santos ◽  
José Narciso Sturaro ◽  
Érica Martins Ferreira Gotardo ◽  
Caroline Candida de Oliveira ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Intestinal Inflammation ◽  
Mesenteric Adipose Tissue ◽  
Tissue Alterations

Mesenteric Adipose Tissue Alterations in Crohn’s Disease Are Associated With the Lymphatic System

2018 ◽  
Vol 25 (2) ◽  
pp. 283-293 ◽  
Author(s):  
Weisong Shen ◽  
Yi Li ◽  
Yujie Zou ◽  
Lei Cao ◽  
Xingchen Cai ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Lymphatic System ◽  
Mesenteric Adipose Tissue ◽  
Tissue Alterations

scholarly journals Global Adiposity and Thickness of Intraperitoneal and Mesenteric Adipose Tissue Depots Are Increased in Women With Polycystic Ovary Syndrome (PCOS)

2013 ◽  
Vol 98 (3) ◽  
pp. 1254-1263 ◽  
Author(s):  
Susana Borruel ◽  
Elena Fernández-Durán ◽  
Macarena Alpañés ◽  
David Martí ◽  
Francisco Álvarez-Blasco ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Mesenteric Adipose Tissue ◽  
Adipose Tissue Depots

scholarly journals Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue

2017 ◽  
Vol 18 (3) ◽  
pp. 341
Author(s):  
Masahiro Yasuda ◽  
Jyunya Kawabata ◽  
Sayaka Akieda-Asai ◽  
Tetsuo Nasu ◽  
Yukari Date
Keyword(s):  
Adipose Tissue ◽  
Guanylyl Cyclase ◽  
Guanylyl Cyclase C ◽  
Mesenteric Adipose Tissue

scholarly journals Enhanced Accumulation of Dietary Triglyceride in Mesenteric Adipose Tissue.

2003 ◽  
Vol 52 (2) ◽  
pp. 83-87
Author(s):  
Yoko SHIRAI ◽  
Masashige SUZUKI
Keyword(s):  
Adipose Tissue ◽  
Mesenteric Adipose Tissue

The characteristics of mesenteric adipose tissue attached to different intestinal segments and their roles in immune regulation

2022 ◽  
Author(s):  
Haowei Zhang ◽  
Yujin Ding ◽  
Qin Zeng ◽  
Dandan Wang ◽  
Ganglei Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Immune Regulation ◽  
Expression Profiles ◽  
Critical Role ◽  
Gene Expression Profiles ◽  
Rna Seq ◽  
Mesenteric Adipose Tissue ◽  
Cell Components ◽  
Subsequent Effect

Background: Mesenteric adipose tissue (MAT) plays a critical role in the intestinal physiological ecosystems. Small and large intestines have evidently intrinsic and distinct characteristics. However, whether there exist any mesenteric differences adjacent to the small and large intestines (SMAT and LMAT) has not been properly characterized. We studied the important facets of these differences, such as morphology, gene expression, cell components and immune regulation of MATs, to characterize the mesenteric differences. Methods: The SMAT and LMAT of mice were utilized for comparison of tissue morphology. Paired mesenteric samples were analyzed by RNA-seq to clarify gene expression profiles. MAT partial excision models were constructed to illustrate the immune regulation roles of MATs, and 16S-seq was applied to detect the subsequent effect on microbiota. Results: Our data show that different segments of mesenteries have different morphological structures. SMAT not only has smaller adipocytes but also contains more fat-associated lymphoid clusters than LMAT. The gene expression profile is also discrepant between these two MATs in mice. B-cell markers were abundantly expressed in SMAT, while development-related genes were highly expressed in LMAT. Adipose-derived stem cells of LMAT exhibited higher adipogenic potential and lower proliferation rates than those of SMAT. In addition, SMAT and LMAT play different roles in immune regulation and subsequently affect microbiota components. Finally, our data clarified the described differences between SMAT and LMAT in humans. Conclusions: There were significant differences in cell morphology, gene expression profiles, cell components, biological characteristics, and immune and microbiota regulation roles between regional MATs.

The Adipokine Metrnl Ameliorates Chronic Colitis in Il-10–/– Mice by Attenuating Mesenteric Adipose Tissue Lesions During Spontaneous Colitis

2019 ◽  
Vol 13 (7) ◽  
pp. 931-941 ◽  
Author(s):  
Lugen Zuo ◽  
Sitang Ge ◽  
Yuanyuan Ge ◽  
Jingjing Li ◽  
Bing Zhu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Activity Index ◽  
Disease Activity Index ◽  
Experimental Colitis ◽  
Protective Effects ◽  
Systemic Delivery ◽  
Chronic Colitis ◽  
Mesenteric Adipose Tissue ◽  
Proinflammatory Mediators ◽  
Ppar Γ

Abstract Background Crosstalk between mesenteric adipose tissue [MAT] and the intestines affects the progression of Crohn’s disease [CD]. The adipokine metrnl regulates adipocyte function and has anti-inflammatory activity. We aimed to explore metrnl expression in CD MAT, investigate the influence of metrnl on the experimental colitis disease course and determine the mechanism underlying this effect. Methods Metrnl expression in MAT specimens obtained from patients with and without CD was tested by immunohistochemistry. Male Il-10–/– mice with spontaneous enteritis were divided into positive control and metrnl-treated [Metrnl-Fc, 10 mg/kg/d, intraperitoneally, 8 weeks] groups. Age-matched male wild-type [WT] mice were used as negative controls. The effects of metrnl on enteritis and mesenteric lesions and the potential controlling mechanisms were evaluated. Results Metrnl expression was higher in human CD MAT than in control MAT. Systemic delivery of metrnl significantly ameliorated chronic colitis in Il-10–/– mice, as demonstrated by decreases in the disease activity index, inflammatory score and proinflammatory mediators. The protective effects of metrnl on MAT included reduced mesenteric hypertrophy, increased adipocyte size, improved adipocyte intrinsic function and ameliorated inflammation. Metrnl treatment activated STAT5/PPAR-γ signaling and promoted adipocyte differentiation in the MAT. Conclusions Metrnl expression was increased in the MAT of CD patients. Metrnl administration attenuated mesenteric lesions by promoting adipocyte function and differentiation partly through STAT5/PPAR-γ signaling pathway activation, thereby ameliorating CD-like colitis in mice.

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