scholarly journals Erratum to “Inhibitory Effects of Litsea cubeba Oil and Its Active Components on Aspergillus flavus”

2021 ◽  
Vol 2021 ◽  
pp. 1-1
Author(s):  
Shiqi Xia ◽  
Hong Lin ◽  
Peilin Zhu ◽  
Peiling Wang ◽  
Shengliang Liao ◽  
...  
Keyword(s):  
Aspergillus Flavus ◽  
Inhibitory Effects ◽  
Active Components ◽  
Litsea Cubeba

scholarly journals Inhibitory Effects of Litsea cubeba Oil and Its Active Components on Aspergillus flavus

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Shiqi Xia ◽  
Hong Lin ◽  
Peilin Zhu ◽  
Peiling Wang ◽  
Shengliang Liao ◽  
...  
Keyword(s):  
Growth Rate ◽  
Aspergillus Flavus ◽  
Fungal Spores ◽  
Aflatoxin Production ◽  
Colony Growth ◽  
Inhibitory Effect ◽  
Inhibitory Effects ◽  
Active Components ◽  
Litsea Cubeba ◽  
Mycelium Biomass

Aspergillus flavus (A. flavus) is a frequent harmful fungal pathogen. It can infect traditional Chinese medicine materials and release aflatoxin, to cause both economic and human health effects. By comparing the inhibitory potential of Litsea cubeba oil and its active components to A. flavus CGMCC 3.4408, citral was confirmed to be the main component that inhibits the growth of A. flavus CGMCC 3.4408, and the EC50 was 163.65 mg L−1. The inhibitory effect of citral on A. flavus CGMCC 3.4408 was studied for colony growth rate, mycelium biomass, aflatoxin production, and microstructure. Citral slowed down the growth rate of colonies and reduced mycelium biomass and toxin production. Moreover, citral altered the morphology of fungal spores and mycelium. In addition, citral also has the inhibitory effects on the isolates of A. flavus from moldy traditional Chinese medicinal materials. Thus, citral can be used as a potential agent to check the growth of A. flavus or related fungal strains.

Inhibition of Aflatoxin-Producing Fungi by Welsh Onion Extracts

1999 ◽  
Vol 62 (4) ◽  
pp. 414-417 ◽  
Author(s):  
J. J. FAN ◽  
J. H. CHEN
Keyword(s):  
Aspergillus Flavus ◽  
Mycelial Growth ◽  
Ethanol Extract ◽  
Aflatoxin Production ◽  
Inhibitory Effects ◽  
Welsh Onion ◽  
Extract Concentration ◽  
Ph Values ◽  
Ethanol Extracts ◽  
Yeast Extract Sucrose

Welsh onion ethanol extracts were tested for their inhibitory activity against the growth and aflatoxin production of Aspergillus flavus and A. parasiticus. The survival of spores of A. flavus and A. parasiticus depended on both the extract concentration and the exposure time of the spores to the Welsh onion extracts. The mycelial growth of two tested fungi cultured on yeast extract–sucrose broth was completely inhibited in the presence of the Welsh onion ethanol extract at a concentration of 10 mg/ml during 30 days of incubation at 25°C. The extracts added to the cultures also inhibited aflatoxin production at a concentration of 10 mg/ml or permitted only a small amount of aflatoxin production with extract concentration of 5 mg/ml after 2 weeks of incubation. Welsh onion ethanol extracts showed more pronounced inhibitory effects against the two tested aflatoxin-producing fungi than did the same added levels of the preservatives sorbate and propionate at pH values near 6.5.

scholarly journals Morphological and Transcriptomic Analysis of the Inhibitory Effects of Lactobacillus plantarum on Aspergillus flavus Growth and Aflatoxin Production

Toxins ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 636 ◽  
Author(s):  
Zhao ◽  
Zhang ◽  
Folly ◽  
Chang ◽  
Wang ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Aspergillus Flavus ◽  
Aflatoxin Production ◽  
Inhibitory Effect ◽  
Transcriptional Level ◽  
Sequencing Data ◽  
Inhibitory Effects ◽  
Cell Wall Polysaccharides ◽  
Colony Forming Units ◽  
Insight Into

Lactobacillus plantarum, as a natural bio-preservative, has attracted a great deal of attention in recent years. In this study, 22 L. plantarum strains were tested against the aflatoxin-producing fungus, Aspergillus flavus; strain IAMU80070 showed the highest antifungal activity. At a concentration of 5 × 105 colony-forming units (CFU) mL−1, it completely inhibited A. flavus growth and decreased aflatoxin production by 93%. Furthermore, ultrastructural examination showed that IAMU80070 destroyed the cellular structure of hyphae and spores. To explore the inhibitory effect of IAMU80070 on A. flavus at the transcriptional level, transcriptome data were obtained and subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The aflatoxin biosynthetic process was the most significantly downregulated functional category, while genes implicated in the synthesis and organization of cell wall polysaccharides were upregulated. Quantitative real-time PCR results verified the credibility and reliability of the RNA sequencing data. These results provided insight into the transcriptome of A. flavus in response to the antagonistic effects of L. plantarum IAMU80070.

Inhibitory Effects of Active Fraction and Its Main Components of Shaofu Zhuyu Decoction on Uterus Contraction

2010 ◽  
Vol 38 (04) ◽  
pp. 777-787 ◽  
Author(s):  
Shulan Su ◽  
Yongqing Hua ◽  
Jin-Ao Duan ◽  
Wei Zhou ◽  
Erxin Shang ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Vanillic Acid ◽  
Uterine Contraction ◽  
Active Fraction ◽  
Inhibitory Effects ◽  
Active Components ◽  
Traditional Use ◽  
Pregnant Mice ◽  
Main Components

Shaofu Zhuyu decoction is a famous formula for treating primary dysmenorrhea in China since the Qing dynasty. In this paper, the inhibitory effects of active-guided fraction and its main bioactive components of Shaofu Zhuyu decoction on a model of non-pregnant mice uterine contraction induced by oxytocin in vitro were investigated. Qualitative and quantitative chemical analyses were used to correlate the chemical composition of active fraction with the spasmolytic effects. Seven ingredients in the active fraction were identified and quantified by HPLC-DAD. Three ingredients, ferulic acid, vanillic acid, and typhaneoside, were evaluated for their effects on mice isolated uterine contraction induced by oxytocin in vitro. The ED50 of them were 63.0 μg/ml, 57.6 μg/ml, 109.7 μg/ml, respectively. Furthermore, the inhibitory activity of the combination of these three compounds was prior to the fraction and seven compounds group. The ED50 was 65.5 μg/ml. The data stated that ferulic acid, vanillic acid, and typhaneoside were possibly the main active components in the bioactive fraction of Shaofu Zhuyu decoction. The study also implied that Shaofu Zhuyu decoction may have direct inhibitory effects on the contractility of the mice uterus and justified the traditional use of the prescription for treating the uterine cramping associated dysmenorrhea.

Litsea cubeba essential oil as the potential natural fumigant: Inhibition of Aspergillus flavus and AFB1 production in licorice

2016 ◽  
Vol 80 ◽  
pp. 186-193 ◽  
Author(s):  
Yanjun Li ◽  
Weijun Kong ◽  
Menghua Li ◽  
Hongmei Liu ◽  
Xue Zhao ◽  
...  
Keyword(s):  
Essential Oil ◽  
Aspergillus Flavus ◽  
Litsea Cubeba ◽  
Natural Fumigant

scholarly journals Isolation and Identification of Benzochroman and Acylglycerols from Massa Medicata Fermentata and Their Inhibitory Effects on LPS-Stimulated Cytokine Production in Bone Marrow-Derived Dendritic Cells

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2400 ◽  
Author(s):  
Ya Sun ◽  
Seo Yang ◽  
Young-Sang Koh ◽  
Young Kim ◽  
Wei Li
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
Scientific Basis ◽  
Inhibitory Effects ◽  
Active Components ◽  
Isolation And Identification ◽  
Chemical Structures ◽  
Tnf Α ◽  
Ic50 Values ◽  
Reported Data

Massa Medicata Fermentata (MMF), known as Shenqu, is an important traditional Chinese medicine widely used to treat indigestion, vomiting, and diarrhea. In this study, a new benzochroman, 3(S)-3,4-dihydro-5,10-di-β-d-glucopyranoside-2,2-dimethyl-2H-naphtho(2,3-b)pyran-3-ol (1), and five known galactosyl acylglycerols (2–6) were isolated from a methanol extract from MMF. In addition, their chemical structures were determined by chemical and spectroscopic methods, which were compared with the previously reported data. Furthermore, the effects of isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1–3 exhibited significant inhibitory effects on the LPS-induced production of IL-6 and IL-12 p40, with IC50 values ranging from 1.6 to 10.2 μM. Compounds 2 and 3 also exhibited strong inhibitory effects on the LPS-stimulated production of TNF-α with IC50 values of 12.0 and 11.2 μM, respectively. The results might provide a scientific basis for the development of the active components in MMF, as well as for novel anti-inflammatory agents.

scholarly journals Rapid Characterization of Chemical Components in Edible Mushroom Sparassis crispa by UPLC-Orbitrap MS Analysis and Potential Inhibitory Effects on Allergic Rhinitis

Molecules ◽  
2019 ◽  
Vol 24 (16) ◽  
pp. 3014 ◽  
Author(s):  
Zhixin Wang ◽  
Jingyu Liu ◽  
Xiangjian Zhong ◽  
Jinjie Li ◽  
Xin Wang ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
High Performance ◽  
Edible Mushroom ◽  
Inflammatory Activity ◽  
Chemical Components ◽  
Inhibitory Effects ◽  
Active Components ◽  
Proinflammatory Mediators ◽  
Sparassis Crispa ◽  
Anti Inflammatory

Sparassis crispa is a kind of edible fungus widely grows in the north temperate zone, which shows various medicinal properties. Due to the complexity of chemical constitutes of this species, few investigations have acquired a comprehensive configuration for the chemical profile of it. In this study, a strategy based on ultra-high performance liquid chromatography (UPLC) combined with Orbitrap mass spectrometer (MS) was established for rapidly characterizing various chemical components in S. crispa. Through the summarized MS/MS fragmentation patterns of reference compounds and systematic identification strategy, a total of 110 components attributed to six categories were identified for the first time. Moreover, allergic rhinitis (AR) is a worldwide inflammatory disease seriously affecting human health, and the development of drugs to treat AR has been a topic of interest. It has been reported that the extracts of S. crispa showed obvious inhibitory effects on degranulation of mast cell- and allergen-induced IgE and proinflammatory mediators, but the active components and specific mechanism were still not clear. Src family kinases (SFKs) participate in the initial stage of allergy occurrence, which are considered the targets of AR treatment. Herein, on the basis of that self-built chemical database, virtual screening was applied to predict the potential SFKs inhibitors in S. crispa, using known crystal structures of Hck, Lyn, Fyn, and Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobilization assay. As results, sparoside A was directly confirmed to have strong anti-inflammatory activity with an IC50 value of 5.06 ± 0.60 μM. This study provides a useful elucidation for the chemical composition of S. crispa, and demonstrated its potential inhibitory effects on AR, which could promote the research and development of effective agents from natural resources.

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