scholarly journals New-Onset Bullous Pemphigoid in a COVID-19 Patient

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Natalie Olson ◽  
David Eckhardt ◽  
Angela Delano
Keyword(s):  
Bullous Pemphigoid ◽  
Type Ii Diabetes Mellitus ◽  
Punch Biopsy ◽  
The Body ◽  
Direct Immunofluorescence ◽  
Class Iii ◽  
Dermoepidermal Junction ◽  
Clinical Criteria ◽  
History Of ◽  
Important Addition

This manuscript presents a report of bullous pemphigoid rash associated with COVID-19 for the first time. The objective of this manuscript is to present a unique dermatological case in the setting of a COVID-19-positive infection to further recognize the virus symptomatology. A 37-year-old female with a past medical history of class III obesity, type II diabetes mellitus, and hypertension presented to the emergency department in September 2020 with inpatient and outpatient follow-up through to November 2020. The patient denied any personal or family history of skin disorders. The patient tested positive for COVID-19 prior to hospitalization and presented to the hospital with severe, persistent, pruritic rash meeting dermatopathological, serologic, and clinical criteria for bullous pemphigoid diagnosis. Histopathology H&E punch biopsy from her left flexor wrist demonstrated epidermal keratinocyte necrosis, subepidermal vesiculation with eosinophils, gossamer stranding of the papillary dermis, and subepidermal edema. Direct immunofluorescence punch biopsy from her left flexor wrist demonstrated strong linear IgG staining at the dermoepidermal junction, with weaker and focal linear C3 staining. Antigen-specific serology was consistent with bullous pemphigoid. There was no previously reported cutaneous association of COVID-19 infection with bullous pemphigoid making this case an important addition to the body of evidence helping to identify bullous pemphigoid in the setting of viral infection.

scholarly journals Biochip Technology for the Serological Diagnosis of Bullous Pemphigoid

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Haik Zarian ◽  
Andrea Saponeri ◽  
Anna Michelotto ◽  
Edoardo Zattra ◽  
Anna Belloni-Fortina ◽  
...  
Keyword(s):  
Bullous Pemphigoid ◽  
Indirect Immunofluorescence ◽  
Immunofluorescence Assay ◽  
Dermoepidermal Junction ◽  
Suitable Alternative ◽  
Clinical Criteria ◽  
Specific Proteins ◽  
Laboratory Investigations ◽  
Circulating Autoantibodies

Bullous pemphigoid is an autoimmune blistering skin disease characterized by the presence of circulating autoantibodies which recognize specific proteins of the epidermis and dermoepidermal junction. Diagnosis is based on clinical criteria and laboratory investigations, notably histology, direct and indirect immunofluorescence, and ELISA. This study describes a new immunofluorescence assay for parallel determination of anti-BP180 and anti-BP230 based on recombinant antigenic substrates. The aim of the study was to detect BP180 and BP230 autoantibodies by BIOCHIP technology using both a specially designed recombinant BP180-NC16A protein and cells expressing the BP230-gc antigen fragment. 18 patients with bullous pemphigoid were included in the study. Autoantibodies to BP180 were detected by the BIOCHIP technique in 83.33% of patients with clinical, serological, and immunohistological confirmed bullous pemphigoid while autoantibodies against BP230-gC were detected only in 39% of patients. The detection of anti-BP180-NC16A and anti-BP230-gC by a new biochip-based immunoassay is a suitable alternative to indirect immunofluorescence and ELISA. This method has the advantage of easily discriminating the different autoantibody specificities. The BIOCHIP method is faster, cheaper, and easy to use when compared with the ELISA approach. For this reason, the new method could be used as an initial screening test to identify patients with bullous pemphigoid, and doubtful results could then be confirmed by ELISA.

scholarly journals Juvenile Bullous Pemphigoid – a Case Report

2013 ◽  
Vol 5 (1) ◽  
pp. 31-36
Author(s):  
Kristina Kostić ◽  
Lidija Kandolf Sekulović ◽  
Radoš D. Zečević
Keyword(s):  
Bullous Pemphigoid ◽  
White Cell Count ◽  
Direct Immunofluorescence ◽  
Elderly Persons ◽  
Dermoepidermal Junction ◽  
Autoimmune Blistering Disease ◽  
Systemic Corticosteroids ◽  
Laboratory Test Results ◽  
Intense Pruritus ◽  
Blistering Disease

Abstract Bullous pemphigoid is an autoimmune blistering disease that predominantly affects elderly persons and rarely children. We present a 12-year-old girl with sudden appearance of tense blisters on an erythematous base on the trunk, neck, hands and legs with intense pruritus. Standard laboratory test results were within the normal range except for blood eosinophilia of 12% of the total white cell count. Skin biopsy specimens showed evolving subepidermal blisters with perivascular lymphohistiocytic, eosinophil and neutrophil infiltrations in the papillary dermis. Direct immunofluorescence of perilesional skin showed linear, continuous deposits of IgG and C3 along the dermoepidermal junction. Indirect immunofluorescence showed circulating anti-basement membrane zone IgG autoantibodies at a titer of 1:80. We started treatment with systemic corticosteroids, methylprednisolone 0,5 mg/kg per day and 500 mg erythromycin 4 times a day during 10 days. After 3 days 50 mg dapsone (DDS, 4,4-diaminodiphenylsulphone) per day was added. After a few days, there were no new changes on the skin and pruritus disappeared completely.

scholarly journals Characteristics of Sympathetic Ophthalmia in a Single International Center

2016 ◽  
Vol 10 (1) ◽  
pp. 154-159 ◽  
Author(s):  
Pablo Jose Guzman-Salas ◽  
Juan Carlos Serna-Ojeda ◽  
Ethel Beatriz Guinto-Arcos ◽  
Miguel Pedroza-Seres
Keyword(s):  
Combined Therapy ◽  
Oral Prednisone ◽  
Sympathetic Ophthalmia ◽  
The Body ◽  
Clinical Criteria ◽  
Ocular Manifestations ◽  
Keratic Precipitates ◽  
Retrospective Clinical Study ◽  
History Of ◽  
Clinical Records

Aim: To report the main features of sympathetic ophthalmia in a referral ophthalmology center. Methods: Retrospective clinical study. We reviewed clinical records of patients with diagnosis of sympathetic ophthalmia attending the Uveitis Department from 2007 to 2013. Patients were selected by clinical criteria. Descriptive statistics were used to assess variables. Results: Twenty patients were included for analysis, 13 males and 7 females. Mean follow up was 1 year. The median age of presentation was 50 years. Fifty percent had history of ocular trauma and 50% had history of intraocular surgery, of which 40% underwent phacoemulsification. The time between injury and onset of symptoms ranged from 1 to 456 months. Most common ocular manifestations were mutton fat keratic precipitates and anterior chamber inflammation. All patients received oral prednisone as single or combined therapy. Sixty percent of the sympathizing eyes improved two or more lines of vision and 20% lost two or more lines of vision. Conclusion: This report from a single center adds to the body of literature of sympathetic ophthalmia occurring in a specific population. Our data found a high proportion of patients with sympathetic ophthalmia after phacoemulsification.

scholarly journals “V.V. Bessel” Collection in the Russian National Museum of Music

2020 ◽  
Vol 17 (2) ◽  
pp. 152-163
Author(s):  
Anna S. Krivtsova
Keyword(s):  
The Body ◽  
Production Volume ◽  
National Museum ◽  
Music Publishing ◽  
Russian Music ◽  
Music Printing ◽  
Relevant Task ◽  
Music Collection ◽  
History Of ◽  
Important Addition

Vasily Vasilyevich Bessel (1843—1907) entered the history of Russian and world music culture as one of the largest music publishers. His company was occupying one of the leading positions in terms of production volume in the Russian music printing market in the late 19th — early 20th century. It was the company that first published many of works by Russian classical composers — A.G. Rubinstein, A.P. Borodin, P.I. Tchaikovsky, M.P. Mussorgsky, N.A. Rimsky-Korsakov, and A.K. Lyadov. V.V. Bessel’s music publishing activities were connected with his works on the history of music printing in Russia and copyright. He left an extensive legacy in the form of numerous handwritten materials, now dispersed in various archives (mainly in Moscow and Saint Petersburg). The Russian National Museum of Music, Collection 42, holds one of the largest archives associated with V.V. Bessel. Major part of it makes up a separate collection called “V.V. Bessel”, which includes unofficial documents, responding mail, as well as literary manuscripts and photographic materials. Due to lack of comprehensive research of that documentary collection, this article provides a brief overview of its content, and the history of formation of V.V. Bessel’s collection. The main purpose of the research is to characterize both published and unknown sources. The article meets the relevant task of modern musicology: disclosure of Moscow and St. Petersburg archival collections. Many of the documents reviewed by the author are an important addition to the only monograph on V.V. Bessel, which belongs to the pen of N.F. Findzein. The article discusses, in more detail, the documents related to the literary weekly “Muzykal’nyi Listok [Musical Sheet]” (1872—1877), the first periodical published by “V. Bessel and Co.”, as well as the correspondence of December 1886 between V.V. Bessel and P.I. Tchaikovsky, which, at the latter’s initiative, ended all the composer’s personal and business contacts with his Petersburg publisher. This study expands the researchers’ understanding of the body of documents stored in the collection under consideration, the problems associated with them, and their prospects.

Idiopathic linear IgA bullous dermatosis treated with prednisone

2021 ◽  
Vol 14 (5) ◽  
pp. e242237
Author(s):  
Christopher Cantoria Garces ◽  
M Fahad Salam ◽  
Brian Nohomovich ◽  
Merryl Treasa Varghese
Keyword(s):  
Case Reports ◽  
Acute Onset ◽  
Direct Immunofluorescence ◽  
Dermoepidermal Junction ◽  
Mucosal Surfaces ◽  
Bullous Dermatosis ◽  
History Of ◽  
Linear Iga Bullous Dermatosis ◽  
Linear Band ◽  
Subepidermal Blister

We present a case of a 43-year-old man with a medical history of paroxysmal atrial fibrillation that presented with acute onset generalised vesiculobullous rash of 1-week duration. The rash was initially noticed on his groin and then spread to his hands, feet and mucosal surfaces. Laboratory tests were unremarkable, including an extensive infection aetiology work-up. Punch biopsies were obtained of a fresh lesion and were stained with H&E and sent for direct immunofluorescence. Light microscopy and immunofluorescence study demonstrated a subepidermal blister with predominant neutrophilic infiltrates and a linear band of IgA at the dermoepidermal junction, respectively. The patient was diagnosed with linear IgA bullous dermatosis and was subsequently treated with 0.5 mg/kg of prednisone daily following previous case reports. At 1-week follow-up as an outpatient, the bullae became crusted, and the rash was nearly completely regressed.

scholarly journals Renal Clinical - Pathological Manifestations in Bullous Pemphigoid

2014 ◽  
Vol 7 (1) ◽  
pp. 98-101
Author(s):  
Ke-Zhong Zhao ◽  
Zhang Lian ◽  
Jian-Feng Liu ◽  
Yong-Hong Cai ◽  
Rui-Hong Han ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Kidney Biopsy ◽  
Autoimmune Disorder ◽  
Basement Membrane Zone ◽  
The Body ◽  
Intravenous Cyclophosphamide ◽  
Mesangial Proliferation ◽  
History Of ◽  
Epidermal Basement Membrane

A 61-year old man was admitted with a 2-month history of skin rash, and proteinuria and intermittent hemoptysis for 2 weeks. The patient had developed circular erythema and blisters all over the body with scab formation. Edema of the legs and eyelids appeared 2 weeks prior to admission. Kidney biopsy showed membranous nephropathy (phase II) with focal segmental mesangial proliferation and deposits of IgG along the GBM. Skin biopsy demonstrated IgG deposits in the epidermal basement membrane zone. The simultaneous development of a rare renal and skin autoimmune disorder, resulting from non-cross-reactive autoantibodies, suggests that a common triggering event could be responsible for the autoimmune injury. This patient with bullous pemphigoid was treated with corticosteroids, which were tapered to an acceptable and effective maintenance dose following treatment with intravenous cyclophosphamide.

Aspergillus Spondylodiscitis After Spinal Stenosis Surgery: A Case Report

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 155-160
Author(s):  
Mohsen Aghapoor ◽  
◽  
Babak Alijani Alijani ◽  
Mahsa Pakseresht-Mogharab ◽  
◽  
...  
Keyword(s):  
Antifungal Drugs ◽  
The Body ◽  
Lower Limbs ◽  
Lumbar Pain ◽  
Case Presentation ◽  
Delay In Diagnosis ◽  
Death Case ◽  
Therapeutic Results ◽  
History Of ◽  
Probable Diagnosis

Background and Importance: Spondylodiscitis is an inflammatory disease of the body of one or more vertebrae and intervertebral disc. The fungal etiology of this disease is rare, particularly in patients without immunodeficiency. Delay in diagnosis and treatment of this disease can lead to complications and even death. Case Presentation: A 63-year-old diabetic female patient, who had a history of spinal surgery and complaining radicular lumbar pain in both lower limbs with a probable diagnosis of spondylodiscitis, underwent partial L2 and complete L3 and L4 corpectomy and fusion. As a result of pathology from tissue biopsy specimen, Aspergillus fungi were observed. There was no evidence of immunodeficiency in the patient. The patient was treated with Itraconazole 100 mg twice a day for two months. Pain, neurological symptom, and laboratory tests improved. Conclusion: The debridement surgery coupled with antifungal drugs can lead to the best therapeutic results.

Re-imagining Reproduction: Unsettling Metaphors in the History of Imperial Science and Commercial Surrogacy in India

Somatechnics ◽  
2015 ◽  
Vol 5 (1) ◽  
pp. 88-103 ◽  
Author(s):  
Kalindi Vora
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
The Body ◽  
Body Parts ◽  
Colonial History ◽  
Women's Bodies ◽  
Commercial Surrogacy ◽  
Art Practices ◽  
History Of ◽  
Travel Industry

This paper provides an analysis of how cultural notions of the body and kinship conveyed through Western medical technologies and practices in Assisted Reproductive Technologies (ART) bring together India's colonial history and its economic development through outsourcing, globalisation and instrumentalised notions of the reproductive body in transnational commercial surrogacy. Essential to this industry is the concept of the disembodied uterus that has arisen in scientific and medical practice, which allows for the logic of the ‘gestational carrier’ as a functional role in ART practices, and therefore in transnational medical fertility travel to India. Highlighting the instrumentalisation of the uterus as an alienable component of a body and subject – and therefore of women's bodies in surrogacy – helps elucidate some of the material and political stakes that accompany the growth of the fertility travel industry in India, where histories of privilege and difference converge. I conclude that the metaphors we use to structure our understanding of bodies and body parts impact how we imagine appropriate roles for people and their bodies in ways that are still deeply entangled with imperial histories of science, and these histories shape the contemporary disparities found in access to medical and legal protections among participants in transnational surrogacy arrangements.

Receptions of the Past: Commemoration, Racism, Desire

Somatechnics ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 288-303
Author(s):  
Michael Connors Jackman
Keyword(s):  
Critical Point ◽  
Social Relations ◽  
White Privilege ◽  
Body Politic ◽  
The Body ◽  
Race And Racism ◽  
Lesbian And Gay ◽  
The Past ◽  
History Of

This article investigates the ways in which the work of The Body Politic (TBP), the first major lesbian and gay newspaper in Canada, comes to be commemorated in queer publics and how it figures in the memories of those who were involved in producing the paper. In revisiting a critical point in the history of TBP from 1985 when controversy erupted over race and racism within the editorial collective, this discussion considers the role of memory in the reproduction of whiteness and in the rupture of standard narratives about the past. As the controversy continues to haunt contemporary queer activism in Canada, the productive work of memory must be considered an essential aspect of how, when and for what reasons the work of TBP comes to be commemorated. By revisiting the events of 1985 and by sifting through interviews with individuals who contributed to the work of TBP, this article complicates the narrative of TBP as a bluntly racist endeavour whilst questioning the white privilege and racially-charged demands that undergird its commemoration. The work of producing and preserving queer history is a vital means of challenging the intentional and strategic erasure of queer existence, but those who engage in such efforts must remain attentive to the unequal terrain of social relations within which remembering forms its objects.

Myriad Aspects of Secular Thinking on Malayali Cuisine

GIS Business ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. 202-206
Author(s):  
SAJITHA M
Keyword(s):  
Social Status ◽  
Daily Life ◽  
Social Indicators ◽  
The Body ◽  
Human Being ◽  
Healthy Life ◽  
The Social ◽  
The World ◽  
History Of ◽  
Civilized Society

Food is one of the main requirements of human being. It is flattering for the preservation of wellbeing and nourishment of the body.  The food of a society exposes its custom, prosperity, status, habits as well as it help to develop a culture. Food is one of the most important social indicators of a society. History of food carries a dynamic character in the socio- economic, political, and cultural realm of a society. The food is one of the obligatory components in our daily life. It occupied an obvious atmosphere for the augmentation of healthy life and anticipation against the diseases.  The food also shows a significant character in establishing cultural distinctiveness, and it reflects who we are. Food also reflected as the symbol of individuality, generosity, social status and religious believes etc in a civilized society. Food is not a discriminating aspect. It is the part of a culture, habits, addiction, and identity of a civilization.Food plays a symbolic role in the social activities the world over. It’s a universal sign of hospitality.[1]

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