scholarly journals Tocilizumab Controls Paraneoplastic Inflammatory Syndrome but Does Not Suppress Tumor Growth of Angiomatoid Fibrous Histiocytoma

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hideaki Sabe ◽  
Akitomo Inoue ◽  
Shigenori Nagata ◽  
Yoshinori Imura ◽  
Toru Wakamatsu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Soft Tissue Tumor ◽  
Fibrous Histiocytoma ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Distant Lymph Node Metastasis ◽  
Autocrine Stimulation ◽  
Control Tumor ◽  
Local Recurrent Tumor ◽  
Inflammatory Syndrome

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that rarely metastasizes but lacks effective systemic therapy once it propagates. In some reports, high interleukin-6 (IL-6) production promotes tumor growth by autocrine stimulation and tocilizumab, an IL-6 receptor antagonist, can control AFH growth. Here, we present a case report on a patient with local recurrence and distant lymph node metastasis of AFH treated with tocilizumab. As a result, the inhibition of the IL-6 signaling pathway controlled paraneoplastic inflammatory syndrome (PIS); however, the local recurrent tumor progressed. This case implied that IL-6 is not necessarily the cause of tumor growth in AFH. Therefore, physicians should bear in mind that watchful observation is needed whether tocilizumab can control tumor progression despite the amelioration of PIS associated with the attenuated effect of IL-6 on AFH.

scholarly journals Subcutaneous Angiomatoid Fibrous Histiocytoma Mimicking Metastatic Melanoma

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
E. Sparreboom ◽  
C. Wetzels ◽  
M. Verdijk ◽  
S. Mulder ◽  
W. Blokx
Keyword(s):  
Lymph Node ◽  
Metastatic Melanoma ◽  
Molecular Diagnostics ◽  
Soft Tissue Tumor ◽  
Fibrous Histiocytoma ◽  
Case Reports ◽  
Relevant Literature ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma ◽  
The Past

Angiomatoid fibrous histiocytoma is an uncommon soft-tissue tumor of intermediate malignancy that is often misdiagnosed initially. As there is not one immunohistochemical marker that consequently stains positive or negative for angiomatoid fibrous histiocytoma, molecular diagnostics are becoming more widely used. So far three translocations have been reported to arise in angiomatoid fibrous histiocytoma: FUS-ATF1, EWSR1-CREB1, or EWSR1-ATF1. We present a case of angiomatoid fibrous histiocytoma on the upper arm of a 40-year-old female, which was initially misdiagnosed as metastatic melanoma in a lymph node. Revision of the pathology revealed an angiomatoid fibrous histiocytoma, which was later confirmed by a EWSR1-CREB1 translocation with molecular diagnostics. Furthermore, we review the relevant literature and provide an overview of all available case reports in the past ten years. This case report illustrates the importance for pathologists of knowing the typical pathology features of AFH and integrating immunohistochemical and molecular findings in order to prevent overdiagnosis of lymph node metastasis of a malignancy.

Primary angiomatoid fibrous histiocytoma of the lung with mediastinal lymph node metastasis

2016 ◽  
Vol 58 ◽  
pp. 134-137 ◽  
Author(s):  
Chee Kiang Tay ◽  
Mariko Siyue Koh ◽  
Angela Takano ◽  
Marie Christine Aubry ◽  
William R. Sukov ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fibrous Histiocytoma ◽  
Mediastinal Lymph Node ◽  
Mediastinal Lymph Node Metastasis ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Tocilizumab for the treatment of paraneoplastic inflammatory syndrome associated with angiomatoid fibrous histiocytoma

ESMO Open ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. e000756
Author(s):  
Lauriane Eberst ◽  
Philippe A Cassier ◽  
Mehdi Brahmi ◽  
Franck Tirode ◽  
Jean-Yves Blay
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Inflammatory Syndrome

62. Angiomatoid fibrous histiocytoma with locoregional lymph node metastasis: A case report

Pathology ◽  
2015 ◽  
Vol 47 ◽  
pp. S118
Author(s):  
Kathleen Young ◽  
Elizabeth Robbins ◽  
Theresa Harvey ◽  
Fiona Bonar ◽  
Annabelle Mahar ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fibrous Histiocytoma ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Locoregional Lymph Node

scholarly journals Angiomatoid Fibrous Histiocytoma in the Forearm: A Case Report

2016 ◽  
Vol 6 (1) ◽  
pp. 36
Author(s):  
Hatim Mohammed A Alshareef ◽  
Ahmed Hassan A Alhasan ◽  
Mohammed G. Felemban ◽  
Ashwaq Mohammed J Almalki ◽  
Amer Mohammed A Alshareef
Keyword(s):  
Young Adults ◽  
Soft Tissue ◽  
Soft Tissue Tumor ◽  
Fibrous Histiocytoma ◽  
Full Range ◽  
Common Site ◽  
Tissue Mass ◽  
Skin Changes ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Children And Young Adults

Background: Angiomatoid fibrous histiocytoma [AFH] is a rare soft tissue tumor most commonly occurring in children, adolescents, and young adults. It is considered to be a tumor of intermediate malignancy because of its less aggressive course. The extremities are the most common site of involvement, followed by the trunk and head and neck.Case presentation: A 28-Year-old male presented with a right forearm mass that has been present for 2 years. There was no associated fever, no trauma, no night pain and no constitutional symptoms. On examination he had a forearm mass dorsally measuring 2x3 cm, firm, rounded, mobile with no skin changes and full range motion joint above and joint below. Lab and imaging studies done which showed soft tissue mass, multilobulated complex heterogeneous with increased vascularity. Patient underwent biopsy and surgical excision.Conclusion: Angiomatoid fibrous histiocytoma is a neoplasm of intermediate biologic potential. Most often, the extremities are the most common site of involvement, followed by the trunk and head and neck of children and young adults. Its rarity may lead to misdiagnosis as either a reactive lesion or a benign or higher-grade tumor. This tumor has a relatively rare metastasis and its overall clinical outcome is excellent. It is clinically important to accurately diagnose this tumor so that wide local excision may be performed and patients may be appropriately monitored and followed up.

scholarly journals Cranial angiomatoid fibrous histiocytoma: A case report and review of literature

2020 ◽  
Vol 11 ◽  
pp. 295
Author(s):  
Amanda E. Sion ◽  
Rizwan A. Tahir ◽  
Abir Mukherjee ◽  
Jack P. Rock
Keyword(s):  
Case Report ◽  
Soft Tissue Tumor ◽  
Fibrous Histiocytoma ◽  
Subcutaneous Tissue ◽  
Low Grade ◽  
Case Description ◽  
Review Of Literature ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Resected Tumor ◽  
Children And Young Adults

Background: Angiomatoid fibrous histiocytoma (AFH) is a rare low-grade soft-tissue tumor that typically arises from the deep dermal and subcutaneous tissue of the extremities in children and young adults. Intracranial AFH is exceedingly rare, and only four cases of primary AFH tumors have been reported to date. Case Description: A 43-year-old male presented to our hospital with headaches, vision changes, and a known brain tumor suspected to be an atypical meningioma. After undergoing craniotomy for resection of the mass, the immunomorphologic features of the resected tumor showed typical features of AFH with ESWR1 (exon7) – ATF1 (exon 5) fusion. Conclusion: AFH is a difficult tumor to diagnose with imaging and histologic studies. Thus, further knowledge is necessary – particularly of intracranial cases – to aid clinicians in its diagnosis and management.

Angiomatoid Fibrous Histiocytoma

2016 ◽  
Vol 78 (3) ◽  
pp. 219-220
Author(s):  
Yoshihiko Inoue ◽  
Shiho Terawaki ◽  
Kazuko Imamura ◽  
Yumiko Kubota ◽  
Masazumi Tsuneyoshi ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma

Survival of Patients and Metastatic and Local Recurrent Tumor Growth in Malignant Melanoma of the Uvea After Ruthenium Plaque Radiotherapy

1993 ◽  
Vol 24 (2) ◽  
pp. 82-90
Author(s):  
Paula Summanen ◽  
Ilkka Immonen ◽  
Jorma Heikkonen ◽  
Petri Tommila ◽  
Leila Laatikainen ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Tumor Growth ◽  
Recurrent Tumor ◽  
Plaque Radiotherapy ◽  
Local Recurrent Tumor

scholarly journals Aneurysmal ("angiomatoid") fibrous histiocytoma in a child

1989 ◽  
Vol 4 (4) ◽  
pp. 159 ◽  
Author(s):  
Chong Jai Kim ◽  
Jung Hee Cho ◽  
Je Geun Chi
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma
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