scholarly journals Subcutaneous Angiomatoid Fibrous Histiocytoma Mimicking Metastatic Melanoma

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
E. Sparreboom ◽  
C. Wetzels ◽  
M. Verdijk ◽  
S. Mulder ◽  
W. Blokx
Keyword(s):  
Lymph Node ◽  
Metastatic Melanoma ◽  
Molecular Diagnostics ◽  
Soft Tissue Tumor ◽  
Fibrous Histiocytoma ◽  
Case Reports ◽  
Relevant Literature ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma ◽  
The Past

Angiomatoid fibrous histiocytoma is an uncommon soft-tissue tumor of intermediate malignancy that is often misdiagnosed initially. As there is not one immunohistochemical marker that consequently stains positive or negative for angiomatoid fibrous histiocytoma, molecular diagnostics are becoming more widely used. So far three translocations have been reported to arise in angiomatoid fibrous histiocytoma: FUS-ATF1, EWSR1-CREB1, or EWSR1-ATF1. We present a case of angiomatoid fibrous histiocytoma on the upper arm of a 40-year-old female, which was initially misdiagnosed as metastatic melanoma in a lymph node. Revision of the pathology revealed an angiomatoid fibrous histiocytoma, which was later confirmed by a EWSR1-CREB1 translocation with molecular diagnostics. Furthermore, we review the relevant literature and provide an overview of all available case reports in the past ten years. This case report illustrates the importance for pathologists of knowing the typical pathology features of AFH and integrating immunohistochemical and molecular findings in order to prevent overdiagnosis of lymph node metastasis of a malignancy.

Primary angiomatoid fibrous histiocytoma of the lung with mediastinal lymph node metastasis

2016 ◽  
Vol 58 ◽  
pp. 134-137 ◽  
Author(s):  
Chee Kiang Tay ◽  
Mariko Siyue Koh ◽  
Angela Takano ◽  
Marie Christine Aubry ◽  
William R. Sukov ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fibrous Histiocytoma ◽  
Mediastinal Lymph Node ◽  
Mediastinal Lymph Node Metastasis ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Tocilizumab Controls Paraneoplastic Inflammatory Syndrome but Does Not Suppress Tumor Growth of Angiomatoid Fibrous Histiocytoma

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hideaki Sabe ◽  
Akitomo Inoue ◽  
Shigenori Nagata ◽  
Yoshinori Imura ◽  
Toru Wakamatsu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Soft Tissue Tumor ◽  
Fibrous Histiocytoma ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Distant Lymph Node Metastasis ◽  
Autocrine Stimulation ◽  
Control Tumor ◽  
Local Recurrent Tumor ◽  
Inflammatory Syndrome

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor that rarely metastasizes but lacks effective systemic therapy once it propagates. In some reports, high interleukin-6 (IL-6) production promotes tumor growth by autocrine stimulation and tocilizumab, an IL-6 receptor antagonist, can control AFH growth. Here, we present a case report on a patient with local recurrence and distant lymph node metastasis of AFH treated with tocilizumab. As a result, the inhibition of the IL-6 signaling pathway controlled paraneoplastic inflammatory syndrome (PIS); however, the local recurrent tumor progressed. This case implied that IL-6 is not necessarily the cause of tumor growth in AFH. Therefore, physicians should bear in mind that watchful observation is needed whether tocilizumab can control tumor progression despite the amelioration of PIS associated with the attenuated effect of IL-6 on AFH.

62. Angiomatoid fibrous histiocytoma with locoregional lymph node metastasis: A case report

Pathology ◽  
2015 ◽  
Vol 47 ◽  
pp. S118
Author(s):  
Kathleen Young ◽  
Elizabeth Robbins ◽  
Theresa Harvey ◽  
Fiona Bonar ◽  
Annabelle Mahar ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fibrous Histiocytoma ◽  
Node Metastasis ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Locoregional Lymph Node

scholarly journals Evaluation of Supraclavicular Lymph Node Metastasis of Gynecologic Malignancies With Two Case Reports

2019 ◽  
Vol 26 (1) ◽  
pp. 117-119
Author(s):  
Hidayet Şal ◽  
Erhan Hüseyin Cömert ◽  
Yasin Semih Ekici ◽  
Emine Seda Güvendağ Güven ◽  
Süleyman Güven
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Case Reports ◽  
Gynecologic Malignancies ◽  
Supraclavicular Lymph Node ◽  
Node Metastasis ◽  
Supraclavicular Lymph Node Metastasis

scholarly journals Esophageal Carcinosarcoma: Analysis of Clinical Features and Prognosis of 24 Cases and a Literature Review

2021 ◽  
Vol 28 ◽  
pp. 107327482110048
Author(s):  
Shusen Chen ◽  
Yu Shi ◽  
Zhengjing Lu ◽  
Mingwei Wang ◽  
Longfei Cong ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Literature Review ◽  
Cancer Patients ◽  
Clinical Features ◽  
Early Stage ◽  
Case Reports ◽  
Radical Esophagectomy ◽  
Node Metastasis ◽  
Esophageal Carcinosarcoma

Objective: Esophageal carcinosarcoma (ECS) is a rare malignant tumor that accounts for only 0.5%-2.8% of all esophageal malignancies. As most current studies are case reports, the relationship between clinical features and prognosis remains controversial. Methods: We investigated the clinical features and prognosis of 24 patients with ECS in a single center from 2006 to 2018. There were 18 male and 6 female patients aged 52-82 years with a median age of 62.5 years. In addition, we included 9 studies on ECS from PubMed and a literature review. Results: The median follow-up time of the 24 patients was 70.5 (range, 10-156)months. The 3-year and 5-year survival rates were 83.3% and 70.8%, respectively. Among the 24 patients, none of the 10 (41.7%) stage T1 cancer patients had lymph node metastasis; however, lymph node metastasis was noted in 8 (57.1%) stage T2-4 cancer patients. The literature review revealed that 211 patients had a 5-year survival rate of 11.8%-68.2%, and 54.5%-95.8% study participants had early stage ECS. Although the information provided in the literature review is limited, it appears to be a characteristic of the early stage of the disease and predicts better prognosis when ECS is diagnosed, which is similar to the result of the current study. Conclusion: Our results indicate that ECS has a favorable prognosis, even among patients with early stage ECS who undergo radical esophagectomy with lymph node dissection. Because of the low incidence of ECS, further studies with more cases need to investigate this rare malignancy.

scholarly journals Two case reports: Breast schwannoma and a rare case of an axillary schwannoma imitating an axillary lymph node metastasis

2021 ◽  
Vol 16 (8) ◽  
pp. 2154-2157
Author(s):  
Martin Duehrkoop ◽  
Bernd Frericks ◽  
Christine Ankel ◽  
Christine Boettcher ◽  
Wolfgang Hartmann ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Axillary Lymph Node ◽  
Rare Case ◽  
Case Reports ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Node Metastasis
Sign in / Sign up

Export Citation Format

Share Document