scholarly journals Prediction Effect of Amplitude-Integrated EEG on the Brain Damage and Long-Term Nervous System Development of Late Preterm Infants

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Sehua Qu ◽  
Lianqiang Shan ◽  
Zhen Zhang ◽  
Wansheng Peng ◽  
Yun Chen ◽  
...  
Keyword(s):  
Nervous System ◽  
Brain Damage ◽  
Preterm Infants ◽  
System Development ◽  
Nervous System Development ◽  
Late Preterm ◽  
Clinical Prediction ◽  
Late Preterm Infants ◽  
The Brain

In order to explore the prediction effect of amplitude-integrated EEG on the brain damage and long-term nervous system development of late preterm infants, this paper uses the hospital’s late preterm infants as the research object and analyzes the prediction effect of amplitude-integrated EEG on the brain damage and long-term nervous system development of late preterm infants through controlled trials. Among them, the test group used amplitude-integrated EEG for prediction analysis, and the control group used traditional clinical prediction methods. Furthermore, the real-time monitoring and short-term prediction effects of amplitude-integrated EEG on brain damage in late preterm babies and the prediction impact on long-term nervous system development are evaluated in this study. It incorporates statistical techniques to evaluate the findings statistically. In addition, a nonparametric rank-sum test is used in this work, and a chi-square test is used to compare enumeration data across groups. Through experimental research, it can be seen that the amplitude-integrated EEG has a pronounced prediction effect on the brain damage and long-term nervous system development of late preterm infants, and the effect is higher than that of the traditional clinical prediction methods.

scholarly journals Extracellular Matrix-Associated Protein Sc1 Is Not Essential for Mouse Development

2000 ◽  
Vol 20 (2) ◽  
pp. 656-660 ◽  
Author(s):  
Peter J. McKinnon ◽  
Susan K. McLaughlin ◽  
Manuela Kapsetaki ◽  
Robert F. Margolskee
Keyword(s):  
Extracellular Matrix ◽  
Nervous System ◽  
Gene Targeting ◽  
System Development ◽  
Nervous System Development ◽  
Mouse Development ◽  
Term Survival ◽  
Insight Into ◽  
Developing Nervous System

ABSTRACT Sc1 is an extracellular matrix-associated protein whose function is unknown. During early embryonic development, Sc1 is widely expressed, and from embryonic day 12 (E12), Sc1 is expressed primarily in the developing nervous system. This switch in Sc1 expression at E12 suggests an importance for nervous-system development. To gain insight into Sc1 function, we used gene targeting to inactivate mouse Sc1. The Sc1-null mice showed no obvious deficits in any organs. These mice were born at the expected ratios, were fertile, and had no obvious histological abnormalities, and their long-term survival did not differ from littermate controls. Therefore, the function of Sc1 during development is not critical or, in its absence, is subserved by another protein.

scholarly journals Noninvasive harmonics optical microscopy for long-term observation of embryonic nervous system development in vivo

2006 ◽  
Vol 11 (5) ◽  
pp. 054022 ◽  
Author(s):  
Szu-Yu Chen ◽  
Cho-Shuen Hsieh ◽  
Shi-Wei Chu ◽  
Cheng-Yung Lin ◽  
Ching-Yi Ko ◽  
...  
Keyword(s):  
Nervous System ◽  
Optical Microscopy ◽  
System Development ◽  
Nervous System Development ◽  
Embryonic Nervous System ◽  
Long Term Observation

scholarly journals Caffeine is a respiratory stimulant without effect on sleep in the short-term in late-preterm infants

2021 ◽  
Author(s):  
Maija Seppä-Moilanen ◽  
Sture Andersson ◽  
Turkka Kirjavainen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Preterm Infants ◽  
Sleep Stage ◽  
Late Preterm ◽  
Short Term ◽  
Late Preterm Infants ◽  
Stage Distribution ◽  
Caffeine Treatment ◽  
Respiratory Stimulant

Abstract Background Caffeine is widely used in preterm infants for apnea control. It has no effect on sleep in the only existing polysomnographic study including ten preterm infants Behavioral and polygraphic studies have conflicting results. Methods We studied 21 late-preterm infants at a median gestational age of 36 weeks. Polysomnography was performed twice, at baseline on day 1 and on the day after the onset of caffeine treatment (20 mg/kg loading and 5 mg/kg morning maintenance dose). Results Caffeine acted short term as a breathing stimulant with reduction of apneas, improved baseline SpO2 (p < 0.001), and decreased 95 percentile of end-tidal carbon dioxide level (p < 0.01). It also increased arousal frequency to SpO2 desaturations of more than 5% (p < 0.001). Caffeine did not affect sleep stage distribution, sleep efficiency, frequency of sleep stage transitions, appearance of REM periods, or the high number of spontaneous arousals. The median spontaneous arousal count was 18 per hour at baseline, and 16 per hour during caffeine treatment (p = 0.88). Conclusions In late-preterm infants, caffeine has a clear short-term respiratory stimulant effect, and it increases the arousal frequency to hypoxia. However, caffeine does not appear to act as a central nervous system stimulant, and it has no acute effect on sleep quality. Impact Effects of caffeine on sleep in preterm infants has previously been investigated with only one full polysomnographic study including ten preterm infants. The study showed no effect. The current study shows that caffeine acts short term as a respiratory stimulant and increases arousal frequency to hypoxia. Although a potent central nervous system (CNS) stimulant in adults, caffeine does not seem to have similar acute CNS effect in late-preterm infants. The onset of caffeine treatment has no short-term effect on sleep stage distribution, sleep efficiency, frequency of sleep stage transitions, appearance of REM periods, or the high number of spontaneous arousals.

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