scholarly journals The Effect of Momordica charantia in the Treatment of Diabetes Mellitus: A Review

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Zhuo Liu ◽  
Jing Gong ◽  
Wenya Huang ◽  
Fuer Lu ◽  
Hui Dong
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
Theoretical Basis ◽  
Momordica Charantia ◽  
In Vivo Experiments ◽  
New Ideas ◽  
Treatment Of Diabetes ◽  
The Common

In recent years, many studies of Momordica charantia (MC) in the treatment of diabetes mellitus (DM) and its complications have been reported. This article reviewed the effect and mechanism of MC against diabetes, including the results from in vitro and in vivo experiments and clinical trials. The common side effects of MC were also summarized. We hope that it might open up new ideas for further mechanism exploration and clinical application as well as provide a scientific theoretical basis for the development of drugs or foods derived from MC.

Plant Products in the Prevention of Diabetes Mellitus

2021 ◽  
Vol 21 ◽  
Author(s):  
Ana M. Džamić ◽  
Jelena S. Matejić
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
Bioactive Compounds ◽  
Plant Extracts ◽  
Docking Studies ◽  
Antidiabetic Activity ◽  
In Vivo Experiments ◽  
Prevention Of Diabetes

: The beneficial effect of plants in treating diabetes is not only well-known in traditional medicine but also confirmed in numerous scientific studies. The basic platform for testing the potential antidiabetic activity of traditionally known plants and their bioactive compounds is a set of in vitro, in vivo experiments, clinical trials and molecular docking studies. Basic assays usually measure enzyme inhibitory activity (α-amylase and α-glucosidase) and other aspects related to diabetes mellitus disease. Recently, the use of plant-derived compounds has proven useful in treating diabetes and reducing complications resulting from high blood sugar levels. The main goal is to establish an action mechanism of plant extracts or active compounds to find new antidiabetic drugs with less toxicological properties. This work aims to collect data and discuss the newest results in the area of plant extracts, compounds and antidiabetic effects using in vitro, in vivo and in silico models. The data covered in this review include plant extracts, polyphenols, terpenoids, saponins, phytosterols, and other bioactive compounds, with some of the investigated plants being less known. Isolation of new compounds might be a plentiful source for treatment and prevention of diabetes mellitus. Clinical trials with adequate monitoring give the best results of plants' product efficacy and safety. Many studies give us the confirmation for importance of patent and use medicinal herbs in the treatment of diabetes.

scholarly journals Cost and Scalability Analysis of Porcine Islet Isolation for Islet Transplantation: Comparison of Juvenile, Neonatal and Adult Pigs

2019 ◽  
Vol 28 (7) ◽  
pp. 967-972 ◽  
Author(s):  
Rachel Vanderschelden ◽  
Mayilone Sathialingam ◽  
Michael Alexander ◽  
Jonathan R. T. Lakey
Keyword(s):  
Diabetes Mellitus ◽  
Cost Effective ◽  
Human Islets ◽  
High Price ◽  
Porcine Islets ◽  
In Vivo Experiments ◽  
Porcine Islet ◽  
Patients With Diabetes

The limited availability of human islets has led to the examination of porcine islets as a source of clinically suitable tissue for transplantation in patients with diabetes mellitus. Islets from porcine donors are commonly used in both in vitro and in vivo experiments studying diabetes mellitus. However, there are significant differences in quality and quantity of islet yield depending on donor pig age, as well as substantial differences in the costs of pancreas procurement in adult versus neonatal and juvenile pigs. In this study, we compared the total cost per islet of juvenile pig pancreata with that of neonatal and adult pigs. Although adult porcine pancreata yield, on average, more than five times the amount of islets than do juvenile and neonatal pancreata, we found that the high price of adult pigs led to the cost per islet being more than twice that of juvenile and neonatal islets (US $0.09 vs $0.04 and $0.02, respectively). In addition, neonatal and juvenile islets are advantageous in their scalability and retention of viability after culture. Our findings indicate that isolating neonatal and juvenile porcine islets is more cost-effective and scalable than isolating adult porcine islets.

Momordica charantia Extracts in Selected Media:Screening of Phytochemical Content and In vitro Evaluation of Anti-Diabetic Properties

2016 ◽  
Vol 53 (2) ◽  
pp. 164 ◽  
Author(s):  
Flora-Glad Chizoba Ekezie ◽  
W. Jessie Suneetha ◽  
K. Uma Maheswari ◽  
T. N. V. K. V. Prasad ◽  
B. Anila Kumari
Keyword(s):  
Diabetes Mellitus ◽  
Citric Acid ◽  
Ethanol Extract ◽  
Momordica Charantia ◽  
Bitter Gourd ◽  
Phytochemical Content ◽  
Patients With Diabetes ◽  
Potential Applications ◽  
Treatment Of Diabetes

Diabetes mellitus is a multifunctional disorder which is increasing rapidly in most parts of the world. It has been estimated that up to one third of patients with diabetes mellitus use some form of complementary and alternative medicine. One plant that has received the most attention for its anti-diabetic properties is Momordica charantia commonly referred to as bitter gourd. In this study, bitter gourd was extracted in various media i.e. ethanol, water, citric acid, sodium carbonate and sodium chloride. The samples were evaluated for their in-vitro ability to inhibit α-amylase and α-glucosidase enzymes activity. Ethanol extract was observed to have maximum inhibition against these enzymes. The IC<sub>50</sub> values recorded for inhibition of α-amylase activity were 81.34, 87.56, 83.89, 97.71 and 83.12 μg/ml respectively for crude extracts of ethanol, water, citric acid, Na<sub>2</sub>CO<sub>3</sub> and NaCl. Similarly, the ability of extracts to inhibit α-glucosidase was reflected in the result pattern ethanol&lt;Na<sub>2</sub>CO<sub>3</sub>&lt;NaCl&lt;aqueous&lt;citric acid (i.e. 72.81&lt;75.66&lt;80.15&lt;81.22&lt;83.85 μg/ml). Therefore, ethanol extract has potential applications in developing drug therapy for the treatment of diabetes using bitter gourd.

scholarly journals Evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus type 2

2020 ◽  
Vol 8 (16) ◽  
pp. 56-64
Author(s):  
Karla Guadalupe Perez-Avila ◽  
Cruz Vargas-De-León ◽  
José Antonio Morales-González ◽  
Eduardo Madrigal-Santillán
Keyword(s):  
Diabetes Mellitus ◽  
Natural Products ◽  
Alternative Treatment ◽  
The Body ◽  
In Vitro Assays ◽  
Glucose Levels ◽  
Natural Treatment ◽  
Treatment Of Diabetes

Diabetes mellitus is a disease that is characterized by the chronic presence of blood glucose levels caused by a defect in the secretion of insulin or in the action of this hormone in the body which must be treated integrally with a multidisciplinary approach. The natural treatment of this disease is a common practice around the world, especially in Latin America, there are several clinical studies, in vivo or in vitro assays that focus on assessing the hypoglycemic capacity of various natural products used empirically by the population for years for the phytotherapeutic treatment of the disease as well as the chemicals related to the mechanism of action that produces the hypoglycaemic effect. In the present article, a brief review of the evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus 2

scholarly journals Hybrid drug combination: A new treatment strategy for type 2 diabetes- A review

2020 ◽  
Vol 11 (2) ◽  
pp. 2008-2017
Author(s):  
Shraddha Sharma ◽  
Vengal Rao P ◽  
Seema Mehdi ◽  
Manjula S N ◽  
Aalap Das
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
Synthetic Drugs ◽  
Treatment Of Diabetes ◽  
New Treatment ◽  
Bioactive Agents ◽  
Oral Hypoglycemic Drugs

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia arising from deregulation in insulin secretion, insulin action, or both. The current synthetic drugs have dose-dependent side effects which confined their uses. The phytochemicals are the natural compounds that have better therapeutic efficacy and interacts synergistically with oral hypoglycemic drugs. The addition of phytochemicals with OHDs may reduce the dose of synthetic drugs as well as their side effects and toxicity. A detailed outline about such combinations like Ferulic acid & THZ/Metformin, Ellagic acid & Pioglitazone (THZ), Chlorogenic acid & THZ/Metformin, Caffeic acid & THZ/Metformin, eugenol acid & THZ/Metformin, cinnamic acid & THZ/Metformin, p- coumaric acid & THZ/Metformin, Arecoline &Vanillic acid with the THZ/ Metformin have been illustrated. This review has also discussed the synergy and mechanism of phytochemical with the OHDs to combat hyperglycemia and other risk associated with it. A comprehensive review was conducted to pile up the information about polyphenols & synthetic drug combinations used for the treatment of diabetes mellitus, which has been carried out in-vitro or in-vivo and may contribute to identifying novel strategies in the treatment of T2D condition. This review shows the importance of the responsible bioactive agents present in medicinal plants in the drive to demonstrate their antidiabetic effects.

scholarly journals Preventive and Protective Properties ofZingiber officinale(Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Yiming Li ◽  
Van H. Tran ◽  
Colin C. Duke ◽  
Basil D. Roufogalis
Keyword(s):  
Diabetes Mellitus ◽  
Zingiber Officinale ◽  
Neural System ◽  
Protective Effects ◽  
Protective Properties ◽  
Safety Issues ◽  
Carbohydrate And Lipid Metabolism ◽  
Treatment Of Diabetes

Zingiber officinale(ginger) has been used as herbal medicine to treat various ailments worldwide since antiquity. Recent evidence revealed the potential of ginger for treatment of diabetes mellitus. Data fromin vitro, in vivo, and clinical trials has demonstrated the antihyperglycaemic effect of ginger. The mechanisms underlying these actions are associated with insulin release and action, and improved carbohydrate and lipid metabolism. The most active ingredients in ginger are the pungent principles, gingerols, and shogaol. Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications. The pharmacokinetics, bioavailability, and the safety issues of ginger are also discussed in this update.

scholarly journals Extrinsic Factors Involved in the Differentiation of Stem Cells into Insulin-Producing Cells: An Overview

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Rebecca S. Y. Wong
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Human Subjects ◽  
Contributing Factors ◽  
Extrinsic Factors ◽  
Oral Hypoglycaemic Agents ◽  
Insulin Producing Cells ◽  
Treatment Of Diabetes

Diabetes mellitus is a chronic disease with many debilitating complications. Treatment of diabetes mellitus mainly revolves around conventional oral hypoglycaemic agents and insulin replacement therapy. Recently, scientists have turned their attention to the generation of insulin-producing cells (IPCs) from stem cells of various sources. To date, many types of stem cells of human and animal origins have been successfully turned into IPCsin vitroand have been shown to exert glucose-lowering effectin vivo. However, scientists are still faced with the challenge of producing a sufficient number of IPCs that can in turn produce sufficient insulin for clinical use. A careful choice of stem cells, methods, and extrinsic factors for induction may all be contributing factors to successful production of functional beta-islet like IPCs. It is also important that the mechanism of differentiation and mechanism by which IPCs correct hyperglycaemia are carefully studied before they are used in human subjects.

scholarly journals TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY

2019 ◽  
Vol 19 (3) ◽  
pp. 72-76
Author(s):  
Suryawati Suryawati ◽  
Safrida Safrida ◽  
Firdausa Sarah ◽  
Azizah Vonna ◽  
Vera Dewi Mulia
Keyword(s):  
Diabetes Mellitus ◽  
Heart Disease ◽  
Folk Medicine ◽  
Hypoglycemic Agents ◽  
Glucose Regulation ◽  
Converting Enzyme ◽  
Trigonella Foenum Graecum ◽  
Treatment Of Diabetes

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.

scholarly journals Development and Characterization of Pioglitazone Nanoparticles for the Effective Treatment of Diabetes Mellitus

2021 ◽  
pp. 172-182
Author(s):  
Revathi A. Gupta ◽  
P. Odaya Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Drug Release ◽  
Average Particle Size ◽  
Tween 80 ◽  
Cubic Phase ◽  
Average Particle ◽  
Drug Release Profile ◽  
Treatment Of Diabetes

Pioglitazone is designated as a BCS class II medication since it is weakly water soluble.The goal of this study was to create starch nanoparticles for the administration of Pioglitazone in attempt to lessen dose-related side effects and maybe prolong its release in the treatment of diabetes.Using starch as a polymer, tween 80 as a stearic barrier, and citric acid to enhance stability, nanoparticles were constructed using the solvent evaporation technique. In-vitro characterization techniques for drug-polymer compatibility, size, surface morphology, encapsulation efficacy, and delivery properties were performed on framed nanoparticles, followed by In-vivo studies.The compatible nature of selected excipients for the manufacture of Pioglitazone nanoparticles was shown by FTIR findings.The results of the XRD analysis revealed that the generated Pioglitazone nanoparticles were non-crystalline in nature.The selected developed Pioglitazone nanoparticles were in cubic phase with average particle size of 160.5 ± 11.24–245.4 ± 15.96 nm with charge ranging from 10.5 ± 6.21-138.6 ± 5.31mV.The encapsulation efficiency of Pioglitazone nanoparticles produced ranged from 57.24 5.80 to 89.96 1.9%. The In-vitro drug release studies of Pioglitazone nanoparticles showed controlled drug release profile. Furthermore, In-vivo investigations on blood glucose profiles revealed that the created Pioglitazone nanoparticles for the treatment of diabetes mellitus had a substantial effect.

Sign in / Sign up

Export Citation Format

Share Document