scholarly journals Effect of Combining Immersion Therapy with Shengji Ointment on Wound Healing Rate and Adverse Reaction Rate in Patients with Second-Degree Burn

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yun Guo ◽  
Junjie Yu
Keyword(s):  
Wound Healing ◽  
Adverse Reaction ◽  
Treatment Group ◽  
Reaction Rate ◽  
Healing Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Degree Burn ◽  
Wound Healing Rate ◽  
Second Degree

Objective. To explore the effect of combining immersion therapy with Shengji ointment on wound healing rate and adverse reaction rate (ARR) in patients with second-degree burn. Methods. The data of 80 patients with second-degree burn treated in our hospital from February 2019 to February 2020 were retrospectively analyzed by the means of retrospective study, and the patients were equally divided into the treatment group and the control group according to their admission order, with 40 cases each. Immersion therapy was performed to all patients (7 d); after that, patients in the control group received routine medication (7 d), and those in the treatment group were treated with Shengji ointment until the wounds were healed, so as to compare their wound healing condition, ARRs, levels of inflammatory factors, and infection incidence. Results. Compared with the control group after treatment, the treatment group presented significantly shorter wound healing time (12.14 ± 1.26 vs. 15.98 ± 1.20, P  < 0.001), better wound healing rate and quality ( P  < 0.05), and lower levels of inflammatory factors ( P  < 0.001); no significant between-group difference in ARRs was shown ( P  > 0.05); 34 patients in the treatment group (85.0%) and 26 patients in the control group (65.0%) had no infections, so the incidence rate of infections was significantly lower in the treatment group than in the control group (P < 0.05). Conclusion. Combining immersion therapy with Shengji ointment can reduce the levels of inflammatory factors in patients with second-degree burn, lower the incidence rate of infections, provide the conditions for wound healing, and increase the wound healing rate, which shall be promoted and applied in practice.

scholarly journals Curative Effect Observation of Applying Silver-Zinc Bacteriostatic Cream to Patients with Second-Degree Burn under Targeted Nursing Intervention and Its Effect on Wound Healing Rate

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Bingqing Li ◽  
Kun Xu ◽  
Xin Liu
Keyword(s):  
Wound Healing ◽  
Adverse Reactions ◽  
Healing Rate ◽  
Nursing Intervention ◽  
Control Group ◽  
Burn Wound ◽  
Degree Burn ◽  
Experimental Group ◽  
Wound Healing Rate ◽  
Second Degree

Second-degree burn is the most common type of burn wound in the clinics, which presents a deeper wound, skin blisters, white or red bottom, and thick and clear fluid inside, is sensitive to tenderness, and turns white by compression [1, 2]. The aim of this study is to explore the efficacy of applying silver-zinc bacteriostatic cream to patients with second-degree burn under targeted nursing intervention and its effect on wound healing rate. A total of 110 patients with second-degree burn treated in our hospital from January 2019 to June 2021 were selected as the research object for the retrospective study. Between the experimental group and the control group, no statistical differences in patients’ general information were observed ( P > 0.05 ); 1 week, 2 weeks, and 3 weeks after treatment, the visual analogue scale (VAS) pain scores of the experimental group were significantly lower ( P < 0.05 ); and the total incidence rate of adverse reactions was remarkably lower in the experimental group ( P < 0.05 ). On the basis of targeted nursing intervention, applying silver-zinc bacteriostatic cream obtains an obviously better clinical efficacy than silver sulfadiazine ointment in treating second-degree burn and works better in promoting wound healing, relieving pain sensation, and reducing adverse reactions.

Effect of Thymosin β4 on Deep Second-Degree Scald Wound Healing in Rats via Wnt/β-Catenin Pathway

2022 ◽  
Vol 12 (3) ◽  
pp. 574-580
Author(s):  
Shusong Li ◽  
Ying Ma ◽  
Zhuoran Liu ◽  
Xiaoyu Zhao ◽  
Li Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Healing Rate ◽  
Tissue Injury ◽  
Inflammatory Factors ◽  
Protein Levels ◽  
Pathway Activation ◽  
Hematoxylin And Eosin ◽  
Wound Healing Rate ◽  
Second Degree

<sec> <title>Objective:</title> The purpose of this research is to explore the influences of thymosin β4 (Tβ4) in deepsecond-degree scald wound healing of rat skin and its relationship with Wnt/β-catenin pathway. </sec> <sec> <title>Methods:</title> Deep second-degree scalded model rats were prepared and divided into normal saline (NS) treatment group, Tβ4 treatment group and FH535 inhibitor group. Then, the concentrations of inflammatory factors in the rats were monitored via adopting the correlated TNF-α and IL-1β ELISA kits. In the meantime, the wound healing rate was analyzed via photography. Subsequently, the qRTPCR procedure was wielded to determine Wnt1 and β-catenin expression in wound tissues, and the degree of wound tissue injury was examined via hematoxylin and eosin (HE) staining. Finally, Western blotting (WB) was adopted to assess Wnt/β-catenin pathway-associated protein levels. </sec> <sec> <title>Results:</title> Releasing amount of TNF-α and IL-1β were conspicuously up-regulated after scalding (p <0.01), and Wnt1 and β-catenin expression at molecular transcription level was also significantly raised (p < 0.01). Besides, treatment with 18 μg of Tβ4 significantly increased the wound healing rate of scalded rats (p < 0.01). In addition, Tβ4 treatment significantly promoted wound healing (p < 0.01) and increased the Wnt1 and β-catenin expression levels (p < 0.01). Moreover, FH535 significantly restrained the Wnt/β-catenin pathway-correlated protein levels (p < 0.01) and wound healing. </sec> <sec> <title>Conclusion:</title> Tβ4 can promote scald wound healing in rats and may play a role via evoking Wnt/β-catenin pathway activation. </sec>

scholarly journals Nutrition Supplementation and Education May Increase the Healing Rate in Diabetic Patients with Foot Ulcers (P19-005-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Raedeh Basiri ◽  
Maria Spicer ◽  
Bahram Arjmandi
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Diabetic Foot ◽  
Healing Rate ◽  
High Protein ◽  
Foot Ulcers ◽  
Control Group ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Wound Healing Rate

Abstract Objectives This study examined the effects of high protein dietary supplementation and nutrition education on the healing of diabetic foot ulcers. Methods Twenty-nine adults with diabetic foot ulcers were recruited from the Tallahassee Memorial Hospital Wound Care Clinic. Participants were randomly assigned to treatment (n = 15) or control (n = 14) group. The treatment group received two carbohydrate controlled high protein shakes to consume daily, and was educated regarding adequate intake of low-fat protein sources, fruits, vegetables, complex carbohydrates and minimizing simple carbohydrates. The control group did not receive any intervention. Daily supplementation provided a total of 500 kilocalories, 28 grams of high-quality protein, and approximately 50% of micronutrient requirements. Anthropometric measurements (weight, height, BMI) and wound planimetry were examined at baseline and every four weeks until the wound healed or up to 12 weeks. Results There was no significant difference between the groups at baseline for BMI (mean = 33.8 ± 7 kg/m2), age (mean = 53.34 ± 11.14 years), duration of diabetes (mean = 13 years), duration of wounds (mean 10.8 months) or wound area (mean = 450 mm2). Wound healing rate (decrease in the area of the wound/week) for the treatment group was three times faster than the control group (151.1 mm2/week vs. 45.2 mm2/week respectively). Conclusions Improved nutritional intake using nutritional supplementation and patient education has a strong positive effect on the wound healing rate of diabetic foot ulcers. Faster wound healing improves quality of life and functionality of patients with diabetic foot ulcers. Funding Sources Dissertation award.

673 Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S193-S193
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
H Ebru ◽  
Ayvazoglu Soy ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Introduction Burn is one of the most severe traumas that causes coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burn may affect the patient’s survival and reduce the complications that may be seen. In the present study we aimed effects of subcutaneous ozone injection on second degree burn wound. Methods A total of 72 Sprague-Dawley male rats included in the study were divided randomly into three groups (control group (CG), silver sulfadiazine group (SG), ozone group (OG)) and each group was divided randomly two subgroups (as sacrificed on d7 and on d14).A deep second degree scald burns were created on the lower back. In CG subcutaneous 0.9% serum saline was injected daily into the burn area. In SG, burns were dressed with silver sulfadiazine daily and in OG subcutaneous ozone was injected daily into the burn area. Tissue hydroxyproline level measurement and histopathological evaluation were done. Results When the groups were compared in terms of weight change, no significant difference was found on the 7th and 14th days. In the evaluation made in terms of tissue hydroxyproline, tissue hydroxyproline level in OG was found to be significantly higher on both the 7th and 14th days (p &lt; 0.001). In histopathological evaluations, it was determined that wound healing in OG was significantly higher than in the other groups. Conclusions According to the results, subcutaneous ozone therapy is more effective than silver sulphadiazine in the healing process of second-degree burn wounds and it can be safely used in the treatment of burn wounds.

scholarly journals Healing Effects of Human Amniotic Membrane and Burned Wool on the Second-degree Burn in Rats

2020 ◽  
Vol 9 ◽  
pp. 1759
Author(s):  
Nader Tanideh ◽  
Farideh Keshavarzi ◽  
Aida Hemat Zadeh ◽  
Sajad Daneshi ◽  
Omid Koohi-Hosseinabadi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Amniotic Membrane ◽  
Granulation Tissue ◽  
Male Rats ◽  
Control Group ◽  
Human Amniotic Membrane ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Degree Burn ◽  
Second Degree

ackground: This study aimed to compare sheep burnt wool and human amniotic membrane (AM) on second-degree burn wound healing in rats. Materials and Methods: Seventy-two adult male rats of Sprague Dawley underwent general anesthesia, and a deep second-degree burn was created on their skin by a hot iron plate. Afterward, human AM, silver sulfadiazine ointment (SSD), and sheep burned wool were used on wound area for burn treatment. On days 7, 14, and 21 of the experiment, the rats were sacrificed, and histopathological assessments were done. Results: Human AM, in comparison with other groups, significantly (P<0.05) showed better improvement in all pathologic variables. Burned wool showed significant improvement compared to the control group on day 7 in the angiogenesis, on day 14 in granulation tissue formation and epithelial formation, and on day 21 in new epithelial formation (P<0.05). Burned wool compared with SSD ointment in granulation tissue formation improved significantly (P<0.05) on days 7 and 14. Also, SSD ointment in comparison with the control group significantly improved (P<0.05) granulation tissue formation and macrophage on day 7. Conclusion: Human AM has a significant effect on the treatment of second-degree burn. Burned wool has a better effect on wound healing than SSD ointment and negative control group without treatment in terms of granulation tissue and epithelium formation. [GMJ.2020;9:e1759]

scholarly journals Study of healing effects of the “Fomitop” gel on artificial burn wounds

2021 ◽  
Vol 31 (3) ◽  
pp. 20-26
Author(s):  
Undraa Bold ◽  
Gerelt Gaadan ◽  
Byambajav Tseesuren ◽  
Undrakhbayar Tserendorj ◽  
Naranmandakh Shinen
Keyword(s):  
Staphylococcus Aureus ◽  
Wound Healing ◽  
Healing Rate ◽  
Histological Analysis ◽  
Micrococcus Luteus ◽  
Silver Sulfadiazine ◽  
Control Group ◽  
Standard Group ◽  
Burn Wounds ◽  
Wound Healing Rate

As a result of previous studies, we have established the “Fomitop” gel with extracts from the fungus Fomitopsis officinalis has antibacterial properties against some strains such as Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, and Enterococcus faecalis. Based on these results, we have conducted this research to identify the “Fomitop” gel has a healing effect on the burn wound. For this purpose, were conducted the comparative analysis of healing effects of the “Fomitop” gel with the standard ointment - silver sulfadiazine cream, on artificial burn wounds created on the back skin of a mouse. Total 27 Balb/c mice were included in the experiment and they are divided into three equivalent groups. In the first treatment, the group was applied to the “Fomitop” gel, the second standard group was applied silver sulfadiazine cream, and the third control group untreated by any ointment. On the 1, 5, 12, 21, and 35th days after wound creation, were taken the histological samples from the wound and near areas of the wound. The wound healing process was evaluated based on histological analysis. The burn wounds of the treatment group of mice (applied “Fomitop” gel) fully healed on the 33rd day of the experiment. While the wound healing rate of the standard group of mice (applied silver sulfadiazine cream) was 92.2% on the same day. And the control group mice wound healing rate was 78% (p<0.05). The results of the histological analysis were confirmed an active regeneration of epithelial cells and wound healing in the treatment group. It was good compared to the standard and control groups. As a result of this study, were determined the “Fomitop” gel application is accelerated the tissue regeneration of burn wounds and so on heals wound in a short time. Фомитоп гелин түрхлэгийн түлэнхийн шарханд үзүүлэх үйлдлийн судалгаа Бид өмнө гүйцэтгэсэн хар модны агил мөөгнөөс бэлтгэсэн “Фомитоп” гелин түрхлэгийн антибиотик төст үйлдлийг шалгах шинжилгээгээр Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Enterococcus faecalis зэрэг бактерийн ургалтыг дарангуйлдаг болохыг илрүүлсэн. Уг үр дүнд үндэслэн “Фомитоп” гелин түрхлэг шархыг идээлүүлэхгүйгээр эдгээх боломжтой эсэхийг тогтоох энэхүү судалгааг гүйцэтгэв. Энэ зорилгоор “Фомитоп” гелин түрхлэгийг хулганы нурууны арьсанд үүсгэсэн химийн гаралтай түлэгдэлтийн зохиомол шарханд үзүүлэх нөлөөг стандарт эм болох мөнгөний сульфадиазин түрхлэгтэй харьцуулан судлав. Судалгаанд Balb/c үүлдрийн нийт 27 цагаан хулганыг тэнцүү тоогоор гурван бүлэгт хувааж хамруулав. Үүнд: 1-р бүлэг-агил мөөгнөөс бэлтгэсэн гелин түрхлэгийг хэрэглэсэн туршилтын бүлэг, 2-р бүлэг-мөнгөний сульфадиазин түрхлэг хэрэглэсэн стандарт бүлэг, 3-р бүлэг түрхлэг хэрэглээгүй хяналтын бүлэг. Шарх үүсгэснээс хойш 1, 5, 12, 21, 35 хоногуудад шарх, түүний ойр орчмын эдээс дээж авч гистологийн шинжилгээ хийж, шархны эдгэрэлтийг үнэлсэн. “Фомитоп” гелин түрхлэгийг хэрэглэсэн эмчилгээний бүлгийн түлэнхийн шарх туршилтын 33 дахь хоногт бүрэн эдгэрсэн бол мөнгөний сульфадиазин түрхлэг хэрэглэсэн стандарт бүлгийн шархны эдгэрэлт тухайн хоногт 92.2%, харин эм хэрэглээгүй хяналтын бүлгийн шархны эдгэрэлт нь 78% байлаа (p<0.05). Мөн гелин түрхлэг хэрэглэсэн бүлэг нь стандарт болон хяналтын бүлэгтэй харьцуулахад түлэнхийн шархны эдгэрэл, хучуур эсийн нөхөн төлжилт идэвхтэй явагдаж байгаа нь гистологийн шинжилгээний үр дүнгээр батлагдав. Судалгааны үр дүнд “Фомитоп” гелин түрхлэг нь түлэнхийн шархны нөхөн төлжилтийг хурдасгах, улмаар богино хугацаанд аниулах үйлдэл үзүүлж байгааг тогтоов.  Түлхүүр үг: Агил мөөг, мөнгөний сульфадиазин, гистологийн шинжилгээ, шархны эдгэрэл

scholarly journals Nanosilver Dressing in Treating Deep II Degree Burn Wound Infection in Patients with Clinical Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Bin’e Wu ◽  
Fengchun Zhang ◽  
Wenbin Jiang ◽  
Aiyan Zhao
Keyword(s):  
Wound Healing ◽  
Wound Infection ◽  
Clinical Studies ◽  
Healing Rate ◽  
Healing Time ◽  
Late Result ◽  
Burn Wound ◽  
Necrosis Factor Alpha ◽  
Degree Burn ◽  
Wound Healing Rate

Background. Patients’ clinical antibiotic treatment of deep II degree burns usually fails to achieve the ideal effect; in order to avoid the late result in pigmentation, scarring, and even limb dysfunction, it also needs to deal effectively with burn wounds. Aim. The purpose of this study is to evaluate nanosilver dressing in treating deep II degree burn wound infection in patients with clinical studies. Materials and Methods. 106 burn patients were classified into the Sulfadiazine Silver Cream (SSC) group ( n = 53 ) and the Nanosilver Burn Dressing (NSBD) group ( n = 53 ). Both of them received basic wound treatment, and wound healing time and pigmentation fading away time of all patients were recorded. And the wound healing rate of the patients was calculated. Serum levels of tumor necrosis factor alpha (TNF-α) and interleukin-1beta (IL-1β) were detected pre- and posttreatment. Results. After basic treatment for all patients, Sulfadiazine Silver Cream was used in the SSC group, and Nanosilver Burn Dressing was used in the NSBD group. It was observed that after treatment, compared with the SSC group, there was significant efficiency; wound healing rate, healing time, and pigmentation fading away time were shortened in the NSBD group, and IL-1β levels were decreased, and the positive rate of bacterial culture was decreased (all P < 0.05 ). Conclusion. Nanosilver Burn Dressing in treating deep II degree burns can effectively reduce the wound infection and promote wound healing. The curative effect was distinct, which was worthy of popularization and application.

Therapeutic Intervention of Aloe Gel Containing Nano-Sized and Micron-Sized Silver Sulfadiazine Gel on Second-Degree Burn: A Comparative Study

2018 ◽  
Vol 17 (3) ◽  
pp. 176-183 ◽  
Author(s):  
Md Abul Barkat ◽  
Harshita ◽  
Faheem Hyder Pottoo ◽  
Satya Prakash Singh ◽  
Farhan J. Ahmad
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Silver Sulfadiazine ◽  
Control Group ◽  
Formulation Development ◽  
Topical Gel ◽  
Degree Burn ◽  
Carbopol 940 ◽  
Aloe Gel ◽  
Second Degree

The current work focuses on the formulation development, optimization, and in vivo assessment of nano-sized silver sulfadiazine ( nSSD) and micron-sized silver sulfadiazine ( mSSD) topical gel composed of Aloe vera gel ( Aloe gel) and Carbopol 940 for the management of second-degree burn wound. The optimized concentration of gel-forming agent (Carbopol 940) was chosen based on best possible consistency and spreadability of the gel. The second-degree burn infliction was developed in the posterior region of rats followed by anesthesia. Afterward, the created wounds were further treated individually by both the gel formulation (1 application daily) for 14 days and observations were recorded. The nSSD gel showed better wound healing and a higher degree of tissue hyperplasia as compared with mSSD gel in rats. In vitro drug release study showed better drug release from nSSD gel (74.25 ± 3.331%) as compared with mSSD gel formulation (61.32 ± 2.112%) after 24 hours. The nSSD and mSSD topical gel-treated rats showed 95.63% and 78.75% wound healing after 14 days, while in the case of control group rats, 48.65% wound contraction was seen after 14 days. Furthermore, the histopathological study revealed that the nSSD gel was more efficient in controlling the wound infection and showed better wound healing as compared with mSSD gel formulation.

scholarly journals The Effectiveness of Edamame Seed (Glycine max L. Merril) Ethanolic Extract to Fibroblast Count on Second Degree Burn Wound Healing

2019 ◽  
Vol 5 (3) ◽  
pp. 154
Author(s):  
Arifah Nur Hasanah ◽  
Ika Rahmawati Sutejo ◽  
Enny Suswati
Keyword(s):  
Wound Healing ◽  
Antioxidant Properties ◽  
Ethanolic Extract ◽  
Negative Control ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Burn wound healing process consists of three phases of inflammation, proliferation and remodelling. The number of fibroblasts has increased during the proliferation phase. Oxidative stress in burn may disrupt proliferation through TGF-β inhibition, result in decreased number of fibroblasts and poor burn wound healing. Genistein in edamame seeds has anti-inflammatory, antibacterial and antioxidant properties. Edamame contains vitamins A, C, and E which is also have antioxidant properties. Edamame has been suggested to protect burn wound healing from oxidative stress. This study aimed to understand the effectiveness of edamame seed (Glycine max L. Merril) ethanolic extract (ED) to fibroblast count in second degree burn wound healing. This is true experimental research with post test only control group design. The study was conducted at University of Jember during November until December 2017. The sample of this research was 24 rat models of second degree burn which was made by attaching hot metal (60 ° C) for 5 seconds on the shaved back of the rats. The sample was divided into 6 groups with topical treatment, among others: positive control group (silver sulfadiazine), negative control group (Na CMC 0.5%), group with ED 20%, ED 40%, ED 60%, and ED 80%. Treatment was given for 15 days and skin sample was taken on the 16th day. Observation of the number of fibroblasts was done by taking pictures of histhologic preparations in Hematoxylin and Eosin staining under 400x magnification of light microscope. The number of fibroblast of each picture was processed using Image-J software. In one way ANOVA test, significance value of 0.011 (p≤0,05) indicated that there was at least a significant difference between 2 groups. LSD’s post hoc analysis showed that there was a significant difference in the group ED 20, 40, and 60% compared with negative control.   Keyword: burn wound healing, vegetable soybean, genistein, fibroblast count, silver sulfadiazine

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