scholarly journals Antioxidant Effects of Salidroside in the Cardiovascular System

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Siyu Sun ◽  
Qinhui Tuo ◽  
Dongxu Li ◽  
Xiulong Wang ◽  
Xuefang Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Health Risks ◽  
Therapeutic Strategies ◽  
Therapeutic Effects ◽  
Evidence Based ◽  
Human Health Risks ◽  
Bioactive Component ◽  
Antioxidant Effects

Cardiovascular disease is one of the main human health risks, and the incidence is increasing. Salidroside is an important bioactive component of Rhodiola rosea L., which is used to treat Alzheimer’s disease, tumor, depression, and other diseases. Recent studies have shown that salidroside has therapeutic effects, to some degree, in cardiovascular diseases via an antioxidative mechanism. However, evidence-based clinical data supporting the effectiveness of salidroside in the treatment of cardiovascular diseases are limited. In this review, we discuss the effects of salidroside on cardiovascular risk factors and cardiovascular diseases and highlight potential antioxidant therapeutic strategies.

Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology

2019 ◽  
Vol 22 (6) ◽  
pp. 411-420 ◽  
Author(s):  
Xian-Jun Wu ◽  
Xin-Bin Zhou ◽  
Chen Chen ◽  
Wei Mao
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Signaling Pathway ◽  
Kegg Pathway ◽  
Enrichment Analysis ◽  
Network Pharmacology ◽  
Pathway Enrichment Analysis ◽  
Therapeutic Effects ◽  
Pathway Enrichment ◽  
Compound Target

Aim and Objective: Cardiovascular disease is a serious threat to human health because of its high mortality and morbidity rates. At present, there is no effective treatment. In Southeast Asia, traditional Chinese medicine is widely used in the treatment of cardiovascular diseases. Quercetin is a flavonoid extract of Ginkgo biloba leaves. Basic experiments and clinical studies have shown that quercetin has a significant effect on the treatment of cardiovascular diseases. However, its precise mechanism is still unclear. Therefore, it is necessary to exploit the network pharmacological potential effects of quercetin on cardiovascular disease. Materials and Methods: In the present study, a novel network pharmacology strategy based on pharmacokinetic filtering, target fishing, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, compound-target-pathway network structured was performed to explore the anti- cardiovascular disease mechanism of quercetin. Results:: The outcomes showed that quercetin possesses favorable pharmacokinetic profiles, which have interactions with 47 cardiovascular disease-related targets and 12 KEGG signaling pathways to provide potential synergistic therapeutic effects. Following the construction of Compound-Target-Pathway (C-T-P) network, and the network topological feature calculation, we obtained top 10 core genes in this network which were AKT1, IL1B, TNF, IL6, JUN, CCL2, FOS, VEGFA, CXCL8, and ICAM1. KEGG pathway enrichment analysis. These indicated that quercetin produced the therapeutic effects against cardiovascular disease by systemically and holistically regulating many signaling pathways, including Fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway and PI3K-Akt signaling pathway.

Prevention of atrial fibrillation – non-modifiable and modifiable risk factors for AF

2020 ◽  
Vol 2 (55) ◽  
pp. 14-19
Author(s):  
Agnieszka Wojdyła-Hordyńska ◽  
Grzegorz Hordyński
Keyword(s):  
Risk Factors ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Combined Treatment ◽  
Lifestyle Changes ◽  
Modifiable Risk Factors

Atrial fibrillation is one of the most common arrhythmias, with a significant increase in incidence in recent years. AF is a major cause of stroke, heart failure, sudden cardiac death, and cardiovascular disease. Timely intervention and modification of risk factors increase chance to stop the disease. Aggressive, multilevel prevention tactics are a component of combined treatment, including – in addition to lifestyle changes, anticoagulant therapy, pharmacotherapy and invasive anti-arrhythmic treatment – prevention of cardiovascular diseases, hypertension, ischemia, valvular disease and heart failure.

Assessment and therapeutic strategy for agitation, confusion, and delirium in the ICU

2016 ◽  
Author(s):  
Michele C. Balas ◽  
E. Wesley Ely
Keyword(s):  
Risk Factors ◽  
Therapeutic Strategy ◽  
Signs And Symptoms ◽  
Therapeutic Strategies ◽  
Screening Tools ◽  
Evidence Based ◽  
Modifiable Risk Factors ◽  
Everyday Clinical Practice ◽  
Delirium Assessment ◽  
Effective Assessment

Agitation and delirium are conditions that are highly prevalent in the intensive care unit (ICU). Both are believed to be caused by a number of modifiable and non-modifiable risk factors, and present with a variety of signs and symptoms. Consequently, these conditions are notoriously difficult to detect and treat. Variations in sedative practices, misperceptions regarding delirium and its association with outcomes, and lack of knowledge regarding screening tools, may all impede effective assessment, and management of agitation and delirium. A further complication is that many of the medications used to treat critically-ill patients are now known to increase the risk of delirium. While studies conducted over the last decade have significantly contributed to our understanding of how best to diagnose, prevent, and manage these common conditions, this knowledge is not always successfully adopted into everyday clinical practice. This chapter provides readers with an evidence-based review of agitation and delirium assessment and therapeutic strategies applicable for use in the ICU setting.

scholarly journals Tailored Interventions to Improve Medication Adherence for Cardiovascular Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Hai-Yan Xu ◽  
Yong-Ju Yu ◽  
Qian-Hui Zhang ◽  
Hou-Yuan Hu ◽  
Min Li
Keyword(s):  
Cardiovascular Disease ◽  
Medication Adherence ◽  
Cardiovascular Diseases ◽  
Healthcare Costs ◽  
Therapeutic Effects ◽  
Improve Medication Adherence ◽  
The Past ◽  
Tailored Interventions ◽  
Past Half Century ◽  
Past Half

Over the past half-century, medical research on cardiovascular disease (CVD) has achieved a great deal; however, medication adherence is unsatisfactory. Nearly 50% of patients do not follow prescriptions when taking medications, which limits the ability to maximize their therapeutic effects and results in adverse clinical outcomes and high healthcare costs. Furthermore, the effects of medication adherence interventions are disappointing, and tailored interventions have been proposed as an appropriate way to improve medication adherence. To rethink and reconstruct methods of improving medication adherence for CVD, the literature on tailored interventions for medication adherence focusing on CVD within the last 5 years is retrieved and reviewed. Focusing on identifying nonadherent patients, detecting barriers to medication adherence, delivering clinical interventions, and constructing theories, this article reviews the present state of tailored interventions for medication adherence in CVD and also rethinks the present difficulties and suggests avenues for future development.

Gender differences in cardiovascular disease prevention

2008 ◽  
Vol 14 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Graham Jackson
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Health Care Professionals ◽  
Coronary Event ◽  
The Other ◽  
Evidence Based ◽  
Modifiable Risk Factors ◽  
Psychosocial Issues ◽  
Men And Women ◽  
Lack Of Exercise

Risk factors are generally shared between men and women with the major differences being hormonal. Nine modifiable risk factors account for over 90% of the risk of a coronary event in men and women – smoking, hypertension, hyperlipidaemia, diabetes, abdominal obesity, lack of exercise, alcohol excess, reduced intake of fruit and vegetables, and psychosocial issues. Approximately half the decline in deaths from coronary heart disease (CHD), between 1980 and 2000, can be attributed to a reduction in the major risk factors and the other half to the use of evidence-based management. As educational efforts to increase awareness of cardiovascular disease (not cancer) to be the leading cause of death and disability in women are also associated with preventative action, it is important that health-care professionals educate themselves about CHD in women and communicate with women themselves, so that women can come forward for advice and evaluation.

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

Occurrence of acute cardiovascular diseases under different atmospheric parameters

2014 ◽  
Vol 155 (27) ◽  
pp. 1078-1082 ◽  
Author(s):  
Nora Boussoussou ◽  
Melinda Boussoussou ◽  
László Entz ◽  
Attila Nemes
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Seasonal Variation ◽  
Cardiovascular Diseases ◽  
Vascular Surgery ◽  
Atmospheric Pressure ◽  
Meteorological Parameters ◽  
Atmospheric Parameters ◽  
Prevention Strategies ◽  
Maximum Daily Temperature

Introduction: Research on the effects of meteorological parameters on cardiovascular diseases may allow the development of novel prevention strategies. Aim: The aim of the authors was to examine the correlation between meteorological parameters and the occurrence of acute cardiovascular diseases. Method: A retrospective analysis was performed in 343 patients diagnosed with acute cardiovascular disease and treated at the Department of Vascular Surgery, Semmelweis University in 2010. Results: Acute cardiovascular diseases showed a seasonal variation with the highest occurrence in winter months (p = 0.0001). The daily increase of the events (n≥3) were associated with front movements days (in 62.5% of cases). A significant correlation was found between the intraday temperature difference (p<0.0001), the intraday atmospheric pressure difference (p = 0.0034), the lowest maximum daily temperature (p<0.0001) and the occurrence of acute cardiovascular diseases. During the days with front movements 64% of the patients were older than 66 years of age. Among risk factors, hypertension showed front sensitivity. Conclusions: Meteorological parameters are minor risk factors in the occurrence of acute cardiovascular diseases. Orv. Hetil., 2014, 155(27), 1078–1082.

Food and plant bioactives for reducing cardiometabolic disease risk: an evidence based approach

2017 ◽  
Vol 8 (6) ◽  
pp. 2076-2088 ◽  
Author(s):  
Arrigo F. G. Cicero ◽  
Federica Fogacci ◽  
Alessandro Colletti
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cardiovascular Disease Risk Factors ◽  
Cardiometabolic Disease ◽  
Evidence Based ◽  
Cardiometabolic Disease Risk

Nutraceuticals active on the main cardiovascular disease risk factors.

scholarly journals Major risk factors and cardiovascular disease prevalence among petrochemical workers

2019 ◽  
Vol 96 (2) ◽  
pp. 152-155 ◽  
Author(s):  
Zulfiya F. Gimaeva ◽  
A. B. Bakirov ◽  
V. A. Kaptsov ◽  
L. K. Karimova
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Preventive Measures ◽  
Clinical Laboratory ◽  
Disease Prevalence ◽  
Occupational Risk ◽  
Laboratory Studies ◽  
Occupational Risk Factors ◽  
Metal Workers

Objective. Based on the assessment of occupational and non-occupational risk factors, development of preventive measures for the reducing of cardiovascular diseases (CVD) prevalence among petrochemical workers. Material and Methods. A total of 2,634 petrochemical workers have been examined. To identify modified and unmodified risk factors for cardiovascular diseases, comprehensive hygienic and clinical laboratory studies have been carried out. Results. The obtained results have shown a higher riskfor the development of cardiovascular disease among operators as compared to metal workers for instrumentation and automation repairs. Based on the assessment of risk factors, preventive measures implemented at personal and corporative levels have been developed.

scholarly journals Obesity as a risk factor for cardiovascular disease: focus on ultrasound

2021 ◽  
Vol 26 (5) ◽  
pp. 4371
Author(s):  
D. A. Tsygankov ◽  
O. M. Polikutina
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Continuous Improvement ◽  
Convincing Evidence ◽  
Research Practice ◽  
Short Period ◽  
Medical Advances ◽  
Disease Focus ◽  
Conventional Risk Factors

For many decades, obesity has been one of the main risk factors for cardiovascular disease. Despite medical advances, the obesity increases contribution to morbidity and mortality from cardiovascular diseases. Numerous anthropometric criteria for obesity are well-studied, simple and inexpensive tools for diagnosing overweight in the population. However, their accuracy is comparatively low. In particular, it is impossible to determine body composition based on these criteria, which is a key point in cardiovascular risk stratification. Despite the relatively short period of ultrasound practice for obesity diagnosis, convincing evidence has already been obtained of their high accuracy and effectiveness in predicting the risk of cardiovascular disease. Given the continuous improvement of ultrasound equipment, the studied criteria should be implemented in routine clinical and research practice. This literature review describes the central parameters used in the ultrasound diagnosis of obesity, their contribution to both conventional risk factors and cardiovascular diseases itself.

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