scholarly journals Tailored Interventions to Improve Medication Adherence for Cardiovascular Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Hai-Yan Xu ◽  
Yong-Ju Yu ◽  
Qian-Hui Zhang ◽  
Hou-Yuan Hu ◽  
Min Li
Keyword(s):  
Cardiovascular Disease ◽  
Medication Adherence ◽  
Cardiovascular Diseases ◽  
Healthcare Costs ◽  
Therapeutic Effects ◽  
Improve Medication Adherence ◽  
The Past ◽  
Tailored Interventions ◽  
Past Half Century ◽  
Past Half

Over the past half-century, medical research on cardiovascular disease (CVD) has achieved a great deal; however, medication adherence is unsatisfactory. Nearly 50% of patients do not follow prescriptions when taking medications, which limits the ability to maximize their therapeutic effects and results in adverse clinical outcomes and high healthcare costs. Furthermore, the effects of medication adherence interventions are disappointing, and tailored interventions have been proposed as an appropriate way to improve medication adherence. To rethink and reconstruct methods of improving medication adherence for CVD, the literature on tailored interventions for medication adherence focusing on CVD within the last 5 years is retrieved and reviewed. Focusing on identifying nonadherent patients, detecting barriers to medication adherence, delivering clinical interventions, and constructing theories, this article reviews the present state of tailored interventions for medication adherence in CVD and also rethinks the present difficulties and suggests avenues for future development.

Abstract WP192: Secular Trends in the Incidence, Mortality and Survival Rates of Cardiovascular Disease in a General Japanese Population: the Hisayama Study, 1961-2009

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Jun Hata ◽  
Toshiharu Ninomiya ◽  
Yasufumi Doi ◽  
Yoichiro Hirakawa ◽  
Masayo Fukuhara ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Survival Rates ◽  
The Past ◽  
Past Half Century ◽  
Incidence And Mortality ◽  
Clear Change ◽  
Past Half

Background: Changes in lifestyle and advances in medical technology during the past half century have been likely to affect the incidence and mortality of cardiovascular diseases and the prevalence of their risk factors in Japan. Methods: We established 5 cohorts consisting of residents of the town of Hisayama, Fukuoka, Japan, aged 40 years or older without a history of cardiovascular disease in 1961, 1974, 1983, 1993, and 2002. Each cohort was followed up for 7 years. Results: The age-adjusted incidence and mortality rates of ischemic stroke decreased significantly in men and women over the past half century. These decreasing trends were the greatest in the earlier period (from the 1960s to the 1970s) and slowed down in the recent period (from the 1980s to the 2000s). The incidence and mortality of intracerebral hemorrhage decreased significantly in men but not in women. The incidence and mortality of coronary heart disease decreased in women, but did not show a clear change in men. Five-year survival rates of stroke and acute myocardial infarction increased significantly with time. While the prevalence of hypertension did not show a drastic secular change, the proportion of individuals with antihypertensive treatment increased consistently, and mean systolic and diastolic blood pressures among hypertensive participants significantly decreased over the study period. On the other hand, the prevalence of glucose intolerance, hypercholesterolemia, and obesity increased steeply. Conclusions: The incidence and mortality rates of ischemic stroke in both sexes, intracerebral hemorrhage in men, and coronary heart disease in women decreased significantly, probably owing to better management of hypertension. However, the decreasing trends in ischemic stroke slowed down recently and there was no clear change for coronary heart disease in men, probably because the benefits of hypertension control were negated by increasing prevalence of metabolic risk factors. In addition to strict control of hypertension, urgent management of metabolic disorders is needed for further prevention of cardiovascular disease in Japan.

EDITORIAL: Migration and competitiveness: Japan and the United States

2013 ◽  
Vol 10 (2) ◽  
pp. 115-124
Author(s):  
Philip L. Martin
Keyword(s):  
United States ◽  
The United States ◽  
Variable Cost ◽  
Fixed Cost ◽  
Special Issue ◽  
Science And Engineering ◽  
The Past ◽  
Past Half Century ◽  
Key Sectors ◽  
Past Half

Japan and the United States, the world’s largest economies for most of the past half century, have very different immigration policies. Japan is the G7 economy most closed to immigrants, while the United States is the large economy most open to immigrants. Both Japan and the United States are debating how immigrants are and can con-tribute to the competitiveness of their economies in the 21st centuries. The papers in this special issue review the employment of and impacts of immigrants in some of the key sectors of the Japanese and US economies, including agriculture, health care, science and engineering, and construction and manufacturing. For example, in Japanese agriculture migrant trainees are a fixed cost to farmers during the three years they are in Japan, while US farmers who hire mostly unauthorized migrants hire and lay off workers as needed, making labour a variable cost.

Reframing the Sciences of the Long Eighteenth Century

2020 ◽  
Vol 50 (1-2) ◽  
pp. 58-66
Author(s):  
Giuliano Pancaldi
Keyword(s):  
Eighteenth Century ◽  
History Of Science ◽  
Science Policy ◽  
Special Issue ◽  
Half Century ◽  
The Past ◽  
Past Half Century ◽  
History Of ◽  
Long Eighteenth Century ◽  
Past Half

Here I survey a sample of the essays and reviews on the sciences of the long eighteenth century published in this journal since it was founded in 1969. The connecting thread is some historiographic reflections on the role that disciplines—in both the sciences we study and the fields we practice—have played in the development of the history of science over the past half century. I argue that, as far as disciplines are concerned, we now find ourselves a bit closer to a situation described in our studies of the long eighteenth century than we were fifty years ago. This should both favor our understanding of that period and, hopefully, make the historical studies that explore it more relevant to present-day developments and science policy. This essay is part of a special issue entitled “Looking Backward, Looking Forward: HSNS at 50,” edited by Erika Lorraine Milam.

Pakistan’s Development: Successes, Failures, and Future Tasks (Presidential Remarks)

1997 ◽  
Vol 36 (4I) ◽  
pp. 321-331
Author(s):  
Sarfraz Khan Qureshi
Keyword(s):  
Indian Subcontinent ◽  
General Meeting ◽  
The Past ◽  
Past Half Century ◽  
The Social ◽  
The Subject ◽  
Golden Jubilee ◽  
Freedom Movement ◽  
Past Half ◽  
Do So

It is an honour for me as President of the Pakistan Society of Development Economists to welcome you to the 13th Annual General Meeting and Conference of the Society. I consider it a great privilege to do so as this Meeting coincides with the Golden Jubilee celebrations of the state of Pakistan, a state which emerged on the map of the postwar world as a result of the Muslim freedom movement in the Indian Subcontinent. Fifty years to the date, we have been jubilant about it, and both as citizens of Pakistan and professionals in the social sciences we have also been thoughtful about it. We are trying to see what development has meant in Pakistan in the past half century. As there are so many dimensions that the subject has now come to have since its rather simplistic beginnings, we thought the Golden Jubilee of Pakistan to be an appropriate occasion for such stock-taking.

Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology

2019 ◽  
Vol 22 (6) ◽  
pp. 411-420 ◽  
Author(s):  
Xian-Jun Wu ◽  
Xin-Bin Zhou ◽  
Chen Chen ◽  
Wei Mao
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Signaling Pathway ◽  
Kegg Pathway ◽  
Enrichment Analysis ◽  
Network Pharmacology ◽  
Pathway Enrichment Analysis ◽  
Therapeutic Effects ◽  
Pathway Enrichment ◽  
Compound Target

Aim and Objective: Cardiovascular disease is a serious threat to human health because of its high mortality and morbidity rates. At present, there is no effective treatment. In Southeast Asia, traditional Chinese medicine is widely used in the treatment of cardiovascular diseases. Quercetin is a flavonoid extract of Ginkgo biloba leaves. Basic experiments and clinical studies have shown that quercetin has a significant effect on the treatment of cardiovascular diseases. However, its precise mechanism is still unclear. Therefore, it is necessary to exploit the network pharmacological potential effects of quercetin on cardiovascular disease. Materials and Methods: In the present study, a novel network pharmacology strategy based on pharmacokinetic filtering, target fishing, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, compound-target-pathway network structured was performed to explore the anti- cardiovascular disease mechanism of quercetin. Results:: The outcomes showed that quercetin possesses favorable pharmacokinetic profiles, which have interactions with 47 cardiovascular disease-related targets and 12 KEGG signaling pathways to provide potential synergistic therapeutic effects. Following the construction of Compound-Target-Pathway (C-T-P) network, and the network topological feature calculation, we obtained top 10 core genes in this network which were AKT1, IL1B, TNF, IL6, JUN, CCL2, FOS, VEGFA, CXCL8, and ICAM1. KEGG pathway enrichment analysis. These indicated that quercetin produced the therapeutic effects against cardiovascular disease by systemically and holistically regulating many signaling pathways, including Fluid shear stress and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, MAPK signaling pathway, IL-17 signaling pathway and PI3K-Akt signaling pathway.

A Scientific Search for Altruism

2018 ◽  
Author(s):  
C. Daniel Batson
Keyword(s):  
Human Nature ◽  
Scientific Method ◽  
Laboratory Experiments ◽  
Fundamental Question ◽  
Empathic Concern ◽  
Altruistic Motivation ◽  
The Past ◽  
Past Half Century ◽  
Series Of Experiments ◽  
Past Half

This book provides an example of how the scientific method can be used to address a fundamental question about human nature. For centuries—indeed for millennia—the egoism–altruism debate has echoed through Western thought. Egoism says that the motivation for everything we do, including all of our seemingly selfless acts of care for others, is to gain one or another self-benefit. Altruism, while not denying the force of self-benefit, says that under certain circumstances we can care for others for their sakes, not our own. Over the past half-century, social psychologists have turned to laboratory experiments to provide a scientific resolution of this human nature debate. The experiments focused on the possibility that empathic concern—other-oriented emotion elicited by and congruent with the perceived welfare of someone in need—produces altruistic motivation to remove that need. With carefully constructed experimental designs, these psychologists have tested the nature of the motivation produced by empathic concern, determining whether it is egoistic or altruistic. This series of experiments has provided an answer to a fundamental question about what makes us tick. Framed as a detective story, the book traces this scientific search for altruism through the numerous twists and turns that led to the conclusion that empathy-induced altruism is indeed part of our nature. It then examines the implications of this conclusion—negative implications as well as positive—both for our understanding of who we are as humans and for how we might create a more humane society.

The Twentysomething Soul

2019 ◽  
Author(s):  
Tim Clydesdale ◽  
Kathleen Garces-Foley
Keyword(s):  
Young Adults ◽  
Religious Commitment ◽  
Religion And Spirituality ◽  
Lost Generation ◽  
Full Spectrum ◽  
Half Century ◽  
The Past ◽  
Past Half Century ◽  
Past Half ◽  
The Way

Few realize how much Americans’ journey through their twenties has changed during the past half-century or understand how incorrect popular assumptions about young adults’ religious, spiritual, and secular lives are. Today’s twentysomethings have been labelled the “lost generation”—for their presumed inability to identify and lead fulfilling lives, “kidults”—for their alleged refusal to “grow up” and accept adult responsibilities, and the “least religious generation”—for their purported disinterest in religion and spirituality. These characterizations are not only unflattering, they are deeply flawed. The Twentysomething Soul tells an optimistic story about American twentysomethings. Drawing on hundreds of interviews and a survey of thousands across America, it introduces readers to the full spectrum of American young adults, many of whom live purposefully, responsibly, and reflectively. Some prioritize faith and spirituality. Others reject their childhood religion to explore alternatives and practice a personal spirituality. Still others sideline religion and spirituality until their lives get settled or reject organized religion completely. There is change occurring in the religious and spiritual lives of young adults, but little of it is among the 1 in 4 American twentysomethings who have consistently prioritized religious commitment during the past half-century. The change is rather among the now 3 in 10 young adults who, though intentionally unaffiliated with religion, affirm a variety of religious, spiritual, and secular beliefs. The Twentysomething Soul will change the way readers view contemporary young adults, giving an accurate—and refreshing—understanding of their religious, spiritual, and secular lives.

Oxford Studies in Philosophy of Religion Volume 9

2019 ◽  
Keyword(s):  
Philosophy Of Science ◽  
Philosophy Of Language ◽  
Philosophy Of Religion ◽  
Half Century ◽  
The Past ◽  
Past Half Century ◽  
Inclusive Approach ◽  
Past Half

This is the ninth volume of Oxford Studies in Philosophy of Religion. As with earlier volumes, these essays follow the tradition of providing a non-sectarian and non-partisan snapshot of the subdiscipline of philosophy of religion. This subdiscipline has become an increasingly important one within philosophy over the last century, and especially over the past half century, having emerged as an identifiable subfield with this timeframe along with other emerging subfields such as the philosophy of science and the philosophy of language. This volume continues the initial intention behind the series of attracting the best work from the premier philosophers of religion, as well as including work by top philosophers outside this area when their work and interests intersect with issues in the philosophy of religion. This inclusive approach to the series provides an opportunity to mitigate some of the costs of greater specialization in our discipline, while at the same time inviting wider interest in the work being done in the philosophy of religion.

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