scholarly journals Effects of Tomato Juice Intake on Salivary 8-Oxo-dG Levels as Oxidative Stress Biomarker after Extensive Physical Exercise

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Ali Pour Khavari ◽  
Siamak Haghdoost
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Physical Exercise ◽  
Method Development ◽  
Cell Signalling ◽  
Daily Intake ◽  
Laboratory Diagnosis ◽  
Tomato Juice ◽  
Age Related ◽  
Stress Biomarker

Reactive oxygen species (ROS) at a normal level are important molecules involved in several cellular processes including immune response and cell signalling. Overproduction of ROS may lead to elevated oxidative stress and consequently to age-related diseases. Most of the studies related to oxidative stress in humans have been done on blood samples. However, blood sampling might be painful, requires special qualified personnel, and has to be performed at medical centers. An alternative to blood is saliva. Saliva sampling is noninvasive and can be performed by the donor. Biomarker determination in saliva is becoming an important part of laboratory diagnosis, but method development is needed before it can be used in the clinics. In the present investigation, 16 donors performed extensive physical exercise by cycling and keeping their heart rate at 80% of maximum for 20 minutes. The physical activity was repeated 3 times: before tomato juice intake, after daily intake of 100 ml tomato juice during 3 weeks, and finally 3 weeks after finishing tomato juice intake (washout period). The level of the stress biomarker, salivary 8-oxo-dG, was determined before and after the physical activity. The results indicate that (a) 20 min extensive physical activity increases the level of 8-oxo-dG in saliva significantly (p=0.0078) and (b) daily intake of 100 ml tomato juice may inhibit (p=0.052) overproduction of salivary 8-oxo-dG by 20 min physical activity. We conclude that the 20 min extensive physical activity increases the level of salivary 8-oxo-dG in healthy donors and 100 ml daily intake of tomato juice may inhibit the increase of 8-oxo-dG in saliva.

PHYSICAL ACTIVITY AS HEALTHY INTERVENTION AGAINST SEVERE OXIDATIVE STRESS IN ELDERLY POPULATION

2013 ◽  
pp. 1-9
Author(s):  
C. TOMAS-ZAPICO ◽  
E. IGLESIAS-GUTIERREZ ◽  
B. FERNANDEZ-GARCIA ◽  
D. DE GONZALO-CALVO
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Elderly Population ◽  
Physiological Basis ◽  
Related Disease ◽  
Age Related ◽  
Wide Range ◽  
Health Related ◽  
Relevant Risk Factor

Severe oxidative stress is a relevant risk factor for major deleterious health-related events in olderpeople and is thought to be an important contributor to age-related disease. Literature has suggested oxidativestress as a therapeutic target for mitigating the biological decline and attenuating the occurrence of adverseclinical events in aged individuals. However, definitive treatments are not known. Regular and moderate physicalactivity has been proposed as possible intervention for slowing age-related decline. This healthy strategy presentsa wide range of beneficial aspects for elderly, from the reduction of morbidity, disability, frailty and mortalityrates to treatment of many age-related disorders. Importantly, the global benefits on health are not shared by anyother strategies. Nevertheless, the physiological basis by which exercise produces its benefits to the organism isnot fully understood. This review summarizes the evidence for the role of physical activity as potential healthyintervention for mitigating the negative aspects of aging through the modulation of the oxidative mechanisms.

scholarly journals Epigenetic Modifications of theα-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Simona Daniele ◽  
Barbara Costa ◽  
Deborah Pietrobono ◽  
Chiara Giacomelli ◽  
Caterina Iofrida ◽  
...  
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Epigenetic Regulation ◽  
Healthy Subjects ◽  
Dna Methyltransferase ◽  
Epigenetic Modification ◽  
Methylation Status ◽  
Peripheral Tissues ◽  
Beneficial Effects ◽  
Age Related

Epigenetic regulation may contribute to the beneficial effects of physical activity against age-related neurodegeneration. For example, epigenetic alterations of the gene encoding forα-synuclein (SNCA) have been widely explored in both brain and peripheral tissues of Parkinson’s disease samples. However, no data are currently available about the effects of physical exercise onSNCAepigenetic regulation in ageing healthy subjects. The present paper explored whether, in healthy individuals, age and physical activity are related to blood intron1-SNCA(SNCAI1) methylation, as well as further parameters linked to such epigenetic modification (total, oligomericα-synuclein and DNA methyltransferase concentrations in the blood). Here, theSNCAI1methylation status increased with ageing, and consistent with this result, lowα-synuclein levels were found in the blood. The direct relationship betweenSNCAI1methylation andα-synuclein levels was observed in samples characterized by bloodα-synuclein concentrations of 76.3 ng/mg protein or lower (confidence interval (CI) = 95%). In this selected population, higher physical activity reduced the total and oligomericα-synuclein levels. Taken together, our data shed light on ageing- and physical exercise-induced changes on theSNCAmethylation status and protein levels ofα-synuclein.

scholarly journals Lipid profile, apolipoprotein A-I and oxidative stress in professional footballers, sedentary individuals, and their relatives

2011 ◽  
Vol 55 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Aline Margioti Zanella ◽  
Marcelo Arruda Nakazone ◽  
Marcela Augusta Souza Pinhel ◽  
Dorotéia Rossi Silva Souza
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Physical Exercise ◽  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Beneficial Effects ◽  
Apolipoprotein A ◽  
And Oxidative Stress ◽  
Cholesterol Fraction

OBJECTIVE: To evaluate whether lipid profile (LP), apolipoprotein A-1 (apo A-I) and malondialdehyde (MDA) have any relationship with physical exercise by comparing the groups of footballers (FG) with sedentary individuals (CG) and their relatives (RFG and RCG). SUBJECTS AND METHODS: Twenty individuals from FG and CG, 60 from RFG, and 57 from RCG were studied. RESULTS: FG showed lower levels of total cholesterol (119.5 ± 37.9 mg/dL), LDL-cholesterol fraction (53.6 ± 30.3), apo A-I (116.7 ± 11.9), and higher level of HDL-cholesterol fraction (HDLc) (49.7 ± 8.5) compared to RFG (148.3 ± 36.9, P = 0.02; 82.4 ± 37.7, P < 0.01; 124.6 ± 10.2, P = 0.03; and 42.7 ± 7.7, P < 0.01; respectively). Moreover, FG had reduced levels of MDA (101.0 ± 77.0 ng/mL) compared to CG (290.0 ± 341.0, P = 0.03) and RFG (209.9 ± 197.5, P = 0.04). CONCLUSIONS: These results suggest an association between physical exercise and lower levels of MDA in FG. Physical activity seems to promote beneficial effects on the LP regardless of the genetic influence considering HDLc levels.

scholarly journals Lifelong Voluntary Exercise Modulates Age-Related Changes in Oxidative Stress

2017 ◽  
Vol 39 (01) ◽  
pp. 21-28 ◽  
Author(s):  
Mohamed Bouzid ◽  
Edith Filaire ◽  
Régis Matran ◽  
Sophie Robin ◽  
Claudine Fabre
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Lipid Peroxidation ◽  
Aging Process ◽  
Antioxidant Defense ◽  
Antioxidant Activities ◽  
Regular Physical Activity ◽  
Voluntary Exercise ◽  
Beneficial Effects ◽  
Age Related

AbstractThe hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise. There was no difference in resting antioxidant activities and lipid peroxidation between YS and OS. However, resting SOD and GR activities were higher in YA compared to OA (p<0.01 and p<0.05, respectively) and resting MDA level was higher in OA compared to YA (p<0.01). After exercise, a significant increase in SOD and GPX activities was observed in YS, YA and OA (p<0.01). Likewise, after exercise a significant increase of MDA level in YA, OS and OA (p<0.01) was observed. In addition, the comparison of YA to OA and YS to OA revealed similar antioxidant activities and lipid peroxidation between YS and OA, whereas antioxidant activities were higher in YA compared to OA. These data suggest that beneficial effects of regular physical activity in antioxidant defense and lipid peroxidation damage could be impaired by the aging process and that regular physical activity in older adults could maintain age-related decreases in antioxidant defense.

Physical Exercise as an Immunomodulator of Chronic Diseases in Aging

2020 ◽  
Vol 17 (6) ◽  
pp. 662-672 ◽  
Author(s):  
Emmanuel Gomes Ciolac ◽  
José Messias Rodrigues da Silva ◽  
Rodolfo Paula Vieira
Keyword(s):  
Physical Activity ◽  
Immune System ◽  
Physical Exercise ◽  
Chronic Diseases ◽  
Narrative Review ◽  
Chronic Obstructive ◽  
Therapeutic Effects ◽  
Older Individuals ◽  
Obstructive Pulmonary Disease ◽  
Age Related

Background: The progressive dysfunction of the immune system during aging appears to be involved in the pathogenesis of several age-related disorders. However, regular physical exercise can present “antiaging” effects on several physiological systems. Methods: A narrative review of studies investigating the chronic effects of exercise and physical activity on the immune system and its association with age-related chronic diseases was carried out according to the guidelines for writing a narrative review. Results: There is compelling evidence suggesting that age-related immune system alterations play a key role on the pathophysiology of atherosclerosis, hypertension, chronic heart failure, type 2 diabetes, obesity, arthritis, and chronic obstructive pulmonary disease. On the other hand, the regular practice of physical activity appears to improve most of the inflammatory/immunological processes involved in these diseases. Conclusion: Epidemiological, experimental, and clinical studies permit us to affirm that regular physical activity improves immunomodulation and may play a key role in the prevention and treatment of several age-related chronic diseases. However, further studies are needed to better describe the prophylactic and therapeutic effects of physical exercise in specific organs of older individuals, as well as the mechanisms involved in such response.

scholarly journals Association between Physical Exercise and Biomarkers of Oxidative Stress among Middle-Aged and Elderly Community Residents with Essential Hypertension in China

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Ying Yu ◽  
Qin Gao ◽  
Wanning Xia ◽  
Lina Zhang ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Essential Hypertension ◽  
Physical Exercise ◽  
Sod Activity ◽  
Community Residents ◽  
Stress Biomarker ◽  
Oxidative Stress Biomarker ◽  
Biomarkers Of Oxidative Stress

This study aimed to investigate the role of different types and frequencies of physical exercise in biomarkers of oxidative stress among middle-aged and elderly community residents with essential hypertension in China. A community-based cross-sectional survey was undertaken in 7 subdistricts. Individuals, 45-79 years old, with essential hypertension (n=402) and without cardiovascular disease (n=1047) were included. Superoxide dismutase (SOD) activities and plasma levels of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were determined. Multilevel linear regression was used to estimate the associations between various types of physical exercise and oxidative stress biomarker levels. Participants engaged in high frequency walking/square dancing or taiji/yoga demonstrated decreased systolic blood pressure in both groups; however, diastolic blood pressure decreased only among individuals with hypertension participating in walking/square dancing. In individuals with hypertension, MDA levels decreased in those participating in walking/square dancing, SOD activity increased in those participating in walking/square dancing, and 4-HNE levels decreased in those involved in taiji/yoga. In individuals without cardiovascular disease, MDA levels decreased in those involved in walking/square dancing or taiji/yoga, SOD activity increased in those performing walking/square dancing, and 4-HNE levels decreased in those involved in taiji/yoga. Oxidative stress marker levels also improved in those involved in walking/square dancing or taiji/yoga groups as the exercise frequency increased. Thus, frequent participation in walking/square dancing or taiji/yoga effectively decreases hypertension-related oxidative stress biomarker levels.

scholarly journals Physical Activity and Episodic Memory: An Analysis of Longitudinal Associations Over 12 Years

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 715-715
Author(s):  
Rio Tate ◽  
Gizem Hueluer
Keyword(s):  
Physical Activity ◽  
Physical Exercise ◽  
Episodic Memory ◽  
Multilevel Models ◽  
Vigorous Physical Activity ◽  
Health Concern ◽  
Future Research ◽  
Cross Sectional ◽  
Age Related ◽  
Longitudinal Associations

Abstract With the increasing prevalence of Alzheimer’s and related dementias, it is becoming a growing public health concern to identify modifiable risk factors to prevent cognitive decline. Previous research suggest that physical exercise may promote cognitive function in aging. However, most of this research is based on experimental or cross-sectional studies and fewer studies have studied longitudinal associations over longer time frames. In the present study, we examined how physical activity is related to cognition in older adults. To do so, we applied multilevel models to data from 29,740 participants (age at baseline: M = 63 years, SD = 11 years, 50 to 102 years) from years 2004-2016, measured biennially (waves 7-13) of the Health and Retirement Study. Our findings showed that at the between-person level, those who practiced light, moderate, and vigorous- physical activity more frequently than others showed higher levels of episodic memory than others at the age of 70. At the within-person level, participants performed better than usual on a test of episodic memory on occasions when they reported more frequent physical activity of light, moderate and vigorous intensity. More frequent vigorous physical activity was related to less age-related decline in episodic memory, while the frequency of moderate physical exercise was unrelated to age-related change in memory. Contrary to our expectations, more frequent light physical exercise was related to more age-related decline in episodic memory. We discuss the implications of these findings for future research and practice.

Age-Related Changes in Activation of Mitogen-Activated Protein Kinase Cascades by Oxidative Stress

1998 ◽  
Vol 3 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Kathryn Z Guyton ◽  
Myriani Gorospe ◽  
Xiantao Wang ◽  
Yolanda D Mock ◽  
Gertrude C Kokkonen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Age Related ◽  
Mitogen Activated Protein ◽  
Age Related Changes

Physical exercise protects dynamic balance and motor coordination of rats treated with vincristine

2020 ◽  
Vol 19 (5) ◽  
pp. 336
Author(s):  
Luiza Minato Sagrillo ◽  
Viviane Nogueira De Zorzi ◽  
Luiz Fernando Freire Royes ◽  
Michele Rechia Fighera ◽  
Beatriz Da Silva Rosa Bonadiman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Locomotor Activity ◽  
Physical Exercise ◽  
Motor Coordination ◽  
Dynamic Balance ◽  
Exercise Group ◽  
Adult Rats ◽  
The Central Nervous System ◽  
Stress Damage ◽  
Training Protocol

Physical exercise has been shown to be an important modulator of the antioxidant system and neuroprotective in several diseases and treatments that affect the central nervous system. In this sense, the present study aimed to evaluate the effect of physical exercise in dynamic balance, motor coordination, exploratory locomotor activity and in the oxidative and immunological balance of rats treated with vincristine (VCR). For that, 40 adult rats were divided into two groups: exercise group (6 weeks of swimming, 1h/day, 5 days/week, with overload of 5% of body weight) and sedentary group. After training, rats were treated with 0.5 mg/kg of vincristine sulfate for two weeks or with the same dose of 0.9% NaCl. The behavioral tests were conducted 1 and 7 days after each dose of VCR. On day 15 we carried out the biochemical analyzes of the cerebellum. The physical exercise was able to protect against the loss of dynamic balance and motor coordination and, had effect per se in the exploratory locomotor activity, and neutralize oxidative stress, damage DNA and immune damage caused by VCR up to 15 days after the end of the training protocol. In conclusion, we observed that previous physical training protects of the damage motor induced by vincristine.Key-words: exercise, oxidative stress, neuroprotection, cerebellum.

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