scholarly journals GTR Treatment in Furcation Grade II Periodontal Defects with the Recently Reintroduced Guidor PLA Matrix Barrier: A Case Series with Chronological Step-by-Step Illustrations

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Anton Friedmann ◽  
Andreas Stavropoulos ◽  
Hakan Bilhan
Keyword(s):  
Tissue Regeneration ◽  
Complete Resolution ◽  
Tooth Loss ◽  
Case Series ◽  
Maintenance Program ◽  
Regenerative Approach ◽  
Furcation Involvement ◽  
Grade Ii ◽  
First Time ◽  
Observation Period

Molars with a furcation involvement (FI) exceeding grade 1 according to Hamp’s classification are at approximately doubled risk of tooth loss. Guided tissue regeneration (GTR) is a regenerative approach in the treatment of periodontal defects and is aimed at achieving new clinical attachment formation. The aim of this case series was to assess the efficacy of a newly reintroduced polylactic acid (PLA) matrix barrier and to evaluate the feasibility of the surgical approach. 11 patients with an average age of 58.7 years were treated with GTR using a PLA matrix barrier. Patients were instructed not to brush and chew on the treated side for 4 weeks. A gentle clinical probing was performed after 6 months for the first time after surgery. The patients were included into individual maintenance program at three months’ interval. The clinical improvement was expressed by reduced horizontal penetration of the probe accompanied by vast resolution of the vertical defect component. The change from grade II to grade I or complete resolution of the FI could be seen in 8 from 11 sites included. The newly reintroduced PLA matrix barrier showed promising results after a 12-month observation period with clinical attachment gain.

scholarly journals Evaluation of success and/or failure of endodontic treatment in non-vital teeth performed at the School of Dentistry at the Universidad del Valle. Case series

2017 ◽  
Vol 22 (2) ◽  
pp. 13-19
Author(s):  
Luis Ochoa ◽  
Stevan Moreno ◽  
David Piarpuzán ◽  
Patricia Rodríguez ◽  
Adriana Herrera ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Tissue Repair ◽  
Tooth Loss ◽  
Case Series ◽  
Dental Students ◽  
Endodontic Treatment ◽  
Necrotic Tissue ◽  
The Third ◽  
Biofilm Removal ◽  
School Of Dentistry

Introduction: The endodontic treatment in non-vital teeth is directed to the elimination of the infection through the biofilm removal biomechanics and remnants of necrotic tissue, in order to eliminate infection and generate periapical tissue repair. Objective: To determine the success or failure of endodontic treatment in non-vital teeth performed by dental students under supervision. Materials and methods: In this article 3 clinical cases of patients undergoing endodontic procedures with non-vital pulps track 4 and 6 years are presented. Results: Two of the 3 cases show a process of incomplete periapical tissue regeneration at the time of observation. The third case shows a process of subsequent periodontal disease to endodontics leading to tooth loss. Conclusions: Is necessary to conduct a study with a sample size calculated to determine what percentage of success and failure of endodontic treatment in non-vital teeth, performed by undergraduate dental students under supervision, and to determine those factors that directly influence both outcomes.

scholarly journals Profiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyed-Mohammad Mazloomi ◽  
Mitra Foroutan-Ghaznavi ◽  
Vahid Montazeri ◽  
Gholamreza Tavoosidana ◽  
Ashraf Fakhrjou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Target Genes ◽  
Case Series ◽  
Clinicopathological Features ◽  
Cell Junctions ◽  
Homologous Gene ◽  
Axillary Lymph ◽  
Luminal A ◽  
Transcriptional Profiles ◽  
First Time

Abstract Background Metastasis accounts for ninety percent of breast cancer (BrCa) mortality. Cortactin, Ras homologous gene family member A (RhoA), and Rho-associated kinase (ROCK) raise cellular motility in favor of metastasis. Claudins (CLDN) belong to tight junction integrity and are dysregulated in BrCa. Thus far, epidemiologic evidence regarding the association of different pro-metastatic genes with pathological phenotypes of BrCa is largely inconsistent. This study aimed to determine the possible transcriptional models of pro-metastatic genes incorporate in holding the integrity of epithelial cell–cell junctions (CTTN, RhoA, ROCK, CLDN-1, CLDN-2, and CLDN-4), for the first time, in association with clinicopathological features of primary BrCa. Methods In a consecutive case-series design, 206 newly diagnosed non-metastatic eligible BrCa patients with histopathological confirmation (30–65 years) were recruited in Tabriz, Iran (2015–2017). Real-time RT-PCR was used. Then fold changes in the expression of target genes were measured. Results ROCK amplification was associated with the involvement of axillary lymph node metastasis (ALNM; ORadj. = 3.05, 95%CI 1.01–9.18). Consistently, inter-correlations of CTTN-ROCK (β = 0.226, P < 0.05) and RhoA-ROCK (β = 0.311, P < 0.01) were determined among patients diagnosed with ALNM+ BrCa. In addition, the overexpression of CLDN-4 was frequently observed in tumors identified by ALNM+ or grade III (P < 0.05). The overexpression of CTTN, CLDN-1, and CLDN-4 genes was correlated positively with the extent of tumor size. CTTN overexpression was associated with the increased chance of luminal-A positivity vs. non-luminal-A (ORadj. = 1.96, 95%CI 1.02–3.77). ROCK was also expressed in luminal-B BrCa tumors (P < 0.05). The estrogen receptor-dependent transcriptions were extended to the inter-correlations of RhoA-ROCK (β = 0.280, P < 0.01), ROCK-CLDN-2 (β = 0.267, P < 0.05), and CLDN-1-CLDN-4 (β = 0.451, P < 0.001). Conclusions For the first time, our findings suggested that the inter-correlations of CTTN-ROCK and RhoA-ROCK were significant transcriptional profiles determined in association with ALNM involvement; therefore the overexpression of ROCK may serve as a potential molecular marker for lymphatic metastasis. The provided binary transcriptional profiles need more approvals in different clinical features of BrCa metastasis.

Guided Tissue Regeneration in Human Class II Furcation Defects Using a Diphenylphosphorylazide-Cross-Linked Collagen Membrane: A Consecutive Case Series

2003 ◽  
Vol 74 (7) ◽  
pp. 1071-1079 ◽  
Author(s):  
Charles S. Zahedi ◽  
S. Asghar Miremadi ◽  
Gérard Brunel ◽  
Eric Rompen ◽  
Jean-Pierre Bernard ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Case Series ◽  
Class Ii ◽  
Guided Tissue Regeneration ◽  
Collagen Membrane ◽  
Consecutive Case ◽  
Human Class ◽  
Furcation Defects

scholarly journals Effect of Microsurgical Subinguinal Varicocele Repair on Chronic Dull Scrotal Pain in Men with Grade II-III Lesions

2015 ◽  
Vol 9 (4) ◽  
pp. 188-191 ◽  
Author(s):  
Saad Elzanaty ◽  
Claus E. Johansen
Keyword(s):  
Pain Assessment ◽  
Complete Resolution ◽  
Testicular Atrophy ◽  
Scrotal Pain ◽  
Grade Ii ◽  
Varicocele Repair

Introduction: We aimed to evaluate the effectiveness of microsurgical subinguinal varicocele repair in patients with grade II-III lesions and chronic dull scrotal pain. Materials and Methods: A total of 29 patients with grade II-III varicocele and chronic dull scrotal pain that had a microsurgical subinguinal varicocele repair were included in the study. They were followed-up for 6-12 months including pain assessment and scrotal examination. Results: Of the 29 patients, 28 (97%) reported complete resolution of pain with no palpable varicocele on scrotal examination. No cases of testicular atrophy or hydrocele formation were reported. Conclusion: These results indicated that microsurgical varicocele repair should be considered in patients with grade II-III lesions and chronic dull scrotal pain.

scholarly journals Clinical and histopathological features of a lingual mucosal horn: First time described clinical case series

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Frédérick Gaultier ◽  
Anne-Laure Ejeil ◽  
Francois Lepelletier ◽  
Bruno Gogly ◽  
Hafida Cherifi ◽  
...  
Keyword(s):  
Clinical Case ◽  
Case Series ◽  
Histopathological Features ◽  
First Time

scholarly journals Intra-discal drain insertion for culture and drainage of pyogenic spondylodiscitis: A one-step diagnostic and therapeutic procedure

2019 ◽  
Vol 26 (1) ◽  
pp. 105-110
Author(s):  
Tal Ackerman ◽  
Jonathan Singer-Jordan ◽  
Adi Shani ◽  
Nimrod Rahamimov
Keyword(s):  
Complete Resolution ◽  
Treatment Guidelines ◽  
Clinical Laboratory ◽  
Case Series ◽  
Retrospective Case ◽  
Disc Space ◽  
Ct Guided ◽  
Pyogenic Spondylodiscitis ◽  
Continuous Drainage ◽  
One Step

Background Pyogenic spondylodiscitis is diagnosed in recent years at higher rates due to the aging population, increased survival of chronic and immune suppressed patients, and the higher rate of invasive procedures leading to bacterial seeding or direct contamination of the disc space. Treatment guidelines encourage bacterial sampling before initiation of antibiotic therapy, and drainage of pus collections. We present our experience with percutaneous CT-guided drain insertion into the disc space itself as a one-step procedure for both culturing and subsequent continuous drainage of the infected disc space. Materials and methods We retrospectively reviewed all cases of pyogenic spondylodiscitis admitted to our spine surgery unit during the past five years and treated with CT-guided percutaneous drain insertion into the infected disc space. All patients were followed until complete resolution of the infection. Results We retrieved electronic records of 12 patients, none presenting with neurological compression symptoms. Cultures taken at the time of drain insertion were positive in 10 patients (83.3%), much higher than the reported yield for needle aspiration (14–48%) and comparable to the yield of open biopsy. In all patients complete resolution of the infection was reached, determined by clinical, laboratory, and imaging parameters. Conclusions Our retrospective case series demonstrates the feasibility and effectiveness of intra-discal CT-guided drainage of an infected disc space. The procedure does not add much burden to current practice as disc-space sampling for culture is commonly performed anyway, and adds the benefit of direct drainage of the pus at its source.

Erosive pustulöse Dermatose der Kopfhaut: häufig übersehen und selten diagnostiziert

2020 ◽  
Vol 8 (1) ◽  
pp. 21-22
Author(s):  
Markus Braun-Falco
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Actinic Keratosis ◽  
Diagnostic Delay ◽  
Case Series ◽  
Older Men ◽  
Uncommon Disease ◽  
First Time

Erosive pustular dermatosis of the scalp (EPDS) is an uncommon disease and primarily affects older men who have photodamaged bald scalp, as was confirmed by our case series. EPDS is probably an overlooked disease, whose diagnosis is often missed because of a higher incidence of other cutaneous diseases affecting the same area and usually secondary to chronic actinic damage, such as actinic keratosis, basal cell carcinoma, and squamous cell carcinoma. For the first time, we report a case series of misdiagnosed EPDS with the aim of understanding why a diagnosis of EPDS was initially missed and try to give some tips to avoid future diagnostic delay.

Species-specific patterns of the use of burrows of Upogebia Leach, 1814 (Decapoda: Gebiidea: Upogebiidae) by the symbiotic alpheid shrimps Stenalpheops anacanthus Miya, 1997 and Athanas japonicus Kubo, 1936 (Decapoda: Caridea: Alpheidae) as revealed by laboratory quantification

2020 ◽  
Author(s):  
Yumi Henmi ◽  
Gyo Itani
Keyword(s):  
Evolutionary Biology ◽  
Evolutionary History ◽  
The Body ◽  
Symbiotic Relationship ◽  
Use Patterns ◽  
Species Specific ◽  
Burrow Use ◽  
First Time ◽  
The Relationship ◽  
Observation Period

Abstract Many alpheid shrimps live symbiotically on the body surface or inside the bodies of other invertebrates, while others use burrows made by other animals. The burrow symbiosis of alpheid shrimps is poorly studied in the context of ecology, probably because the cryptic infaunal nature of the relationship is hard to observe. The limited knowledge of the pattern of burrow use by alpheid shrimps leaves a gap in our understanding of their evolutionary history. We described and compared the behavior of Stenalpheops anacanthus  Miya, 1997 and Athanas japonicus  Kubo, 1936, two alpheid species living symbiotically in the burrows of the same host, Upogebia yokoyai  Makarov, 1938. We found that both alpheid species used U. yokoyai burrows in aquaria, but their burrow use patterns were quite different. The average time taken for S. anacanthus to enter the burrow for the first time was much shorter (1 min) than that of A. japonicus (13 min). Subsequently, S. anacanthus made longer use of the burrow (80% of the observation period) than A. japonicus (49%). The tail-first exit frequency, which may indicate a sudden expulsion from the burrow by the host, was more frequent in A. japonicus (25%) than in S. anacanthus (7%). Such differences could be attributed to the nature of the symbiotic relationship, obligate in S. anacanthus but facultative in A. japonicus. Because of the diversity of symbiotic lifestyles, there is considerable potential to study the ecology and evolutionary biology of burrow-symbiotic alpheids further.

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