scholarly journals Clinical and histopathological features of a lingual mucosal horn: First time described clinical case series

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Frédérick Gaultier ◽  
Anne-Laure Ejeil ◽  
Francois Lepelletier ◽  
Bruno Gogly ◽  
Hafida Cherifi ◽  
...  
Keyword(s):  
Clinical Case ◽  
Case Series ◽  
Histopathological Features ◽  
First Time

Regenerative treatment of peri-implantitis following implant surface decontamination with titanium brush and antimicrobial photodynamic therapy: a case series with reentry

2020 ◽  
Author(s):  
Pier Poli ◽  
Francisley Avila Souza ◽  
Mattia Manfredini ◽  
Carlo Maiorana ◽  
Mario Beretta
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Case ◽  
Case Series ◽  
Antimicrobial Photodynamic Therapy ◽  
Implant Surface ◽  
Surface Decontamination

Not required for Clinical case letters according to the authors' guidelines.

Breast cancer associated with pregnancy: a clinical case

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (1) ◽  
pp. 102-108
Author(s):  
Yu E Dobrokhotova ◽  
S E Arakelov ◽  
S Zh Danelyan ◽  
E I Borovkova ◽  
A E Zykov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Clinical Case ◽  
First Trimester ◽  
First Year ◽  
Total Mastectomy ◽  
First Time

Associated with pregnancy is breast cancer, which was first detected during pregnancy, during the first year after childbirth or at any time against lactation. Diagnosis of the disease in the first trimester is an indication for abortion. The detection of the disease after 20 weeks and the desire of the woman to maintain pregnancy is the basis for conducting a total mastectomy followed by polychemotherapy with doxorubicin with cyclophosphamide or with fluorouracil. Radiation therapy during pregnancy is not applied. The timing and method of delivery are determined individually and depend on the stage of the process and the period of pregnancy, when it was identified. A clinical case of a patient with edematous-infiltrative form of breast cancer of the IV stage, diagnosed for the first time in 22 weeks of pregnancy, is presented.

scholarly journals Profiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Seyed-Mohammad Mazloomi ◽  
Mitra Foroutan-Ghaznavi ◽  
Vahid Montazeri ◽  
Gholamreza Tavoosidana ◽  
Ashraf Fakhrjou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Target Genes ◽  
Case Series ◽  
Clinicopathological Features ◽  
Cell Junctions ◽  
Homologous Gene ◽  
Axillary Lymph ◽  
Luminal A ◽  
Transcriptional Profiles ◽  
First Time

Abstract Background Metastasis accounts for ninety percent of breast cancer (BrCa) mortality. Cortactin, Ras homologous gene family member A (RhoA), and Rho-associated kinase (ROCK) raise cellular motility in favor of metastasis. Claudins (CLDN) belong to tight junction integrity and are dysregulated in BrCa. Thus far, epidemiologic evidence regarding the association of different pro-metastatic genes with pathological phenotypes of BrCa is largely inconsistent. This study aimed to determine the possible transcriptional models of pro-metastatic genes incorporate in holding the integrity of epithelial cell–cell junctions (CTTN, RhoA, ROCK, CLDN-1, CLDN-2, and CLDN-4), for the first time, in association with clinicopathological features of primary BrCa. Methods In a consecutive case-series design, 206 newly diagnosed non-metastatic eligible BrCa patients with histopathological confirmation (30–65 years) were recruited in Tabriz, Iran (2015–2017). Real-time RT-PCR was used. Then fold changes in the expression of target genes were measured. Results ROCK amplification was associated with the involvement of axillary lymph node metastasis (ALNM; ORadj. = 3.05, 95%CI 1.01–9.18). Consistently, inter-correlations of CTTN-ROCK (β = 0.226, P < 0.05) and RhoA-ROCK (β = 0.311, P < 0.01) were determined among patients diagnosed with ALNM+ BrCa. In addition, the overexpression of CLDN-4 was frequently observed in tumors identified by ALNM+ or grade III (P < 0.05). The overexpression of CTTN, CLDN-1, and CLDN-4 genes was correlated positively with the extent of tumor size. CTTN overexpression was associated with the increased chance of luminal-A positivity vs. non-luminal-A (ORadj. = 1.96, 95%CI 1.02–3.77). ROCK was also expressed in luminal-B BrCa tumors (P < 0.05). The estrogen receptor-dependent transcriptions were extended to the inter-correlations of RhoA-ROCK (β = 0.280, P < 0.01), ROCK-CLDN-2 (β = 0.267, P < 0.05), and CLDN-1-CLDN-4 (β = 0.451, P < 0.001). Conclusions For the first time, our findings suggested that the inter-correlations of CTTN-ROCK and RhoA-ROCK were significant transcriptional profiles determined in association with ALNM involvement; therefore the overexpression of ROCK may serve as a potential molecular marker for lymphatic metastasis. The provided binary transcriptional profiles need more approvals in different clinical features of BrCa metastasis.

scholarly journals Surgical approach combining implantoplasty and reconstructive therapy with locally delivered antibiotic in the treatment of peri‐implantitis: A prospective clinical case series

2021 ◽  
Author(s):  
Iria González Regueiro ◽  
Natalia Martínez Rodriguez ◽  
Cristina Barona Dorado ◽  
Ignacio Sanz‐Sánchez ◽  
Eduardo Montero ◽  
...  
Keyword(s):  
Surgical Approach ◽  
Clinical Case ◽  
Case Series

scholarly journals Coronavirus disease 2019 infection in kidney transplant recipients: A clinical case series

2021 ◽  
Vol 32 (2) ◽  
pp. 579
Author(s):  
Arefeh Babazadeh ◽  
Masoumeh Asgharpour ◽  
ZeinabMohseni Afshar ◽  
Soheil Ebrahimpour ◽  
Sahar Oladzad
Keyword(s):  
Kidney Transplant ◽  
Clinical Case ◽  
Case Series ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients

Tiagabine in treatment refractory bipolar disorder: a clinical case series

2002 ◽  
Vol 4 (5) ◽  
pp. 283-289 ◽  
Author(s):  
Trisha Suppes ◽  
Karrie A Chisholm ◽  
Dawn Dhavale ◽  
Mark A Frye ◽  
Lori L Altshuler ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Clinical Case ◽  
Case Series ◽  
Treatment Refractory
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