scholarly journals Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Ping-Hsun Wu ◽  
Yi-Ting Lin ◽  
Cheng-Sheng Chen ◽  
Yi-Wen Chiu ◽  
Jer-Chia Tsai ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cognitive Function ◽  
Linear Regression ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Linear Regression Analysis ◽  
Hemodialysis Patients ◽  
Dementia Diagnosis ◽  
Turnover Markers ◽  
Prior Stroke

Background. Patients undergoing hemodialysis experience a greater risk of cognitive impairment than the general population, but limited data elucidates the biomarkers on this. We evaluated the association of bone turnover markers on cognitive function among 251 prevalent hemodialysis enrollees in a cross-sectional study. Methods. 251 hemodialysis patients (median age=57.8, 55% men) and 37 control subjects (mean age=61.2, 56% men) without a prior stroke or dementia diagnosis were enrolled. Serum concentrations of 8 bone markers were analyzed as the association of cognitive function (Montreal Cognitive Assessment (MoCA) and Cognitive Abilities Screening Instrument (CASI)) using linear regression analysis. Results. A lower cognitive function was noted in hemodialysis patients compared to control subjects. The receptor activator of nuclear factor kappa-B ligand (RANKL) was the only bone marker found to be associated with cognitive function (MoCA and CASI tests) in hemodialysis patients without a prior stroke or dementia diagnosis. In stepwise multiple linear regression analysis, the association remained significant in MoCA (β=1.14, 95% CI 0.17 to 2.11) and CASI (β=3.06, 95% CI 0.24 to 5.88). Short-term memory (β=0.52, 95% CI 0.01 to 1.02), mental manipulation (β=0.51, 95% CI 0.05 to 0.96), and abstract thinking (β=0.57, 95% CI 0.06 to 1.09) were the significant subdomains in the CASI score related to RANKL. Conclusions. Serum RANKL levels were potentially associated with better cognitive function in hemodialysis patients. Further large-scale and prospective studies are needed to confirm our findings.

Cross-Sectional Examination of Homocysteine Levels with Sarcopenia and Its Components in Memory Clinic Outpatients

2021 ◽  
pp. 1-10
Author(s):  
Yosuke Yamada ◽  
Hiroyuki Umegaki ◽  
Fumie Kinoshita ◽  
Chi Hsien Huang ◽  
Taiki Sugimoto ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Linear Regression ◽  
Logistic Regression Analysis ◽  
Linear Regression Analysis ◽  
Multivariate Logistic Regression Analysis ◽  
Memory Clinic ◽  
Cross Sectional

Background: Homocysteine is a common risk factor for cognitive impairment and sarcopenia. However, very few studies have shown an association between sarcopenia and serum homocysteine levels after adjustment for cognitive function. Objective: The purpose of this study was to investigate the relationship between homocysteine and sarcopenia in memory clinic patients. Methods: This cross-sectional study investigated outpatients in a memory clinic. We enrolled 1,774 participants (≥65 years old) with measured skeletal muscle mass index (SMI), hand grip strength (HGS), and homocysteine. All participants had undergone cognitive assessments and were diagnosed with dementia, mild cognitive impairment, or normal cognition. Patient characteristics were compared according to sarcopenia presence, SMI level, or HGS. Multivariate logistic regression analysis was performed to determine the association of homocysteine with sarcopenia, low SMI, or low HGS. Next, linear regression analysis was performed using HGS as a continuous variable. Results: Logistic regression analysis showed that low HGS was significantly associated with homocysteine levels (p = 0.002), but sarcopenia and low SMI were not. In linear regression analysis, HGS was negatively associated with homocysteine levels after adjustment for Mini-Mental State Examination score (β= –2.790, p <  0.001) or clinical diagnosis of dementia (β= –3.145, p <  0.001). These results were similar for men and women. Conclusion: Our results showed a negative association between homocysteine and HGS after adjustment for cognitive function. Our findings strengthen the assumed association between homocysteine and HGS. Further research is needed to determine whether lower homocysteine levels lead to prevent muscle weakness.

scholarly journals Impact of age on survival predictability of bone turnover markers in hemodialysis patients

2013 ◽  
Vol 28 (10) ◽  
pp. 2535-2545 ◽  
Author(s):  
Paungpaga Lertdumrongluk ◽  
Wei Ling Lau ◽  
Jongha Park ◽  
Connie M. Rhee ◽  
Csaba P. Kovesdy ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Hemodialysis Patients ◽  
Turnover Markers

scholarly journals Hypoalbuminemia differently affects the serum bone turnover markers in hemodialysis patients

2019 ◽  
Vol 16 (12) ◽  
pp. 1583-1592 ◽  
Author(s):  
Cai Mei Zheng ◽  
Chia Chao Wu ◽  
Chien Lin Lu ◽  
Yi Chou Hou ◽  
Mai Szu Wu ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Hemodialysis Patients ◽  
Turnover Markers

scholarly journals SAT-030 INFLUENCE OF HYPOALBUMINEMIA ON BONE TURNOVER MARKERS AMONG HEMODIALYSIS PATIENTS

2019 ◽  
Vol 4 (7) ◽  
pp. S15-S16
Author(s):  
C.M. Zheng ◽  
Y.H. Hsu ◽  
Y.F. Lin ◽  
C.C. Wu ◽  
K.C. Lu
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Hemodialysis Patients ◽  
Turnover Markers

scholarly journals Loss of Integrity of Corpus Callosum White Matter Hyperintensity Penumbra Predicts Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment

2021 ◽  
Vol 13 ◽  
Author(s):  
Yage Qiu ◽  
Ling Yu ◽  
Xin Ge ◽  
Yawen Sun ◽  
Yao Wang ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
White Matter ◽  
Linear Regression ◽  
Corpus Callosum ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
The Relationship

Loss of white matter (WM) integrity contributes to subcortical vascular mild cognitive impairment (svMCI). Diffusion tensor imaging (DTI) has revealed damage beyond the area of WM hyperintensity (WMH) including in normal-appearing WM (NAWM); however, the functional significance of this observation is unclear. To answer this question, in this study we investigated the relationship between microstructural changes in the WMH penumbra (WMH-P) and cognitive function in patients with svMCI by regional tract-based analysis. A total of 111 patients with svMCI and 72 patients with subcortical ischemic vascular disease (SIVD) without cognitive impairment (controls) underwent DTI and neuropsychological assessment. WMH burden was determined before computing mean values of fractional anisotropy (FA) and mean diffusivity (MD) within WMHs and WMH-Ps. Pearson’s partial correlations were used to assess the relationship between measurements showing significant intergroup differences and composite Z-scores representing global cognitive function. Multiple linear regression analysis was carried out to determine the best model for predicting composite Z-scores. We found that WMH burden in the genu, body, and splenium of the corpus callosum (GCC, BCC, and SCC respectively); bilateral anterior, superior, and posterior corona radiata; left sagittal stratum was significantly higher in the svMCI group than in the control group (p &lt; 0.05). The WMH burden of the GCC, BCC, SCC, and bilateral anterior corona radiata was negatively correlated with composite Z-scores. Among diffusion parameters showing significant differences across the 10 WM regions, mean FA values of WMH and WMH-P of the BCC were correlated with composite Z-scores in svMCI patients. The results of the multiple linear regression analysis showed that the FA of WMH-P of the BCC and WMH burden of the SCC and GCC were independent predictors of composite Z-score, with the FA of WMH-P of the BCC making the largest contribution. These findings indicate that disruption of the CC microstructure—especially the WMH-P of the BCC—may contribute to the cognitive deficits associated with SIVD.

Impact of lowering dialysate calcium concentration on serum bone turnover markers in hemodialysis patients

Bone ◽  
2005 ◽  
Vol 36 (5) ◽  
pp. 909-916 ◽  
Author(s):  
T HAMANO ◽  
S OSETO ◽  
N FUJII ◽  
T ITO ◽  
M KATAYAMA ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Calcium Concentration ◽  
Hemodialysis Patients ◽  
Turnover Markers ◽  
Dialysate Calcium

CIRCULATING BONE TURNOVER MARKERS AND THEIR RELATIONSHIPS IN HEMODIALYSIS PATIENTS WITH VITAMIN D DEFICIENCY

2019 ◽  
Vol 72 (11) ◽  
Author(s):  
Paweł Kulicki ◽  
Paweł Żebrowski ◽  
Antoni Sokalski ◽  
Wiesław Klatko ◽  
Magdalena Birecka ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Vitamin D Deficiency ◽  
Bone Turnover Markers ◽  
Hemodialysis Patients ◽  
Turnover Markers

scholarly journals Predictors of Short-Term Changes in Serum Intact Parathyroid Hormone Levels in Hemodialysis Patients: Role of Phosphorus, Calcium, and Gender1

1998 ◽  
Vol 83 (11) ◽  
pp. 3860-3866
Author(s):  
Olafur S. Indridason ◽  
Carl F. Pieper ◽  
L. Darryl Quarles
Keyword(s):  
Regression Analysis ◽  
Linear Regression ◽  
Secondary Hyperparathyroidism ◽  
Serum Calcium ◽  
Linear Regression Analysis ◽  
Hemodialysis Patients ◽  
Phosphorus Concentration ◽  
And Gender ◽  
Independent Effects ◽  
Pth Level

Several factors have been identified as important in the pathogenesis of secondary hyperparathyroidism in end-stage renal disease, including serum calcium, phosphorus, and calcitriol. To examine the independent effects of key factors, we prospectively studied 52 new hemodialysis patients with mild secondary hyperparathyroidism (PTH, 110–670 pg/mL) treated with a standardized regimen of calcium supplements, phosphorus binders, and no vitamin D derivatives. We used simple and multivariable linear regression analysis to examine the relationship between changes in PTH (ΔPTH) levels observed over a 4-week period and various biochemical and demographic variables. By simple linear regression we found that changes in serum phosphorus (r2 = 0.31; β = 41.6; P = 0.0001), initial phosphorus concentration (r2 = 0.15; β = 33.4; P = 0.005), initial PTH level (r2 = 0.29; β = 0.58; P = 0.0001), changes in serum calcium (r2 = 0.12; β = −74.0; P = 0.01), and gender (r2 = 0.07; β = 76.1; P = 0.05) were significantly associated with ΔPTH. However, upon multivariable regression analysis, only the changes in phosphorus (partial r2 = 0.31; β = 37.0; P = 0.0001), initial PTH level (partial r2 = 0.23; β = 0.50; P = 0.0001), and gender (partial r2 = 0.05; β = 63.1; P = 0.02) remained significantly associated with ΔPTH. Neither the serum concentration of 1,25-dihydroxyvitamin D3, bicarbonate, aluminum, or albumin nor changes in the serum bicarbonate concentration, the presence of diabetes, KT/V, or age were significantly associated with theΔ PTH. Our findings are consistent with independent effects of phosphorus and gender on parathyroid gland function in patients with dialysis-dependent renal failure through mechanisms that remain to be defined.

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