scholarly journals Comment on “Effect of Multilaminate Small Intestinal Submucosa as a Barrier Membrane on Bone Formation in a Rabbit Mandible Defect Model”

2020 ◽  
Vol 2020 ◽  
pp. 1-2
Author(s):  
Nazanin Daei ◽  
Siavash Ahmadi-Noorbakhsh
Keyword(s):  
Bone Formation ◽  
Small Intestinal Submucosa ◽  
Defect Model ◽  
Barrier Membrane ◽  
Mandible Defect ◽  
Small Intestinal ◽  
Intestinal Submucosa

scholarly journals Effect of Multilaminate Small Intestinal Submucosa as a Barrier Membrane on Bone Formation in a Rabbit Mandible Defect Model

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Weiyi Wu ◽  
Bowen Li ◽  
Yuhua Liu ◽  
Xinzhi Wang ◽  
Lin Tang
Keyword(s):  
Bone Regeneration ◽  
Porous Scaffold ◽  
Small Intestinal Submucosa ◽  
Control Group ◽  
Collagen Membrane ◽  
Defect Model ◽  
Barrier Membrane ◽  
Small Intestinal ◽  
Intestinal Submucosa

A barrier membrane (BM) is essential for guided bone regeneration (GBR) procedures. Absorbable BMs based on collagen have been widely applied clinically due to their excellent biocompatibility. The extracellular matrix (ECM) provides certain advantages that can compensate for the rapid degradation and insufficient mechanical strength of pure collagen membrane due to the porous scaffold structure. Recently, small intestinal submucosa (SIS), one of the most widely used ECM materials, has drawn much attention in bone tissue engineering. In this study, we adopted multilaminate SIS (mSIS) as a BM and evaluated its in vivo and in vitro properties. mSIS exhibited a multilaminate structure with a smooth upper surface and a significantly coarser bottom layer according to microscopic observation. Tensile strength was 13.10 ± 2.56 MPa. In in vivo experiments, we selected a rabbit mandibular defect model and subcutaneous implantation to compare osteogenesis and biodegradation properties with one of the most commonly used commercial collagen membranes. mSIS was retained for up to 3 months and demonstrated longer biodegradation time than commercial collagen membrane. Quantification of bone regeneration revealed significant differences in each group. Micro-computed tomography (micro-CT) revealed that the quantity and maturity of bones in the mSIS group were significantly higher than those in the blank control group (P < 0.05) and were similar to those in a commercial collagen membrane group (P > 0.05) at 4 and 12 weeks after surgery. Hematoxylin and eosin staining revealed large amounts of mature lamellar bone at 12 weeks in mSIS and commercial collagen membrane groups. Therefore, we conclude that mSIS has potential as a future biocompatible BM in GBR procedures.

44: Laparoscopic Augmentation Cystoplasty: A Comparison between Native Ileum Versus Small Intestinal Submucosa in the Porcine Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 12-12
Author(s):  
David A. Anderson ◽  
David S. Wang ◽  
Peter C. Fretz ◽  
Thai T. Nguyen ◽  
Howard N. Winfield
Keyword(s):  
Porcine Model ◽  
Small Intestinal Submucosa ◽  
Augmentation Cystoplasty ◽  
Small Intestinal ◽  
Intestinal Submucosa

Immunomodulatory response of layered small intestinal submucosa in a rat bladder regeneration model

2018 ◽  
Vol 107 (6) ◽  
pp. 1960-1969 ◽  
Author(s):  
Ding Xia ◽  
Qing Yang ◽  
Kar‐Ming Fung ◽  
Rheal A. Towner ◽  
Nataliya Smith ◽  
...  
Keyword(s):  
Small Intestinal Submucosa ◽  
Rat Bladder ◽  
Bladder Regeneration ◽  
Small Intestinal ◽  
Intestinal Submucosa

Small intestinal submucosa xenograft to manage lower urinary tract prostheses perforation: a new path?

2021 ◽  
Author(s):  
Florence Cour ◽  
Pierre Munier ◽  
Kevin Kaulanjan ◽  
Adrien Vidart ◽  
Pierre-Olivier Bosset ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Lower Urinary Tract ◽  
Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa ◽  
Lower Urinary

scholarly journals The use of small intestinal submucosa graft for hypospadias repair: Pilot study

2013 ◽  
Vol 11 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Hazem Orabi ◽  
Ahmed S. Safwat ◽  
Ahmed Shahat ◽  
Hisham M. Hammouda
Keyword(s):  
Pilot Study ◽  
Small Intestinal Submucosa ◽  
Hypospadias Repair ◽  
Small Intestinal ◽  
Intestinal Submucosa

Safety and efficacy of the porcine small intestinal submucosa dural substitute: results of a prospective multicenter study and literature review

2007 ◽  
Vol 106 (6) ◽  
pp. 1028-1033 ◽  
Author(s):  
Ghassan K. Bejjani ◽  
Joseph Zabramski ◽  
_ _
Keyword(s):  
Wound Infection ◽  
Small Intestinal Submucosa ◽  
Csf Leak ◽  
Dural Repair ◽  
Dural Substitute ◽  
Csf Leakage ◽  
Porcine Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

Object Dural substitutes are often needed after neurosurgical procedures to expand or replace dura mater resected during surgery. A new dural repair material derived from porcine small intestinal submucosa (SIS) was evaluated in a prospective multicenter clinical study. Methods Between 2000 and 2003, 59 patients at five different institutions underwent dural reconstruction with the SIS dural substitute, with a minimum follow up of 6 months. The primary goals of the study were to assess the efficacy and safety of the SIS dural substitute according to the rate of cerebrospinal fluid (CSF) leakage, infection, and meningitis. Chiari malformation Type I decompression (32 patients) and tumor resection (18 patients) were the most common procedures performed, with 81% of SIS grafts implanted in the posterior fossa or spine. There was one case of a CSF leak (1.7%), two cases of wound infection (3.4%), and no cases of bacterial meningitis (0%) in the 58 patients available for follow up. In both cases of wound infection, the SIS graft acted as a barrier to infection and was not removed. Intraoperatively, a watertight seal was achieved in all 59 cases. On follow-up imaging available in 27 patients there was no evidence of any adverse reaction to the graft or of cerebral inflammation. Conclusions The SIS dural substitute demonstrated substantial efficacy in these patients after a mean follow up of 7.3 ± 2.2 months. Rates of infection, CSF leakage, and meningitis were comparable to those reported for other dural substitute materials. A lack of adverse reactions to the graft, favorable safety profile, and clinical efficacy all point to the utility of this material as an alternative for dural repair.

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