scholarly journals Modeling Impulsive Intake of Glucose: The Significance of Diet to Glucose-Insulin System

Complexity ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Xiangyun Shi ◽  
Jiaoyan Yao ◽  
Xueyong Zhou
Keyword(s):  
Diabetes Mellitus ◽  
Dietary Advice ◽  
Diabetic Patients ◽  
Exogenous Glucose ◽  
Glucose Intake ◽  
Existence And Stability ◽  
Borderline Diabetes ◽  
Treatment Of Diabetes ◽  
The Stability ◽  
Delay Dependent

It is important to get good dietary advice such as a daily value of exogenous glucose intake to keep blood glucose within reasonable range for everyone, especially for those with diabetes mellitus or with borderline diabetes mellitus. In this paper, two novel glucose-insulin models with impulsive glucose intake are considered to investigate the significance of diet to the glucose-insulin system. For the first model, we prove the positiveness, boundedness, and permanence of the solutions and then the existence and stability of the periodic solutions are demonstrated. For the second model, we consider the insulin secretion delay based on the first model. The sufficient delay-dependent conditions which determine the stability of the periodic solution are also obtained. In addition, the theoretical results are verified by numerical simulation. The results can give people some dietary advice how to prevent diabetes, and also, the intake amount and frequency of the exogenous glucose from diet are recommended for diabetic patients to assist in the treatment of diabetes.

scholarly journals Effectiveness of Coriander Seed Extract in decreasing Blood Glucose level among Diabetic Patients

2020 ◽  
Vol 11 (3) ◽  
pp. 2879-2883
Author(s):  
Sheela R ◽  
Merlin Shiny Sheeba ◽  
Poornima ◽  
Priya
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Low Income ◽  
Seed Extract ◽  
Medical Expenditure ◽  
Diabetic Patients ◽  
Treatment Of Diabetes ◽  
Coriander Seed

Diabetes Mellitus (DM) belongs to a group of metabolic disorders. It is characterised by Chronic Hyperglycemia and disturbance of carbohydrate, lipid and protein metabolism. The cause for this condition arises from a disease in insulin secretion. The International Diabetes Federation (IDF) expresses that worldwide 415 million individuals have Diabetes Mellitus. It also predicts that by 2040 this will ascend to 642 billion. The other prediction is that 77% of individuals with Diabetes live in middle and low-income countries. 12% of the worldwide population spend on the treatment of Diabetes. With the escalating medical expenditure in treating Diabetes, a person from middle or low income may find it challenging to meet the expenses. It is an expected tendency for an individual from this category to opt for a more straightforward treatment that suits their pocket. In the recent past, all over the world, people from all walks of life know essential things about natural remedies. A lot of researches are going on in support of using natural products per se. One such study is this – on the Effectiveness of Coriander Seed Extract in decreasing Blood Glucose level among Diabetic Patients.Coriandrum Sativum is a plant that has been utilised in the administration of Diabetes. It is a herbaceous plant originally from the Mediterranean and Middle Eastern locales, having a place in the family Apiaceae. It is known to have antifungal, antibacterial, free radical searching, and lipid peroxidation activities. The study was conducted to assess the level of pretest and posttest blood glucose level. And, also to evaluate the effect of coriander seed extract in the treatment of Diabetes Mellitus. An experimental study was chosen to assess the effectiveness of coriander seed extract among diabetic clients. The present study was conducted at Mappedu. 60 male and female who come under inclusion criteria were selected by purposive sampling technique. Data was collected by using a socio-demographic variable, and random blood glucose was assessed by CBG machine. The results revealed that coriander seed extract has a significant effect on decreasing blood glucose level among diabetic patients.

scholarly journals Polynomial approach modeling among diabetic patients associated with age in rural hilly population of Dehradun district, Uttarakhand

2018 ◽  
Vol 6 (3) ◽  
pp. 917
Author(s):  
Shubham Pandey ◽  
Ankit Singh ◽  
Ashish Gaur
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Quadratic Polynomial ◽  
Polynomial Model ◽  
Cumulative Distribution ◽  
Diabetic Patients ◽  
Scientific Model ◽  
Cubic Polynomial ◽  
The Stability

Background: Diabetes mellitus is a form of infections that includes issues with the hormone insulin. It is described by constant rise of blood glucose level surprising ordinary esteem. In this paper, an exertion has been made to fit scientific model to diabetic patients and additionally its total dispersion for both genders related with time of rural population from Dehradun district, Uttarakhand.Methods: For this reason, the information have been taken from field overview in rural hilly population of Dehradun district. In this investigation, an endeavor has been given to demonstrate that the polynomial model is attempted to fit to the conveyance of diabetic patients related with age and also its cumulative distribution.Results: The fitted model provides statistically significant values with R2=0.9997 and ρcv2= 0.994857. This is the polynomial of degree four, i.e. bi-quadratic polynomial model. The polynomial model is assumed for the cumulative distribution of diabetic patients associated with age and the fitted model provides statistically significant values providing R2= 0.99998 and ρcv2= 0.999983 and shrink-age coefficient=0.00001414. This is the polynomial of degree three, i.e. cubic polynomial model. From this statistic we see that the fitted models are highly cross-validated, and their shrinkages are 0.004842857 and 0.00001414 for the models (1) and (2) respectively.Conclusions: It is discovered that the distribution of diabetic patients for both genders related with age takes after bi-quadratic polynomial model. In addition, it is found that cumulative distribution of diabetic patients takes as cubic polynomial model. Cross validity prediction power is utilized to the fitted model to verify the stability of the model in this study.

scholarly journals A Case Report of Diabetes Mellitus Type 2 with Adjuvant Use of Bauhinia forficata in Pharmacological Treatment

2020 ◽  
pp. 49-56
Author(s):  
Igor Domingos de Souza ◽  
Eliza Miranda Ramos ◽  
Francisco José Mendes dos Reis ◽  
Hugo Miguel Ramos Vieira ◽  
Iara Barbosa Ramos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Herbal Medicines ◽  
Postprandial Glucose ◽  
Human Organism ◽  
Diabetic Patients ◽  
Unified Health System ◽  
Treatment Of Diabetes ◽  
Bauhinia Forficata

Introduction: Bauhinia forficata, has presented in several interesting effects for the diabetic human organism as the adjuvant treatment. Its effects have been tested and proven in scientific studies in the Unified Health System in Brazil. Aims: Verify the effects of the medicinal plant Bauhinia forficata as an aid in the control of glycemic indexes. Methodology: Case report with exploratory descriptive study with a quantitative approach, using direct observation techniques of the Dáder method adapted to the use of herbal medicines such as Bauhinia forficata.  Results: In this study, there was a decrease in triglyceride levels with a drop of 77%, which despite not reaching the recommended values ​​for diabetic patients (<150 mg/dl) is quite significant. Conclusion: Bauhinia forficata used in the treatment of diabetes mellitus has anti-inflammatory actions that contribute to reduce glycated hemoglobin and, thus decrease fasting and postprandial glucose.

scholarly journals Unsaturated fatty acid as functional food for the treatment of Diabetes mellitus type 2

2021 ◽  
Vol 10 (9) ◽  
pp. e41410917231
Author(s):  
Naiane Silva Cardoso ◽  
Julia Rosental de Souza Cruz ◽  
Ramon Alves de Oliveira Paula ◽  
Stella Maris da Silveira Duarte ◽  
Maria Rita Rodrigues ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Glucose Transporter ◽  
Unsaturated Fatty Acids ◽  
Monounsaturated Fatty Acids ◽  
Pancreatic Function ◽  
Diabetic Patients ◽  
Treatment Of Diabetes

Several studies have been demonstrating to a relationship between unsaturated fatty acids, improvement of pancreatic function and insulin secretion. In this context, this review presents the most recent findings on the pathophysiology of type 2 diabetes mellitus, the action mechanism of unsaturated fatty acids on pancreatic function, and clinical studies in diabetic patients. We evaluated here articles from MedLine/PubMed and the Science direct database, published between 2014 and 2020. Of the 637 results, 13 were selected. From their analysis, we could observe that mono and polyunsaturated fatty acids can improve glycemic control as well as reduce cardiovascular risk. The most recurrent antidiabetic action regarding monounsaturated fatty acids is the ability to preserve insulin signaling, whereas polyunsaturated fatty acids action consists in the increasing expression of the type 4 glucose transporter. However, a complete understanding of the relationship between fatty acids, insulin and inflammation should be considered in future investigations.

Socio-Demographic Features and Knowledge of Diabetes Mellitus among Diabetic Patients in Kuwait

1997 ◽  
Vol 17 (1) ◽  
pp. 65-76 ◽  
Author(s):  
Mahmoud Al-Bustan ◽  
Sobia Majeed ◽  
Milad S. Bitar ◽  
Adnan Al-Asousi
Keyword(s):  
Diabetes Mellitus ◽  
Educational Achievement ◽  
Diabetes Education ◽  
Sample Survey ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Male Ratio ◽  
Significant Difference ◽  
Individual Knowledge ◽  
Treatment Of Diabetes

Objective: To determine the socio-demographic profile and assess knowledge about the nature, symptoms, complications, and treatment of diabetes mellitus among diabetic patients in Kuwait. Methods and Results: A cross-sectional sample survey of 788 patients attending specialized diabetic clinics was conducted in 1995. Kuwaitis were significantly more represented in this sample than in the general population (52.5% versus 37%). Female to male ratio among Kuwait population was 1.07 and among non-Kuwaitis it was 0.28. Age at diagnosis ranged between sixteen to eighty years with a mean of 48 ± 10.8 years. Overall knowledge was assessed by percentage of correct responses for individual knowledge questions. There was no significant difference in knowledge of diabetes seen among Kuwaitis (66%) and non-Kuwaitis (64%). No sex difference in knowledge was seen. Knowledge about diabetes was highest among diabetic patients with increasing educational achievement but lowest with advancing age. Conclusion: Most patients lack a lot of information that could have a significant impact on their motivation and ability to remain healthy. To overcome this growing problem, instructing a standard diabetes education system was found to be one way of improving in morbidity due to diabetes and reduced hospital admission.

Phenformin-Induced Lactic Acidosis: A Forgotten Adverse Drug Reaction

1993 ◽  
Vol 27 (10) ◽  
pp. 1183-1187 ◽  
Author(s):  
Margaret E. McGuinness ◽  
Robert L. Talbert
Keyword(s):  
Diabetes Mellitus ◽  
Lactic Acidosis ◽  
Lactate Concentration ◽  
Blood Gases ◽  
Diabetic Patients ◽  
Arterial Blood ◽  
The Us ◽  
History Of ◽  
Treatment Of Diabetes ◽  
Upper Abdominal

OBJECTIVE: To document a case of severe metabolic and lactic acidosis secondary to phenformin. This adverse effect has almost been forgotten as 15 years have passed since its withdrawal from the US market. CASE SUMMARY: A 64-year-old man presented with a four-day history of left upper abdominal pain and a one-week history of constipation and diarrhea. His arterial blood gases were pH 6.7, pCO2 2.80 kPa, and pO2 12.00 kPa with 90% oxygen saturation on room air. Serum chemistries indicated an unmeasurable serum bicarbonate concentration, anion gap 52 mmol/L, lactate concentration 29.5 mmol/L, blood urea nitrogen 6.63 mmol/L, creatinine 229.84 μmol/L, and blood glucose 4.35 mmol/L. There were low levels of urine and serum ketones. In the emergency department, he required resuscitation for hypotension and bradycardia. His diagnosis was lactic and ketoacidosis secondary to phenformin. The patient was treated with NaCl 0.9%, sodium bicarbonate, insulin, and hemodialysis. Although he survived the initial insult of lactic and ketoacidosis, his hospital course was complicated and he died on hospital day 105. CONCLUSIONS: Treatment of lactic acidosis is difficult and challenging. The continued availability of phenformin in neighboring countries, and the renewed interest in biguanide therapy for treating diabetes mellitus make it an important diagnosis of exclusion in diabetic patients who present with severe acidosis. Metformin, another biguanide under investigation for the treatment of diabetes mellitus, is associated with a much lower incidence of lactic acidosis than is phenformin.

scholarly journals Metformin and Lactic Acidosis in Diabetic Patients

2021 ◽  
Vol 3 (1) ◽  
pp. 21
Author(s):  
Baiyan Zhao ◽  
Zhilu Li ◽  
Zhangyi He ◽  
Xinxin Zhou ◽  
Yiying Yu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lactic Acidosis ◽  
Clinical Treatment ◽  
Diabetic Patients ◽  
Fatality Rate ◽  
Basic Drug ◽  
Treatment Of Diabetes ◽  
The Relationship

Metformin is the basic drug in the clinical treatment of Diabetes, often used in the treatment of Type 2 Diabetes Mellitus (T2DM).Its effect has been fully verified in the clinical treatment of T2DM. However, in the treatment of T2DM with metformin, there is still a certain probability of related lactic acidosis, and the fatality rate is high. Therefore, is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients? This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis, so as to further explore the relationship between metformin and lactic acidosis in diabetic patients, and provide help and reference for metformin drugs in the clinical treatment of T2DM.

In Silico ADMET Evaluation of Natural DPP-IV Inhibitors for Rational Drug Design against Diabetes

2020 ◽  
Vol 21 (10) ◽  
pp. 768-777
Author(s):  
Rajeev K. Singla ◽  
Bairong Shen
Keyword(s):  
Diabetes Mellitus ◽  
In Silico ◽  
Rational Drug Design ◽  
Diabetic Patients ◽  
Dpp Iv ◽  
Rational Drug ◽  
In Silico Admet ◽  
Pharmacokinetic Properties ◽  
Treatment Of Diabetes ◽  
The Many

Background: As a metabolic and lifestyle disorder, diabetes mellitus poses a prodigious health risk. Out of the many key targets, DPP-IV is one of the very imperative therapeutic targets for the treatment of diabetic patients. Methods: In our current study, we have done the in silico simulations of ADME-T properties for naturally originated potent DPP-IV inhibitors like quinovic acid, stigmasterol, quinovic acid-3-beta-D-glycopyranoside, zygophyloside E, and lupeol. Structural topographies associated with different pharmacokinetic properties have been systematically assessed. Results: Glycosylation on quinovic acid is found to be noteworthy for the improvement of pharmacokinetic and toxicological properties, which leads to the prediction that zygophyloside E can be further tailored down to get the lead DPP-IV inhibitor. Conclusion: This assessment provides useful insight into the future development of novel drugs for the treatment of diabetes mellitus.

scholarly journals Priorities of self-monitoring of blood glucose in a treatment of diabetes mellitus

2019 ◽  
Vol 10 (1) ◽  
pp. 36-41
Author(s):  
Elena V. Biryukova ◽  
Mikhail V. Shinkin ◽  
Catherine S. Ganekova
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Glycated Hemoglobin ◽  
Point Of View ◽  
Diabetic Patients ◽  
Self Monitoring ◽  
Glucose Lowering ◽  
Lowering Therapy ◽  
Treatment Of Diabetes ◽  
Glucose Lowering Therapy

Aim. To describe a role of self-monitoring of glycemia in a treatment of diabetes mellitus (DM) and in a prevention of vascular complications of DM. Materials and methods. Data of 57 scientific sources from Russian and foreign literature published within 2005-2017 are considered. Results and conclusions. DM is a chronic disease associated with a development of micro- and macrovascular complications and to prevent them is an important task of modern medicine. In patients with DM an incidence of cardiovascular diseases is 2-3 times higher compared with the general population. Hyperglycemia is among the major damaging factors for the cardiovascular system. Clinical studies have clearly demonstrated that programs of therapeutic management of diabetic patients which include regular self-monitoring of glycemia lead to a better reduction of glycated hemoglobin levels compared to programs without self-monitoring as well as they help many patients to avoid late complications. СКГ rate is correlated with glycated hemoglobin levels. Regular self-monitoring allows you to avoid sudden and dangerous fluctuations in glycemia, including hypoglycemia, which contribute to high cardiovascular risk. The use of self-monitoring of glycemia in combination with structured patient education is associated with improving the quality of life of patients with DM. Current view on self-monitoring implies a certain frequency of blood glucose systematic measurement (varies depending on the type of glucose-lowering therapy and the degree of diabetes compensation) and is an important reference point used by both the doctor and the patient to assess a treatment outcome and to correct it if necessary. An availability of modern glucometers and skills of their correct and regular use turn a patient into an active and valuable participant in a management of DM. Achieving and maintaining the target glycemia levels depends largely on an accuracy of the glucometer since measurement results provide the basis for changing a glucose-lowering therapy if necessary. From the physician's point of view, the most important criterion for selecting a glucometer is compliance with the accuracy standards, and from the patient’s point of view this is convenience and ease of use. Thanks to improving technologies that increases an accuracy of blood glucose measurements, the procedure for self-monitoring of glycemia is simplified, which contributes to glucose-lowering therapy effectiveness and treatment compliance.

THE TREATMENT OF DIABETES MELLITUS WITH ORAL TOLBUTAMIDE

1957 ◽  
Vol 35 (1) ◽  
pp. 953-960
Author(s):  
Allen Gold
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dose ◽  
Diabetic Control ◽  
Diabetic Patients ◽  
Age Group ◽  
Exogenous Insulin ◽  
Duration Of Diabetes ◽  
Group A ◽  
Treatment Of Diabetes ◽  
Group B

Experience in the treatment of 76 diabetic patients with tolbutamide is described. In 25 patients the drug was discontinued after trials of from 1 week to several months because of poor diabetic control. These treatment failures could be divided into: Group A, completely unresponsive to tolbutamide; Group B, showing hypoglycemic response in the presence of exogenous insulin only; and Group C, responsive in the absence of added insulin, but response inadequate for proper diabetic control.Fifty-one patients who would otherwise have needed insulin were considered adequately controlled on diet and tolbutamide, 1.0 to 3.0 g. daily. No toxic effects were observed. Patients who responded to the drug had a higher mean age, a shorter duration of diabetes, and a lower mean insulin dose. Many exceptions to these individual criteria occurred.It is the author's opinion that oral tolbutamide is established as an adequate replacement for insulin injections in a large proportion of diabetics in the older age group.

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