THE TREATMENT OF DIABETES MELLITUS WITH ORAL TOLBUTAMIDE

1957 ◽  
Vol 35 (1) ◽  
pp. 953-960
Author(s):  
Allen Gold
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dose ◽  
Diabetic Control ◽  
Diabetic Patients ◽  
Age Group ◽  
Exogenous Insulin ◽  
Duration Of Diabetes ◽  
Group A ◽  
Treatment Of Diabetes ◽  
Group B

Experience in the treatment of 76 diabetic patients with tolbutamide is described. In 25 patients the drug was discontinued after trials of from 1 week to several months because of poor diabetic control. These treatment failures could be divided into: Group A, completely unresponsive to tolbutamide; Group B, showing hypoglycemic response in the presence of exogenous insulin only; and Group C, responsive in the absence of added insulin, but response inadequate for proper diabetic control.Fifty-one patients who would otherwise have needed insulin were considered adequately controlled on diet and tolbutamide, 1.0 to 3.0 g. daily. No toxic effects were observed. Patients who responded to the drug had a higher mean age, a shorter duration of diabetes, and a lower mean insulin dose. Many exceptions to these individual criteria occurred.It is the author's opinion that oral tolbutamide is established as an adequate replacement for insulin injections in a large proportion of diabetics in the older age group.

THE TREATMENT OF DIABETES MELLITUS WITH ORAL TOLBUTAMIDE

1957 ◽  
Vol 35 (11) ◽  
pp. 953-960 ◽  
Author(s):  
Allen Gold
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dose ◽  
Diabetic Control ◽  
Diabetic Patients ◽  
Age Group ◽  
Exogenous Insulin ◽  
Duration Of Diabetes ◽  
Group A ◽  
Treatment Of Diabetes ◽  
Group B

Experience in the treatment of 76 diabetic patients with tolbutamide is described. In 25 patients the drug was discontinued after trials of from 1 week to several months because of poor diabetic control. These treatment failures could be divided into: Group A, completely unresponsive to tolbutamide; Group B, showing hypoglycemic response in the presence of exogenous insulin only; and Group C, responsive in the absence of added insulin, but response inadequate for proper diabetic control.Fifty-one patients who would otherwise have needed insulin were considered adequately controlled on diet and tolbutamide, 1.0 to 3.0 g. daily. No toxic effects were observed. Patients who responded to the drug had a higher mean age, a shorter duration of diabetes, and a lower mean insulin dose. Many exceptions to these individual criteria occurred.It is the author's opinion that oral tolbutamide is established as an adequate replacement for insulin injections in a large proportion of diabetics in the older age group.

scholarly journals To study levels of serum fibrinogen in type 2 diabetes mellitus and its association with diabetic microvascular complications

2017 ◽  
Vol 4 (1) ◽  
pp. 10
Author(s):  
Gurinder Mohan ◽  
Ranjeet Kaur ◽  
Aakash Aggarwal ◽  
Parminder Singh
Keyword(s):  
Diabetes Mellitus ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
High Serum ◽  
Diabetic Patients ◽  
Coagulation Disorder ◽  
Urine Albumin ◽  
Group A ◽  
Diabetic Microvascular Complications ◽  
Group B

Background: Diabetes mellitus is a hypercoagulable state associated with atherosclerosis leading to development of vascular complications, including microvascular complications.Methods: In our study a total of 60 diabetic patients with duration of diabetes more than 5 years, attending the OPD/ indoor of SGRDIMSR, Amritsar, Punjaqqb, India were included. They were divided in two groups, group A of 30 patients including diabetics with any of the three microvascular complications (diabetic nephropathy, diabetic retinopathy and diabetic neuropathy) and group B of 30 patients including diabetics without any microvascular complication. Group C comprised of 30 age and sex matched non-diabetic subjects who served as controls. Subjects with liver cirrhosis, malignancy or coagulation disorder were excluded. After taking the consent, detailed history taking and detailed physical examination and relevant investigations were done. The serum fibrinogen (hemostasis marker), HBA1C and UACR (urine albumin creatinine ratio) along with routine investigations were measured.Results: It was observed that serum fibrinogen levels were significantly higher in diabetic patients (266.16±54.73 mg/dl) as compared to non-diabetic controls (174.66±18.32 mg/dl); p <0.001.Further, serum fibrinogen levels were found to be significantly higher in diabetic patients with microvascular complications (293.43±51.09 mg/dl) as compared to those without microvascular complications (238.90±44.12); p<0.001.Conclusions: Significantly high serum fibrinogen level was found in diabetic patients as compared to controls and was in positive correlation with development of microvascular complications.

scholarly journals Relationship between Hemoglobin A1c Level and Severity of Coronary Artery Disease Among The Hospitalized Patients with Acute Coronary Syndrome

2018 ◽  
Vol 33 (2) ◽  
pp. 80-84
Author(s):  
Syed Dawood Md Taimur ◽  
Sahela Nasrin ◽  
M Maksumul Haq ◽  
MA Rashid ◽  
Hemanta I Gomes ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Hemoglobin A1c ◽  
Diabetic Patients ◽  
Age Group ◽  
Coronary Syndrome ◽  
Vessel Disease ◽  
Group A ◽  
Artery Disease ◽  
Group B

Background : Diabetes mellitus is one of the important risk factors for coronary artery disease. The hemoglobin A1c is used for evaluating glycemic control in diabetic patients. Here, we conducted the study to evaluate the relationship between HbA1c level and severity of coronary artery disease among the hospitalized patients with ACS. Materials & Methods : This cross sectional study was conducted in the department of Cardiology, Ibrahim Cardiac Hospital & Research Institute, Dhaka, Bangladesh from September 2015 to December 2015. Total of one hundred patients were studied and they were grouped on the basis of their glycaemic status. One hundred patients with acute coronary syndrome were enrolled in this study. Out of them fifty were diabetic (HbA1c>6.5%) and rest of were nondiabetics (HbA1c<6.5%) ( group-A and B). Results: Out of one hundred patients fifty eight were male and fourty two were female. Mean age of patients in group-A was 58.54±10.22 years and mean age of patients in group-B was 54.52±13.69 years. Mean age of male and female was 57.72±11.48 years and 54.0±13.08 years respectively. Mean HbA1c of patients in group-A was 11.43±1.43% and group-B was 6.34±0.915%. 38% of group-A and 22% of group-B had triple vessel disease, 26% of group-A and 20% of group- B had double vessel disease and 28% of group-A and 18% of group-B had single vessel disease, and 8% of group-A and 40% of group-B had normal coronary arteries. 48% patients of age group 46-50 in group-A had more incidence in coronary artery disease than other age group which was statistically significant ( p=0.035). 61-75 years age group in group-B patients had coronary artery disease than other age groups which was statistically not significant(p=0.084). Patients of group-A was significantly relation with coronary artery disease (p>.001) and six times greater coronary artery disease than patients of group-B (OR= 6.15, 95% CI for OR =2.074 -18.289). Conclusions: In this way the importance of appropriate glycaemic control has been emphasized in diabetic patients. This study showed the relation between HbA1c levels and the severity of CAD in patient with type-II diabetes mellitus .Our findings demonstrate that elevated HbA1c level was risk factor for severity of coronary artery disease in ACS patients. Bangladesh Heart Journal 2018; 33(2) : 80-84

Diabetes mellitus: An adverse prognosis in cancer patients—Study of a cohort treated at Instituto Oncológico Henry Moore (IOHM).

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e18212-e18212
Author(s):  
Ernesto Gil Deza ◽  
Julio Cesar Bragagnolo ◽  
Eduardo L. Morgenfeld ◽  
Marta Dragosky ◽  
Natasha Gercovich ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cox Regression ◽  
Diabetic Patients ◽  
Cancer Evolution ◽  
Oncological Treatment ◽  
Oral Hypoglycemics ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Adverse Factor

e18212 Background: Numerous studies have evaluated the unfavorable impact of diabetes mellitus (DM) on cancer evolution. The objective of this paper is to study the coexistence of DM and cancer diagnosis; and its influence on the evolution of a cohort followed at IOHM. Methods: Between 9/26/2012 and 11/28/2018 all new patients (Pt) admitted to IOHM filled out a Past Medical History Form (PMHF) (ASCO 2013 ABST. e17539) with their preexisting clinical conditions.The database was locked and anonymized. Those with a history of DM or who were taking insulin and/ or oral antidiabetics were selected (Group A). The stage and evolution of their tumors were compared with those of non-diabetic patients (Group B). Results: Out of 15,617 Pt, 1,829 Pt (11,7%) had DM (Group A); 1,087 Pt were being treated with oral hypoglycemics (59%); 178 Pt with insulin (10%) and 564 Pt (31%) were not on antidiabetics drugs. They were compared to 13,788 Pt without DM (Group B). Oncological treatment was similar in both groups. Mortality was greaterin DM Patients adjusted by sex, age, PS, BMI, Dx and stage; Multivariate Cox Regression (p = 0.0001). The results are presented in the chart below. Conclusions: 1) In a cohort of 15,617 cancer Pt, 11,7% had DM. 2) DM Pt's tumors were more advanced. 3) Under similar treatments, DM Pt presented higher mortality. 4) Based on this, we advocate for DM in oncological Pt to be considered as an independent adverse factor.[Table: see text]

scholarly journals Pattern of Musculoskeletal Disorders in Adult Diabetics patient

2019 ◽  
Vol 48 (1) ◽  
pp. 5-12
Author(s):  
Shaila Sharmin ◽  
Fatema Newaz ◽  
Syed Mozaffor Ahmed ◽  
Abu Shahin ◽  
Md Israt Hasan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Musculoskeletal Disorders ◽  
Frozen Shoulder ◽  
Diabetic Patients ◽  
Physical Medicine ◽  
Osteoarthritis Of Knee ◽  
Physical Medicine And Rehabilitation ◽  
Group A ◽  
Group B ◽  
Flexor Tenosynovitis

Diabetes mellitus is associated with several musculoskeletal (MSK) disorders. Due to increased incidence and life expectancy causes increased prevalence and clinical importance of MSK alterations in diabetic subjects. It is difficult to find out the direct relation with metabolic control. This study was conducted to explore the pattern of musculoskeletal disorders in the diabetic patients. A cross-sectional study was conducted from January' 2016 to June' 2016 at Department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University, Dhaka with 190 cases divided in two groups. Patients aged 40-70 years with musculoskeletal disorder with diabetes mellitus (type 2) for five years attending in the department of Physical Medicine and Rehabilitation were included in group A. Patients with MSK disorder without diabetes aged 40- 70 years were included in group B. Main outcome measures were done by Chi square test and unpaired t test were calculated by using SPSS-20. Out of 190 patients, more than half (53.68%) patients were belonged to age 51- 60 years in group A and 49(51.58%) in group B. Majority (56.84%) patients were female in group A and 43(45.26%) in group B. Twenty three (24.21%) patients were house wives in group A and 25(26.32%) in group B. Fifty two (54.73%) patients had osteoarthritis of knee in group A and 26(27.36%) in group B. Twenty one (22.11%) patients had frozen shoulder in group A and 9(9.47%) in group B. Sixteen (16.84%) patients had Flexor tenosynovitis in group A and 04(4.21%) in group B. Fifteen (15.78%) patients had Fibromyalgia in group A and 05(5.26%) in group B. Twelve (12.63%) patients had Planter fascities in group A and 03(3.16%) in group B. Which were statistically significant (p<0.05) but other musculoskeletal disorders were not statistically significant (p>0.05) between two groups. More than half patients were belonged to age 51-60 years and female were predominate in both groups. Common musculoskeletal disorders in diabetic patients were osteoarthritis of knee, frozen shoulder, Flexor tenosynovitis, Fibromyalgia, Planter fascities, Rheumatoid arthritis, Carpel tunnel syndrome, Lumbar spondylosis, Cervicalspondylosis and DISH. This study will also be helpful for different organizations working in this area including physiatrist in their program for delivering a comprehensive treatment service. As a result patients were more benefited. Bangladesh Med J. 2019 Jan; 48 (1): 5-12

scholarly journals Relationship of C-peptide levels to duration of Type 1 diabetes – A study from Sindh, Pakistan

2020 ◽  
Vol 36 (4) ◽  
Author(s):  
Asher Fawwad ◽  
Nazish Waris ◽  
Saima Askari ◽  
Graham Ogle ◽  
Muhammad Yakoob Ahmedani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Group ◽  
C Peptide ◽  
Duration Of Diabetes ◽  
Group A ◽  
Group B ◽  
Relationship Of

Objective: To determine the relationship of C-peptide levels with duration of type 1 diabetes mellitus. Methods: This prospective study was conducted at Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University (BMU), Karachi-Pakistan from December 2013 to December 2015. A total of 184 subjects were recruited during the study period, 100 in Group-A and 84 in Group-B. Subjects clinically diagnosed with type 1 diabetes Mellitus (T1DM) were categorized into two groups based on duration of diabetes: Group-A (with ≤1-year duration of diabetes) and Group-B (with >1-year duration of diabetes). Ninety-nine of the 100 enrolled subjects in Group-A were diagnosed as having T1DM, with one subject who presented at 11.9 years of age and diagnosed with T2DM excluded from this study. Blood samples were drawn for biochemical parameters. Data for baseline characteristics and clinical parameters (HbA1c and C-peptide) were obtained from hospital management system of BIDE. Results: Fifty-seven (57.6%) subjects in Group-A, and 39 (46.4%) in Group-B were males. Mean±SD duration of diabetes (years) was 0.64±0.6 (range 0-1) in Group-A, and 7.65±5.5 (range 1-23) in Group-B. Family history of T1DM and T2DM was 1(1%) and 27(27.3%) in Group-A, and 8(9.52%) and 21(25%) in Group-B, respectively. Twenty-one (21.2%) subjects presented in diabetic ketoacidosis (DKA) in Group-A and 18(21.4%), in Group-B. Mean±SD for HbA1c was non-significantly higher in Group-A 11.12±2.31 compared to Group-B 10.42±1.45. Mean±SD for C-peptide was 1.91±1.53 ng/mL (0.60±0.481 nmol/L) in Group-A, and 1.82±1.01 (0.57±0.32 nmol/L) in Group-B (p=0.984). Conclusion: The study found that subjects with longer duration of T1DM had non-significantly decreased C-peptide levels compared to a group in which C-peptide was measured at or soon after diagnosis. Furthermore, C-peptide levels in many subjects with longer duration were higher than expected in classic T1DM. doi: https://doi.org/10.12669/pjms.36.4.1531 How to cite this:Fawwad A, Waris N, Askari S, Ogle G, Ahmedani MY, Basit A. Relationship of C-peptide levels to duration of Type 1 diabetes – A study from Sindh, Pakistan. Pak J Med Sci. 2020;36(4):---------. doi: https://doi.org/10.12669/pjms.36.4.1531 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals SERUM SIALIC ACID CONCENTRATION AND TYPE II DIABETES MELLITUS

2006 ◽  
Vol 13 (04) ◽  
pp. 508-510
Author(s):  
MOHAMMAD JAWAID SABZWARI ◽  
MUKHTAR AHMAD ◽  
MUHAMMAD TAHIR MAJEED ◽  
Muhammad Riaz ◽  
Muhammad Umair
Keyword(s):  
Diabetes Mellitus ◽  
Sialic Acid ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Diabetic Patients ◽  
Type Ii ◽  
Serum Triglycerides ◽  
Serum Sialic Acid ◽  
Group A ◽  
Group B

Sialic Acid (SA) is an acetylated product of neuraminic acid. In presentstudy, the relationship between sialic acid and type II diabetic patients was investigated. Ninety (90) subjects, 41 malesand 49 females, were included in the study. They were divided into two groups according to presence or absence oftype II diabetes mellitus (DM). Group A comprised of 72 patients with type II DM and group B 18 subjects withoutdiabetes mellitus as a control group. The following parameters were assessed: sialic acid, blood glucose, lipid profile(serum triglycerides and total cholesterol) and HbA1c. Type II DM Patients had higher levels (P<0.05) of sialic acid(2.259±0.252 mmol/L) as compared to the control group (2.048±0.32 mmol/L).

scholarly journals FVC, FEV1 and FEV1/FVC% in Type 2 Diabetes and Their Relationships with Duration of the Disease

1970 ◽  
Vol 4 (2) ◽  
pp. 81-87 ◽  
Author(s):  
Md Omar Ali ◽  
Shelina Begum ◽  
Noorzahan Begum ◽  
Taskina Ali ◽  
Sultana Ferdousi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Metabolic Diseases ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Duration Of Diabetes ◽  
Group A ◽  
Type 2 Diabetic

Background: Diabetes mellitus is a chronic debilitating disease affecting various organs including lungs. The magnitude of the complications of this disease is related to its duration. Objective: To observe FVC, FEV1 and FEV1/FVC% in type 2 diabetic patients and their relationship with duration of the disease. Methods: This cross-sectional study was carried out in the Department of Physiology, BSMMU, Dhaka, from July 2007 to June 2008 on 60 type 2 diabetic male patients of age 40-60 years (Group B). For comparison, 30 age and BMI matched apparently healthy non diabetic subjects (Group A) were also studied. Patients were selected from the out patient department of Bangladesh Institute of research on diabetes, endocrine and metabolic diseases. Based on duration of diabetes, diabetic patients were divided into B1 (5-10 years) and B2 (10-20 years). FVC, FEV1 and FEV1/FVC% of all the subjects were measured by a digital microspirometer. Data were analyzed by One way ANOVA test, Unpaired Student's 't' test and Pearson's correlation coefficient test as applicable. Results: Mean of the percentage of the predicted values of FVC and FEV1, were significantly (p<0.001) lower in both those of Gr. B1 and B2 than that in A and were also significantly (p<0.001) lower in Gr. B2 when compared with Gr. B1. Again, FEV1/FVC% was significantly (p<0.01) higher in Gr. B2 than those in Gr. B1 and A whereas this value was lower in Gr. B1 than those of group A but it was not statistically significant. However, FVC and FEV1 showed negative and FEV1/FVC% showed positive correlations with duration of diabetes. All these correlations were statistically non significant. Conclusion: From the result of this study it can be concluded that the ventilatory function of lung may be reduced in type 2 diabetes which may be related to the duration of the disease. Key words: FVC, FEV1, diabetes mellitus DOI: 10.3329/jbsp.v4i2.4178 J Bangladesh Soc Physiol. 2009 Dec;4(2): 81-87  

scholarly journals Study of Thyroid Disorders in Type 2 Diabetic and Non-Diabetic Patients Attending a Tertiary Care Hospital

2020 ◽  
Vol 7 (46) ◽  
pp. 2669-2673
Author(s):  
Ravinder Pal Singh ◽  
Rajan Goyal ◽  
Nitin Kumar Gupta ◽  
Prerna Prerna ◽  
Abhinav Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Tertiary Care ◽  
Overt Hypothyroidism ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Healthy Individuals ◽  
Group A ◽  
Group B ◽  
Type 2 Diabetic

BACKGROUND Patients with DM are at increased risk of thyroid disease, especially those with poor glycaemic control. The following mechanisms are thought to be responsible. In patients with DM, the nocturnal TSH peak is blunted or abolished; the TSH response to TRH, from the hypothalamus, is impaired thus leading to hypothyroidism. We wanted to study the thyroid disorders in type 2 diabetic and non-diabetic patients attending a tertiary care hospital. METHODS This is an analytical observational study conducted among 100 type 2 diabetic and 100 non-diabetic patients attending medicine OPD in the Department of General Medicine of Narayan Medical College & Hospital, Jamuhar, Distt. Rohtas over a 6- month period from Oct 2019 to April 2020. RESULTS The mean age of group A and group B was found to be 51.79 ± 10.374 and 49.86 ± 9.538 respectively. In group A (diabetes mellitus patients), 71 (71 %) patients were euthyroid whereas in group B (healthy individuals) 84 (84 %) patients were euthyroid. In Group A (diabetes mellitus group) either subclinical or overt hypothyroidism was seen in 26 (26 %) patients and hyperthyroidism was seen in 3 (3 %) patients. In Group B (healthy individuals) either subclinical or overt hypothyroidism was seen in 14 (14 %) patients and hyperthyroidism was seen in 2 (2 %) patients. CONCLUSIONS The comparison of the patients of control and cases groups on the basis of whether they had a normal or abnormal thyroid function test showed that patients with diabetes mellitus type 2 (Group A) were more likely to be having abnormal thyroid function test as compared to healthy individuals (Group B) and this difference was found to be statistically significant (p = 0.027). KEYWORDS Type 2 DM, Hypothyroid, Hyperglycaemia, Hyperthyroid

scholarly journals Comparative Study of the Effect of Ethanol Extract of Psidium Guajava Linn Leaves with Glibenclamide on Experimentally Induced Diabetes Mellitus in Rats

2017 ◽  
Vol 5 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Azmary Momtaz ◽  
Khaleda Sharmin ◽  
Sharmin Rahman ◽  
Nashid Sultana ◽  
Rayhana Sharmin
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Ethanol Extract ◽  
Psidium Guajava ◽  
Diabetic Control ◽  
Control Group ◽  
Diabetic Control Group ◽  
Group A ◽  
Group B ◽  
Experimentally Induced

Background: Diabetes Mellitus is a major health problem not only in urban but also in the rural areas of Bangladesh. Regarding its treatment, a suitable drug is yet to be available which can permanently cure this disease. Over 400 traditional plants have been reported for the treatment of diabetes, but only a small number have received scientific and medical evaluation to assess their efficacy.Objective: The study was performed to compare the anti diabetic effect of Psidium guajava Linn leaves with an oral anti diabetic drug (Glibenclamide), in experimentally induced diabetic rats.Materials and method: The experiment was carried out in the department of Pharmacology & Therapeutics of Dhaka Medical College, Dhaka, Bangladesh from July 2012 to June 2013. Twenty four healthy rats of Long Evans Norwegian strain were divided into 4 groups (group A, B, C and D) comprising 6 rats in each. Group A (normal control) received standard rat food for 14 days. Diabetes was induced by administration of Alloxan 120 mg/kg/body weight in group B, C and D. Group B (diabetic control group) was given standard rat food. Group C and D was treated with ethanol extract of Psidium guajava leaves 100 mg/kg body weight and Glibenclamide 1.5 mg/kg/day orally respectively. Total duration of the experiment was 15 days.Results: Administration of ethanol extract of Psidium guajava leaves in group C and Glibenclamide in group D produced a significant reduction (p<0.001) in blood glucose level as compared to group B (diabetic control group).Conclusion: Ethanol extract of Psidium guajava leaves can be considered as a potential anti diabetic agent like Glibenclamide but it requires further investigations.Delta Med Col J. Jan 2017 5(1): 9-14

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