scholarly journals Preparation and Characterization of a Novel Polysaccharide-Iron(III) Complex in Auricularia auricula Potentially Used as an Iron Supplement

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Tong Liu ◽  
Tingting Liu ◽  
Hongcheng Liu ◽  
Hongxiu Fan ◽  
Bingyu Chen ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Water Solubility ◽  
High Efficiency ◽  
Ph Value ◽  
Health Benefit ◽  
Iron Complex ◽  
Deficiency Anemia ◽  
Iron Supplement

Iron deficiency anemia has been a widespread disease. As an effective and stable iron supplement, the physiochemical properties of the polysaccharide iron complex have been widely studied. In this study, we characterized a novel polysaccharide-iron(III) complex extracted in an edible fungal species Auricularia auricular (AAPS-iron(III)). The highest iron content (28.40%) in the AAPS-iron(III) complex was obtained under the optimized preparation conditions including an AAPS to FeCl3∙6H2O ratio of 2:3 (w/w), a pH value of 8.0 in solution, a reaction temperature of 50°C, and a reaction time of 3 h. The physical and chemical properties of the AAPS-iron(III) complex were characterized by qualitative and quantitative analyses using scanning electron microscope, particle size distribution, thermogravimetric analyzer, Fourier transform infrared spectroscopy, circular dichroism, and 1H nuclear magnetic resonance. Result showed that, although the iron was bound to the polysaccharide, it was released under artificial gastrointestinal conditions. The AAPS-iron(III) complex exhibited high stability (under 50-256°C) and water solubility. The AAPS-iron(III) complex also showed high antioxidant activity in vitro, demonstrating an additional health benefit over other typical nonantioxidant iron nutritional supplements. Furthermore, the AAPS-iron(III) complex showed high efficiency on the treatment of the iron deficiency anemia in the model rats. Therefore, the AAPS-iron(III) complex can be used as a nutritional fortifier to supply iron in industrial processing and to assist the treatment of iron deficiency anemia.

Concomitant Administration of Oral Iron Supplement with Antisecretory Agents among Hospitalized Adults with Iron Deficiency Anemia

2019 ◽  
Vol 119 (9) ◽  
pp. A22
Author(s):  
C. Sanchez ◽  
V. Rodriguez Aponte ◽  
A. Cintron Rosado ◽  
J. Molina Cruz ◽  
J. Morales Irizarry ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Concomitant Administration ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Iron Supplement

In vitro cytokine production in patients with iron deficiency anemia

2004 ◽  
Vol 113 (3) ◽  
pp. 340-344 ◽  
Author(s):  
Michael Bergman ◽  
Hanna Bessler ◽  
Hertzel Salman ◽  
Dimitri Siomin ◽  
Rachel Straussberg ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Cytokine Production ◽  
Deficiency Anemia

Iron Deficiency Anemia: Recovery from in vitro Oxidative Stress

1993 ◽  
Vol 90 (2) ◽  
pp. 94-98 ◽  
Author(s):  
M. Bartal ◽  
D. Mazor ◽  
A. Dvilansky ◽  
N. Meyerstein
Keyword(s):  
Oxidative Stress ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia

scholarly journals MÖSSBAUER SPECTROSCOPY OF FERROUS FUMARATE IN PHARMACEUTICAL PRODUCT USED TO TREAT ANEMIA

2020 ◽  
Vol 21 (3) ◽  
pp. 43-49
Author(s):  
F.G. Vagizov ◽  
◽  
J. Nicolas Pineda M. ◽  
Keyword(s):  
Iron Deficiency ◽  
Isomer Shift ◽  
Debye Temperature ◽  
Quadrupole Splitting ◽  
Iron Deficiency Anemia ◽  
Public Health Problem ◽  
World Health ◽  
Deficiency Anemia ◽  
Mössbauer Measurements

The World Health Organization (WHO) considers iron deficiency anemia a serious public health problem in developing countries and recommends the use of iron tablets containing iron II for prevention and treatment. The results of Mössbauer measurements of the drug “Ferretab”, which is widely used in medicine for the treatment and prevention of iron deficiency anemia, are presented. This drug contains fumarate iron, C4H2FeO4, and has a small amount of folic acid. In this paper, the temperature dependence of isomer shift and quadrupole splitting values of 57Fe nuclei in iron fumarate were studied. The measurements show that when the temperature increases, the isomer shift and quadrupole splitting of 57Fe nuclei in iron fumarate decreases, the decrease in the isomer shift value is associated with the second-order Doppler effect. Based on Mössbauer measurements, the Debye temperature of this drug was determined. The Debye temperature gives us information about the strong bonding of 57Fe atoms with the environment. A high temperature value means a strong bond and vice versa, a small temperature value means a bond with low rigidity. The coupling constant (Debye temperature) defined for “Ferretab” iron nuclei has been compared with different Debye temperatures found in previous studies on some iron deficiency anemia drugs. Additionally, the values were compared with various clinical studies conducted in in-vivo and in-vitro for comparison of the efficacy of some of the most commonly used drugs to treat and prevent iron deficiency anemia. According to these comparisons, it was established a possible relationship between the Debye temperature of the iron atoms of the drugs under study and their effectiveness. It was noted that the lower the Debye temperature of iron atoms of the drug, the more iron absorbs the human body.

Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload

2018 ◽  
Vol 9 (10) ◽  
pp. 5390-5401 ◽  
Author(s):  
Huan He ◽  
Yang Qiao ◽  
Zeyu Zhang ◽  
Zelong Wu ◽  
Dan Liu ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Vitamin C ◽  
Iron Overload ◽  
Iron Deficiency Anemia ◽  
Liver Damage ◽  
Ferrous Iron ◽  
Reducing Agent ◽  
Deficiency Anemia ◽  
Iron Supplement ◽  
Dual Action

Vitamin C, an excellent reducing agent, aids in increasing absorbable ferrous iron in iron deficiency anemia.

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