Dual action of vitamin C in iron supplement therapeutics for iron deficiency anemia: prevention of liver damage induced by iron overload

2018 ◽  
Vol 9 (10) ◽  
pp. 5390-5401 ◽  
Author(s):  
Huan He ◽  
Yang Qiao ◽  
Zeyu Zhang ◽  
Zelong Wu ◽  
Dan Liu ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Vitamin C ◽  
Iron Overload ◽  
Iron Deficiency Anemia ◽  
Liver Damage ◽  
Ferrous Iron ◽  
Reducing Agent ◽  
Deficiency Anemia ◽  
Iron Supplement ◽  
Dual Action

Vitamin C, an excellent reducing agent, aids in increasing absorbable ferrous iron in iron deficiency anemia.

PITFALLS IN THE DIAGNOSIS AND TREATMENT OF IRON DEFICIENCY ANEMIA IN PEDIATRICS

PEDIATRICS ◽  
1964 ◽  
Vol 34 (1) ◽  
pp. 117-121
Author(s):  
David H. Clement
Keyword(s):  
Iron Deficiency ◽  
Physical Examination ◽  
Iron Deficiency Anemia ◽  
Ferrous Iron ◽  
Reticulocyte Count ◽  
Diagnosis And Treatment ◽  
Deficiency Anemia ◽  
Iron Stores ◽  
Mother Loss ◽  
Oral Preparation

Errors in the diagnosis and treatment of iron-deficiency anemia involve several areas. In the history one may overlook anemia in the mother, loss of infant blood from the placental circuit or later as melena, as well as a diet high in milk and low in iron-rich foods. In the physical examination pallor should not be estimated from facial color alone. In the laboratory a reticulocyte count should be determined before as well as during treatment. Regarding treatment it is important to give enough iron (6 mg/kg/day) for long enough to replenish iron stores. An effective, oral preparation of ferrous iron alone in gradually increasing doses is preferred. Failure to respond suggests several possibilities discussed above.

Effects of Oral Vitamin C on Hepcidin Levels and Erythropoietin Requirements in Functional Iron Deficiency Anemia among Hemodialysis Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mahmoud Mohamed Zaki Ali ◽  
Maha Abd ElMoniem Behairy ◽  
Reem Mohsen El Sharabasy ◽  
Ahmed Hamed Ahmed Gharib
Keyword(s):  
Iron Deficiency ◽  
Vitamin C ◽  
Iron Deficiency Anemia ◽  
Hemodialysis Patients ◽  
Deficiency Anemia ◽  
Study Group ◽  
Oral Vitamin ◽  
Functional Iron Deficiency ◽  
Serum Hepcidin ◽  
Hs Crp

Abstract Background Hepcidin has long been postulated as a key regulatory peptide in iron homeostasis. Its reduced clearance and elevated levels in hemodialysis (HD) patients lead to functional iron deficiency (FID) and ESA resistance. Vitamin C may be used as adjuvant therapy in FID anemia, but there are limited studies investigating the direct relation between vitamin C and hepcidin levels in HD patients. We aimed to test the reducing effect of Oral vitamin C therapy on hepcidin levels among hemodialysis patients with functional iron deficiency anemia. Patients and Methods This study is an open label randomized controlled clinical trial. It was conducted in the hemodialysis units of Ain Shams University hospitals. 48 adult prevalent HD patients were included and were divided into two groups. Group 1 (study group) included 31 patients who received the conventional treatment of erythropoietin stimulating agents (ESAs) together with oral supplementation of vitamin C 500 mg every other day for 3 months in addition to IV iron therapy. Group 2 (control group) included 17 patients who received only the conventional therapy of ESAs according to their hemoglobin (Hb) levels in addition to IV iron therapy. Laboratory parameters including serum hepcidin levels, highly sensitive CRP (hs-CRP) titer, CBC, kidney function tests and iron indices were measured at the baseline of the study and after 3 months. Results Oral vitamin C therapy resulted in a statistically significant reduction in both hepcidin and hs-CRP levels in the study group after 3 months. The study group showed a significant reduction in serum iron and ferritin levels (P < 0.05). A Decrease in EPO requirements and elevation of hemoglobin level were observed in the study group but were not statistically significant as a short term effect of oral vitamin C, in comparison to the control group. A highly significant correlation was observed between serum hepcidin and hs-CRP (R=0.46, P<0.01). Conclusion Oral vitamin C may be a promising therapy in decreasing serum hepcidin and hs-CRP levels in prevalent hemodialysis patients with functional iron deficiency anemia.

Concomitant Administration of Oral Iron Supplement with Antisecretory Agents among Hospitalized Adults with Iron Deficiency Anemia

2019 ◽  
Vol 119 (9) ◽  
pp. A22
Author(s):  
C. Sanchez ◽  
V. Rodriguez Aponte ◽  
A. Cintron Rosado ◽  
J. Molina Cruz ◽  
J. Morales Irizarry ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Concomitant Administration ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Iron Supplement

scholarly journals Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

Blood ◽  
2011 ◽  
Vol 117 (2) ◽  
pp. 647-650 ◽  
Author(s):  
Anne Lenoir ◽  
Jean-Christophe Deschemin ◽  
Léon Kautz ◽  
Andrew J. Ramsay ◽  
Marie-Paule Roth ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Serine Protease ◽  
Iron Deficiency Anemia ◽  
Iron Homeostasis ◽  
Deficiency Anemia ◽  
Hepatic Iron ◽  
Master Regulator ◽  
Liver Iron ◽  
The Relationship

Abstract Hepcidin is the master regulator of iron homeostasis. In the liver, iron-dependent hepcidin activation is regulated through Bmp6 and its membrane receptor hemojuvelin (Hjv), whereas, in response to iron deficiency, hepcidin repression seems to be controlled by a pathway involving the serine protease matriptase-2 (encoded by Tmprss6). To determine the relationship between Bmp6 and matriptase-2 pathways, Tmprss6−/− mice (characterized by increased hepcidin levels and anemia) and Bmp6−/− mice (exhibiting severe iron overload because of hepcidin deficiency) were intercrossed. We showed that loss of Bmp6 decreased hepcidin levels; increased hepatic iron; and, importantly, corrected hematologic abnormalities in Tmprss6−/− mice. This finding suggests that elevated hepcidin levels in patients with familial iron-refractory, iron-deficiency anemia are the result of excess signaling through the Bmp6/Hjv pathway.

scholarly journals Stomatitis sebagai Manifestasi Oral dari Anemia Defisiensi Zat Besi disertai Trombositosis

e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 181
Author(s):  
Sarah Mersil
Keyword(s):  
Iron Deficiency ◽  
Vitamin C ◽  
Triamcinolone Acetonide ◽  
Iron Deficiency Anemia ◽  
Deficiency Anemia ◽  
Ferrous Gluconate ◽  
Nutritional Anemia ◽  
Oral Manifestation ◽  
Vegetables And Fruits ◽  
Stomatitis Aphthosa

Abstract: Studies in Indonesia stated that the main cause of nutritional anemia in adolescents is due to lack of iron intake, which is called iron deficiency anemia. One of its oral manifestations is stomatitis. Thrombocytosis is also found in iron deficiency anemia. We reported a case of a 22-year-old female patient with complaints of stomatitis and further examination showed the occurrence of iron deficiency anemia and thrombocytosis. The patient was instructed to maintain good diet containing meat, vitamin C-rich vegetables and fruits, have good sleep pattern, take care of her oral health, and not to force herself to overwork. Triamcinolone acetonide in ora base 0.1% was applied on the lesion by using cotton bud after meal and before bedtime until the lesion disappeared or became painless. The patient was referred to an internist for further examination. After two weeks, the lesion had disappeared, and there was no new lesion. However, the patient had not checked to the internist, therefore, ferrous gluconate 250 mg twice daily was given to her for 30 days. In conclusion, the patient was diagnosed as stomatitis aphthosa as an oral manifestation of iron deficiency anemia associated with secondary thrombocytosis.Keywords: stomatitis, iron deficiency anemia, thrombocytosis Abstrak: Penelitian di Indonesia menyatakan bahwa penyebab utama terjadinya anemia gizi pada remaja ialah kurangnya asupan zat besi, yang disebut anemia defisiensi zat besi. Salah satu manifestasi oralnya ialah stomatitis. Kondisi trombositosis juga ditemukan pada anemia defisiensi zat besi. Kami melaporkan kasus seorang perempuan berusia 22 tahun dengan keluhan stomatitis dan hasil pemeriksaan penunjang menunjukkan anemia defisiensi zat besi dan trombositosis. Pasien diinstruksikan untuk menjaga pola makan yang baik dengan mengonsumsi daging serta buah dan sayuran mengandung vitamin C, tidur serta istirahat yang cukup, tidak memaksakan diri secara berlebihan, serta menjaga kebersihan mulut. Diberikan obat oles yaitu triamcinolone acetonide in orabase 0,1% untuk dioles pada lesi menggunakan cotton bud sehabis makan dan sebelum tidur sampai lesi sembuh atau tidak sakit lagi. Pasien dirujuk ke spesialis penyakit dalam untuk tindak lanjut dari kondisi sistemiknya. Kontrol setelah dua minggu sariawan sudah hilang, tidak muncul sariawan baru. Pasien belum ke dokter spesialis penyakit dalam untuk memeriksa kondisi anemia yang dideritanya. Oleh karena itu diberikan ferrous gluconate 250 mg dua kali sehari selama 30 hari. Simpulan kasus ini ialah suatu stomatitis sebagai salah satu manifestasi oral pada anemia defisiensi besi yang disertai trombositosis sekunder.Kata kunci: stomatitis, anemia defisiensi zat besi, trombositosis

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