scholarly journals Different Brain Activation after Acupuncture at Combined Acupoints and Single Acupoint in Hypertension Patients: An Rs-fMRI Study Based on ReHo Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Jiping Zhang ◽  
Xiaowen Cai ◽  
Yanjie Wang ◽  
Yu Zheng ◽  
Shanshan Qu ◽  
...  
Keyword(s):  
Language Production ◽  
Emotional Processing ◽  
Acupuncture Treatment ◽  
Image Data ◽  
Brain Regions ◽  
Primary Study ◽  
Brain Areas ◽  
Significant Difference ◽  
Before And After ◽  
Group 3

Background. Acupuncture is proved to be effective on hypertension by numerous studies and resting-state functional magnetic resonance imaging (Rs-fMRI) is a widely used technique to study its mechanism. Along with lower blood pressure, patients with hypertension receiving acupuncture also presented improvement in function of cognition, emotion, language, sematic sensation, and so on. This study was a primary study to explore the acting path of acupuncture at combined acupoints in stimulated brain areas related to such functions. Methods. In this research, regional homogeneity (ReHo) was applied to analyze the Rs-fMRI image data of brain activities after acupuncture at LR3, KI3, and LR3+KI3 and to compare the differences of functional brain activities between stimulating combined acupoints and single acupoint under pathological conditions. A total of thirty hypertension patients underwent Rs-fMRI scanning before acupuncture treatment and then were randomly divided into three groups following random number table, the LR3 group (3 males and 7 females), the KI3 group (3 males and 7 females), and the LR3+ KI3 group (4 males and 6 females) for needling, respectively. When the 30-min treatment finished, they received a further Rs-fMRI scanning. The Rs-fMRI data before and after the acupuncture treatment were analyzed through ReHo. Results. Compared with preacupuncture, respectively, ReHo values increased in Brodmann areas (BAs) 3, 18, and 40 and decreased in BAs 7 and 31 in LR3+ KI3 group. However, ReHo values only decreased in BA7 of KI3 group while the results showed no significant difference of brain regions in LR3 group between pre- and postacupuncture. Compared with LR3 group, LR3+KI3 group exhibited decreased ReHo values in BAs 7, 9, and 31. Meanwhile, compared with KI3 group, LR3+KI3 group exhibited increased ReHo values in the BAs 2, 18, 30, and 40 and decreased ReHo values in BA13. Conclusion. Combined acupoints of LR3 and KI3 could act on wider brain areas than the sum of single acupoints, whose functions include emotional processing, cognition, somatic sensation, spatial orientation, language production, and vision.

scholarly journals Cerebral Targeting of Acupuncture at Combined Acupoints in Treating Essential Hypertension: An Rs-fMRI Study and Curative Effect Evidence

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Yanjie Wang ◽  
Yu Zheng ◽  
Shanshan Qu ◽  
Jiping Zhang ◽  
Zheng Zhong ◽  
...  
Keyword(s):  
Mental Health ◽  
Synergistic Effect ◽  
Acupuncture Treatment ◽  
Brain Regions ◽  
Short Term ◽  
Curative Effect ◽  
Brain Areas ◽  
Fmri Study ◽  
Sf 36 ◽  
Before And After

The study attempted to explore that the synergistic effect of acupoints combination is not a simple superposition of single acupoint’s effect by comparing and analyzing the changes of blood pressure (BP), SF-36, and brain regions after acupuncture treatment. 47 patients were randomly divided into LR3+KI3 group, LR3 group, and KI3 group. Subjects received Rs-fMRI scan, BP measurement, and SF-36 questionnaires before and after treatment and short-term acupuncture treatment. After treatment, there were no significant differences in BP and SF-36 among 3 groups, compared to the case before treatment, SBP of 3 groups decreased, and DBP significantly decreased while vitality and mental health significantly increased in LR3+KI3 group. Both number and scopes of changes of brain regions in LR3+KI3 group were the largest, which mainly included BAs 3, 4, 8, 19, 21, 24, 32, 44, and 45. In conclusion, acupuncture at LR3+KI3 may auxiliarily reduce BP and improve the vitality and mental health of patients, and the changes of brain regions were related to somatesthesia, movement, vision, audition, emotion and mood, language, memory, etc. BAs 4, 9, 10, 24, 31, 32, and 46 may be the targeting brain areas of acupuncture in assisting hypotension. It is suggested that acupoints combination of LR3+KI3 maybe generates a synergistic effect, and it is not simple sum of single acupoint effect.

scholarly journals Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

2020 ◽  
Author(s):  
Xuan Wei ◽  
Han Lv ◽  
Qian Chen ◽  
Zhaodi Wang ◽  
Chunli Liu ◽  
...  
Keyword(s):  
Mixed Model ◽  
Pulse Sequence ◽  
Therapy Group ◽  
Image Data ◽  
Superior Temporal Gyrus ◽  
Brain Regions ◽  
Mixed Model Analysis ◽  
Sound Therapy ◽  
Before And After ◽  
Post Hoc

Abstract Background: Many neuroanatomical alterations have been detected in patients with tinnitus in previous studies. However, little is known about morphological and structural covariance network (SCN) changes before and after long-term sound therapy. This study aimed to explore alterations in brain anatomical and SCN changes in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis 24 weeks before and after sound therapy. Methods: Thirty-three tinnitus patients underwent magnetic resonance imaging scans at baseline and after 24 weeks of sound therapy. Twenty-six age- and sex-matched healthy control (HC) individuals also underwent two scans over a 24-week interval; 3.0T MRI and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was acquired in the tinnitus group to assess the severity of tinnitus and tinnitus-related distress. Two-way mixed model analysis of variance (ANOVA) and post hoc analyses were performed to determine differences between the two groups (patients and HCs) and between the two scans (at baseline and at the 24th week). Two-sample t tests, paired-samples t tests, and Pearson’s correlation analysis were used in the post hoc analysis.Results: Interaction effects between the two groups and the two scans demonstrated significantly different gray matter (GM) volume in the right parahippocampus gyrus, right caudate, left superior temporal gyrus, left cuneus gyrus and right calcarine gyrus; we found significantly decreased GM volume in the above five brain regions among the tinnitus patients before sound therapy (baseline) compared to that in the HC group. The 24-week sound therapy group demonstrated significantly greater brain volume compared with the baseline group among these brain regions. We did not find significant differences in brain regions between the 24-week sound therapy and HC groups. The SCN results showed that the left superior temporal gyrus and left rolandic operculum were significantly different in nodal efficiency, nodal degree centrality and nodal betweenness centrality after FDR correction. Decreased THI scores and GM volume changes between the left thalamus and right thalamus were not correlated. Conclusions: This study characterized the effect of sound therapy on brain GM volume, especially in the left superior temporal lobe. Notably, sound therapy had a normalizing effect on tinnitus patients.

scholarly journals A Clinical Randomized Controlled Trial of Acupuncture Treatment of Gastroparesis Using Different Acupoints

2020 ◽  
Vol 2020 ◽  
pp. 1-14 ◽  
Author(s):  
Wu Xuefen ◽  
Li Ping ◽  
Liu Li ◽  
Chen Xiaoli ◽  
Zenghui Yue
Keyword(s):  
Acupuncture Treatment ◽  
Controlled Trial ◽  
Barium Meal ◽  
Synergy Effect ◽  
Gastric Emptying Rate ◽  
Sf 36 ◽  
Significant Difference ◽  
Before And After ◽  
Group A ◽  
Group B

Objective. To explore the effect of “selecting acupoints by site” on the synergy effect of “acupoint compatibility” according to the clinical efficacy of acupuncture treatment of patients with gastroparesis. Methods. A total of 99 patients who met the diagnostic criteria for gastroparesis were enrolled in 3 clinical centers and randomly divided into group A (33 cases), group B (33 cases, 1 case of shedding), and group C (33 cases, 1 case of shedding). In group A, acupuncture was performed at Zhongwan (CV 12) and Zusanli (ST 36); in group B, acupuncture was performed at Neiguan (PC 6) and Zusanli (ST 36); in group C, acupuncture was performed at nonacupoint and Zusanli (ST 36). Treatment was performed for 30 minutes every day, 5 days as a course of treatment. There were 2 days off between courses and three courses in total. Differences in a main symptom index of gastroparesis (GCSI) scores, 9 symptom scores, and a health questionnaire (SF-36) were compared between each group before and after treatment and 4 weeks after the end of treatment. The difference of gastric emptying rate was compared before and after treatment. Results. The GCSI scores of each group after treatment and at follow-up were significantly lower than those before treatment (P<0.01), and the reduction in group A was greater than that of groups B and C (P<0.01). The score of each symptom was meaningfully lower than that before treatment (P<0.01 or P<0.05). The effect was best in group A, followed by group B. After treatment, the barium meal in the stomach of the three groups was significantly reduced compared with before treatment (P<0.01). There was no statistical difference between the groups. The results of SF-36 showed that acupuncture treatment can improve health status, to a certain extent, and there was no significant difference in the three groups. Conclusion. (1) Acupuncture is an effective method for the treatment of gastroparesis. (2) The combination of Zhongwan (CV 12) with Zusanli (ST 36) showed the most promising effect on relief of the symptoms in patients with gastroparesis. (3) “Selecting acupoints by site” is the key factor affecting the synergy effect of “acupoint compatibility.” This trial was registered with the International Center for Clinical Trials (registration no. NCT02594397).

scholarly journals Networks Are Associated With Acupuncture Treatment in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: A Resting-State Imaging Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Tingting Zhao ◽  
Lixia Pei ◽  
Houxu Ning ◽  
Jing Guo ◽  
Yafang Song ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Connectivity ◽  
Resting State ◽  
Large Scale ◽  
Acupuncture Treatment ◽  
Brain Regions ◽  
Attention Network ◽  
Frontoparietal Network ◽  
Before And After ◽  
Irritable Bowel

Background: Irritable Bowel Syndrome (IBS), as a functional gastrointestinal disorder, is characterized by abdominal pain and distension. Recent studies have shown that acupuncture treatment improves symptoms of diarrhea-predominant irritable bowel syndrome (IBS-D) by altering networks in certain brain regions. However, few studies have used resting-state functional magnetic resonance imaging (fMRI) to compare altered resting-state inter-network functional connectivity in IBS-D patients before and after acupuncture treatment.Objective: To analyze altered resting-state inter-network functional connectivity in IBS-D patients before and after acupuncture treatment.Methods: A total of 74 patients with IBS-D and 31 healthy controls (HCs) were recruited for this study. fMRI examination was performed in patients with IBS-D before and after acupuncture treatment, but only at baseline in HCs. Data on the left frontoparietal network (LFPN), default mode network (DMN), salience network (SN), ventral attention network (VAN), auditory network (AN), visual network (VN), sensorimotor network (SMN), dorsal attention network (DAN), and right frontoparietal network (RFPN) were subjected to independent component analysis (ICA). The functional connectivity values of inter-network were explored.Results: Acupuncture decreased irritable bowel syndrome symptom severity score (IBS-SSS) and Hamilton Anxiety Scale (HAMA). It also ameliorated symptoms related to IBS-D. Notably, functional connectivity between AN and VAN, SMN and DMN, RFPN and VAN in IBS-D patients after acupuncture treatment was different from that in HCs. Furthermore, there were differences in functional connectivity between DMN and DAN, DAN and LFPN, DMN and VAN before and after acupuncture treatment. The inter-network changes in DMN-VAN were positively correlated with changes in HAMA, life influence degree, and IBS-SSS in IBS-D.Conclusion: Altered inter-network functional connectivity is involved in several important hubs in large-scale networks. These networks are altered by acupuncture stimulation in patients with IBS-D.

scholarly journals Kekerasan permukaan email setelah aplikasi gel karbamid peroksida 10%

2016 ◽  
Vol 8 (2) ◽  
pp. 118
Author(s):  
Pambudi Santoso T
Keyword(s):  
Mineral Water ◽  
Enamel Surface ◽  
Carbamide Peroxide ◽  
Significant Difference ◽  
Before And After ◽  
Alternative Material ◽  
Group 3 ◽  
Group 2 ◽  
One Way Anova ◽  
Control Post

The influence of strawberries as bleaching alternative material toward surfacemicrohardness of the teeth is still unknown so that a research should be conducted toquantitatively assess the effects of bleaching with 10% carbamide peroxide andblended strawberry paste on post-extracted incisive teeth by performing superficialmicrohardness analysis. Three groups of sample i.e. group 1 (control): post-extractedincisive teeth soaked in ordinary mineral water, group 2: soaked in carbamideperoxide 10% gel, and group 3: soaked in 100% strawberry paste. The microhardessof each sample group is tested before and after the application of bleaching materials.The result was there was significant difference of strawberry paste compared to CP10% gel and mineral water soaked incisive teeth. The data obtained are tabulated,then analyzed with one way Anova and LSD. It can be concluded that the applicationof carbamide peroxide 10% gel in 6 weeks doesn’t decrease the microhardness ofteeth enamel surface. However, the application of strawberry paste decreases themicrohardness of enamel surface

scholarly journals Saliva Contamination Effect on Shear Bond Strength of Self-etching Primer with Different Debond Times

2007 ◽  
Vol 77 (5) ◽  
pp. 901-906 ◽  
Author(s):  
Tamer Turk ◽  
Selma Elekdag-Turk ◽  
Devrim Isci ◽  
Fethiye Cakmak ◽  
Nurhat Ozkalayci
Keyword(s):  
Control Group ◽  
Group 4 ◽  
Contamination Effect ◽  
Significant Difference ◽  
Before And After ◽  
Group 3 ◽  
Bond Strengths ◽  
Group 2 ◽  
Saliva Contamination ◽  
Group 1

Abstract Objective: To evaluate shear bond strengths (SBSs) of a self-etching primer (SEP) following saliva contamination at different stages of bonding at debond times of 5, 15, and 30 minutes and 24 hours. Materials and Methods: Two-hundred forty human premolars were divided into four groups: group 1, uncontaminated; group 2, saliva contamination after priming; group 3, saliva contamination before priming; and group 4, saliva contamination before and after priming. Four subgroups according to debond times of 5, 15, 30 minutes and 24 hours were composed. Metal brackets were bonded with an SEP (Transbond Plus) and light-cure adhesives paste (Transbond XT). SBS values and the adhesive remnants were determined. Results: The highest SBS was obtained at a debond time of 24 hours for the control group. This was significantly different from the other groups. SBSs at 5, 15, and 30 minutes showed no significant difference from each other in the control group (P &gt; .05). Lowest SBSs were obtained at a debond time of 5 minutes for groups 1, 2, 3, and 4 (8.38, 7.10, 7.06, and 6.26 MPa, respectively) and were not significantly different from each other (P &gt; .05). SBSs at 24 hours were not significantly different from each other for groups 2, 3, and 4 (P &gt; .05). Significant differences were found in the adhesive remnant (P &lt; .001). Conclusions: SEP (Transbond Plus) may produce clinically acceptable bracket bonding after 5, 15, and 30 minutes from time of placement on the teeth, even with light and heavy saliva contamination.

scholarly journals EFEKTIVITAS LAYANAN BIMBINGAN KELOMPOK DALAM MENINGKATKAN ASERTIVITAS SISWA

2018 ◽  
Author(s):  
Firman - Firman
Keyword(s):  
Computer Software ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
Equivalent Control ◽  
Kolmogorov Smirnov ◽  
Group 3 ◽  
The Difference ◽  
Group 2 ◽  
Group Guidance

Nowadays found some student at SMK N 9 Padang prefer to follow a decision of a friend than follow self decision. This research to reveal; 1) the difference assertiveness students group experiment before and after given group guidance 2) the difference assertiveness students the control group before and after without group guidance 3) the difference assertiveness student group experiment given group guidance with student the control group without given group guidance. This research is a quantitative with approach Quasi Experiment Design in type design the Non Equivalent Control Group. The population research was students of X Tata Boga SMK N 9 Padang and samples in this research chosen using a technique purposive sampling. The instrumen used the Questionare. Data then analyzed using Wilcoxon Signed Ranks Test and Kolmogorov Smirnov Two Independent Samples with program computer software Statistical Product and Service Solution (SPSS) Version 20. Based on the research, this research founds; 1) there are significant difference assertiveness students group experiment before and after given guidance group 2) there is no significant difference assertiveness students the control group before and after without given guidance group 3) there are significant difference assertiveness students the experiment group given guidance group with the control group without given guidance group.

scholarly journals Cortical Thickness Alterations in Patients With Tinnitus Before and After Sound Therapy: A Surface-Based Morphometry Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Xuan Wei ◽  
Han Lv ◽  
Qian Chen ◽  
Zhaodi Wang ◽  
Chunli Liu ◽  
...  
Keyword(s):  
Parietal Cortex ◽  
Cortical Thickness ◽  
Mixed Model ◽  
Pulse Sequence ◽  
Brain Regions ◽  
Posterior Cingulate Cortex ◽  
Sound Therapy ◽  
Significant Difference ◽  
Before And After ◽  
Surface Based Morphometry

This study aimed to explore brain surface-based morphometry cortical thickness changes in patients with idiopathic tinnitus before and after 24 weeks of sound therapy. In this prospective observational study, we recruited 33 tinnitus patients who had undergone 24 weeks of sound therapy and 26 matched healthy controls. For the two groups of subjects, a 3D-BRAVO pulse sequence was acquired both at baseline and at the 24th week. Structural image data preprocessing was performed using the DPABISurf toolbox. The Tinnitus Handicap Inventory (THI) score was assessed to determine the severity of tinnitus before and after treatment. Two-way mixed-model analysis of variance (ANOVA) and Pearson’s correlation analysis were used in the statistical analysis. Student–Newman–Keuls (SNK) tests were used in the post hoc analysis. Significantly lower cortical thickness was found in the left somatosensory and motor cortex (SMC), left posterior cingulate cortex (PCC), and right orbital and polar frontal cortex (OPFC) of the participants in the tinnitus group at baseline than in the participants in the HC group at baseline and after 24 weeks; in the tinnitus group, significantly higher cortical thickness was found after the 24 weeks sound therapy in comparison to the baseline in the left SMC, bilateral superior parietal cortex (SPC), left inferior parietal cortex (IPC), left PCC, and right OPFC. In the HC group, no statistically significant difference in cortical thickness was found after the 24 weeks treatment in comparison to the baseline in the bilateral SMC, bilateral SPC, left IPC, left PCC, or right OPFC. The changes in cortical thickness before and after sound therapy can provide certain reference values for clinical tinnitus treatment. These brain regions could serve as potential targets for neuroimaging.

scholarly journals Neuroanatomical Alterations in Patients With Tinnitus Before and After Sound Therapy: A Combined VBM and SCN Study

2021 ◽  
Vol 14 ◽  
Author(s):  
Xuan Wei ◽  
Han Lv ◽  
Qian Chen ◽  
Zhaodi Wang ◽  
Chunli Liu ◽  
...  
Keyword(s):  
Mixed Model ◽  
Pulse Sequence ◽  
Therapy Group ◽  
Image Data ◽  
Superior Temporal Gyrus ◽  
Brain Regions ◽  
Mixed Model Analysis ◽  
Sound Therapy ◽  
Before And After ◽  
Post Hoc

Many neuroanatomical alterations have been detected in patients with tinnitus in previous studies. However, little is known about the morphological and structural covariance network (SCN) changes before and after long-term sound therapy. This study aimed to explore alterations in brain anatomical and SCN changes in patients with idiopathic tinnitus using voxel-based morphometry (VBM) analysis 24 weeks before and after sound therapy. Thirty-three tinnitus patients underwent magnetic resonance imaging scans at baseline and after 24 weeks of sound therapy. Twenty-six age- and sex-matched healthy control (HC) individuals also underwent two scans over a 24-week interval; 3.0T MRI and high-resolution 3D structural images were acquired with a 3D-BRAVO pulse sequence. Structural image data preprocessing was performed using the VBM8 toolbox. The Tinnitus Handicap Inventory (THI) score was assessed for the severity of tinnitus before and after treatment. Two-way mixed model analysis of variance (ANOVA) and post hoc analyses were performed to determine differences between the two groups (patients and HCs) and between the two scans (at baseline and on the 24th week). Student-Newman-Keuls (SNK) tests were used in the post hoc analysis. Interaction effects between the two groups and the two scans demonstrated significantly different gray matter (GM) volume in the right parahippocampus gyrus, right caudate, left superior temporal gyrus, left cuneus gyrus, and right calcarine gyrus; we found significantly decreased GM volume in the above five brain regions among the tinnitus patients before sound therapy (baseline) compared to that in the HC group. The 24-week sound therapy group demonstrated significantly greater brain volume compared with the baseline group among these brain regions. We did not find significant differences in brain regions between the 24-week sound therapy and HC groups. The SCN results showed that the left superior temporal gyrus and left rolandic operculum were significantly different in nodal efficiency, nodal degree centrality, and nodal betweenness centrality after FDR correction. This study characterized the effect of sound therapy on brain GM volume, especially in the left superior temporal lobe. Notably, sound therapy had a normalizing effect on tinnitus patients.

scholarly journals There Is More to Mindfulness Than Emotion Regulation: A Study on Brain Structural Networks

2021 ◽  
Vol 12 ◽  
Author(s):  
Sabina Baltruschat ◽  
Antonio Cándido ◽  
Antonio Maldonado ◽  
Carmen Verdejo-Lucas ◽  
Elvira Catena-Verdejo ◽  
...  
Keyword(s):  
Emotion Regulation ◽  
Emotional Processing ◽  
Semantic Processing ◽  
Emotional Reactivity ◽  
Brain Regions ◽  
Five Facet Mindfulness Questionnaire ◽  
Dispositional Mindfulness ◽  
Neural Basis ◽  
Brain Areas ◽  
Structural Networks

Dispositional mindfulness and emotion regulation are two psychological constructs closely interrelated, and both appear to improve with the long-term practice of mindfulness meditation. These constructs appear to be related to subcortical, prefrontal, and posterior brain areas involved in emotional processing, cognitive control, self-awareness, and mind wandering. However, no studies have yet discerned the neural basis of dispositional mindfulness that are minimally associated with emotion regulation. In the present study, we use a novel brain structural network analysis approach to study the relationship between structural networks and dispositional mindfulness, measured with two different and widely used instruments [Mindfulness Attention Awareness Scale (MAAS) and Five Facet Mindfulness Questionnaire (FFMQ)], taking into account the effect of emotion regulation difficulties. We observed a number of different brain regions associated with the different scales and dimensions. The total score of FFMQ and MAAS overlap with the bilateral parahippocampal and fusiform gyri. Additionally, MAAS scores were related to the bilateral hippocampus and the FFMQ total score to the right insula and bilateral amygdala. These results indicate that, depending on the instrument used, the characteristics measured could differ and could also involve different brain systems. However, it seems that brain areas related to emotional reactivity and semantic processing are generally related to Dispositional or trait mindfulness (DM), regardless of the instrument used.

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